Research Topics
| SHAHIN contact LOCKMANSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trialShahin Lockman
Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS Med 9:e1001236. 2012..Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based initial ART...
Treatment-for-prevention: clinical considerationsShahin Lockman
Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
Curr Opin HIV AIDS 7:131-9. 2012..toxicity, adherence, drug resistance, and risk compensation...- Antiretroviral therapies in women after single-dose nevirapine exposureShahin Lockman
Brigham and Women s Hospital, Boston, MA, USA
N Engl J Med 363:1499-509. 2010..Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus... 
Reduction of HIV-1 drug resistance after intrapartum single-dose nevirapineShahin Lockman
Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA 02115, USA
Lancet 370:1668-70. 2007- Molecular and conventional epidemiology of Mycobacterium tuberculosis in Botswana: a population-based prospective study of 301 pulmonary tuberculosis patientsS Lockman
Division of Tuberculosis Elimination, National Centers for HIV AIDS, STD and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road N E, MS E 10, Atlanta, GA 30333, USA
J Clin Microbiol 39:1042-7. 2001..DNA fingerprinting helps determine loci of TB transmission in the community... - Response to antiretroviral therapy after a single, peripartum dose of nevirapineShahin Lockman
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 356:135-47. 2007..A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants... - Etiology of pulmonary infections in predominantly HIV-infected adults with suspected tuberculosis, BotswanaS Lockman
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Int J Tuberc Lung Dis 7:714-23. 2003..In countries with high HIV rates, diagnosis of lower respiratory disease etiology is both challenging and clinically important... - Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
AIDS 20:1281-8. 2006..This strategy avoids the potential for maternal nevirapine resistance... - Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi StudyIbou Thior
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 296:794-805. 2006..These results demonstrate the risk of formula feeding to infants in sub-Saharan Africa, and the need for studies of alternative strategies. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00197587... - Minor resistant variants in nevirapine-exposed infants may predict virologic failure on nevirapine-containing ARTIain J MacLeod
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Ave, Boston, MA 02115, United States
J Clin Virol 48:162-7. 2010..This may result in NVP resistance in both mother and infant. The significance of low levels of NVP resistance mutations in infants treated with NVP-containing antiretroviral treatment (ART) is unknown... - Ultrasensitive detection of minor drug-resistant variants for HIV after nevirapine exposure using allele-specific PCR: clinical significanceChristopher F Rowley
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
AIDS Res Hum Retroviruses 26:293-300. 2010..These data suggest a clinical role for highly sensitive assays to detect and quantify resistant viruses at low frequencies... - Comparative prediction of perinatal human immunodeficiency virus type 1 transmission, using multiple virus load markersMonty Montano
Harvard School of Public Health, Boston, Massachusetts, USA
J Infect Dis 188:406-13. 2003..30; 95% CI, 2.11-50.38). When blood HIV-1 DNA load was combined with CVF HIV-1 DNA load, the association with transmission increased (OR, 25.0; 95% CI 2.73-228.60)... - Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicityAndrea L Ciaranello
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
AIDS 22:2359-69. 2008..We sought to identify the currently recommended regimen to prevent mother-to-child transmission that optimally balances risks of pediatric HIV infection and neurologic mitochondrial toxicity... - Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, BotswanaJennifer Y Chen
Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 54:102-6. 2010..We analyzed rates of HIV testing, CD4 cell count testing, and HAART initiation during pregnancy... - Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in BotswanaRoger L Shapiro
Botswana Harvard AIDS Institute Partnership, Botswana
AIDS Educ Prev 15:221-30. 2003..Breast examination may be a useful adjunct to self-report, but needs to be validated and standardized. Low adherence to infant feeding strategies that differ from local norms will reduce their effectiveness in preventing MTCT... - Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in BotswanaRoger L Shapiro
Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, Massachusetts 02215, USA
J Infect Dis 199:414-8. 2009..001) predicted late MTCT. These findings support the safety of 1 month of breast-feeding in combination with maternal and infant antiretroviral prophylaxis. Trial registration. ClinicalTrials.gov identifiers: NCT00197691 and NCT00197652... - Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milkRoger L Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Infect Dis 192:713-9. 2005..The ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described... - Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in BotswanaRoger L Shapiro
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Infect Dis 196:562-9. 2007..Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown... - Improvement in allele-specific PCR assay with the use of polymorphism-specific primers for the analysis of minor variant drug resistance in HIV-1 subtype CChristopher F Rowley
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Lowry Building, Suite GB, 110 Francis Street, Boston, MA 02215, USA
J Virol Methods 149:69-75. 2008..15-1.36% and 5.20-5.71% resistance for the same 1% and 5% samples. The results demonstrate the need to account for sequence polymorphisms when designing and implementing this highly specific assay... - Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatmentRoger L Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Infect Dis 192:720-7. 2005..The magnitude of infant antiretroviral (ARV) exposure from breast milk is unknown... - Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysisKaren H Costenbader
Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 50:849-57. 2004..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect... - Serum concentrations of antimycobacterial drugs in patients with pulmonary tuberculosis in BotswanaJordan W Tappero
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 41:461-9. 2005..CONCLUSIONS: These data, predominantly from HIV-infected patients with TB, suggest that low isoniazid, rifampin, and ethambutol concentrations are common in Botswana. In contrast, pyrazinamide usually is well absorbed... - The design and validation of a novel phenotypic assay to determine HIV-1 coreceptor usage of clinical isolatesNina H Lin
Infectious Diseases Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 504, Boston, MA 02114, USA
J Virol Methods 169:39-46. 2010..This assay provides a sensitive, efficient and relatively low-cost approach suitable for use by research laboratories for assessing HIV-1 coreceptor usage of plasma samples... - Acceptability of infant male circumcision as part of HIV prevention and male reproductive health efforts in Gaborone, Botswana, and surrounding areasRebeca M Plank
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
AIDS Behav 14:1198-202. 2010..Neonatal male circumcision appears to be acceptable in Botswana and deserves urgent attention in resource-limited regions with high HIV prevalence, with the aim to expand services in safe, culturally acceptable and sustainable ways... - Roundtable. Revisiting the role of single-dose nevirapine for preventing perinatal HIV transmissionHoosen Coovadia
AIDS Clin Care 17:61-4. 2005 - Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infantsWoong Hwan Bae
Harvard College, Harvard Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
AIDS 22:1633-40. 2008..To assess hematologic and hepatic toxicities associated with in utero and breastfeeding exposure to maternal highly active antiretroviral therapy (HAART) among infants in Botswana... - Voluntary counseling and testing among post-partum women in BotswanaIbou Thior
The Botswana Harvard AIDS Institute Partnership, Botswana
Patient Educ Couns 65:296-302. 2007..To determine uptake and socio-demographics predictors of acceptance of voluntary counseling and testing (VCT) among post-partum women in Botswana...
Research Grants
- Effects of HIV and ARV Exposure on Child Health and Neurodevelopment in Botswana.SHAHIN contact LOCKMAN; Fiscal Year: 2010..We hope to evaluate both of these questions in Botswana in order to improve neurodevelopmental and health outcomes among children born to HIV-infected mothers globally. ..
- Maternal and Infant Health and HAART Outcomes in the Mashi PMTCT Study, BotswanaShahin Lockman; Fiscal Year: 2009..placebo exposure; and pediatric neurodevelopmental and growth outcomes, by infant feeding modality and antiretroviral exposure history. ..
- Health of HIV-Infected Mothers after pMTCT, BotswanaShahin Lockman; Fiscal Year: 2007..This already-existing cohort with access to ART provides a unique opportunity to answer questions that have significant public health implications with a relatively small investment of additional resources. ..
- RESPIRATORY DISEASES/BSI STUDYShahin Lockman; Fiscal Year: 2004....
- Maternal and Infant Health and HAART Outcomes in the Mashi PMTCT Study, BotswanaShahin Lockman; Fiscal Year: 2010..placebo exposure;and pediatric neurodevelopmental and growth outcomes, by infant feeding modality and antiretroviral exposure history. ..