Genomes and Genes
Affiliation: Harvard University
- The diurnal rhythm of hypocretin in young and old F344 ratsFrank Desarnaud
West Roxbury Veterans Affairs Medical Center and Harvard Medical School, Mass 02132, USA
Sleep 27:851-6. 2004..In young rats and monkeys, levels of HCRT-1 are highest at the end of the wake-active period and lowest toward the end of the sleep period. However, the effects of age on the diurnal rhythm of HCRT-1 are not known...
- Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease modelsHaruhisa Inoue
Neuroregeneration Laboratories, Udall Parkinson s Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 104:14430-5. 2007....
- Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neuronsLing Lin
Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Mol Cell Neurosci 28:547-55. 2005..In this system, netrin-1 stimulated and slit-2 opposed DA neurite growth. Such regulation may be important for DA axonal maintenance, regeneration, and phenotypic target recognition...
- Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeuticsLing Lin
Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Trends Neurosci 32:142-9. 2009..Novel drugs and treatments could emerge from this new understanding...
- Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and SlitsLing Lin
Udall Parkinson s Disease Research Center of Excellence and Neuroregeneration Laboratories, Harvard Medical School McLean Hospital, Belmont, Massachusetts 02478, USA
Stem Cells 24:2504-13. 2006..This may result from developmental differences generated by present in vitro methods of cell patterning or conditioning during ES cell differentiation...
- Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protectionChee Yeun Chung
Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Hum Mol Genet 14:1709-25. 2005..These results indicate that certain differentially expressed molecules in A9 and A10 DA neurons may play key roles in their relative vulnerability to toxins and PD...
- Relationship between CSF hypocretin levels and hypocretin neuronal lossDmitry Gerashchenko
West Roxbury VA Medical Center and Harvard Medical School, West Roxbury, MA 02132, USA
Exp Neurol 184:1010-6. 2003..In those narcoleptics where CSF levels are within the normal range, it is possible that not all of the HCRT neurons are lost and that the surviving HCRT neurons might be increasing output of CSF HCRT...
- Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and AChOle Isacson
Neuroregeneration Laboratory, McLean Hospital, Program in Neuroscience and Dept of Neurology, Harvard Medical School, Belmont, MA 02478 9106, USA
Trends Neurosci 25:79-84. 2002..This eventually leads to synaptic and dendritic loss with age...
- A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepinessSeung Chul Hong
Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon, Korea
Sleep 29:1429-38. 2006....
- CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?Isabelle Arnulf
Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
Sleep 29:1017-24. 2006..To determine if hypocretin deficiency is associated with abnormally low serum leptin levels, a putative cause of increased body mass index in narcoleptics...
- Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndromeOludare B Taiwo
University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science Veterinary Medicine Building, 1988 Fitch Avenue, St Paul, MN 55113, USA
Sleep Med 8:260-5. 2007..Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities...
- The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouseKrister S Eriksson
Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA, USA
BMC Neurosci 9:26. 2008..We noticed high peripherin expression in the posterior hypothalamus of mice, and decided to investigate further the exact location of expression and function of peripherin in the mouse posterior hypothalamus...
- Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfatesJoyce Shi Ying Lam
Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
Neurosci Lett 434:150-4. 2008....
- The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsyScott J Schatzberg
Animal Medical Center, New York, NY 10021, USA
J Vet Intern Med 18:586-8. 2004
- Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsyMarketa Hecht
Center for Narcolepsy, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif, USA
Sleep 26:809-10. 2003..To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression...
- Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activityPaulo J F Martins
Department of Psychobiology Sleep Institute, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Regul Pept 117:155-8. 2004....
- HLA and hypocretin studies in Korean patients with narcolepsySeung Chul Hong
Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon
Sleep 25:440-4. 2002..Very few studies have evaluated narcolepsy in Asian countries, outside of Japan. Our goal was to study narcolepsy at the genetic, clinical and pathophysiological level in Korea...
- Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndromeAnn Charlotte Granholm
Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Hippocampus 13:905-14. 2003..These findings demonstrate that estrogen can alleviate deficits in cholinergic and dendritic elements in the hippocampal formation and further strengthens the rationale to explore estrogen replacement therapy in women with DS...
- Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factorLing Lin
Department of Internal Medicine Rheumatology, Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
J Exp Med 200:115-22. 2004..Conversely, ectopic Mitf expression suppresses the expression of IRF-4, the plasma cell marker CD138, and antibody secretion. Thus, Mitf regulates B cell homeostasis by suppressing the antibody-secreting fate...
- Effects of exogenous hyaluronan on midline crossing and axon divergence in the optic chiasm of mouse embryosLing Lin
Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR
Eur J Neurosci 26:1-11. 2007..These findings together indicate the crucial functions of this matrix molecule in regulating midline crossing and axon divergence, probably through interactions with guidance molecules including CD44, at the midline of the chiasm...
- Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndromeChristopher L Hunter
Department of Physiology and Neuroscience and the Center on Aging, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
Neurosci Res 45:437-45. 2003..These findings demonstrate that elevated APP and decreased NGF levels in limbic areas correlate with the progressive memory decline and cholinergic degeneration seen in middle-aged trisomic mice...
- Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase gene from Ginkgo bilobaJie Lu
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan SJTU Nottingham Plant Biotechnology R and D Center, Morgan Tan International Center for Life Sciences, Fudan University, Shanghai, China
Mol Biol Rep 35:413-20. 2008..The cloning of GbHDR gene will enable us to further understand the role of GbHDR involved in terpene triclatones biosynthetic pathway in G. biloba at molecular level...
- Localization of hyaluronan in the optic pathway of mouse embryosLing Lin
Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Neuroreport 18:355-8. 2007....
- Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepinessJose E Martinez-Rodriguez
Neurology Service, Hospital Clinic i Provincial de Barcelona and Institut d lnvestigació Biomédica August Pi i Sunyer IDIBAPS, Barcelona, Spain
Sleep 26:287-90. 2003..Since narcolepsy is characterized by a dysfunction of the hypothalamic hypocretin system, we investigated whether patients with myotonic dystrophy type 1 with excessive daytime sleepiness have abnormalities in the hypocretin system...
- Changes in expression of fibroblast growth factor receptors during development of the mouse retinofugal pathwayLing Lin
Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
J Comp Neurol 451:22-32. 2002..This region overlaps with a lateral extension of the SSEA-1-positive cells, suggesting a possible relation of these cells to the elevated expression of FGFR...
- Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer diseaseMatthew L Hemming
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Med 4:e262. 2007..The objective of this study was to determine if enhancing the clearance of Abeta in the brain by ex vivo gene delivery of an Abeta-degrading protease can reduce amyloid plaque burden...
- Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasmChung Kit Chan
Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong
Neuroreport 18:1533-8. 2007....
- Characterizing the cancer genome in lung adenocarcinomaBarbara A Weir
Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 450:893-8. 2007..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
- tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosisKebin Hu
Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 19:503-14. 2008..Together, these findings illustrate that tPA is a survival factor that prevents apoptosis of renal interstitial fibroblasts and myofibroblasts through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism...
- Disruption effects of monophthalate exposures on inter-Sertoli tight junction in a two-compartment culture modelYun Hui Zhang
Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, People s Republic of China
Environ Toxicol 23:302-8. 2008....
- Clinical aspects of narcolepsy-cataplexy across ethnic groupsMichele L Okun
Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304 5742, USA
Sleep 25:27-35. 2002..A large sample of narcoleptic patients was also used to further describe symptomatology and natural history for this sleep disorder...
- Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggestedCarmen Alaez
Department of Immunology and Immunogenetics, INDRE, Mexico City, Mexico
BMC Med Genet 9:79. 2008..The purpose of the present study was to investigate the association of HLA class II DRB1/DQB1 alleles with narcolepsy-cataplexy in Mexican Mestizo patients...
- Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic functionLing Lin
Metabolic Diseases Branch National Institutes of Diabetes, Digestive and Kidney Diseases, NIH, Room 8C 101, Building 10, 10 Center Drive, MSC 1752, Bethesda, MD 20892 1752, USA
Mol Cancer Res 5:183-93. 2007..These experiments identify for the first time a proapoptotic activity of endogenous parafibromin likely to be important in its role as a tumor suppressor and show a functional role for the NLS of parafibromin in this activity...
- Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patientsJustin P Rubio
The Neurogenetics Laboratory, The Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia
Immunogenetics 59:177-86. 2007..0006; OR 2.83 [1.54-5.19]). Together, these data confirm that an alternate MS risk locus exists in the extended class I region in Tasmanian MS patients independent of DRB1*15...
- DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in KoreansSeung Chul Hong
Department of Neuropsychiatry, St Vincent s Hospital, The Catholic University of Korea, Suwon, Korea
Hum Immunol 68:59-68. 2007..A predisposing effect of DQA1*0303 was also suggested. These results indicate a remarkable consistency in the complex HLA association present in narcolepsy across multiple ethnic groups...
- Amygdala enterostatin induces c-Fos expression in regions of hypothalamus that innervate the PVNLing Lin
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
Brain Res 1020:147-53. 2004....
- CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88Ling Lin
Department of Internal Medicine Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
Eur J Immunol 34:1483-7. 2004..Thus, CpG DNA redirects Ig isotype production by regulating the specificity of class-switch recombination...
- Perturbation of CD44 function affects chiasmatic routing of retinal axons in brain slice preparations of the mouse retinofugal pathwayLing Lin
Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, P R China
Eur J Neurosci 17:2299-312. 2003..These findings provide evidence that a normal function of CD44 molecules in the chiasmatic neurons is essential for axon crossing and axon divergence at the mouse optic chiasm...
- The F1-ATPase beta-subunit is the putative enterostatin receptorMiejung Park
Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Peptides 25:2127-33. 2004..The data provides evidence that the F1-ATPase beta-subunit is the enterostatin receptor and suggests that enterostatin and beta-casomorphin1-7 bind to distinct sites on the protein...
- Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expressionGeoffrey E Woodard
1Metabolic Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Oncogene 24:1272-6. 2005..These results demonstrate that human parafibromin is a nucleocytoplasmic protein with functions consistent with its postulated role as a tumor suppressor protein...
- Chiasmatic neurons in the ventral diencephalon of mouse embryos--changes in arrangement and heterogeneity in surface antigen expressionLing Lin
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, PR China
Brain Res Dev Brain Res 158:1-12. 2005..These findings suggest an action of this surface carbohydrate on the control of axon growth and guidance in the mouse optic pathway...
- Different metabolic responses to central and peripheral injection of enterostatinLing Lin
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Am J Physiol Regul Integr Comp Physiol 290:R909-15. 2006..These findings suggest that enterostatin regulates energy expenditure and substrate partitioning through both peripheral and central effects...
- CSF hypocretin levels are normal in Huntington's disease patientsStephanie E Gaus
Sleep 28:1607-8. 2005
- Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adultsEmmanuel Mignot
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
Brain 129:1609-23. 2006..These results suggest a high prevalence of narcolepsy without cataplexy, as defined by the International Classification of Sleep Disorders, and/or a large number of false-positives for the MSLT...
- Normal hypocretin-1 levels in the cerebrospinal fluid of patients with fatal familial insomniaJose E Martinez-Rodriguez
Sleep 26:1068. 2003
- Effects of myocardial transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor for the improvement of heart function and angiogenesis after myocardial infarctionJinfu Yang
Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
Cardiology 107:17-29. 2007....
- Enterostatin inhibition of dietary fat intake is dependent on CCK-A receptorsLing Lin
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Am J Physiol Regul Integr Comp Physiol 285:R321-8. 2003..The data suggest that both the peripheral and central responses to enterostatin are mediated through or dependent on peripheral and central CCK-A receptors...
- [Angiogenic effect of bone marrow mesenchymal stem cells transfected with human VEGF gene on myocardial infarcts in rats]Wen Wu Zhou
Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:763-6, 771. 2006..To evaluate the angiogenic effect of the bone marrow mesenchymal stem cells (MSCs) transfected with human vascular endothelial growth factor (VEGF(165)) gene on myocardial infarcts in rats...
- Enterostatin inhibition of dietary fat intake is modulated through the melanocortin systemLing Lin
Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Peptides 28:643-9. 2007..Enterostatin also reduced the expression of AgRP in the hypothalamus and amygdala and in GT1-7 cells. These data suggest enterostatin inhibits dietary fat intake through a melanocortin signaling pathway...
- [Effect of reduced glutathione as anti-leukemic immune adjuvant]Jing xin Pan
Departement of Hematology, The Second Affilialed Hospital of Fujian Medical University, Quanzhou 362000, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:359-62. 2006..It is concluded that GSH may reverse ROM and increase K562 cell suppression rate, and GSH is as effective as DHT, but GSH has less side-effect than DHT. Therefore, GSH would be better antileukemia immune adjuvant...
- REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsySona Nevsimalova
Department of Neurology, 1st Medical Faculty, Charles University, Prague, Czech Republic
Sleep Med 8:784-6. 2007..Both girls were human leukocyte antigen (HLA)-DQB1 *0602 positive, and their cerebrospinal fluid (CSF) hypocretin level (Hcrt-1) was extremely low...