STEVEN LOCKLEY

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Human phase response curve to a 1 h pulse of bright white light
    Melissa A St Hilaire
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Physiol 590:3035-45. 2012
  2. pmc Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina
    Farhan H Zaidi
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London W6 8RF, United Kingdom
    Curr Biol 17:2122-8. 2007
  3. doi request reprint Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind
    Steven W Lockley
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    J Sleep Res 17:207-16. 2008
  4. ncbi request reprint Effects of health care provider work hours and sleep deprivation on safety and performance
    Steven W Lockley
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:7-18. 2007
  5. pmc Visual impairment and circadian rhythm disorders
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Dialogues Clin Neurosci 9:301-14. 2007
  6. ncbi request reprint Circadian photoreception: spotlight on the brain
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Biol 16:R795-7. 2006
  7. ncbi request reprint When policy meets physiology: the challenge of reducing resident work hours
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Orthop Relat Res 449:116-27. 2006
  8. ncbi request reprint Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans
    Steven W Lockley
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sleep 29:161-8. 2006
  9. ncbi request reprint Timed melatonin treatment for delayed sleep phase syndrome: the importance of knowing circadian phase
    Steven W Lockley
    Sleep 28:1214-6. 2005
  10. ncbi request reprint Effective implementation of work-hour limits and systemic improvements
    Christopher P Landrigan
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:19-29. 2007

Research Grants

Detail Information

Publications21

  1. pmc Human phase response curve to a 1 h pulse of bright white light
    Melissa A St Hilaire
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Physiol 590:3035-45. 2012
    ..7 h PRC despite representing only 15% of the light exposure duration, consistent with previous studies showing a non-linear duration–response function for the effects of light on circadian resetting...
  2. pmc Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina
    Farhan H Zaidi
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London W6 8RF, United Kingdom
    Curr Biol 17:2122-8. 2007
    ....
  3. doi request reprint Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind
    Steven W Lockley
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    J Sleep Res 17:207-16. 2008
    ..Treatment for circadian rhythm disorders should be targeted in normalizing these phase relationships...
  4. ncbi request reprint Effects of health care provider work hours and sleep deprivation on safety and performance
    Steven W Lockley
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:7-18. 2007
    ..They also report making 300% more fatigue-related medical errors that lead to a patient's death...
  5. pmc Visual impairment and circadian rhythm disorders
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Dialogues Clin Neurosci 9:301-14. 2007
    ..Daily melatonin administration, which provides a replacement synchronizing daily "time cue, " is a promising therapeutic strategy, although optimal treatment dose and timing remain to be determined...
  6. ncbi request reprint Circadian photoreception: spotlight on the brain
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Biol 16:R795-7. 2006
    ..Recent studies have begun to shed light on the areas of the brain that respond to such 'non-visual' photoreception in the human eye...
  7. ncbi request reprint When policy meets physiology: the challenge of reducing resident work hours
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Orthop Relat Res 449:116-27. 2006
    ..An evidence-based approach is needed to minimize the well-documented risk that current work hour practices confer on resident health and patient safety while optimizing education and continuity of care...
  8. ncbi request reprint Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans
    Steven W Lockley
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sleep 29:161-8. 2006
    ..To assess the wavelength-dependent sensitivity of the acute effects of ocular light exposure on alertness, performance, waking electroencephalogram (EEG), and cortisol...
  9. ncbi request reprint Timed melatonin treatment for delayed sleep phase syndrome: the importance of knowing circadian phase
    Steven W Lockley
    Sleep 28:1214-6. 2005
  10. ncbi request reprint Effective implementation of work-hour limits and systemic improvements
    Christopher P Landrigan
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    Jt Comm J Qual Patient Saf 33:19-29. 2007
    ..Sleep deprivation, ubiquitous among nurses and physicians, recently has been shown to greatly increase rates of serious medical errors and occupational injuries among health care workers in the United States...
  11. ncbi request reprint High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:4502-5. 2003
    ..Thus photopic lux, the standard unit of illuminance, is inappropriate when quantifying the photic drive required to reset the human circadian pacemaker...
  12. ncbi request reprint The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects
    Lisa M Hack
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, GU2 7XH, UK
    J Biol Rhythms 18:420-9. 2003
    ..Optimal treatment with melatonin for this non-24-h sleep disorder should correct the underlying circadian disorder (to entrain the sleep-wake cycle) in addition to improving sleep acutely...
  13. pmc Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake
    Jamie M Zeitzer
    Department of Psychiatry, Stanford University, Palo Alto, CA 94304, USA
    Sleep 30:1437-43. 2007
    ..To determine the effects of sleep and sleep deprivation on plasma melatonin concentrations in humans and whether these effects are age-dependent...
  14. ncbi request reprint Effect of reducing interns' weekly work hours on sleep and attentional failures
    Steven W Lockley
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:1829-37. 2004
    ....
  15. ncbi request reprint Safety considerations for the use of blue-light blocking glasses in shift-workers
    Steven W Lockley
    J Pineal Res 42:210-1. 2007
  16. ncbi request reprint Effect of reducing interns' work hours on serious medical errors in intensive care units
    Christopher P Landrigan
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1838-48. 2004
    ..Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors...
  17. ncbi request reprint The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care
    Jeffrey M Rothschild
    Divisions of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:1694-700. 2005
    ..We sought to study the incidence and nature of adverse events and serious errors in the critical care setting...
  18. ncbi request reprint Integration of human sleep-wake regulation and circadian rhythmicity
    Derk Jan Dijk
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford GU27XH, United Kingdom
    J Appl Physiol 92:852-62. 2002
    ..Recent findings on the physiological and molecular-genetic correlates of circadian sleep disorders suggest that the timing of the sleep-wake cycle and circadian rhythms is closely integrated but is, in part, regulated differentially...
  19. pmc Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
    Environ Health Perspect 115:1357-62. 2007
    ..Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge...
  20. pmc Effect of intern's consecutive work hours on safety, medical education and professionalism
    Christopher P Landrigan
    Crit Care 9:528-30; author reply 528-30. 2005
  21. ncbi request reprint The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects
    Donna L Robilliard
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
    J Sleep Res 11:305-12. 2002
    ..No significant difference was observed between the two variants. These results do not support Clock 3111C as a marker for diurnal preference, tau, or delayed sleep phase syndrome in humans...

Research Grants19

  1. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    CHARLES CZEISLER; Fiscal Year: 2007
    ....
  2. Mechanism Underlying the Effects of Blue Light in Humans
    STEVEN LOCKLEY; Fiscal Year: 2007
    ..abstract_text> ..
  3. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    CHARLES CZEISLER; Fiscal Year: 2005
    ....
  4. TREATMENT OF CIRCADIAN SLEEP DISORDERS W/BRIGHT LIGHT
    CHARLES CZEISLER; Fiscal Year: 1993
    ....
  5. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    CHARLES CZEISLER; Fiscal Year: 1999
    ....
  6. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    Steven W Lockley; Fiscal Year: 2010
    ....