Luzheng Liu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity
    Luzheng Liu
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Harvard Skin Disease Research Center, Boston, Massachusetts, USA
    Nat Med 16:224-7. 2010
  2. ncbi request reprint Dynamic programming of CD8+ T cell trafficking after live viral immunization
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 25:511-20. 2006
  3. pmc Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Immunol 9:15. 2008
  4. pmc Disruption of TNF-α/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection
    Tian Tian
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 132:1425-34. 2012
  5. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
  6. pmc Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus
    Tian Tian
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:70-8. 2009
  7. pmc Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis
    Madeliene E Gainers
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:8509-18. 2007
  8. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
  9. pmc Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Suite 672, Boston, MA 02115, USA
    J Virol 79:7363-70. 2005
  10. pmc Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus
    Ann Chahroudi
    Emory Vaccine Center, Atlanta, Georgia 30329, USA
    J Virol 80:8469-81. 2006

Collaborators

Detail Information

Publications11

  1. pmc Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity
    Luzheng Liu
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Harvard Skin Disease Research Center, Boston, Massachusetts, USA
    Nat Med 16:224-7. 2010
    ..m.) injection as used in MVA clinical trials. Thus, delivery of rVACV-based vaccines, including MVA vaccines, through physically disrupted epidermis has clear-cut advantages over conventional vaccination via hypodermic injection...
  2. ncbi request reprint Dynamic programming of CD8+ T cell trafficking after live viral immunization
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 25:511-20. 2006
    ..These observations demonstrate a mechanism by which T cells provide both immediate tissue-specific immune control at the pathogen entry site and a more flexible systemic protection against pathogen dissemination...
  3. pmc Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Immunol 9:15. 2008
    ..Using in vitro and in vivo murine models, we systematically investigated the susceptibility of murine DCs to MVA infection, and the immunological consequences of the infection...
  4. pmc Disruption of TNF-α/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection
    Tian Tian
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 132:1425-34. 2012
    ..Our data suggest that lack of TNFR1 leads to a skin-specific immune deficiency, and that resident skin cells have a crucial role in mediating an optimal immune defense to VV cutaneous infection via TNF-α/TNFR1 signaling...
  5. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..These findings have important implications for our understanding of protective immune memory at epithelial interfaces with the environment, and suggest novel strategies for vaccines that protect against tissue tropic organisms...
  6. pmc Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus
    Tian Tian
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:70-8. 2009
    ....
  7. pmc Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis
    Madeliene E Gainers
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:8509-18. 2007
    ....
  8. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
    ..Therefore, the majority of true circulating Treg express functional skin-homing receptors, and human Treg may regulate local immune responses in normal human skin...
  9. pmc Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Suite 672, Boston, MA 02115, USA
    J Virol 79:7363-70. 2005
    ....
  10. pmc Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus
    Ann Chahroudi
    Emory Vaccine Center, Atlanta, Georgia 30329, USA
    J Virol 80:8469-81. 2006
    ....
  11. ncbi request reprint Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates
    Luzheng Liu
    Emory Vaccine Center and Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Med 8:185-9. 2002
    ..As such, the FCC assay can provide a valuable tool for studies of infectious disease pathogenesis and development of new vaccines and immunotherapies...