MARA contact LORENZI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Defective myogenic response to posture change in retinal vessels of well-controlled type 1 diabetic patients with no retinopathy
    Mara Lorenzi
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 51:6770-5. 2010
  2. pmc The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient
    Mara Lorenzi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Diabetes Res 2007:61038. 2007
  3. pmc Retinal haemodynamics in individuals with well-controlled type 1 diabetes
    M Lorenzi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, and Diabetes Center and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Diabetologia 51:361-4. 2008
  4. ncbi request reprint Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    Zeina Dagher
    Harvard Medical School, Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 53:2404-11. 2004
  5. pmc The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy
    Chiara Gerhardinger
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Diabetes 58:1659-67. 2009
  6. ncbi request reprint Mechanisms and strategies for prevention in diabetic retinopathy
    Mara Lorenzi
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Curr Diab Rep 6:102-7. 2006
  7. ncbi request reprint Aspirin at low-intermediate concentrations protects retinal vessels in experimental diabetic retinopathy through non-platelet-mediated effects
    Wei Sun
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford St, Boston, Massachusetts 02114, USA
    Diabetes 54:3418-26. 2005
  8. ncbi request reprint A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy
    Wei Sun
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 55:2757-62. 2006
  9. ncbi request reprint A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    Veronica Asnaghi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 52:506-11. 2003
  10. ncbi request reprint Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
    Giulio Romeo
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Diabetes 51:2241-8. 2002

Collaborators

Detail Information

Publications11

  1. doi request reprint Defective myogenic response to posture change in retinal vessels of well-controlled type 1 diabetic patients with no retinopathy
    Mara Lorenzi
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 51:6770-5. 2010
    ..The authors sought to identify early abnormalities of retinal vessels that are not prevented by the current therapeutic approach...
  2. pmc The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient
    Mara Lorenzi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Diabetes Res 2007:61038. 2007
    ....
  3. pmc Retinal haemodynamics in individuals with well-controlled type 1 diabetes
    M Lorenzi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, and Diabetes Center and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Diabetologia 51:361-4. 2008
    ..Based on this, the aim of this study was to investigate whether patients with type 1 diabetes treated entirely or mostly in the post-DCCT era and tested in the absence of confounding factors show retinal haemodynamic abnormalities...
  4. ncbi request reprint Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    Zeina Dagher
    Harvard Medical School, Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 53:2404-11. 2004
    ..Excess aldose reductase activity can be a mechanism for human diabetic retinopathy...
  5. pmc The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy
    Chiara Gerhardinger
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Diabetes 58:1659-67. 2009
    ..We aimed to identify candidate drug targets by investigating the molecular effects of drugs that prevent retinal capillary demise in the diabetic rat...
  6. ncbi request reprint Mechanisms and strategies for prevention in diabetic retinopathy
    Mara Lorenzi
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Curr Diab Rep 6:102-7. 2006
    ..The challenge for the next few years is to find ways faster than clinical trials to ascertain the relevance to human diabetic retinopathy of adjunct drugs successful in animal studies...
  7. ncbi request reprint Aspirin at low-intermediate concentrations protects retinal vessels in experimental diabetic retinopathy through non-platelet-mediated effects
    Wei Sun
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford St, Boston, Massachusetts 02114, USA
    Diabetes 54:3418-26. 2005
    ..Aspirin at low-intermediate concentrations selectively prevented microangiopathy. The minimal effective dose of aspirin should now be sought...
  8. ncbi request reprint A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy
    Wei Sun
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 55:2757-62. 2006
    ....
  9. ncbi request reprint A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    Veronica Asnaghi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 52:506-11. 2003
    ..These findings have implications for how to evaluate the role of the polyol pathway in diabetic retinopathy...
  10. ncbi request reprint Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
    Giulio Romeo
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Diabetes 51:2241-8. 2002
    ..A proapoptotic program triggered by NF-kappaB selectively in retinal pericytes in response to hyperglycemia is a possible mechanism for the early demise of pericytes in diabetic retinopathy...
  11. ncbi request reprint Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy
    Jing Zhang
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Diabetes 51:3499-504. 2002
    ..These are novel clues for probing how diabetes affects and damages vascular cells...

Research Grants18

  1. Mechanisms of action of drugs that prevent experimental diabetic retinopathy
    MARA contact LORENZI; Fiscal Year: 2010
    ....
  2. Retinal Blood Flow and Microthrombi in Type 1 Diabetes
    Mara Lorenzi; Fiscal Year: 2004
    ....
  3. HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Mara Lorenzi; Fiscal Year: 2002
    ..If a chain of causal relationships is established, the studies will bring to the fore targets for rational interventions. ..
  4. HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Mara Lorenzi; Fiscal Year: 1993
    ..In addition, since the DNA repair mechanisms are under genetic control, the occurrence of DNA damage-repair may be envisioned to play a role in the different individual susceptibility to diabetic vascular complications...
  5. HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Mara Lorenzi; Fiscal Year: 1999
    ..Lastly, cell cultures of retinal microvascular pericytes and endothelial cells will be used to determine whether elevated hexose can initiate apoptosis (and if so, by what mechanism) and/or have an effect on the expression of IGF-I. ..
  6. Mechanisms of action of drugs that prevent experimental diabetic retinopathy
    MARA contact LORENZI; Fiscal Year: 2010
    ..In addition, the studies are poised to generate a paradigm for applications of anti-TGF- therapy to other pathologies. ..