S A Lipton

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Neuropathogenesis of acquired immunodeficiency syndrome dementia
    S A Lipton
    Laboratory of Cellular and Molecular Neuroscience, Harvard Medical School and Children s Hospital, Boston MA, USA
    Curr Opin Neurol 10:247-53. 1997
  2. pmc Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor
    S A Lipton
    Laboratory of Cellular and Molecular Neuroscience, Children s Hospital, and Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Enders Building, Suite 361, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:5923-8. 1997
  3. ncbi request reprint Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species
    S A Lipton
    Laboratory of Cellular and Molecular Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    Brain Pathol 6:507-17. 1996
  4. ncbi request reprint Neuroprotective versus neurodestructive effects of NO-related species
    S A Lipton
    CNS Research Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biofactors 8:33-40. 1998
  5. ncbi request reprint ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston 02115, USA
    Brain Res 780:337-41. 1998
  6. pmc hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors
    J C McDermott
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts
    Mol Cell Biol 13:2564-77. 1993
  7. ncbi request reprint Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved
    D Krainc
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genomics 29:809-11. 1995
  8. ncbi request reprint Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro
    Z H Pan
    CNS Research Institute, Brigham and Women s Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 12:3137-45. 2000
  9. ncbi request reprint Cloning and characterization of mouse GABA(C) receptor subunits
    A Greka
    Cerebrovascular and NeuroScience Research Institute, Brigham and Woman s Hospital, Boston, MA 02115, USA
    Neuroreport 9:229-32. 1998
  10. ncbi request reprint Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1
    D Krainc
    CNS Research Institute, Brigham and Women s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:26218-24. 1998

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Neuropathogenesis of acquired immunodeficiency syndrome dementia
    S A Lipton
    Laboratory of Cellular and Molecular Neuroscience, Harvard Medical School and Children s Hospital, Boston MA, USA
    Curr Opin Neurol 10:247-53. 1997
    ..Some of these potential new treatments have now entered clinical trials...
  2. pmc Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor
    S A Lipton
    Laboratory of Cellular and Molecular Neuroscience, Children s Hospital, and Program in Neuroscience, Harvard Medical School, 300 Longwood Avenue, Enders Building, Suite 361, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:5923-8. 1997
    ..Accordingly, homocysteine neurotoxicity through overstimulation of N-methyl-D-aspartate receptors may contribute to the pathogenesis of both homocystinuria and modest hyperhomocysteinemia...
  3. ncbi request reprint Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species
    S A Lipton
    Laboratory of Cellular and Molecular Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    Brain Pathol 6:507-17. 1996
    ..With the very recent development of clinically-tolerated NMDA antagonists, as discussed here, there is hope for future pharmacological intervention...
  4. ncbi request reprint Neuroprotective versus neurodestructive effects of NO-related species
    S A Lipton
    CNS Research Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biofactors 8:33-40. 1998
    ....
  5. ncbi request reprint ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston 02115, USA
    Brain Res 780:337-41. 1998
    ..ICAM-1 deficiency minimizes necrosis but not apoptosis after temporary MCAO in mice, thereby leaving the potential for delayed neuronal cell death despite ICAM-1 inactivation...
  6. pmc hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors
    J C McDermott
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts
    Mol Cell Biol 13:2564-77. 1993
    ....
  7. ncbi request reprint Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved
    D Krainc
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genomics 29:809-11. 1995
  8. ncbi request reprint Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro
    Z H Pan
    CNS Research Institute, Brigham and Women s Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 12:3137-45. 2000
    ....
  9. ncbi request reprint Cloning and characterization of mouse GABA(C) receptor subunits
    A Greka
    Cerebrovascular and NeuroScience Research Institute, Brigham and Woman s Hospital, Boston, MA 02115, USA
    Neuroreport 9:229-32. 1998
    ..Mouse rho1 and rho2 also co-assemble to form heteromeric receptors. These findings form the basis for further study on GABA(C) receptors using the mouse model...
  10. ncbi request reprint Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1
    D Krainc
    CNS Research Institute, Brigham and Women s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:26218-24. 1998
    ....
  11. ncbi request reprint Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Stroke 30:134-9. 1999
    ..To determine the role of Mac-1 during ischemia and reperfusion in the brain, we analyzed the effect of transient focal cerebral ischemia in mice genetically engineered with a specific deficiency in Mac-1...
  12. ncbi request reprint Redox modulation of the NMDA receptor by NO-related species
    S A Lipton
    CNS Research Institute, Brigham and Women s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Prog Brain Res 118:73-82. 1998
    ..Thus, this chemical reaction is gaining acceptance as a newly-recognized molecular switch to control protein function via reactive thiol groups such as those encountered on the NMDA receptor...
  13. pmc Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis
    M Kaul
    CNS Research Institute, Brigham and Women s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:8212-6. 1999
    ..Moreover, gp120SF2-induced neuronal apoptosis depends predominantly on an indirect pathway via activation of chemokine receptors on macrophages/microglia, whereas SDF-1 may act directly on neurons or astrocytes...
  14. ncbi request reprint Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
    S Das
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 393:377-81. 1998
    ..These data suggest that NR3A is involved in the development of synaptic elements by modulating NMDAR activity...
  15. ncbi request reprint Neuronal injury associated with HIV-1: approaches to treatment
    S A Lipton
    Cerebrovascular and NeuroScience Research Institute, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pharmacol Toxicol 38:159-77. 1998
    ..With the very recent development of clinically tolerated NMDA antagonists, there is hope for future pharmacological intervention...
  16. ncbi request reprint Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury
    S G Soriano
    Department of Anesthesia Children s Hospital, Boston, MA 02115, USA
    Ann Neurol 39:618-24. 1996
    ..These data support the premise that neutrophil adhesion in ischemic areas may be deleterious and that ICAM-1 deficiency reduces neurological damage after transient focal cerebral ischemia...
  17. ncbi request reprint Calcium, free radicals and excitotoxins in neuronal apoptosis
    S A Lipton
    CNS Research Institute, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cell Calcium 23:165-71. 1998
    ..In collaboration, our two research laboratories have been defining excitotoxic signals that lead to apoptosis versus necrosis via, among other pathways, Ca2+ signaling mechanisms; this is the subject of this brief review...
  18. ncbi request reprint The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid
    E B Dreyer
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 7:2502-7. 1995
    ..Our findings suggest that the observed effects on glia and neurons of gp120 may be secondary, at least in part, to its initial activation of macrophages...
  19. pmc Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block
    D Zhang
    Laboratory of Cellular and Molecular Neuroscience, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 92:11756-60. 1995
    ..This study reveals not only the molecular mechanism underlying PTX blockade of GABA receptors but also the heteromeric nature of native receptors in the rat retina that underlie the PTX-resistant GABAC response...
  20. pmc MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex
    D Leifer
    Department of Neurology, Children s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 90:1546-50. 1993
    ..The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture...
  21. ncbi request reprint Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat
    P E Stieg
    CNS Research Institute, Neurosurgical Service, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Pharmacol 375:115-20. 1999
    ..0001). At this dosage, memantine manifests few, if any, neurobehavioral side effects. Thus memantine appears to be both safe and effective in neonatal as well as adult animal models of stroke...
  22. ncbi request reprint Neuronal protection and destruction by NO
    S A Lipton
    The CNS Research Institute, Brigham and Women s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115 USA
    Cell Death Differ 6:943-51. 1999
    ..NO- -unlike NO* but reminiscent of NO+ transfer - reacts with critical thiol groups of the NMDA receptor to curtail excessive Ca2+ influx and thus provide neuroprotection from excitotoxic insults...
  23. pmc An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth
    E B Dreyer
    Laboratory of Cellular and Molecular Neuroscience, Children s Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 92:11195-9. 1995
    ..The Thy-1-binding protein may participate in axonal or dendritic development in the nervous system...
  24. ncbi request reprint Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging
    D A Le
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Drugs Aging 18:717-24. 2001
    ..In this review, we present the evidence that clinically safer NMDA antagonists such as memantine and nitroglycerin, and the combination drug nitro-memantine, are promising as drugs in treating neurodegenerative diseases...