L A Lipsitz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Vasomotor instability preceding tilt-induced syncope: does respiration play a role?
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, Massachusetts 02131, USA
    J Appl Physiol 83:383-90. 1997
  2. ncbi request reprint Physiological complexity, aging, and the path to frailty
    Lewis A Lipsitz
    Hebrew Rehabilitation Center for Aged, Boston, MA 12131, USA
    Sci Aging Knowledge Environ 2004:pe16. 2004
  3. ncbi request reprint Dynamics of stability: the physiologic basis of functional health and frailty
    Lewis A Lipsitz
    Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, and Harvard Medical School Division on Aging, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 57:B115-25. 2002
  4. pmc Enhanced vasoreactivity and its response to antihypertensive therapy in hypertensive elderly women
    Lewis A Lipsitz
    Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hypertension 47:377-83. 2006
  5. ncbi request reprint The elderly people of post-Soviet Ukraine: medical, social, and economic challenges
    Lewis A Lipsitz
    Hebrew SeniorLife Research and Training Institute, Division of Gerontology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 12131, USA
    J Am Geriatr Soc 53:2216-20. 2005
  6. ncbi request reprint Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel Deaconess Medical Center Department of Medicine, Harvard Medical School Division on Aging, Boston, MA 02131, USA
    Stroke 31:1897-903. 2000
  7. ncbi request reprint Complex demodulation of cardiorespiratory dynamics preceding vasovagal syncope
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Department of Medicine, Harvard Medical School, Boston, Mass 02131, USA
    Circulation 98:977-83. 1998
  8. ncbi request reprint Antihypertensive therapy increases cerebral blood flow and carotid distensibility in hypertensive elderly subjects
    Lewis A Lipsitz
    Hebrew Rehabilitation Center for Aged, Boston, MA 02131, USA
    Hypertension 45:216-21. 2005
  9. ncbi request reprint Predicting cerebral blood flow response to orthostatic stress from resting dynamics: effects of healthy aging
    K Narayanan
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, MA 02131, USA
    Am J Physiol Regul Integr Comp Physiol 281:R716-22. 2001
  10. ncbi request reprint Effects of chronic estrogen replacement therapy on beat-to-beat blood pressure dynamics in healthy postmenopausal women
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel Hospital Department of Medicine, Boston, MA 02131, USA
    Hypertension 26:711-5. 1995

Research Grants

  1. Nonlinear Dynamics of Frailty in Aging
    Lewis Lipsitz; Fiscal Year: 2007
  2. HARVARD OLDER AMERICANS INDEPENDENCE CENTER
    Lewis Lipsitz; Fiscal Year: 2006
  3. Translational Research in Aging Training Program
    Lewis Lipsitz; Fiscal Year: 2007
  4. HRCA/HARVARD RESEARCH NURSING HOME
    Lewis Lipsitz; Fiscal Year: 2007

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Vasomotor instability preceding tilt-induced syncope: does respiration play a role?
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, Massachusetts 02131, USA
    J Appl Physiol 83:383-90. 1997
    ..Thus vasomotor instability before syncope is not related to alterations in respiration or the cardiovagal baroreflex but may reflect oscillating central sympathetic outflow to the vasculature...
  2. ncbi request reprint Physiological complexity, aging, and the path to frailty
    Lewis A Lipsitz
    Hebrew Rehabilitation Center for Aged, Boston, MA 12131, USA
    Sci Aging Knowledge Environ 2004:pe16. 2004
    ..Aging and disease are associated with a loss of complexity in the dynamics of many physiological systems. This loss of complexity may reduce the ability to adapt to stress and lead to the syndrome of frailty...
  3. ncbi request reprint Dynamics of stability: the physiologic basis of functional health and frailty
    Lewis A Lipsitz
    Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, and Harvard Medical School Division on Aging, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 57:B115-25. 2002
    ..Nonlinear mathematical techniques that quantify physiologic dynamics may predict the onset of frailty, and interventions aimed toward restoring healthy dynamics may prevent functional decline...
  4. pmc Enhanced vasoreactivity and its response to antihypertensive therapy in hypertensive elderly women
    Lewis A Lipsitz
    Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hypertension 47:377-83. 2006
    ..These results highlight the beneficial effects of antihypertensive therapy on the systemic vasculature, particularly for elderly women in whom enhanced vasoreactivity may contribute to excessive cardiovascular morbidity and mortality...
  5. ncbi request reprint The elderly people of post-Soviet Ukraine: medical, social, and economic challenges
    Lewis A Lipsitz
    Hebrew SeniorLife Research and Training Institute, Division of Gerontology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 12131, USA
    J Am Geriatr Soc 53:2216-20. 2005
    ..By understanding the expectations and former medical practices of elderly patients who have emigrated from Ukraine, Western physicians will be better able to meet their emotional and medical needs...
  6. ncbi request reprint Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel Deaconess Medical Center Department of Medicine, Harvard Medical School Division on Aging, Boston, MA 02131, USA
    Stroke 31:1897-903. 2000
    ..Although aging and hypertension may predispose hypertensive elderly subjects to cerebral hypoperfusion during orthostatic stress, their effects on the acute cerebral autoregulatory response to hypotension are not known...
  7. ncbi request reprint Complex demodulation of cardiorespiratory dynamics preceding vasovagal syncope
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Department of Medicine, Harvard Medical School, Boston, Mass 02131, USA
    Circulation 98:977-83. 1998
    ..The dynamic autonomic processes leading to vasovagal syncope are poorly understood...
  8. ncbi request reprint Antihypertensive therapy increases cerebral blood flow and carotid distensibility in hypertensive elderly subjects
    Lewis A Lipsitz
    Hebrew Rehabilitation Center for Aged, Boston, MA 02131, USA
    Hypertension 45:216-21. 2005
    ..Treatment reduced cerebrovascular resistance and did not impair cerebral autoregulation. Therefore, judicious long-term treatment of systolic hypertension in otherwise healthy elderly subjects does not cause cerebral hypoperfusion...
  9. ncbi request reprint Predicting cerebral blood flow response to orthostatic stress from resting dynamics: effects of healthy aging
    K Narayanan
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, MA 02131, USA
    Am J Physiol Regul Integr Comp Physiol 281:R716-22. 2001
    ..19 +/- 0.35; P < 0.003, young vs. elderly). Thus rapidly acting regulatory mechanisms that reduce the transmission of beat-to-beat changes in AP to CBFV may be engaged during posture change in young but not elderly subjects...
  10. ncbi request reprint Effects of chronic estrogen replacement therapy on beat-to-beat blood pressure dynamics in healthy postmenopausal women
    L A Lipsitz
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel Hospital Department of Medicine, Boston, MA 02131, USA
    Hypertension 26:711-5. 1995
    ..02).(abstract truncated at 250 words)..
  11. ncbi request reprint The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment
    S L Mitchell
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass USA
    Arch Intern Med 157:327-32. 1997
    ..The provision of artificial enteral nutrition to an aged person with severe cognitive impairment is a complex dilemma in the long-term care setting...
  12. ncbi request reprint Estrogen replacement therapy improves baroreflex regulation of vascular sympathetic outflow in postmenopausal women
    B E Hunt
    Laboratory for Cardiovascular Research, Research and Training Institute, Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Circulation 103:2909-14. 2001
    ..However, the data available in older women are equivocal regarding estrogen's ability to reduce resting arterial pressure or to improve its regulation...
  13. ncbi request reprint Vibrating insoles and balance control in elderly people
    Attila A Priplata
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Lancet 362:1123-4. 2003
    ..008), and critical mean square displacement (p=0.012). Noise-based devices, such as randomly vibrating insoles, could ameliorate age-related impairments in balance control...
  14. pmc Chronic musculoskeletal pain and the occurrence of falls in an older population
    Suzanne G Leveille
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    JAMA 302:2214-21. 2009
    ..Chronic pain is a major contributor to disability in older adults; however, the potential role of chronic pain as a risk factor for falls is poorly understood...
  15. pmc Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston Study
    F A Sorond
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, 45 Francis St, Boston, MA 02115, USA
    Neurology 74:1627-33. 2010
    ..To determine whether alterations in cerebral blood flow regulation are associated with slow gait speed and falls in community-dwelling elderly individuals...
  16. ncbi request reprint Patterns of orthostatic blood pressure change and their clinical correlates in a frail, elderly population
    W L Ooi
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Mass 02131, USA
    JAMA 277:1299-304. 1997
    ..To determine patterns of within-day orthostatic blood pressure (BP) changes and clinical factors correlated with them in frail, elderly nursing home residents...
  17. pmc The sit-to-stand technique for the measurement of dynamic cerebral autoregulation
    Farzaneh A Sorond
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 35:21-9. 2009
    ..The sit-to-stand technique appears to be a suitable measure of individual ARI values for inferring dynamic cerebral autoregulation...
  18. pmc Effect of blood pressure and diabetes mellitus on cognitive and physical functions in older adults: a longitudinal analysis of the advanced cognitive training for independent and vital elderly cohort
    Hsu Ko Kuo
    Division on Aging, Harvard Medical School, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 53:1154-61. 2005
    ..To evaluate the effect of blood pressure (BP) and diabetes mellitus (DM) on cognitive and physical performance in older, independent-living adults...
  19. pmc Autoregulation in the posterior circulation is altered by the metabolic state of the visual cortex
    Kazuma Nakagawa
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 40:2062-7. 2009
    ..We examined the role of cerebral vasodilation caused by metabolic activation (ie, visual stimulus) on autoregulatory characteristics in the 2 vascular territories...
  20. ncbi request reprint Aging, muscle activity, and balance control: physiologic changes associated with balance impairment
    Carrie A Laughton
    Department of Biomedical Engineering, Center for BioDynamics, Boston University, 44 Cummington St, Boston, MA 02215, USA
    Gait Posture 18:101-8. 2003
    ..It is unclear whether increases in muscle activity preclude greater postural instability or if increased muscle activity is a compensatory response to increases in postural sway...
  21. pmc Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study I
    Dae Hyun Kim
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Am Geriatr Soc 54:1751-7. 2006
    ..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment...
  22. pmc Cerebral blood flow regulation during cognitive tasks: effects of healthy aging
    Farzaneh A Sorond
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02115, USA
    Cortex 44:179-84. 2008
    ..Our data suggest that there is differential blood flow increase in the ACA and PCA in young versus elderly subjects during cognitive tasks...
  23. ncbi request reprint Serum anticholinergic activity changes with acute illness in elderly medical patients
    J M Flacker
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 54:M12-6. 1999
    ..This study used serial measures of serum anticholinergic activity levels to determine whether these levels change following illness resolution, and if such changes are specific to those with delirium...
  24. ncbi request reprint Nursing home characteristics and the development of pressure sores and disruptive behaviour
    W L Ooi
    Hebrew Rehabilitation Center for Aged, Research and Training Institute, Boston, MA 02131, USA
    Age Ageing 28:45-52. 1999
    ..To determine how nursing home characteristics affect pressure sores and disruptive behaviour...
  25. pmc Association between concurrent and remote blood pressure and disability in older adults
    Ihab Hajjar
    Harvard Medical School, Beth Israel Deaconess Medical Center, Hebrew SeniorLife, Boston, MA 29206, USA
    Hypertension 50:1026-32. 2007
    ..Older adults with uncontrolled hypertension are at a particularly increased risk for disability...
  26. pmc Cardiolocomotor coupling in young and elderly people
    Vera Novak
    Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 62:86-92. 2007
    ..Walking is a complex act that requires the coordination of locomotor, cardiovascular, and autonomic systems. Aging affects each of these systems and may alter physiological mechanisms regulating the interactions between them...
  27. pmc Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes
    Vera Novak
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St, Boston, MA 02215, USA
    Diabetes Care 29:1529-34. 2006
    ....
  28. pmc Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study
    Ihab Hajjar
    Harvard Medical School, Institute for Aging Research Hebrew SeniorLife, Division of Gerontology, Beth Israel Deaconess Medical Center, Boston MA, USA
    Circulation 123:858-65. 2011
    ....
  29. ncbi request reprint Sex differences in the emergency department evaluation of elderly patients with syncope
    Shamai A Grossman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, WCC2, One Deaconess Road, Boston, Massachusetts 02115, USA
    J Gerontol A Biol Sci Med Sci 60:1202-5. 2005
    ..Recent studies have shown significant differences in both presentation and therapy in women with coronary disease and congestive heart failure...
  30. pmc Long-term effects of analgesics in a population of elderly nursing home residents with persistent nonmalignant pain
    Aida Won
    Gerontology Division and Harvard Medical School Division on Aging, Beth Israel Deaconess Medical Center, 110 Francis Street, LMOB 1A, Boston, MA, USA
    J Gerontol A Biol Sci Med Sci 61:165-9. 2006
    ..Little is known about the long-term effects of analgesics on functional status and well-being of nursing home residents with chronic pain...
  31. pmc The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population
    Suzanne G Leveille
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    BMC Geriatr 8:16. 2008
    ....
  32. pmc Dynamic models for the study of frailty
    Lewis A Lipsitz
    Hebrew SeniorLife Institute for Aging Research, Beth Israel Deaconess Medical Center Gerontology Division, Harvard Medical School, 1200 Centre Street, Boston, MA 02131, United States
    Mech Ageing Dev 129:675-6. 2008
    ..This model can be used to demonstrate how the degradation of signaling pathways within a physiologic system can result in the loss of complex dynamics that characterizes frailty...
  33. pmc Physiological complexity and system adaptability: evidence from postural control dynamics of older adults
    Brad Manor
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St Suite 1B, Boston, MA 02215, USA
    J Appl Physiol 109:1786-91. 2010
    ..Relatively low baseline complexity may, therefore, indicate control systems that are more vulnerable to cognitive and other stressors...
  34. pmc Renin angiotensin system gene polymorphisms modify angiotensin-converting enzyme inhibitors' effect on cognitive function: the health, aging and body composition study
    Ihab Hajjar
    Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 58:1035-42. 2010
    ....
  35. pmc Optimizing the tracking of falls in studies of older participants: comparison of quarterly telephone recall with monthly falls calendars in the MOBILIZE Boston Study
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131 1097, USA
    Am J Epidemiol 171:1031-6. 2010
    ..Retrospective 3-month recall of falls resulted in underreporting of falls by as much as 25% compared with daily calendars. Calendars should be considered the preferred method of ascertaining falls in longitudinal studies...
  36. pmc Poor adherence to medications may be associated with falls
    Sarah D Berry
    MD Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 65:553-8. 2010
    ....
  37. pmc Variation in blood pressure is associated with white matter microstructure but not cognition in African Americans
    Elizabeth C Leritz
    VA Boston Healthcare System and Brigham, and Women s Hospital
    Neuropsychology 24:199-208. 2010
    ..These data provide important evidence that variation in BP may contribute to significant alterations in specific neural regions of white matter in nonmedicated individuals without symptoms of overt CVD...
  38. pmc Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston study
    Ihab Hajjar
    Harvard Medical School, Institute for Aging Research Hebrew SeniorLife Beth Israel Deaconess Medical Center, Division of Gerontology, Boston, MA 02130, USA
    Stroke 41:635-40. 2010
    ..Our objective was to investigate the associations between polymorphisms in representative genes of the renin angiotensin system with measures of cerebral blood flow regulation in older adults...
  39. pmc Validation and comparison of two frailty indexes: The MOBILIZE Boston Study
    Dan K Kiely
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre St, Boston, MA 02131, USA
    J Am Geriatr Soc 57:1532-9. 2009
    ..To validate two established frailty indexes and compare their ability to predict adverse outcomes in a diverse, elderly, community-dwelling sample of men and women...
  40. pmc Frailty and the degradation of complex balance dynamics during a dual-task protocol
    Hyun Gu Kang
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 64:1304-11. 2009
    ....
  41. pmc Subsensory vibrations to the feet reduce gait variability in elderly fallers
    Andrew M Galica
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    Gait Posture 30:383-7. 2009
    ..This study supports the hypothesis that subsensory vibratory noise applied to the soles of the feet can reduce gait variability in elderly participants. Future studies are needed to determine if this intervention reduces falls risk...
  42. doi request reprint Prevalence and characteristics of traumatic intracranial hemorrhage in elderly fallers presenting to the emergency department without focal findings
    Anupama S Gangavati
    Department of Medicine, Division of Gerontology, Beth Israel Deaconess Medical Center, Massachusetts 02215, USA
    J Am Geriatr Soc 57:1470-4. 2009
    ..To determine the prevalence and associated characteristics of traumatic intracranial hemorrhage (ICH) in elderly fallers presenting to the emergency department (ED) without focal findings...
  43. pmc A novel aging phenotype of slow gait, impaired executive function, and depressive symptoms: relationship to blood pressure and other cardiovascular risks
    Ihab Hajjar
    Department of Medicine, Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, and Department of Psychiatry, Brigham and Women s Children Hospital, 1200 Center Street, Boston, MA, USA
    J Gerontol A Biol Sci Med Sci 64:994-1001. 2009
    ....
  44. pmc Issues in conducting epidemiologic research among elders: lessons from the MOBILIZE Boston Study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Am J Epidemiol 168:1444-51. 2008
    ..It is hoped that this paper will encourage and inform future epidemiologic research in this important segment of the population...
  45. doi request reprint An educational intervention for providers to promote bone health in high-risk older patients
    Mark J Simone
    Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Geriatr Soc 59:291-6. 2011
    ....
  46. pmc Foot pressure distribution during walking in young and old adults
    Mary Josephine Hessert
    Division of Gerontology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    BMC Geriatr 5:8. 2005
    ..The effects of healthy aging on FPD during walking are not well known. This study evaluated FPD during normal walking in healthy young and elderly subjects...
  47. ncbi request reprint The value of cardiac enzymes in elderly patients presenting to the emergency department with syncope
    Shamai A Grossman
    Department of Emergency Medicine Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Gerontol A Biol Sci Med Sci 58:1055-8. 2003
    ..Most patients admitted to the hospital from the emergency department (ED) with syncope do not have a myocardial infarction (MI), yet a common practice is to draw serial cardiac enzymes...
  48. ncbi request reprint Selective impairment of frontal-executive cognitive function in african americans with cardiovascular risk factors
    Kenneth G Pugh
    Beth Israel Deaconess Medical Center, Department of Medicine, Gerontology Division, Boston, Massachusetts, USA
    J Am Geriatr Soc 51:1439-44. 2003
    ..To determine whether a summary cardiovascular risk score is associated with an increased risk of frontal-executive cognitive impairment...
  49. ncbi request reprint Effect of systolic blood pressure and carotid stiffness on baroreflex gain in elderly subjects
    Seiji Mukai
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Gerontology Division, Beth Israel Deaconess Medical Center, and Division on Aging, Harvard Medical School, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 58:626-30. 2003
    ..Aging is also associated with systolic blood pressure (SBP) elevation and carotid artery stiffness, which may both affect baroreflex gain...
  50. ncbi request reprint Cerebral pressure-flow relations in hypertensive elderly humans: transfer gain in different frequency domains
    Jorge M Serrador
    Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center Gerontology Palmer 117, One Deaconess Road, Boston, MA 02215, USA
    J Appl Physiol 98:151-9. 2005
    ..Pressure regulation of cerebral blood flow is unrelated to cerebrovascular reactivity to CO(2)...
  51. ncbi request reprint Persistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residents
    Aida B Won
    Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 52:867-74. 2004
    ..To determine the prevalence of analgesics used, their prescribing patterns, and associations with particular diagnoses and medications in patients with persistent pain...
  52. pmc Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension
    Vera Novak
    Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biomed Eng Online 3:39. 2004
    ..The autoregulatory dynamics are difficult to assess because of the nonstationarity and nonlinearity of the component signals...
  53. ncbi request reprint Effect of blood pressure on cognitive functions in elderly persons
    Hsu Ko Kuo
    Hebrew Rehabilitation Center for Aged, 1200 Centre St, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 59:1191-4. 2004
    ..The aim of this study was to determine the effect of BP and its postural change on cognitive functions in otherwise healthy elders...
  54. pmc Loss of otolith function with age is associated with increased postural sway measures
    Jorge M Serrador
    Harvard Medical School, Boston, MA, United States Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurosci Lett 465:10-5. 2009
    ..These data suggest a role for loss of otolith function in contributing to fall risk in the elderly. Further prospective, longitudinal studies are necessary to confirm these findings...
  55. ncbi request reprint What is physiologic complexity and how does it change with aging and disease?
    Ary L Goldberger
    Cardiovascular Division, Department of Medicine, and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 23:23-6. 2002
  56. ncbi request reprint Neural mechanisms of delirium: current hypotheses and evolving concepts
    J M Flacker
    The Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel Hospital Department of Medicine, and Harvard Medical School, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 54:B239-46. 1999
    ..Further situation-specific studies of delirium pathophysiology should lead to more effective prevention and treatment strategies...
  57. ncbi request reprint Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence
    L A Lipsitz
    Department of Medicine, Beth Israel Hospital, Boston, MA
    JAMA 267:1806-9. 1992
    ....
  58. ncbi request reprint Quantifying fractal dynamics of human respiration: age and gender effects
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Biomed Eng 30:683-92. 2002
    ....
  59. ncbi request reprint Predicting the dynamic postural control response from quiet-stance behavior in elderly adults
    Elizabeth T Hsiao-Wecksler
    Department of Biomedical Engineering, Center of BioDynamics, Boston University, Boston, MA, USA
    J Biomech 36:1327-33. 2003
    ....
  60. ncbi request reprint Noise-enhanced human sensorimotor function
    James J Collins
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    IEEE Eng Med Biol Mag 22:76-83. 2003
  61. pmc Desferroxamine infusion increases cerebral blood flow: a potential association with hypoxia-inducible factor-1
    Farzaneh A Sorond
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Sci (Lond) 116:771-9. 2009
    ..The findings of the present study provide preliminary data suggesting that activators of HIF-1, such as desferroxamine, may protect neurons against ischaemic injury by dilating cerebral vessels and enhancing cerebral perfusion...
  62. ncbi request reprint Noise-enhanced balance control in older adults
    Denise C Gravelle
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    Neuroreport 13:1853-6. 2002
    ..These findings suggest that electrical noise-based devices may be effective in improving balance control in elderly people...
  63. pmc Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease
    Stefanie H Freeman
    C S Kubik Laboratory for Neuropathology, Department of Pathology, Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    J Neuropathol Exp Neurol 67:1205-12. 2008
    ..These data suggest that loss of neuronal and dendritic architecture, rather than loss of neurons, underlies neocortical volume loss with increasing age in the absence of Alzheimer disease...
  64. pmc Predicting adverse outcomes in syncope
    Shamai A Grossman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Emerg Med 33:233-9. 2007
    ..This pathway may be useful in identifying patients with syncope who are likely to have adverse outcome or critical interventions. Implementation and multicenter validation is needed before widespread application...
  65. ncbi request reprint Noise-enhanced balance control in patients with diabetes and patients with stroke
    Attila A Priplata
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Ann Neurol 59:4-12. 2006
    ..Sway data of 12 healthy elderly subjects from a previous study on vibrating insoles were added for comparison...
  66. pmc Regional cerebral autoregulation during orthostatic stress: age-related differences
    Farzaneh A Sorond
    Brigham and Women s Hospital, Neurology Stroke Division, 45 Francis St, Boston, MA 02115, USA
    J Gerontol A Biol Sci Med Sci 60:1484-7. 2005
    ....
  67. pmc Cognitive function in normal-weight, overweight, and obese older adults: an analysis of the Advanced Cognitive Training for Independent and Vital Elderly cohort
    Hsu Ko Kuo
    Division on Aging, Harvard Medical School, Boston, Massachusetts, USA
    J Am Geriatr Soc 54:97-103. 2006
    ..To assess how elevated body mass index (BMI) affects cognitive function in elderly people...
  68. ncbi request reprint Is pulse pressure a predictor of cardiovascular complications in a frail elderly nursing home population?
    Morad Askari
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, MA 02131, USA
    Aging Clin Exp Res 16:206-11. 2004
    ..The aims of this project are to determine the value of PP in predicting CV complications in a nursing home population, and to compare its predictive value with SBP, DBP, and mean arterial pressure (MAP)...
  69. ncbi request reprint Orthostatic hypotension in the elderly: diagnosis and treatment
    Vishal Gupta
    Beth Israel Deaconess Medical Center, Hebrew SeniorLife, and Harvard Medical School, Boston, Mass 02131, USA
    Am J Med 120:841-7. 2007
    ..With proper evaluation and management, the occurrence of adverse events, including falls, fracture, functional decline, and myocardial ischemia, can be significantly reduced...
  70. ncbi request reprint Reduced hip extension during walking: healthy elderly and fallers versus young adults
    D C Kerrigan
    Harvard Medical School, Department of Physical Medicine and Rehabilitation, and Spaulding Rehabilitation Hospital, Boston, MA, USA
    Arch Phys Med Rehabil 82:26-30. 2001
    ....
  71. ncbi request reprint Postprandial hypotension: epidemiology, pathophysiology, and clinical management
    R W Jansen
    Hebrew Rehabilitation Center for Aged, Beth Israel Hospital, Boston, Massachusetts
    Ann Intern Med 122:286-95. 1995
    ..To show the clinical relevance of postprandial hypotension and to review its pathophysiology and management...
  72. ncbi request reprint Does artificial enteral nutrition prolong the survival of institutionalized elders with chewing and swallowing problems?
    S L Mitchell
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Department of Medicine of Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 53:M207-13. 1998
    ..The objective of this study was to determine the impact of feeding tubes on the survival of nursing home residents with chewing and swallowing problems, and to follow the course of the tube-fed residents over one year...
  73. pmc Impaired executive function is associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA
    J Am Geriatr Soc 54:937-41. 2006
    ..To determine the extent to which preoperative performance on tests of executive function and memory was associated with delirium after coronary artery bypass graft (CABG) surgery...
  74. ncbi request reprint Noise-enhanced human balance control
    Attila Priplata
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev Lett 89:238101. 2002
    ..These results suggest that noise-based devices, such as randomly vibrating shoe inserts, may enable people to overcome functional difficulties due to age-related sensory loss...
  75. ncbi request reprint Orthostatic hypotension
    Seiji Mukai
    Hebrew Rehabilitation Center for Aged, Research and Training Institute, Beth Israel Deaconess Medical Center, Department of Medicine, Division on Aging, Harvard Medical School, Boston, MA, USA
    Clin Geriatr Med 18:253-68. 2002
    ..The careful evaluation and management of orthostatic hypotension will hopefully result in a significant reduction in falls, syncope, and fractures, and an attenuation of functional decline in elderly patients...
  76. pmc Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations
    J W Hamner
    Laboratory for Cardiovascular Research, Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, MA 02131, USA
    J Physiol 559:965-73. 2004
    ....
  77. ncbi request reprint Large neutral amino acid changes and delirium in febrile elderly medical patients
    J M Flacker
    Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, and Harvard Medical School Division on Aging, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 55:B249-52; discussion B253-4. 2000
    ..Tryptophan/LNAA was not associated with delirium during illness or at recovery. These findings identify another potentially fruitful area of investigation for the prevention and treatment of delirium in older persons...
  78. pmc The yield of head CT in syncope: a pilot study
    S A Grossman
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, WCC2, One Deaconess Road, Boston, MA 02115, USA
    Intern Emerg Med 2:46-9. 2007
    ..Although head CT is often routinely performed in emergency department (ED) patients with syncope, few studies have assessed its value...
  79. ncbi request reprint Noise-enhanced vibrotactile sensitivity in older adults, patients with stroke, and patients with diabetic neuropathy
    Wen Liu
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Arch Phys Med Rehabil 83:171-6. 2002
    ..To test the hypothesis that vibrotactile detection thresholds in older adults, patients with stroke, and patients with diabetic neuropathy can be significantly reduced with the introduction of mechanical noise...
  80. doi request reprint Establishing standards of quality for elderly patients undergoing pancreatic resection
    Wande B Pratt
    Department of Surgery, Harvard Medical School, Boston, MA 02215, USA
    Arch Surg 144:950-6. 2009
    ..To evaluate pancreatic surgery as a model for high-acuity surgery in elderly patients for immediate and long-term outcomes, predictors of adverse outcomes, and hospital costs...
  81. pmc Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery
    James L Rudolph
    VA Boston Healthcare System, Geriatric Research, Education, and Clinical Center, 150 S Huntington Ave, Boston, MA 02130, USA
    Circulation 119:229-36. 2009
    ..The purpose of the present prospective study was to develop a prediction rule for delirium in a cardiac surgery cohort and to validate it in an independent cohort...
  82. ncbi request reprint Modeling baroreflex regulation of heart rate during orthostatic stress
    Mette S Olufsen
    Dept of Mathematics, North Carolina State Univ, Campus Box 8205, Raleigh, NC 27695, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1355-68. 2006
    ....
  83. pmc Blood pressure and blood flow variation during postural change from sitting to standing: model development and validation
    Mette S Olufsen
    Department of Mathematics, North Carolina State University, Raleigh, 27695, USA
    J Appl Physiol 99:1523-37. 2005
    ..Finally, we formulate an inverse least-squares problem to estimate parameters and demonstrate that our mathematical model is in agreement with physiological data from a young subject during postural change from sitting to standing...
  84. ncbi request reprint Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors on health outcomes of very old patients with heart failure?
    Kate L Lapane
    Department of Community Health, Center for Gerontology and Health Care Research, Brown University, Providence, Rhode Island 02912, USA
    J Am Geriatr Soc 50:1198-204. 2002
    ..We estimated the effect of aspirin use on the rate of mortality, morbidity, and decline in physical functioning in nursing home residents with HF taking angiotensin-converting enzyme (ACE) inhibitors...
  85. ncbi request reprint Dynamics of cerebral blood flow regulation explained using a lumped parameter model
    Mette S Olufsen
    Department of Mathematics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Am J Physiol Regul Integr Comp Physiol 282:R611-22. 2002
    ..This biphasic change in cerebrovascular resistance is consistent with an initial vasoconstriction, followed by cerebral autoregulatory vasodilation...
  86. ncbi request reprint Cerebral white matter changes and geriatric syndromes: is there a link?
    Hsu Ko Kuo
    Hebrew Rehabilitation Center for Aged, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 59:818-26. 2004
    ..After these lesions develop and impair executive cognitive functions, the patient's ability to comply with a complex risk reduction program may be significantly compromised...
  87. ncbi request reprint The role of homocysteine in multisystem age-related problems: a systematic review
    Hsu Ko Kuo
    Hebrew Rehabilitation Center for Aged, 1200 Centre Street, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 60:1190-201. 2005
    ..More research is needed to investigate whether lifelong homocysteine lowering can prevent the development of late-life morbidity...
  88. ncbi request reprint Satisfaction with primary care providers of older adults living in senior housing
    Richard N Jones
    J Am Geriatr Soc 51:582-3. 2003
  89. ncbi request reprint The microvascular frontal-subcortical syndrome of aging
    Kenneth G Pugh
    Department of Medicine, Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurobiol Aging 23:421-31. 2002
    ....

Research Grants8

  1. Nonlinear Dynamics of Frailty in Aging
    Lewis Lipsitz; Fiscal Year: 2007
    ....
  2. HARVARD OLDER AMERICANS INDEPENDENCE CENTER
    Lewis Lipsitz; Fiscal Year: 2006
    ..abstract_text> ..
  3. Translational Research in Aging Training Program
    Lewis Lipsitz; Fiscal Year: 2007
    ..abstract_text> ..
  4. HRCA/HARVARD RESEARCH NURSING HOME
    Lewis Lipsitz; Fiscal Year: 2007
    ..Our institutional commitments, longstanding collaboration among investigators, track record of productivity, administrative structure, and proven leadership all assure that this program will achieve its stated goals. ..