SHAHIN contact LOCKMAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial
    Shahin Lockman
    Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 9:e1001236. 2012
  2. doi request reprint Treatment-for-prevention: clinical considerations
    Shahin Lockman
    Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 7:131-9. 2012
  3. pmc Antiretroviral therapies in women after single-dose nevirapine exposure
    Shahin Lockman
    Brigham and Women s Hospital, Boston, MA, USA
    N Engl J Med 363:1499-509. 2010
  4. ncbi request reprint Reduction of HIV-1 drug resistance after intrapartum single-dose nevirapine
    Shahin Lockman
    Brigham and Women s Hospital, Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 370:1668-70. 2007
  5. pmc Molecular and conventional epidemiology of Mycobacterium tuberculosis in Botswana: a population-based prospective study of 301 pulmonary tuberculosis patients
    S Lockman
    Division of Tuberculosis Elimination, National Centers for HIV AIDS, STD and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road N E, MS E 10, Atlanta, GA 30333, USA
    J Clin Microbiol 39:1042-7. 2001
  6. ncbi request reprint Response to antiretroviral therapy after a single, peripartum dose of nevirapine
    Shahin Lockman
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 356:135-47. 2007
  7. ncbi request reprint Etiology of pulmonary infections in predominantly HIV-infected adults with suspected tuberculosis, Botswana
    S Lockman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Int J Tuberc Lung Dis 7:714-23. 2003
  8. ncbi request reprint Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS 20:1281-8. 2006
  9. ncbi request reprint Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
  10. pmc Minor resistant variants in nevirapine-exposed infants may predict virologic failure on nevirapine-containing ART
    Iain J MacLeod
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Ave, Boston, MA 02115, United States
    J Clin Virol 48:162-7. 2010

Detail Information

Publications27

  1. pmc Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial
    Shahin Lockman
    Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 9:e1001236. 2012
    ..Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based initial ART...
  2. doi request reprint Treatment-for-prevention: clinical considerations
    Shahin Lockman
    Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 7:131-9. 2012
    ..toxicity, adherence, drug resistance, and risk compensation...
  3. pmc Antiretroviral therapies in women after single-dose nevirapine exposure
    Shahin Lockman
    Brigham and Women s Hospital, Boston, MA, USA
    N Engl J Med 363:1499-509. 2010
    ..Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus...
  4. ncbi request reprint Reduction of HIV-1 drug resistance after intrapartum single-dose nevirapine
    Shahin Lockman
    Brigham and Women s Hospital, Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 370:1668-70. 2007
  5. pmc Molecular and conventional epidemiology of Mycobacterium tuberculosis in Botswana: a population-based prospective study of 301 pulmonary tuberculosis patients
    S Lockman
    Division of Tuberculosis Elimination, National Centers for HIV AIDS, STD and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road N E, MS E 10, Atlanta, GA 30333, USA
    J Clin Microbiol 39:1042-7. 2001
    ..DNA fingerprinting helps determine loci of TB transmission in the community...
  6. ncbi request reprint Response to antiretroviral therapy after a single, peripartum dose of nevirapine
    Shahin Lockman
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 356:135-47. 2007
    ..A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants...
  7. ncbi request reprint Etiology of pulmonary infections in predominantly HIV-infected adults with suspected tuberculosis, Botswana
    S Lockman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Int J Tuberc Lung Dis 7:714-23. 2003
    ..In countries with high HIV rates, diagnosis of lower respiratory disease etiology is both challenging and clinically important...
  8. ncbi request reprint Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS 20:1281-8. 2006
    ..Single-dose nevirapine given to women and infants reduces mother-to-child HIV transmission, but nevirapine resistance develops in a large percentage of women...
  9. ncbi request reprint Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study
    Ibou Thior
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 296:794-805. 2006
    ..Postnatal transmission of human immunodeficiency virus-1 (HIV) via breastfeeding reverses gains achieved by perinatal antiretroviral interventions...
  10. pmc Minor resistant variants in nevirapine-exposed infants may predict virologic failure on nevirapine-containing ART
    Iain J MacLeod
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Ave, Boston, MA 02115, United States
    J Clin Virol 48:162-7. 2010
    ..This may result in NVP resistance in both mother and infant. The significance of low levels of NVP resistance mutations in infants treated with NVP-containing antiretroviral treatment (ART) is unknown...
  11. pmc Ultrasensitive detection of minor drug-resistant variants for HIV after nevirapine exposure using allele-specific PCR: clinical significance
    Christopher F Rowley
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    AIDS Res Hum Retroviruses 26:293-300. 2010
    ..These data suggest a clinical role for highly sensitive assays to detect and quantify resistant viruses at low frequencies...
  12. ncbi request reprint Comparative prediction of perinatal human immunodeficiency virus type 1 transmission, using multiple virus load markers
    Monty Montano
    Harvard School of Public Health, Boston, Massachusetts, USA
    J Infect Dis 188:406-13. 2003
    ..30; 95% CI, 2.11-50.38). When blood HIV-1 DNA load was combined with CVF HIV-1 DNA load, the association with transmission increased (OR, 25.0; 95% CI 2.73-228.60)...
  13. pmc Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicity
    Andrea L Ciaranello
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    AIDS 22:2359-69. 2008
    ..We sought to identify the currently recommended regimen to prevent mother-to-child transmission that optimally balances risks of pediatric HIV infection and neurologic mitochondrial toxicity...
  14. doi request reprint Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, Botswana
    Jennifer Y Chen
    Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 54:102-6. 2010
    ..We analyzed rates of HIV testing, CD4 cell count testing, and HAART initiation during pregnancy...
  15. ncbi request reprint Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in Botswana
    Roger L Shapiro
    Botswana Harvard AIDS Institute Partnership, Botswana
    AIDS Educ Prev 15:221-30. 2003
    ..Breast examination may be a useful adjunct to self-report, but needs to be validated and standardized. Low adherence to infant feeding strategies that differ from local norms will reduce their effectiveness in preventing MTCT...
  16. pmc Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana
    Roger L Shapiro
    Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
    J Infect Dis 199:414-8. 2009
    ..001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652...
  17. ncbi request reprint Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:713-9. 2005
    ..The ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described...
  18. ncbi request reprint Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana
    Roger L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Infect Dis 196:562-9. 2007
    ..Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown...
  19. pmc Improvement in allele-specific PCR assay with the use of polymorphism-specific primers for the analysis of minor variant drug resistance in HIV-1 subtype C
    Christopher F Rowley
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Lowry Building, Suite GB, 110 Francis Street, Boston, MA 02215, USA
    J Virol Methods 149:69-75. 2008
    ..15-1.36% and 5.20-5.71% resistance for the same 1% and 5% samples. The results demonstrate the need to account for sequence polymorphisms when designing and implementing this highly specific assay...
  20. ncbi request reprint Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment
    Roger L Shapiro
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 192:720-7. 2005
    ..The magnitude of infant antiretroviral (ARV) exposure from breast milk is unknown...
  21. ncbi request reprint Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 50:849-57. 2004
    ..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect...
  22. ncbi request reprint Serum concentrations of antimycobacterial drugs in patients with pulmonary tuberculosis in Botswana
    Jordan W Tappero
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 41:461-9. 2005
    ..We conducted a pharmacokinetic study of antimycobacterial drugs involving a cohort of patients with pulmonary tuberculosis (TB) in Gaborone, Botswana, to assess the prevalence of and risk factors for low drug concentrations in serum...
  23. pmc The design and validation of a novel phenotypic assay to determine HIV-1 coreceptor usage of clinical isolates
    Nina H Lin
    Infectious Diseases Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 504, Boston, MA 02114, USA
    J Virol Methods 169:39-46. 2010
    ..This assay provides a sensitive, efficient and relatively low-cost approach suitable for use by research laboratories for assessing HIV-1 coreceptor usage of plasma samples...
  24. pmc Acceptability of infant male circumcision as part of HIV prevention and male reproductive health efforts in Gaborone, Botswana, and surrounding areas
    Rebeca M Plank
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    AIDS Behav 14:1198-202. 2010
    ..Neonatal male circumcision appears to be acceptable in Botswana and deserves urgent attention in resource-limited regions with high HIV prevalence, with the aim to expand services in safe, culturally acceptable and sustainable ways...
  25. ncbi request reprint Roundtable. Revisiting the role of single-dose nevirapine for preventing perinatal HIV transmission
    Hoosen Coovadia
    AIDS Clin Care 17:61-4. 2005
  26. pmc Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infants
    Woong Hwan Bae
    Harvard College, Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
    AIDS 22:1633-40. 2008
    ..To assess hematologic and hepatic toxicities associated with in utero and breastfeeding exposure to maternal highly active antiretroviral therapy (HAART) among infants in Botswana...
  27. pmc Voluntary counseling and testing among post-partum women in Botswana
    Ibou Thior
    The Botswana Harvard AIDS Institute Partnership, Botswana
    Patient Educ Couns 65:296-302. 2007
    ..To determine uptake and socio-demographics predictors of acceptance of voluntary counseling and testing (VCT) among post-partum women in Botswana...

Research Grants10

  1. Effects of HIV and ARV Exposure on Child Health and Neurodevelopment in Botswana.
    SHAHIN contact LOCKMAN; Fiscal Year: 2010
    ..We hope to evaluate both of these questions in Botswana in order to improve neurodevelopmental and health outcomes among children born to HIV-infected mothers globally. ..
  2. Maternal and Infant Health and HAART Outcomes in the Mashi PMTCT Study, Botswana
    Shahin Lockman; Fiscal Year: 2009
    ..placebo exposure; and pediatric neurodevelopmental and growth outcomes, by infant feeding modality and antiretroviral exposure history. ..
  3. Health of HIV-Infected Mothers after pMTCT, Botswana
    Shahin Lockman; Fiscal Year: 2007
    ..This already-existing cohort with access to ART provides a unique opportunity to answer questions that have significant public health implications with a relatively small investment of additional resources. ..
  4. RESPIRATORY DISEASES/BSI STUDY
    Shahin Lockman; Fiscal Year: 2004
    ....
  5. Maternal and Infant Health and HAART Outcomes in the Mashi PMTCT Study, Botswana
    Shahin Lockman; Fiscal Year: 2010
    ..placebo exposure;and pediatric neurodevelopmental and growth outcomes, by infant feeding modality and antiretroviral exposure history. ..