Augusto Litonjua

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Vitamin D deficiency as a risk factor for childhood allergic disease and asthma
    Augusto A Litonjua
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    Curr Opin Allergy Clin Immunol 12:179-85. 2012
  2. pmc Fat-soluble vitamins and atopic disease: what is the evidence?
    Augusto A Litonjua
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Nutr Soc 71:67-74. 2012
  3. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
  4. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
  5. ncbi request reprint Variation in total and specific IgE: effects of ethnicity and socioeconomic status
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:751-7. 2005
  6. ncbi request reprint Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:1056-62. 2005
  7. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
  8. ncbi request reprint Lung function in type 2 diabetes: the Normative Aging Study
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Med 99:1583-90. 2005
  9. ncbi request reprint The significance of beta2-adrenergic receptor polymorphisms in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 12:12-7. 2006
  10. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008

Research Grants

  1. BETA-2 ADRENERGIC RECEPTOR POLYMORPHISMS AND ASTHMA
    Augusto Litonjua; Fiscal Year: 2002
  2. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2007
  3. Longitudinal Lung Function Changes--Aging/Genetics/Risk
    Augusto Litonjua; Fiscal Year: 2007
  4. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009

Detail Information

Publications87

  1. pmc Vitamin D deficiency as a risk factor for childhood allergic disease and asthma
    Augusto A Litonjua
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    Curr Opin Allergy Clin Immunol 12:179-85. 2012
    ..The purpose of this review is to update the last review in this journal and examine the evidence of the relationship between vitamin D deficiency and childhood asthma and allergies...
  2. pmc Fat-soluble vitamins and atopic disease: what is the evidence?
    Augusto A Litonjua
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Nutr Soc 71:67-74. 2012
    ..Ongoing clinical trials will help determine whether results of observational studies can be applied to the clinical setting...
  3. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
    ..A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results...
  4. pmc Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers
    Mousheng Xu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:90. 2011
    ..We hypothesized that the use of random forests classifiers to select SNPs would result in an improved predictive model of asthma exacerbations. We tested this hypothesis in a population of childhood asthmatics...
  5. ncbi request reprint Variation in total and specific IgE: effects of ethnicity and socioeconomic status
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:751-7. 2005
    ..Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization...
  6. ncbi request reprint Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:1056-62. 2005
    ..Variants in the CD14 gene (CD14) are hypothesized to be associated with atopic disorders. However, most studies have only investigated one polymorphism in this gene...
  7. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  8. ncbi request reprint Lung function in type 2 diabetes: the Normative Aging Study
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Med 99:1583-90. 2005
    ..We conducted this analysis to determine whether diabetic subjects have different rates of lung function change compared with non-diabetic subjects...
  9. ncbi request reprint The significance of beta2-adrenergic receptor polymorphisms in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 12:12-7. 2006
    ..The gene that encodes the beta2-adrenergic receptor (ADRB2) is one of the most studied candidate genes in asthma. This review examines recent articles of the relationship between ADRB2 polymorphisms and asthma...
  10. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...
  11. pmc Childhood asthma may be a consequence of vitamin D deficiency
    Augusto A Litonjua
    Channing Laboratory and Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 9:202-7. 2009
    ..It has been postulated that vitamin D deficiency may explain a portion of the asthma epidemic. The purpose of this review is to present the evidence for a role of vitamin D in asthma...
  12. pmc Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 84:903-11. 2006
    ..Low intakes of dietary antioxidants may contribute to increases in asthma and allergy...
  13. ncbi request reprint Beta 2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking men
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 126:66-74. 2004
    ..To investigate the relationship of common single nucleotide polymorphisms (SNPs) of the beta(2)-adrenergic receptor (AR) gene at codons 16 and 27, and the intermediate phenotype of airways hyperresponsiveness...
  14. ncbi request reprint Is vitamin D deficiency to blame for the asthma epidemic?
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 120:1031-5. 2007
    ..Providing adequate vitamin D supplementation in pregnancy may lead to significant decreases in asthma incidence in young children...
  15. ncbi request reprint Race, socioeconomic factors, and area of residence are associated with asthma prevalence
    A A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatr Pulmonol 28:394-401. 1999
    ..5, 11.7, respectively, for the children. We conclude that a large proportion of the racial/ethnic differences in asthma prevalence in our study is explained by factors related to income, area of residence, and level of education...
  16. pmc Dietary factors and the development of asthma
    Augusto A Litonjua
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Allergy Clin North Am 28:603-29, ix. 2008
    ..It is likely that nutrients may exert their strongest effect early in life, when both the immune system and the lungs are not yet fully developed...
  17. pmc Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study
    A A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Thorax 57:581-5. 2002
    ..The relationship between body mass index (BMI) and the development of an objective marker for asthma, methacholine airway hyperresponsiveness (AHR), was investigated in adult men...
  18. doi request reprint Asthma and obesity: common early-life influences in the inception of disease
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:1075-84; quiz 1085-6. 2008
    ....
  19. ncbi request reprint Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 90:422-8. 2003
    ..To confirm these findings, we tested the hypothesis that serum cytokines are associated with longitudinal lung function decline...
  20. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
    ..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs...
  21. pmc Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    Circulation 117:1802-9. 2008
    ....
  22. pmc Effect of vitamin D and inhaled corticosteroid treatment on lung function in children
    Ann Chen Wu
    Center for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215 5301, USA
    Am J Respir Crit Care Med 186:508-13. 2012
    ..Low vitamin D levels are associated with asthma and decreased airway responsiveness. Treatment with inhaled corticosteroids improves airway responsiveness and asthma control...
  23. ncbi request reprint Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:1671-7. 2005
    ..The Met772-AC9 polymorphism represents one of most likely several multi-gene polymorphisms along the receptor-relaxation axis, which together may provide for a composite pharmacogenetic index for asthma therapy...
  24. pmc Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica
    John M Brehm
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:765-71. 2009
    ..Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood...
  25. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  26. pmc Development of a Pharmacogenetic Predictive Test in asthma: proof of concept
    Ann Chen Wu
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215 5301, USA
    Pharmacogenet Genomics 20:86-93. 2010
    ..To assess the feasibility of developing a Combined Clinical and Pharmacogenetic Predictive Test, comprised of multiple single nucleotide polymorphisms (SNPs) that is associated with poor bronchodilator response (BDR)...
  27. pmc Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
    Dawn L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:493-502. 2009
    ..4 x 10(-4). IREB2 protein and mRNA were increased in lung-tissue samples from COPD subjects in comparison to controls. In summary, gene-expression and genetic-association results have implicated IREB2 as a COPD susceptibility gene...
  28. ncbi request reprint Sensitization to aeroallergens and airway hyperresponsiveness at 7 years of age
    Elizabeth C TePas
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 129:1500-8. 2006
    ..To investigate the relationship between current and early life factors and airway responsiveness to inhaled methacholine in children with a median age of 7.0 years...
  29. ncbi request reprint A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 110:736-42. 2002
    ..It has been postulated that exposure to bacterial endotoxins and animals early in life might confer protection against the development of asthma and allergies...
  30. pmc Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease
    Kai Jen Chuang
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Circulation 118:1314-20. 2008
    ..The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes...
  31. pmc Cumulative community-level lead exposure and pulse pressure: the normative aging study
    Todd Perlstein
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Environ Health Perspect 115:1696-700. 2007
    ..Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease...
  32. ncbi request reprint Respiratory illnesses in early life and asthma and atopy in childhood
    Clare D Ramsey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:150-6. 2007
    ..The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood...
  33. pmc Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:921-928.e4. 2008
    ..Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown...
  34. ncbi request reprint Predictors of cord blood IgE levels in children at risk for asthma and atopy
    Christina V Scirica
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:81-8. 2007
    ..Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels...
  35. pmc Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
    Audrey H Poon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacogenet Genomics 18:373-82. 2008
    ..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma...
  36. pmc Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 126:250-5, 255.e1-4. 2010
    ..Previous studies have found associations between individual foods or nutrients consumed during pregnancy and asthma or wheeze in children, but these may be confounded by overall dietary pattern...
  37. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)...
  38. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
    ..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter...
  39. ncbi request reprint The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  40. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
    ..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR...
  41. pmc Ischemic heart disease and stroke in relation to blood DNA methylation
    Andrea Baccarelli
    Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and IRCCS Ca, Granda Policlinico Maggiore Hospital Foundation, Milan, Italy
    Epidemiology 21:819-28. 2010
    ..We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke...
  42. pmc Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 40:751-5. 2009
    ..Two common nonsynonymous SNPs did not demonstrate significant associations in either a family-based or case-control analysis. Exonic SNPs in the elastin gene do not appear to be common risk factors for severe COPD...
  43. pmc Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter
    Elissa Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:935-40. 2009
    ..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation...
  44. pmc Regulatory haplotypes in ARG1 are associated with altered bronchodilator response
    Qing Ling Duan
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Crit Care Med 183:449-54. 2011
    ..We previously identified single nucleotide polymorphisms in the arginase 1 (ARG1) gene, which are associated with β₂-agonist bronchodilator response (BDR)...
  45. pmc Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Med Genet 12:26. 2011
    ..We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts...
  46. pmc Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations
    Ann Chen Wu
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 182:884-9. 2010
    ..We hypothesized that exposure to environmental fungi may modulate the effect of chitinases in individuals with asthma...
  47. pmc Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pharmacogenet Genomics 18:733-7. 2008
    ..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted...
  48. pmc Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    John M Brehm
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 126:52-8.e5. 2010
    ..Vitamin D status might play a role in preventing asthma exacerbations...
  49. pmc Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 182:605-13. 2010
    ..Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q...
  50. pmc Folliculin mutations are not associated with severe COPD
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 9:120. 2008
    ....
  51. pmc Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 41:324-31. 2009
    ....
  52. pmc Predicting response to short-acting bronchodilator medication using Bayesian networks
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, MA, USA
    Pharmacogenomics 10:1393-412. 2009
    ..We sought to relate candidate gene SNP data with bronchodilator response and measure the predictive accuracy of a model constructed with genetic variants...
  53. pmc Predictors of poor response during asthma therapy differ with definition of outcome
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics 10:1231-42. 2009
    ..To evaluate phenotypic and genetic variables associated with a poor long-term response to inhaled corticosteroid therapy for asthma, based independently on lung function changes or asthma exacerbations...
  54. pmc Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children
    Elsie M Taveras
    Obesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    J Allergy Clin Immunol 121:1161-1166.e3. 2008
    ..Few prospective data link early childhood adiposity with asthma-related symptoms...
  55. pmc Endotoxin exposure and eczema in the first year of life
    Wanda Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 114:13-8. 2004
    ..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies...
  56. pmc Paternal history of asthma and airway responsiveness in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:552-8. 2005
    ..Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma...
  57. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  58. ncbi request reprint Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1239-43. 2003
    ..Our findings suggest that maternal history of asthma influences the relation between day care-related exposures and childhood asthma...
  59. pmc Prenatal, perinatal, and heritable influences on cord blood immune responses
    Ben M Willwerth
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 96:445-53. 2006
    ..Maternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses...
  60. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  61. ncbi request reprint Bottle feeding in the bed or crib before sleep time and wheezing in early childhood
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 110:e77. 2002
    ..We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life...
  62. ncbi request reprint Ambient air pollution and oxygen saturation
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:383-7. 2004
    ..Further investigation may contribute to our understanding of the mechanisms through which particulates may increase respiratory and cardiac morbidity among vulnerable populations...
  63. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  64. ncbi request reprint Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 360:781-2. 2002
    ..There was no association between wheezing and exposure to dog or dog allergen, and the father's allergy status had no effect on the relation between childhood wheezing and cat exposure...
  65. ncbi request reprint Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
    ..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1...
  66. ncbi request reprint FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1285-91. 2007
    ..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations...
  67. ncbi request reprint Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Landmark Center West, 415, 401 Park Dr, Boston, MA 02215, USA
    Chest 132:1890-7. 2007
    ..Ozone has heterogeneous effects on lung function. We investigated whether obesity and airways hyperresponsiveness (AHR) modify the acute effects of ozone on lung function in the elderly...
  68. ncbi request reprint Low-normal gestational age as a predictor of asthma at 6 years of age
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 114:e327-32. 2004
    ..However, the role of these factors in the development of asthma in later life among children who do not develop perinatal respiratory disease remains unclear...
  69. ncbi request reprint Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood
    Juan C Celedon
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 156:241-5. 2002
    ..It has been hypothesized that day care--related infections may explain the inverse relation between day care attendance in early life and asthma in childhood...
  70. pmc Statin use reduces decline in lung function: VA Normative Aging Study
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, Landmark Center West, 415, 401 Park Drive, Boston, MA 02215, USA
    Am J Respir Crit Care Med 176:742-7. 2007
    ..Decreased lung function has been linked to increased inflammation and oxidative stress. Statins have demonstrated antiinflammatory and antioxidant properties...
  71. ncbi request reprint Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:72-5. 2002
    ..4; OR for two or more versus no courses of antibiotics, 0.9; 95% CI, 0.5 to 1.4). Our findings do not support the hypothesis that antibiotic use in early life is associated with the subsequent development of asthma and atopy in childhood...
  72. pmc Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:144-9. 2007
    ..There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age...
  73. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  74. pmc Air pollution and ST-segment depression in elderly subjects
    Diane R Gold
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:883-7. 2005
    ..Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic...
  75. ncbi request reprint Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age
    Carlos A Camargo
    Center for D receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 85:788-95. 2007
    ..Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown...
  76. ncbi request reprint Genome-wide association studies of family data in pharmacogenetics: a case study
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Pharm Des 15:3764-72. 2009
    ..In this manuscript, we discuss these considerations and provide concrete examples with GWAS data for an asthma clinical trial using parent-offspring trios...
  77. pmc Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction
    Jemma B Wilk
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Respir Crit Care Med 186:622-32. 2012
    ..Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known...
  78. pmc Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease
    Deog Kyeom Kim
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 186:1238-47. 2012
    ..A genome-wide association study (GWAS) for circulating chronic obstructive pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker levels and COPD susceptibility...
  79. ncbi request reprint Uric acid and the development of hypertension: the normative aging study
    Todd S Perlstein
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hypertension 48:1031-6. 2006
    ..01 to 1.12; P=0.03). The baseline serum uric acid level is a durable marker of risk for the development of hypertension. The association is independent of elements of the metabolic syndrome, alcohol intake, and renal function...
  80. ncbi request reprint Prevalence and titer of IgE antibodies to mouse allergens
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 120:1058-64. 2007
    ..Positive skin tests to allergens derived from mouse urine have been reported among patients with asthma. Very few data are available detailing the titer of IgE Ab to mouse allergen and how it varies by location and population...
  81. pmc Maternal diet vs lack of exposure to sunlight as the cause of the epidemic of asthma, allergies and other autoimmune diseases
    Scott T Weiss
    Thorax 62:746-8. 2007
  82. ncbi request reprint Maternal vitamin D intake during pregnancy and early childhood wheezing
    Graham Devereux
    Department of Environmental, University of Aberdeen, Aberdeen, United Kingdom
    Am J Clin Nutr 85:853-9. 2007
    ..Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children...
  83. ncbi request reprint Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility
    Dennis W McGraw
    Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Physiol Genomics 27:171-7. 2006
    ..These genes or pathways may also represent additional targets in the treatment of asthma and related obstructive lung diseases...
  84. ncbi request reprint Serum cytokine levels, cigarette smoking and airway responsiveness among pregnant women
    Masashi Tsunoda
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA, USA
    Int Arch Allergy Immunol 130:158-64. 2003
    ..Because cytokines are important intermediates in airway responses, we investigated the relationship between serum cytokines and airway responsiveness in a well-characterized population of pregnant women...
  85. pmc Sensitization to mouse allergen and asthma and asthma morbidity among women in Boston
    Wanda Phipatanakul
    J Allergy Clin Immunol 120:954-6. 2007
  86. pmc A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease
    Cassandra M Kelleher
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 33:355-62. 2005
    ..These results suggest that the G773D variant confers structural and functional consequences relevant to the pathogenesis of COPD...
  87. ncbi request reprint Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men
    Unhee Lim
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    J Nutr 135:1989-94. 2005
    ..A more complete understanding of the molecular mechanism awaits identification of the functional effect of the polymorphism...

Research Grants12

  1. BETA-2 ADRENERGIC RECEPTOR POLYMORPHISMS AND ASTHMA
    Augusto Litonjua; Fiscal Year: 2002
    ..End of Abstract) ..
  2. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2007
    ..Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders. ..
  3. Longitudinal Lung Function Changes--Aging/Genetics/Risk
    Augusto Litonjua; Fiscal Year: 2007
    ..The results of this proposal will shed light on potential mechanisms that affect lung function decline in aging. ..
  4. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009
    ..Blood for genetic material is currently being collected on the two cohorts, and endotoxin will be measured from stored, frozen house dust. ..