Jiandie Lin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Metabolic control through the PGC-1 family of transcription coactivators
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Metab 1:361-70. 2005
  2. pmc Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex
    Marcus P Cooper
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 20:2996-3009. 2006
  3. ncbi request reprint Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    Julie St-Pierre
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 127:397-408. 2006
  4. ncbi request reprint Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:505-15. 2005
  5. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
  6. ncbi request reprint Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    Marc Uldry
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 3:333-41. 2006
  7. pmc Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance
    Claudia R Vianna
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 4:453-64. 2006
  8. ncbi request reprint Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
  9. ncbi request reprint Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
  10. pmc PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16260-5. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Metabolic control through the PGC-1 family of transcription coactivators
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Metab 1:361-70. 2005
    ..These actions also raise new opportunities for the development of novel therapeutics...
  2. pmc Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex
    Marcus P Cooper
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 20:2996-3009. 2006
    ..These data link LRP130 and PGC-1alpha to defective hepatic energy homeostasis in LSFC, and reveal a novel regulatory mechanism of glucose homeostasis...
  3. ncbi request reprint Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    Julie St-Pierre
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 127:397-408. 2006
    ..These studies reveal that PGC-1alpha is a broad and powerful regulator of ROS metabolism, providing a potential target for the therapeutic manipulation of these important endogenous toxins...
  4. ncbi request reprint Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:505-15. 2005
    ..These data show that PGC-1alpha links nutritional status to heme biosynthesis and acute hepatic porphyria...
  5. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
    ..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes...
  6. ncbi request reprint Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    Marc Uldry
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 3:333-41. 2006
    ....
  7. pmc Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance
    Claudia R Vianna
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 4:453-64. 2006
    ..Importantly, these abnormalities do not cause insulin resistance in skeletal muscle but cause substantially reduced insulin action in the liver...
  8. ncbi request reprint Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
    ..These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis...
  9. ncbi request reprint Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  10. pmc PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16260-5. 2006
    ..Thus, the high levels of PGC-1alpha in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1alpha during atrophy should enhance the FoxO-dependent loss of muscle mass...
  11. pmc An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:7111-6. 2003
    ..Furthermore, these data suggest an autofeedback loop whereby the calcium-signaling pathway may result in a stable induction of PGC-1alpha, contributing to the relatively stable nature of muscle fiber-type determination...
  12. ncbi request reprint Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    J Biol Chem 281:14683-90. 2006
    ..These data point to a crucial role for the PGC-1alpha/HNF4alpha partnership in hepatic lipoprotein metabolism...
  13. ncbi request reprint Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle
    Zoltan Arany
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Metab 1:259-71. 2005
    ..As mice lacking PGC-1alpha age, cardiac dysfunction becomes evident in vivo. These data indicate that PGC-1alpha is vital for the heart to meet increased demands for ATP and work in response to physiological stimuli...
  14. ncbi request reprint PGC-1beta in the regulation of hepatic glucose and energy metabolism
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:30843-8. 2003
    ..These data illustrate that PGC-1beta and PGC-1alpha have distinct arrays of activities in hepatic energy metabolism...
  15. ncbi request reprint Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    Julie St-Pierre
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:26597-603. 2003
    ..Together, these data indicate that PGC-1alpha and PGC-1beta profoundly alter mitochondrial metabolism and suggest that these proteins are likely to play different physiological functions...
  16. ncbi request reprint Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 418:797-801. 2002
    ..These data indicate that PGC-1 alpha is a principal factor regulating muscle fibre type determination...
  17. ncbi request reprint Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:1645-8. 2002
    ..HCF is shown to bind to both PGC-1alpha and -1beta and augment their transcriptional activity...