M Lipsitch

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Antibiotics in agriculture: when is it time to close the barn door?
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:5752-4. 2002
  2. pmc Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools
    Tyler H Koep
    Clinical and Translational Sciences, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    BMC Infect Dis 13:71. 2013
  3. pmc Estimating rates of carriage acquisition and clearance and competitive ability for pneumococcal serotypes in Kenya with a Markov transition model
    Marc Lipsitch
    Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 23:510-9. 2012
  4. pmc Evolution, safety, and highly pathogenic influenza viruses
    Marc Lipsitch
    Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Science 336:1529-31. 2012
  5. pmc Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009
    Edward Goldstein
    Department of Epidemiology, Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA
    BMC Infect Dis 10:211. 2010
  6. pmc Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era
    Grace M Lee
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
    BMC Infect Dis 9:110. 2009
  7. ncbi request reprint Potential benefits of a serodiagnostic test for herpes simplex virus type 1 (HSV-1) to prevent neonatal HSV-1 infection
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Sex Transm Dis 29:399-405. 2002
  8. pmc Historical intensity of natural selection for resistance to tuberculosis
    Marc Lipsitch
    Departments of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genetics 161:1599-607. 2002
  9. pmc Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 196:1221-7. 2007
  10. pmc Effect of human leukocyte antigen heterozygosity on infectious disease outcome: the need for allele-specific measures
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Med Genet 4:2. 2003

Detail Information

Publications100

  1. pmc Antibiotics in agriculture: when is it time to close the barn door?
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:5752-4. 2002
  2. pmc Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools
    Tyler H Koep
    Clinical and Translational Sciences, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    BMC Infect Dis 13:71. 2013
    ..However, the variability and predictors of AH in the indoor school environment and the feasibility of classroom humidification to levels that could decrease viral survival have not been studied...
  3. pmc Estimating rates of carriage acquisition and clearance and competitive ability for pneumococcal serotypes in Kenya with a Markov transition model
    Marc Lipsitch
    Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 23:510-9. 2012
    ..Animal studies suggest that carriage induces an acquired immune response that reduces duration of colonization in a nonserotype-specific fashion...
  4. pmc Evolution, safety, and highly pathogenic influenza viruses
    Marc Lipsitch
    Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Science 336:1529-31. 2012
    ..Thus, we propose that future experiments with virulent pathogens whose accidental or deliberate release could lead to extensive spread in human populations should be limited by explicit risk-benefit considerations...
  5. pmc Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009
    Edward Goldstein
    Department of Epidemiology, Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA
    BMC Infect Dis 10:211. 2010
    ....
  6. pmc Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era
    Grace M Lee
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
    BMC Infect Dis 9:110. 2009
    ..aureus and MRSA colonization in young children in the context of widespread use of PCV7; and (2) examine risk factors for S. aureus colonization in the post-PCV7 era, including the absence of vaccine-type S. pneumoniae colonization...
  7. ncbi request reprint Potential benefits of a serodiagnostic test for herpes simplex virus type 1 (HSV-1) to prevent neonatal HSV-1 infection
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Sex Transm Dis 29:399-405. 2002
    ..Changes in sexual practices have led to an increase in the incidence of genital herpes simplex virus type 1 (HSV-1) infections. Such infections affect an estimated 400 newborns each year, with serious consequences...
  8. pmc Historical intensity of natural selection for resistance to tuberculosis
    Marc Lipsitch
    Departments of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genetics 161:1599-607. 2002
    ..Natural selection by PTB deaths during the European TB epidemic alone cannot account for the presently low level of TB disease observed among Europeans and their descendants just prior to the appearance of antibiotic treatment...
  9. pmc Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 196:1221-7. 2007
    ..If sustained, such patterns provide some cause for optimism that rapid evolution of PCV escape strains with drug resistance or high virulence is unlikely...
  10. pmc Effect of human leukocyte antigen heterozygosity on infectious disease outcome: the need for allele-specific measures
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Med Genet 4:2. 2003
    ....
  11. pmc Patterns of antigenic diversity and the mechanisms that maintain them
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    J R Soc Interface 4:787-802. 2007
    ....
  12. pmc Antiviral resistance and the control of pandemic influenza
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e15. 2007
    ..Nonetheless, antiviral resistance has received little attention when evaluating these plans...
  13. pmc Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Med 2:e15. 2005
    ....
  14. pmc Negative controls: a tool for detecting confounding and bias in observational studies
    Marc Lipsitch
    Department of Epidemiology, Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 21:383-8. 2010
    ....
  15. pmc Improving the evidence base for decision making during a pandemic: the example of 2009 influenza A/H1N1
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA 02115, USA
    Biosecur Bioterror 9:89-115. 2011
    ..We describe other inputs to decision making besides epidemiologic and surveillance data, and we conclude with key lessons of the 2009 pandemic for designing and planning surveillance in the future...
  16. ncbi request reprint Competition among Streptococcus pneumoniae for intranasal colonization in a mouse model
    M Lipsitch
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA corrected
    Vaccine 18:2895-901. 2000
    ..The findings provide a basis for further studies of in vivo interactions between strains of S. pneumoniae...
  17. pmc No coexistence for free: neutral null models for multistrain pathogens
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemics 1:2-13. 2009
    ..Neutral models can be a parsimonious starting point for studying mechanisms of strain coexistence; implications for past and future studies are discussed...
  18. pmc Effects of antiviral usage on transmission dynamics of herpes simplex virus type 1 and on antiviral resistance: predictions of mathematical models
    M Lipsitch
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 44:2824-35. 2000
    ..The predictions of this model contrast with the more rapid increases in antimicrobial resistance anticipated by models and observed for other pathogenic bacteria and viruses. The reasons for these contrasting predictions are discussed...
  19. ncbi request reprint Measuring and interpreting associations between antibiotic use and penicillin resistance in Streptococcus pneumoniae
    M Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 32:1044-54. 2001
    ..Recommendations for the design and analysis of future studies of antibiotic treatment and pneumococcal resistance are proposed...
  20. ncbi request reprint The rise and fall of antimicrobial resistance
    M Lipsitch
    Dept of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Trends Microbiol 9:438-44. 2001
    ..Open questions and approaches for testing the hypotheses proposed here are outlined...
  21. ncbi request reprint Invited commentary: real-time tracking of control measures for emerging infections
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 160:517-9; discussion 520. 2004
  22. pmc Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins
    Alan Basset
    Division of Infectious Diseases, Children s Hospital Boston, Enders 861 3, 300 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 75:5460-4. 2007
    ..Overall, our results show that intranasal immunization with a mixture of pneumococcal proteins protects against colonization in an antibody-independent, CD4+ T-cell-dependent manner...
  23. pmc The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model
    D Bogaert
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Vaccine 28:681-5. 2010
    ..We therefore conclude that complement prevents sepsis following pneumococcal colonization in a neutrophil-independent fashion, but and WCV-induced adaptive immunity is complement-independent...
  24. pmc Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence
    Alan Basset
    Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Enders 861 3, Boston, MA 02115, USA
    J Clin Microbiol 45:1684-9. 2007
    ..3% after 2000; P = 0.019). Therefore, our data show that the pilus is present in a minority of strains and is associated with certain serotypes and that its frequency has been reduced by the conjugate pneumococcal vaccine...
  25. ncbi request reprint Resistance to antimicrobial chemotherapy: a prescription for research and action
    B R Levin
    Emory University, Atlanta, Georgia 30322, USA
    Am J Med Sci 315:87-94. 1998
    ..It concludes with an update on the theoretical and empirical research on the between- and within-host population biology and evolution of resistance to antimicrobial chemotherapy most of which has been done since that meeting...
  26. ncbi request reprint Interpreting results from trials of pneumococcal conjugate vaccines: a statistical test for detecting vaccine-induced increases in carriage of nonvaccine serotypes
    M Lipsitch
    Department of Biology, Graduate School of Arts and Sciences, Emory University, Atlanta, GA
    Am J Epidemiol 154:85-92. 2001
    ..The implications of the findings and the assumptions and limitations of this technique are then discussed...
  27. pmc Transmission dynamics and control of severe acute respiratory syndrome
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 300:1966-70. 2003
    ..Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic...
  28. pmc Pneumococcal capsular polysaccharide structure predicts serotype prevalence
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    PLoS Pathog 5:e1000476. 2009
    ....
  29. pmc Distribution of vaccine/antivirals and the 'least spread line' in a stratified population
    E Goldstein
    Harvard School of Public Health, Boston, MA 02115, USA
    J R Soc Interface 7:755-64. 2010
    ..These results, which rely on the structure of the EpiSims network, are compared with the current influenza vaccination coverage levels in the US population...
  30. pmc Vaccine allocation in a declining epidemic
    E Goldstein
    Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J R Soc Interface 9:2798-803. 2012
    ....
  31. pmc Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci
    R Malley
    Divisions of Infectious Diseases, Children s Hospital, Harvard University of Public Health, Boston, Massachusetts 02115, USA
    Infect Immun 69:4870-3. 2001
    ..These studies suggest that killed whole-cell unencapsulated pneumococci given intranasally with an adjuvant may provide multitypic protection against capsulated pneumococci...
  32. pmc Bacterial vaccines and serotype replacement: lessons from Haemophilus influenzae and prospects for Streptococcus pneumoniae
    M Lipsitch
    Emory University, Atlanta, Georgia, USA
    Emerg Infect Dis 5:336-45. 1999
    ....
  33. pmc The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions
    M Lipsitch
    Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 97:1938-43. 2000
    ..The predictions of the model are compared with those of other models and published data. The implications for resistance control and study design are discussed, along with the limitations and assumptions of the model...
  34. pmc Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology, Harvard School of Public Health, Boston, MA 02115, USA
    Infect Immun 73:7043-6. 2005
    ..Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection...
  35. pmc Interleukin-17A mediates acquired immunity to pneumococcal colonization
    Ying Jie Lu
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 4:e1000159. 2008
    ..We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines...
  36. ncbi request reprint Population dynamics of tuberculosis treatment: mathematical models of the roles of non-compliance and bacterial heterogeneity in the evolution of drug resistance
    M Lipsitch
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Int J Tuberc Lung Dis 2:187-99. 1998
    ..Patient non-compliance and/or spatial heterogeneity in drug concentration or effectiveness may contribute to the emergence of drug resistance during multiple-drug chemotherapy of tuberculosis...
  37. pmc Natural selection, infectious transfer and the existence conditions for bacterial plasmids
    C T Bergstrom
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 155:1505-19. 2000
    ..Second, plasmids may persist because of their ability to shuttle intermittently favored genes back and forth between various (noncompeting) bacterial strains, ecotypes, or even species...
  38. pmc Reconstructing influenza incidence by deconvolution of daily mortality time series
    Edward Goldstein
    Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:21825-9. 2009
    ..s...
  39. pmc Pre-dispensing of antivirals to high-risk individuals in an influenza pandemic
    Edward Goldstein
    Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA
    Influenza Other Respi Viruses 4:101-12. 2010
    ....
  40. pmc SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model
    Gili Regev-Yochay
    Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Bacteriol 189:6532-9. 2007
    ..We conclude that a suicide gene of pneumococcus is spxB, which induces an apoptosis-like death in pneumococci and confers a selective advantage in nasopharyngeal cocolonization...
  41. pmc Carried pneumococci in Massachusetts children: the contribution of clonal expansion and serotype switching
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Pediatr Infect Dis J 30:302-8. 2011
    ..Vaccination against 7 serotypes of Streptococcus pneumoniae has led to the near extinction of vaccine serotypes in both disease and asymptomatic carriage. In carriage, vaccine serotypes have been replaced by nonvaccine serotypes...
  42. doi request reprint Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Infect Dis 197:1511-8. 2008
    ..We found no evidence of specific protection for type 6B, group 15, or type 19F. Our findings imply that at least some serotypes generate anti-capsular antibodies that can reduce the risk of carriage in unimmunized toddlers...
  43. ncbi request reprint Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease
    Richard Malley
    Division of Infectious Diseases, Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 196:928-35. 2007
    ..We thus conclude that, in adult patients with COPD, resistance to pneumococcal colonization is unlikely to be determined by higher serum antibody concentrations to pneumococcal antigens...
  44. pmc The pneumococcal pilus predicts the absence of Staphylococcus aureus co-colonization in pneumococcal carriers
    Gili Regev-Yochay
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 48:760-3. 2009
    ..aureus were significantly lower for individuals carrying a piliated versus a nonpiliated S. pneumoniae strain, suggesting the pilus may be a determinant of the negative association...
  45. pmc Antimicrobial use and antimicrobial resistance: a population perspective
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachussetts 02115, USA
    Emerg Infect Dis 8:347-54. 2002
    ..These mechanisms can operate even when treatment has a modest, or even negative, effect on an individual host's colonization with resistant organisms...
  46. pmc Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
    Richard Malley
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1966-71. 2003
    ..We conclude that the interaction of pneumolysin with TLR4 is critically involved in the innate immune response to pneumococcus...
  47. ncbi request reprint Estimating variability in the transmission of severe acute respiratory syndrome to household contacts in Hong Kong, China
    Virginia E Pitzer
    Department of Epidemiology, School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Epidemiol 166:355-63. 2007
    ..This study suggests that the probability of transmission of SARS is dependent upon characteristics of the index patients and does not simply reflect temporal variability in the viral load of SARS cases...
  48. pmc Too little of a good thing: a paradox of moderate infection control
    Ted Cohen
    Division of Social Medicine and Health Inequalities Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Epidemiology 19:588-9. 2008
    ..For those pathogens that cause more severe disease among hosts of an older age, interventions that limit transmission can paradoxically increase the burden of disease in a population...
  49. pmc Weather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia I. Patterns of lagged weather effects reflect biological mechanisms
    Hailay D Teklehaimanot
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Malar J 3:41. 2004
    ..The impact of temperature on the duration of a mosquito's life cycle and the sporogonic phase of the parasite could explain the inconsistent findings...
  50. pmc Generation interval contraction and epidemic data analysis
    Eben Kenah
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Math Biosci 213:71-9. 2008
    ..This approach leads naturally to partial likelihoods for epidemic data that are very similar to those that arise in survival analysis, opening a promising avenue of methodological research in infectious disease epidemiology...
  51. pmc Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells
    Krzysztof Trzcinski
    Harvard School of Public Health, Department of Epidemiology, 665 Huntington Avenue, Building 1, Room 903, Boston, MA 02115, USA
    Infect Immun 76:2678-84. 2008
    ..These results are consistent with the recruitment and/or activation of phagocytic or other nonspecific effectors by antigen-specific CD4(+) T cells...
  52. pmc Little evidence for genetic susceptibility to influenza A (H5N1) from family clustering data
    Virginia E Pitzer
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 13:1074-6. 2007
    ..We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event...
  53. pmc The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men
    Alethea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 44:1115-22. 2007
    ..However, the potential reduction in secondary transmission associated with ART may be offset by the longer duration of infectiousness...
  54. pmc Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA
    Gili Regev-Yochay
    Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Vaccine 28:4842-6. 2010
    ..These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage...
  55. pmc Single-step capsular transformation and acquisition of penicillin resistance in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Bacteriol 186:3447-52. 2004
    ..This suggests that in natural settings selection by host immunity and selection by antibiotics may be interrelated because of "hitchhiking" effects due to linkage of resistance determinants and the capsule locus...
  56. pmc Age-specific immunoglobulin g (IgG) and IgA to pneumococcal protein antigens in a population in coastal kenya
    Catherine Laine
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Infect Immun 72:3331-5. 2004
    ..001). No decline was observed in the sera of the elderly. Anti-protein IgG concentrations were only weakly correlated (0.30 < r < 0.56; P < 0.0001), as were IgA concentrations (0.24 < r < 0.54; P < 0.0001)...
  57. pmc Alert threshold algorithms and malaria epidemic detection
    Hailay Desta Teklehaimanot
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 10:1220-6. 2004
    ..The comparative method developed here may be useful for testing other proposed alert thresholds and for application in other populations...
  58. pmc Weather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia II. Weather-based prediction systems perform comparably to early detection systems in identifying times for interventions
    Hailay D Teklehaimanot
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Malar J 3:44. 2004
    ..Early warning methods that provide earlier alerts (usually by the use of weather variables) may permit control measures to interrupt transmission earlier in the epidemic, perhaps at the expense of some level of accuracy...
  59. pmc Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide
    Richard Malley
    Division of Infectious Diseases, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 74:2187-95. 2006
    ..C-Ps also protected in a model of fatal aspiration pneumonia by heavily capsulated serotype 3. These findings suggest a novel immunization strategy against S. pneumoniae...
  60. pmc Construction of otherwise isogenic serotype 6B, 7F, 14, and 19F capsular variants of Streptococcus pneumoniae strain TIGR4
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Appl Environ Microbiol 69:7364-70. 2003
    ..The constructed capsular variants of TIGR4 are suitable for use in studies on the role of S. pneumoniae capsular polysaccharide in immunity, colonization, and pathogenesis...
  61. pmc CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization
    Richard Malley
    Division of Infectious Diseases, Department of Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:4848-53. 2005
    ..Thus, we find that immunity to pneumococcal colonization can be induced in the absence of antibody, independent of the capsular type, and this protection requires the presence of CD4(+) T cells at the time of challenge...
  62. pmc Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Room 903, Building 1, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 49:1591-2. 2005
    ..Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis...
  63. ncbi request reprint Modeling community- and individual-level effects of child-care center attendance on pneumococcal carriage
    Susan S Huang
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Clin Infect Dis 40:1215-22. 2005
    ..This variation is not fully explained by risk factors at the individual level but may be explained by factors producing effects at both the individual and community levels, such as child-care center (CCC) attendance...
  64. pmc In vitro bactericidal activity of Streptococcus pneumoniae and bactericidal susceptibility of Staphylococcus aureus strains isolated from cocolonized versus noncocolonized children
    Gili Regev-Yochay
    Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Microbiol 46:747-9. 2008
    ..Thus, in vitro killing is not the major determinant of the pattern of cocolonization...
  65. pmc Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV-tuberculosis coinfected populations
    Ted Cohen
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, One Brigham Circle, 1620 Tremont Street, Boston, MA 02120, USA
    Proc Natl Acad Sci U S A 103:7042-7. 2006
    ....
  66. pmc Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae
    Gili Regev-Yochay
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Bacteriol 188:4996-5001. 2006
    ..These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies...
  67. ncbi request reprint Incremental increase in fitness cost with increased beta -lactam resistance in pneumococci evaluated by competition in an infant rat nasal colonization model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Infect Dis 193:1296-303. 2006
    ....
  68. pmc Broad conditions favor the evolution of phase-variable loci
    M E Palmer
    Department of Biology, Stanford University, Stanford, California, USA
    MBio 4:e00430-12. 2013
    ..Our results indicate that conditions favoring evolution and maintenance of SSR loci in bacteria are quite broad...
  69. pmc Reproductive numbers, epidemic spread and control in a community of households
    E Goldstein
    Harvard School of Public Health, Boston, MA 02115, USA
    Math Biosci 221:11-25. 2009
    ..Along the way, we have also shown that in choosing between increasing vaccine efficacy and increasing coverage levels by the same factor, preference should go to efficacy...
  70. pmc When to start antiretroviral therapy in resource-limited settings
    Rochelle P Walensky
    Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
    Ann Intern Med 151:157-66. 2009
    ..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years...
  71. pmc Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Infect Dis 51:692-9. 2010
    ..We evaluated whether risk of death due to IPD is a stable serotype-associated property across studies and then compared the pooled effect estimates with epidemiologic and biological correlates...
  72. pmc Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals
    Carl T Bergstrom
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Proc Natl Acad Sci U S A 101:13285-90. 2004
    ..As a consequence, cycling is unlikely to be effective and may even hinder resistance control. These results may explain the limited success reported thus far from clinical trials of antimicrobial cycling...
  73. pmc Use of cumulative incidence of novel influenza A/H1N1 in foreign travelers to estimate lower bounds on cumulative incidence in Mexico
    Marc Lipsitch
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6895. 2009
    ..Accordingly, the total number of cases will be underestimated and disease severity overestimated. This problem is manifest in the current epidemic of novel influenza A/H1N1...
  74. pmc Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 51:392-400. 2010
    ..We forecast outcomes of this approach if implemented in Washington DC...
  75. ncbi request reprint The analysis of hospital infection data using hidden Markov models
    Ben Cooper
    Department of Epidemiology, Kresge Building, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 5:223-37. 2004
    ..Compared to the standard hidden Markov model, the new approach is more parsimonious, is more biologically plausible, and allows key epidemiological parameters to be estimated...
  76. ncbi request reprint Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States
    Althea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 9:424-30. 2003
    ....
  77. pmc Upgrading antibiotic use within a class: tradeoff between resistance and treatment success
    Y Claire Wang
    Department of Health Policy and Management, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:9655-60. 2006
    ..We discuss the implications of these considerations in regard to antibiotic choices for Streptococcus pneumoniae...
  78. pmc Exploring the relationship between incidence and the average age of infection during seasonal epidemics
    Virginia E Pitzer
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Theor Biol 260:175-85. 2009
    ....
  79. pmc Scaling up antiretroviral therapy in South Africa: the impact of speed on survival
    Rochelle P Walensky
    The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Infect Dis 197:1324-32. 2008
    ..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012...
  80. ncbi request reprint Transmissibility of 1918 pandemic influenza
    Christina E Mills
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 432:904-6. 2004
    ..But because influenza is frequently transmitted before a specific diagnosis is possible and there is a dearth of global antiviral and vaccine stores, aggressive transmission reducing measures will probably be required...
  81. pmc Estimates of the prevalence of pandemic (H1N1) 2009, United States, April-July 2009
    Carrie Reed
    Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop A32, Atlanta, GA 30033, USA
    Emerg Infect Dis 15:2004-7. 2009
    ..Correcting for under-ascertainment using a multiplier model, we estimate that 1.8 million-5.7 million cases occurred, including 9,000-21,000 hospitalizations...
  82. ncbi request reprint Multiple equilibria: tuberculosis transmission require unrealistic assumptions
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115 6028, USA
    Theor Popul Biol 63:169-70. 2003
  83. pmc Estimation of the reproductive number and the serial interval in early phase of the 2009 influenza A/H1N1 pandemic in the USA
    Laura Forsberg White
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Influenza Other Respi Viruses 3:267-76. 2009
    ..Appropriate public health responses to this pandemic depend in part on early estimates of key epidemiological parameters of the virus in defined populations...
  84. pmc Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: a Côte d'Ivoire appraisal
    Elena Losina
    Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Med 6:e1000173. 2009
    ..Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa...
  85. ncbi request reprint Projected benefits of active surveillance for vancomycin-resistant enterococci in intensive care units
    Eli N Perencevich
    Veterans Affairs Maryland Healthcare System, Baltimore, Maryland, USA
    Clin Infect Dis 38:1108-15. 2004
    ..Passive surveillance was minimally effective. Using the best available data, active surveillance is projected to be effective for reducing VRE transmission in ICU settings...
  86. ncbi request reprint Mechanisms by which antibiotics promote dissemination of resistant pneumococci in human populations
    Matthew H Samore
    Division of Clinical Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Am J Epidemiol 163:160-70. 2006
    ..Penicillins accelerate clearance of susceptible strains. The effect of penicillins in increasing resistance is shared equally by treated and untreated members of the population...
  87. pmc Age- and serogroup-related differences in observed durations of nasopharyngeal carriage of penicillin-resistant pneumococci
    Liselotte Högberg
    Department of Epidemiology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
    J Clin Microbiol 45:948-52. 2007
    ..The results highlight the importance of taking both serogroup and age of the carriers into account when studying the dynamics of pneumococcal transmission in young children...
  88. ncbi request reprint Serum serotype-specific pneumococcal anticapsular immunoglobulin g concentrations after immunization with a 9-valent conjugate pneumococcal vaccine correlate with nasopharyngeal acquisition of pneumococcus
    Ron Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Infect Dis 192:367-76. 2005
    ..We attempted to correlate postvaccination serum serotype-specific pneumococcal anticapsular immunoglobulin (Ig) G concentrations with new acquisitions of vaccine-type (VT) serotypes and the VT-related serotype 6A...
  89. ncbi request reprint Diversity and antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae carriage isolates in the post-heptavalent conjugate vaccine era
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College, London, UK
    J Infect Dis 195:347-52. 2007
    ..Possible mechanisms include de novo acquisition of resistance, serotype switching, introduction of new clones, and expansion of existing clones...
  90. ncbi request reprint Does pneumococcal conjugate vaccine influence Staphylococcus aureus carriage in children?
    Gili Regev-Yochay
    Clin Infect Dis 47:289-91; author reply 291-2. 2008
  91. pmc Seasonality of antibiotic-resistant streptococcus pneumoniae that causes acute otitis media: a clue for an antibiotic-restriction policy?
    Ron Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Israel
    J Infect Dis 197:1094-102. 2008
    ..We attempted to determine whether reduced antibiotic consumption, which is observed yearly in children during the warm season, is associated with a reduction in antibiotic resistance in pneumococcal acute otitis media (AOM)...
  92. ncbi request reprint Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, Enterococci, and Escherichia coli
    Anthony D Harris
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, and VA Maryland Health Care System, Baltimore, MD, USA
    Clin Infect Dis 34:1558-63. 2002
    ..68). The selection of control patients from the potentially suboptimal control type 1 can falsely identify certain antibiotics and overestimate the OR of the resistance-defining antibiotic...
  93. ncbi request reprint Projection of the future dimensions and costs of the genital herpes simplex type 2 epidemic in the United States
    David N Fisman
    City of Hamilton Social and Public Health Services Department, McMaster University, Hamilton, Ontario, Canada
    Sex Transm Dis 29:608-22. 2002
    ....
  94. ncbi request reprint Multiple outbreaks and flu containment plans
    Marc Lipsitch
    Science 312:845. 2006
  95. ncbi request reprint Antibiotic resistance--the interplay between antibiotic use in animals and human beings
    Randall S Singer
    College of Veterinary Medicine, University of Illinois, IL, USA
    Lancet Infect Dis 3:47-51. 2003
  96. pmc The influence of hitchhiking and deleterious mutation upon asexual mutation rates
    Michael E Palmer
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genetics 173:461-72. 2006
    ..We close by commenting on the importance of other factors, such as spatiotemporal variation, and on the origin of variation in mutation rates...
  97. pmc Pandemic flu: we are not prepared
    Marc Lipsitch
    MedGenMed 7:56. 2005
  98. pmc Public health interventions and epidemic intensity during the 1918 influenza pandemic
    Richard J Hatchett
    Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:7582-7. 2007
    ..These findings support the hypothesis that rapid implementation of multiple NPIs can significantly reduce influenza transmission, but that viral spread will be renewed upon relaxation of such measures...
  99. pmc Pandemic influenza: risk of multiple introductions and the need to prepare for them
    Christina E Mills
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 3:e135. 2006

Research Grants13

  1. Mechanisms of Capsular Diversity in Streptococcus Pneumoniae
    Marc Lipsitch; Fiscal Year: 2009
    ....
  2. Methodological Approaches to Planning and Analysis of N*
    Marc Lipsitch; Fiscal Year: 2007
    ..The goal of this work is to design tools that will aid in understanding and generalizing the output of computationally complex models of disease transmission. ..
  3. Mechanisms of Capsular Diversity in Streptococcus Pneumoniae
    Marc Lipsitch; Fiscal Year: 2007
    ....
  4. VACCINATION AND THE EVOLUTIONARY DYNAMICS OF PNEUMOCOCCI
    Marc Lipsitch; Fiscal Year: 2005
    ..abstract_text> ..
  5. Epidemiologic Methods: Resistant Nosocomial Infections
    Marc Lipsitch; Fiscal Year: 2004
    ..This will in turn lead to better practices to reduce the incidence of ARNI. ..
  6. Mechanisms of Capsular Diversity in Streptococcus Pneumoniae
    Marc Lipsitch; Fiscal Year: 2010
    ....