Ling Lin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The diurnal rhythm of hypocretin in young and old F344 rats
    Frank Desarnaud
    West Roxbury Veterans Affairs Medical Center and Harvard Medical School, Mass 02132, USA
    Sleep 27:851-6. 2004
  2. pmc Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
    Haruhisa Inoue
    Neuroregeneration Laboratories, Udall Parkinson s Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 104:14430-5. 2007
  3. ncbi request reprint Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons
    Ling Lin
    Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Cell Neurosci 28:547-55. 2005
  4. pmc Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics
    Ling Lin
    Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 32:142-9. 2009
  5. pmc Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits
    Ling Lin
    Udall Parkinson s Disease Research Center of Excellence and Neuroregeneration Laboratories, Harvard Medical School McLean Hospital, Belmont, Massachusetts 02478, USA
    Stem Cells 24:2504-13. 2006
  6. pmc Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection
    Chee Yeun Chung
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Hum Mol Genet 14:1709-25. 2005
  7. ncbi request reprint Relationship between CSF hypocretin levels and hypocretin neuronal loss
    Dmitry Gerashchenko
    West Roxbury VA Medical Center and Harvard Medical School, West Roxbury, MA 02132, USA
    Exp Neurol 184:1010-6. 2003
  8. ncbi request reprint Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh
    Ole Isacson
    Neuroregeneration Laboratory, McLean Hospital, Program in Neuroscience and Dept of Neurology, Harvard Medical School, Belmont, MA 02478 9106, USA
    Trends Neurosci 25:79-84. 2002
  9. ncbi request reprint A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon, Korea
    Sleep 29:1429-38. 2006
  10. ncbi request reprint CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?
    Isabelle Arnulf
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Sleep 29:1017-24. 2006

Collaborators

Detail Information

Publications52

  1. pmc The diurnal rhythm of hypocretin in young and old F344 rats
    Frank Desarnaud
    West Roxbury Veterans Affairs Medical Center and Harvard Medical School, Mass 02132, USA
    Sleep 27:851-6. 2004
    ..In young rats and monkeys, levels of HCRT-1 are highest at the end of the wake-active period and lowest toward the end of the sleep period. However, the effects of age on the diurnal rhythm of HCRT-1 are not known...
  2. pmc Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
    Haruhisa Inoue
    Neuroregeneration Laboratories, Udall Parkinson s Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 104:14430-5. 2007
    ....
  3. ncbi request reprint Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons
    Ling Lin
    Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Cell Neurosci 28:547-55. 2005
    ..In this system, netrin-1 stimulated and slit-2 opposed DA neurite growth. Such regulation may be important for DA axonal maintenance, regeneration, and phenotypic target recognition...
  4. pmc Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics
    Ling Lin
    Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 32:142-9. 2009
    ..Novel drugs and treatments could emerge from this new understanding...
  5. pmc Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits
    Ling Lin
    Udall Parkinson s Disease Research Center of Excellence and Neuroregeneration Laboratories, Harvard Medical School McLean Hospital, Belmont, Massachusetts 02478, USA
    Stem Cells 24:2504-13. 2006
    ..This may result from developmental differences generated by present in vitro methods of cell patterning or conditioning during ES cell differentiation...
  6. pmc Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection
    Chee Yeun Chung
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Hum Mol Genet 14:1709-25. 2005
    ..These results indicate that certain differentially expressed molecules in A9 and A10 DA neurons may play key roles in their relative vulnerability to toxins and PD...
  7. ncbi request reprint Relationship between CSF hypocretin levels and hypocretin neuronal loss
    Dmitry Gerashchenko
    West Roxbury VA Medical Center and Harvard Medical School, West Roxbury, MA 02132, USA
    Exp Neurol 184:1010-6. 2003
    ..In those narcoleptics where CSF levels are within the normal range, it is possible that not all of the HCRT neurons are lost and that the surviving HCRT neurons might be increasing output of CSF HCRT...
  8. ncbi request reprint Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh
    Ole Isacson
    Neuroregeneration Laboratory, McLean Hospital, Program in Neuroscience and Dept of Neurology, Harvard Medical School, Belmont, MA 02478 9106, USA
    Trends Neurosci 25:79-84. 2002
    ..This eventually leads to synaptic and dendritic loss with age...
  9. ncbi request reprint A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon, Korea
    Sleep 29:1429-38. 2006
    ....
  10. ncbi request reprint CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?
    Isabelle Arnulf
    Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Sleep 29:1017-24. 2006
    ..To determine if hypocretin deficiency is associated with abnormally low serum leptin levels, a putative cause of increased body mass index in narcoleptics...
  11. ncbi request reprint Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome
    Oludare B Taiwo
    University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science Veterinary Medicine Building, 1988 Fitch Avenue, St Paul, MN 55113, USA
    Sleep Med 8:260-5. 2007
    ..Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities...
  12. pmc The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
    Krister S Eriksson
    Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA, USA
    BMC Neurosci 9:26. 2008
    ..We noticed high peripherin expression in the posterior hypothalamus of mice, and decided to investigate further the exact location of expression and function of peripherin in the mouse posterior hypothalamus...
  13. doi request reprint Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates
    Joyce Shi Ying Lam
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Neurosci Lett 434:150-4. 2008
    ....
  14. ncbi request reprint The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy
    Scott J Schatzberg
    Animal Medical Center, New York, NY 10021, USA
    J Vet Intern Med 18:586-8. 2004
  15. ncbi request reprint Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy
    Marketa Hecht
    Center for Narcolepsy, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif, USA
    Sleep 26:809-10. 2003
    ..To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression...
  16. ncbi request reprint Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity
    Paulo J F Martins
    Department of Psychobiology Sleep Institute, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Regul Pept 117:155-8. 2004
    ....
  17. ncbi request reprint HLA and hypocretin studies in Korean patients with narcolepsy
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon
    Sleep 25:440-4. 2002
    ..Very few studies have evaluated narcolepsy in Asian countries, outside of Japan. Our goal was to study narcolepsy at the genetic, clinical and pathophysiological level in Korea...
  18. ncbi request reprint Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome
    Ann Charlotte Granholm
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hippocampus 13:905-14. 2003
    ..These findings demonstrate that estrogen can alleviate deficits in cholinergic and dendritic elements in the hippocampal formation and further strengthens the rationale to explore estrogen replacement therapy in women with DS...
  19. pmc Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor
    Ling Lin
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:115-22. 2004
    ..Conversely, ectopic Mitf expression suppresses the expression of IRF-4, the plasma cell marker CD138, and antibody secretion. Thus, Mitf regulates B cell homeostasis by suppressing the antibody-secreting fate...
  20. ncbi request reprint Effects of exogenous hyaluronan on midline crossing and axon divergence in the optic chiasm of mouse embryos
    Ling Lin
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR
    Eur J Neurosci 26:1-11. 2007
    ..These findings together indicate the crucial functions of this matrix molecule in regulating midline crossing and axon divergence, probably through interactions with guidance molecules including CD44, at the midline of the chiasm...
  21. ncbi request reprint Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome
    Christopher L Hunter
    Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Neurosci Res 45:437-45. 2003
    ..These findings demonstrate that elevated APP and decreased NGF levels in limbic areas correlate with the progressive memory decline and cholinergic degeneration seen in middle-aged trisomic mice...
  22. ncbi request reprint Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase gene from Ginkgo biloba
    Jie Lu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan SJTU Nottingham Plant Biotechnology R and D Center, Morgan Tan International Center for Life Sciences, Fudan University, Shanghai, China
    Mol Biol Rep 35:413-20. 2008
    ..The cloning of GbHDR gene will enable us to further understand the role of GbHDR involved in terpene triclatones biosynthetic pathway in G. biloba at molecular level...
  23. ncbi request reprint Localization of hyaluronan in the optic pathway of mouse embryos
    Ling Lin
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Neuroreport 18:355-8. 2007
    ....
  24. ncbi request reprint Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepiness
    Jose E Martinez-Rodriguez
    Neurology Service, Hospital Clinic i Provincial de Barcelona and Institut d lnvestigació Biomédica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Sleep 26:287-90. 2003
    ..Since narcolepsy is characterized by a dysfunction of the hypothalamic hypocretin system, we investigated whether patients with myotonic dystrophy type 1 with excessive daytime sleepiness have abnormalities in the hypocretin system...
  25. ncbi request reprint Changes in expression of fibroblast growth factor receptors during development of the mouse retinofugal pathway
    Ling Lin
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Comp Neurol 451:22-32. 2002
    ..This region overlaps with a lateral extension of the SSEA-1-positive cells, suggesting a possible relation of these cells to the elevated expression of FGFR...
  26. pmc Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease
    Matthew L Hemming
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 4:e262. 2007
    ..The objective of this study was to determine if enhancing the clearance of Abeta in the brain by ex vivo gene delivery of an Abeta-degrading protease can reduce amyloid plaque burden...
  27. ncbi request reprint Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm
    Chung Kit Chan
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong
    Neuroreport 18:1533-8. 2007
    ....
  28. pmc Characterizing the cancer genome in lung adenocarcinoma
    Barbara A Weir
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 450:893-8. 2007
    ..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
  29. pmc tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis
    Kebin Hu
    Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 19:503-14. 2008
    ..Together, these findings illustrate that tPA is a survival factor that prevents apoptosis of renal interstitial fibroblasts and myofibroblasts through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism...
  30. doi request reprint Disruption effects of monophthalate exposures on inter-Sertoli tight junction in a two-compartment culture model
    Yun Hui Zhang
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, People s Republic of China
    Environ Toxicol 23:302-8. 2008
    ....
  31. ncbi request reprint Clinical aspects of narcolepsy-cataplexy across ethnic groups
    Michele L Okun
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304 5742, USA
    Sleep 25:27-35. 2002
    ..A large sample of narcoleptic patients was also used to further describe symptomatology and natural history for this sleep disorder...
  32. pmc Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested
    Carmen Alaez
    Department of Immunology and Immunogenetics, INDRE, Mexico City, Mexico
    BMC Med Genet 9:79. 2008
    ..The purpose of the present study was to investigate the association of HLA class II DRB1/DQB1 alleles with narcolepsy-cataplexy in Mexican Mestizo patients...
  33. ncbi request reprint Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function
    Ling Lin
    Metabolic Diseases Branch National Institutes of Diabetes, Digestive and Kidney Diseases, NIH, Room 8C 101, Building 10, 10 Center Drive, MSC 1752, Bethesda, MD 20892 1752, USA
    Mol Cancer Res 5:183-93. 2007
    ..These experiments identify for the first time a proapoptotic activity of endogenous parafibromin likely to be important in its role as a tumor suppressor and show a functional role for the NLS of parafibromin in this activity...
  34. ncbi request reprint Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients
    Justin P Rubio
    The Neurogenetics Laboratory, The Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia
    Immunogenetics 59:177-86. 2007
    ..0006; OR 2.83 [1.54-5.19]). Together, these data confirm that an alternate MS risk locus exists in the extended class I region in Tasmanian MS patients independent of DRB1*15...
  35. ncbi request reprint DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, The Catholic University of Korea, Suwon, Korea
    Hum Immunol 68:59-68. 2007
    ..A predisposing effect of DQA1*0303 was also suggested. These results indicate a remarkable consistency in the complex HLA association present in narcolepsy across multiple ethnic groups...
  36. ncbi request reprint Amygdala enterostatin induces c-Fos expression in regions of hypothalamus that innervate the PVN
    Ling Lin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Brain Res 1020:147-53. 2004
    ....
  37. ncbi request reprint CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88
    Ling Lin
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 34:1483-7. 2004
    ..Thus, CpG DNA redirects Ig isotype production by regulating the specificity of class-switch recombination...
  38. ncbi request reprint Perturbation of CD44 function affects chiasmatic routing of retinal axons in brain slice preparations of the mouse retinofugal pathway
    Ling Lin
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, P R China
    Eur J Neurosci 17:2299-312. 2003
    ..These findings provide evidence that a normal function of CD44 molecules in the chiasmatic neurons is essential for axon crossing and axon divergence at the mouse optic chiasm...
  39. ncbi request reprint The F1-ATPase beta-subunit is the putative enterostatin receptor
    Miejung Park
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 25:2127-33. 2004
    ..The data provides evidence that the F1-ATPase beta-subunit is the enterostatin receptor and suggests that enterostatin and beta-casomorphin1-7 bind to distinct sites on the protein...
  40. ncbi request reprint Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression
    Geoffrey E Woodard
    1Metabolic Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 24:1272-6. 2005
    ..These results demonstrate that human parafibromin is a nucleocytoplasmic protein with functions consistent with its postulated role as a tumor suppressor protein...
  41. ncbi request reprint Chiasmatic neurons in the ventral diencephalon of mouse embryos--changes in arrangement and heterogeneity in surface antigen expression
    Ling Lin
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, PR China
    Brain Res Dev Brain Res 158:1-12. 2005
    ..These findings suggest an action of this surface carbohydrate on the control of axon growth and guidance in the mouse optic pathway...
  42. pmc Different metabolic responses to central and peripheral injection of enterostatin
    Ling Lin
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 290:R909-15. 2006
    ..These findings suggest that enterostatin regulates energy expenditure and substrate partitioning through both peripheral and central effects...
  43. ncbi request reprint CSF hypocretin levels are normal in Huntington's disease patients
    Stephanie E Gaus
    Sleep 28:1607-8. 2005
  44. ncbi request reprint Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults
    Emmanuel Mignot
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
    Brain 129:1609-23. 2006
    ..These results suggest a high prevalence of narcolepsy without cataplexy, as defined by the International Classification of Sleep Disorders, and/or a large number of false-positives for the MSLT...
  45. ncbi request reprint Normal hypocretin-1 levels in the cerebrospinal fluid of patients with fatal familial insomnia
    Jose E Martinez-Rodriguez
    Sleep 26:1068. 2003
  46. ncbi request reprint Effects of myocardial transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor for the improvement of heart function and angiogenesis after myocardial infarction
    Jinfu Yang
    Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Cardiology 107:17-29. 2007
    ....
  47. ncbi request reprint Enterostatin inhibition of dietary fat intake is dependent on CCK-A receptors
    Ling Lin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 285:R321-8. 2003
    ..The data suggest that both the peripheral and central responses to enterostatin are mediated through or dependent on peripheral and central CCK-A receptors...
  48. ncbi request reprint [Angiogenic effect of bone marrow mesenchymal stem cells transfected with human VEGF gene on myocardial infarcts in rats]
    Wen Wu Zhou
    Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:763-6, 771. 2006
    ..To evaluate the angiogenic effect of the bone marrow mesenchymal stem cells (MSCs) transfected with human vascular endothelial growth factor (VEGF(165)) gene on myocardial infarcts in rats...
  49. pmc Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system
    Ling Lin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 28:643-9. 2007
    ..Enterostatin also reduced the expression of AgRP in the hypothalamus and amygdala and in GT1-7 cells. These data suggest enterostatin inhibits dietary fat intake through a melanocortin signaling pathway...
  50. ncbi request reprint [Effect of reduced glutathione as anti-leukemic immune adjuvant]
    Jing xin Pan
    Departement of Hematology, The Second Affilialed Hospital of Fujian Medical University, Quanzhou 362000, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:359-62. 2006
    ..It is concluded that GSH may reverse ROM and increase K562 cell suppression rate, and GSH is as effective as DHT, but GSH has less side-effect than DHT. Therefore, GSH would be better antileukemia immune adjuvant...
  51. ncbi request reprint REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy
    Sona Nevsimalova
    Department of Neurology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Sleep Med 8:784-6. 2007
    ..Both girls were human leukocyte antigen (HLA)-DQB1 *0602 positive, and their cerebrospinal fluid (CSF) hypocretin level (Hcrt-1) was extremely low...