Research Topics
Genomes and GenesSpecies | JENNIFER HSIANG LING LINSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Publications
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 87:734-43. 2008..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
Association between sex hormones and colorectal cancer risk in men and womenJennifer H Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 11:419-424.e1. 2013..There is observational and clinical evidence that indicates that sex hormones affect development of colorectal cancer in men and women. However, the relationship between endogenous sex hormone levels and colorectal cancer is unclear...- The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal womenJennifer H Lin
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e42079. 2012..It is possible that the CYP19A1 gene which alters sex hormones production may influence HGF levels. We examined the association between the CYP19A1 gene variants and plasma HGF concentrations... - Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expressionJennifer H Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 72:3020-8. 2012..Together, our molecular pathological epidemiology findings suggest a preventive effect of hormone therapy against colorectal carcinogenesis that depends, in part, on loss of cyclin-dependent kinase inhibitor CDKN1A... - Boosting alternating decision trees modeling of disease trait informationKuang Yu Liu
HCNR Center for Bioinformatics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
BMC Genet 6:S132. 2005..In conclusion, our findings suggest that the ADTrees method may offer a more accurate representation of the disease status that allows for better detection of linkage evidence... - Intakes of calcium and vitamin D and breast cancer risk in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Arch Intern Med 167:1050-9. 2007..Animal data suggest the potential anticarcinogenic effects of calcium and vitamin D on breast cancer development. However, epidemiologic data relating calcium and vitamin D levels to breast cancer have been inconclusive... - Plasma cysteinylglycine levels and breast cancer risk in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Cancer Res 67:11123-7. 2007..66 (0.97-2.84; P(trend) = 0.03) in the overweight and obese group. Our findings suggest that women who are susceptible to experiencing oxidative stress may be at a greater risk for developing breast cancer... - Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trialJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
J Natl Cancer Inst 101:14-23. 2009..However, findings from randomized trials of the association between antioxidant use and cancer risk have been mostly negative... - Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Cancer Causes Control 21:897-908. 2010.... - Plasma homocysteine and cysteine and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 70:2397-405. 2010..The increased risk of breast cancer associated with high cysteine levels warrants further investigation... - Estrogen and progesterone-related gene variants and colorectal cancer risk in womenJennifer H Lin
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
BMC Med Genet 12:78. 2011..Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited... 
Predicting adherence to tamoxifen for breast cancer adjuvant therapy and preventionJennifer H Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Cancer Prev Res (Phila) 4:1360-5. 2011..g., other SERMs and aromatase inhibitors) are critical, as is the development of effective/targeted interventions to improve adherence and thus treatment outcomes in at-risk women...- Dietary intakes of flavonols and flavones and coronary heart disease in US womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 165:1305-13. 2007..93; p for trend = 0.04). The lower risk associated with kaempferol intake was probably attributable to broccoli consumption. These prospective data do not support an inverse association between flavonol or flavone intake and CHD risk... - Oral contraceptives, reproductive factors, and risk of colorectal cancer among women in a prospective cohort studyJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 165:794-801. 2007..09). No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer... - Total magnesium intake and colorectal cancer incidence in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Cancer Epidemiol Biomarkers Prev 15:2006-9. 2006 - Dietary fat and fatty acids and risk of colorectal cancer in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 160:1011-22. 2004..However, intake of fried foods and/or other factors related to their intake may be associated with colorectal cancer development. This finding warrants further examination... - Intakes of calcium and vitamin D and risk of colorectal cancer in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 161:755-64. 2005..Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk... - Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States)Jennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Cancer Causes Control 16:225-33. 2005..We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study... - Hemoglobin A1c concentrations and risk of colorectal cancer in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Cancer Epidemiol Biomarkers Prev 14:3010-2. 2005 - Are there mappable genes for family resemblance for the magnitude of intra-individual variation in systolic blood pressure?Jennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
BMC Genet 4:S11. 2003..To determine whether genomic regions affecting this phenotype could be identified, we pursued a "model-free" multipoint quantitative linkage analysis... - Linkage and association analyses of microsatellites and single-nucleotide polymorphisms in nuclear familiesJennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
BMC Genet 6:S25. 2005..In summary, our finding suggests that the SNP-based genome scan has the potential to be as powerful as the traditional MS-based scan and offers good identification of peak location for further fine-mapped association analysis... - A prospective study of hemoglobin A1c concentrations and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Cancer Res 66:2869-75. 2006..These data suggest that higher HbA1c concentrations do not seem to increase risk of breast cancer among apparently healthy women... - Flavonoid intake and colorectal cancer risk in men and womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Epidemiol 164:644-51. 2006..These data provide little support for the hypothesis of an association between flavonoid intake and colorectal cancer risk, at least within the ranges of intakes consumed in the populations studied... - A prospective study of multivitamin supplement use and risk of breast cancerKen Ishitani
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 167:1197-206. 2008.... - Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in womenShumin M Zhang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 163:108-15. 2006..An alternative explanation is that other factors related to dietary intakes of folate and vitamin B(6) account for the inverse associations... - C-reactive protein and risk of breast cancerShumin M Zhang
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
J Natl Cancer Inst 99:890-4. 2007..71 to 1.16; P(trend) = .19; crude incidence rates: 273 versus 305 per 100,000 person-years). Our data suggest that baseline plasma CRP levels are not associated with the increased risk of breast cancer in apparently healthy women... - Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control studyI Min Lee
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Clin Chem Lab Med 48:259-62. 2010..To date, no prospective epidemiological data are available, particularly in women, on mean leukocyte telomere length as a risk predictor... - Body mass index and risk of colorectal cancer in women (United States)Jennifer Lin
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
Cancer Causes Control 15:581-9. 2004..We prospectively investigated the role of BMI in colorectal cancer risk along with the modifying effects of estrogen in a large cohort from the Women's Health Study... - Caffeine consumption and the risk of breast cancer in a large prospective cohort of womenKen Ishitani
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Arch Intern Med 168:2022-31. 2008..Prospective data relating caffeine consumption to breast cancer risk are limited...
Research Grants
- Sex steroid hormones, gene variants, and colorectal cancerJENNIFER HSIANG LING LIN; Fiscal Year: 2010....
- Hormones, hormone-related genes, and colorectal cancerJennifer Lin; Fiscal Year: 2007..Findings from the proposed study of estrogen and progesterone will enhance our understanding of these lifestyle and genetic factors in relation to colorectal carcinogenesis. ..
- Sex steroid hormones, gene variants, and colorectal cancerJennifer Lin; Fiscal Year: 2009....