Fa Hsuan Lin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Functional MRI using regularized parallel imaging acquisition
    Fa Hsuan Lin
    Massachusetts General Hospital, Department of Radiology, MGH HMS MIT, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:343-53. 2005
  2. pmc Functional and effective connectivity of visuomotor control systems demonstrated using generalized partial least squares and structural equation modeling
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Hum Brain Mapp 30:2232-51. 2009
  3. ncbi request reprint Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain
    Fa Hsuan Lin
    MGH HMS MIT Athinoula A Martinos Center for Biomedical Imaging, Charlestown 02129, and Department of Radiology, Massachusetts General Hospital, Boston, USA
    Magn Reson Med 57:249-57. 2007
  4. pmc Event-related single-shot volumetric functional magnetic resonance inverse imaging of visual processing
    Fa Hsuan Lin
    MGH HST Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 42:230-47. 2008
  5. ncbi request reprint Dynamic magnetic resonance inverse imaging of human brain function
    Fa Hsuan Lin
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 56:787-802. 2006
  6. ncbi request reprint Assessing and improving the spatial accuracy in MEG source localization by depth-weighted minimum-norm estimates
    Fa Hsuan Lin
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149 13th St Charlestown, MA 02129, USA
    Neuroimage 31:160-71. 2006
  7. pmc Linear constraint minimum variance beamformer functional magnetic resonance inverse imaging
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 43:297-311. 2008
  8. ncbi request reprint Distributed current estimates using cortical orientation constraints
    Fa Hsuan Lin
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 27:1-13. 2006
  9. ncbi request reprint Parallel MRI reconstruction using variance partitioning regularization
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 58:735-44. 2007
  10. ncbi request reprint PROPELLER-EPI with parallel imaging using a circularly symmetric phased-array RF coil at 3.0 T: application to high-resolution diffusion tensor imaging
    Tzu Chao Chuang
    Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, R O C
    Magn Reson Med 56:1352-8. 2006

Research Grants

Collaborators

Detail Information

Publications49

  1. pmc Functional MRI using regularized parallel imaging acquisition
    Fa Hsuan Lin
    Massachusetts General Hospital, Department of Radiology, MGH HMS MIT, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:343-53. 2005
    ..Human motor and visual fMRI data acquired at different field strengths and array coils also demonstrate that regularized SENSE improves the detection of functionally active brain regions...
  2. pmc Functional and effective connectivity of visuomotor control systems demonstrated using generalized partial least squares and structural equation modeling
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Hum Brain Mapp 30:2232-51. 2009
    ....
  3. ncbi request reprint Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain
    Fa Hsuan Lin
    MGH HMS MIT Athinoula A Martinos Center for Biomedical Imaging, Charlestown 02129, and Department of Radiology, Massachusetts General Hospital, Boston, USA
    Magn Reson Med 57:249-57. 2007
    ..Thus, this technology is a promising means of reducing the scan times of 3D acquisitions and time-resolved 2D measurements...
  4. pmc Event-related single-shot volumetric functional magnetic resonance inverse imaging of visual processing
    Fa Hsuan Lin
    MGH HST Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 42:230-47. 2008
    ..Robust results from both single subject and group analyses demonstrate the sensitivity and feasibility of using volumetric InI in high temporal resolution investigations of human brain function...
  5. ncbi request reprint Dynamic magnetic resonance inverse imaging of human brain function
    Fa Hsuan Lin
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 56:787-802. 2006
    ..InI is expected to improve the time resolution of MRI and provide increased flexibility in the trade-off between spatial and temporal resolution for studies of dynamic activation patterns in the human brain...
  6. ncbi request reprint Assessing and improving the spatial accuracy in MEG source localization by depth-weighted minimum-norm estimates
    Fa Hsuan Lin
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149 13th St Charlestown, MA 02129, USA
    Neuroimage 31:160-71. 2006
    ..The application of depth weighting to auditory and somatosensory experimental data illustrated the beneficial effect of depth weighting on the accuracy of spatiotemporal mapping of neuronal sources...
  7. pmc Linear constraint minimum variance beamformer functional magnetic resonance inverse imaging
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 43:297-311. 2008
    ..Robust results from both single subject and group analyses demonstrate the excellent sensitivity and specificity of volumetric InI in detecting the spatial and temporal structure of task-related brain activity...
  8. ncbi request reprint Distributed current estimates using cortical orientation constraints
    Fa Hsuan Lin
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 27:1-13. 2006
    ..We also applied the method to in vivo auditory and somatosensory data...
  9. ncbi request reprint Parallel MRI reconstruction using variance partitioning regularization
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 58:735-44. 2007
    ..Our anatomical and functional MRI results show that the VPR method can be applied to both static and dynamic MRI experiments to suppress noise amplification in parallel MRI reconstructions for improved image quality...
  10. ncbi request reprint PROPELLER-EPI with parallel imaging using a circularly symmetric phased-array RF coil at 3.0 T: application to high-resolution diffusion tensor imaging
    Tzu Chao Chuang
    Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, R O C
    Magn Reson Med 56:1352-8. 2006
    ..It is concluded that parallel PROPELLER-EPI is an effective technique that can substantially reduce susceptibility-induced geometric distortions at high field strength...
  11. pmc fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 78:372-84. 2013
    ..This may open new avenues for using fMRI to follow rapid activation sequences in the brain...
  12. pmc Spectral spatiotemporal imaging of cortical oscillations and interactions in the human brain
    Fa Hsuan Lin
    MGH MIT MHS Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 23:582-95. 2004
    ..Spectral spatiotemporal imaging of cortical oscillations and interactions in the human brain can provide further understanding of large-scale neural activity and communication between different brain regions...
  13. doi request reprint Accelerated proton echo planar spectroscopic imaging (PEPSI) using GRAPPA with a 32-channel phased-array coil
    Shang Yueh Tsai
    Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 59:989-98. 2008
    ..At 4-fold acceleration the mean CRLB for NAA, tCr, and Cho was less than 11%. In conclusion, the use of a 32-channel coil array and GRAPPA reconstruction can significantly reduce the measurement time for mapping brain metabolites...
  14. ncbi request reprint Fast mapping of the T2 relaxation time of cerebral metabolites using proton echo-planar spectroscopic imaging (PEPSI)
    Shang Yueh Tsai
    Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 57:859-65. 2007
    ..Consistent spatial distributions of T2 were found in six healthy subjects, and disagreement among subjects was less than 10%. In summary, the PEPSI technique is a robust method to obtain fast mapping of metabolite T2...
  15. pmc Functional magnetic resonance inverse imaging of human visuomotor systems using eigenspace linearly constrained minimum amplitude (eLCMA) beamformer
    Shr Tai Liou
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
    Neuroimage 55:87-100. 2011
    ....
  16. pmc Onset timing of cross-sensory activations and multisensory interactions in auditory and visual sensory cortices
    Tommi Raij
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Bldg 149, 13 St, Charlestown, MA, USA
    Eur J Neurosci 31:1772-82. 2010
    ..Audiovisual interactions started at 85 ms in the left auditory, 80 ms in the right auditory and 74 ms in the visual cortex, i.e., 3-21 ms after inputs from the two modalities converged...
  17. pmc Cancellation of EEG and MEG signals generated by extended and distributed sources
    Seppo P Ahlfors
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, 02129, USA
    Hum Brain Mapp 31:140-9. 2010
    ..Furthermore, the selective cancellation may be used to explain some observed differences between EEG and MEG in terms of focal vs. widespread cortical activity...
  18. pmc Whole-head rapid fMRI acquisition using echo-shifted magnetic resonance inverse imaging
    Wei Tang Chang
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 78:325-38. 2013
    ..With the capabilities of being able to distinguish the timing differences in the millisecond scale, echo-shifted InI could be a useful fMRI tool for obtaining temporal information at a time scale closer to that of neuronal dynamics...
  19. pmc PROPELLER EPI: an MRI technique suitable for diffusion tensor imaging at high field strength with reduced geometric distortions
    Fu Nien Wang
    Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, R O C
    Magn Reson Med 54:1232-40. 2005
    ..A higher signal-to-noise ratio (SNR) compared to single-shot EPI at an identical total scan time was achieved, which is advantageous for routine DTI applications in clinical practice...
  20. pmc Multi-projection magnetic resonance inverse imaging of the human visuomotor system
    Kevin Wen Kai Tsai
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 61:304-13. 2012
    ..mInI can be applied to BOLD-contrast fMRI experiments to characterize the dynamics of the activated brain areas with a high spatiotemporal resolution...
  21. pmc Noise amplification in parallel whole-head ultra-low-field magnetic resonance imaging using 306 detectors
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 70:595-600. 2013
    ..Corroborating with previous studies, the g-factor in 2D sensitivity-encoded ultra-low-field MRI with 9 to 16-fold 2D accelerations using the SQUID array studied here may be acceptable...
  22. ncbi request reprint Multivariate analysis of neuronal interactions in the generalized partial least squares framework: simulations and empirical studies
    Fa Hsuan Lin
    Harvard MIT Division of Health Sciences and Technology, Charlestown, MA 02446, USA
    Neuroimage 20:625-42. 2003
    ..Overall, studies of synthetic and empirical data suggest that PLS analysis, using PCA decomposition, provides a stable and powerful tool for exploration of fMRI/behavior data...
  23. pmc Primary and multisensory cortical activity is correlated with audiovisual percepts
    Margo McKenna Benoit
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02114, USA
    Hum Brain Mapp 31:526-38. 2010
    ....
  24. pmc Attention-driven auditory cortex short-term plasticity helps segregate relevant sounds from noise
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 108:4182-7. 2011
    ..In conclusion, a simple gain model alone cannot explain auditory selective attention. In nonprimary auditory cortices, attention-driven short-term plasticity retunes neurons to segregate relevant sounds from noise...
  25. pmc Dissociable influences of auditory object vs. spatial attention on visual system oscillatory activity
    Jyrki Ahveninen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 7:e38511. 2012
    ..sound location ("where"). The alpha modulations could be interpreted to reflect enhanced crossmodal inhibition of feature-specific visual pathways and adjacent audiovisual association areas during "what" vs. "where" auditory attention...
  26. pmc Human posterior auditory cortex gates novel sounds to consciousness
    Iiro P Jaaskelainen
    Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6809-14. 2004
    ..Our converging findings suggest that transient adaptation of feature-specific neurons within human posterior auditory cortex filters superfluous sounds from entering one's awareness...
  27. pmc Dynamic Granger-Geweke causality modeling with application to interictal spike propagation
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan
    Hum Brain Mapp 30:1877-86. 2009
    ..Our novel computational tool can be used to help elucidate complex directional interactions in the human brain...
  28. ncbi request reprint Increasing FMRI sampling rate improves granger causality estimates
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland
    PLoS ONE 9:e100319. 2014
    ..We therefore conclude that the high-temporal resolution of InI improves the Granger causality connectivity analysis of the human brain. ..
  29. pmc Physiological noise reduction using volumetric functional magnetic resonance inverse imaging
    Fa Hsuan Lin
    Institute of Biomedical Engineering and Environmental Sciences, National Taiwan University, Taipei, Taiwan
    Hum Brain Mapp 33:2815-30. 2012
    ....
  30. pmc K-space reconstruction of magnetic resonance inverse imaging (K-InI) of human visuomotor systems
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 49:3086-98. 2010
    ..This robust and sensitive K-InI reconstruction can be applied to dynamic MRI acquisitions using a large-n coil array to improve the spatiotemporal resolution...
  31. pmc Ultrafast inverse imaging techniques for fMRI
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 62:699-705. 2012
    ..InI may become a helpful tool for clinicians and neuroscientists for revealing the complex dynamics of brain functions during task-related and resting states...
  32. pmc Spatially sparse source cluster modeling by compressive neuromagnetic tomography
    Wei Tang Chang
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 53:146-60. 2010
    ..Overall, the CENT method is demonstrated to be a promising tool for adaptive modeling of distributed neuronal currents associated with cognitive tasks...
  33. pmc Reconstruction of MRI data encoded by multiple nonbijective curvilinear magnetic fields
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 68:1145-56. 2012
    ..Reconstructions using simulations and empirical experimental data are compared with those using conventional linear gradients to demonstrate that the general combination of SEMs can improve image reconstructions...
  34. ncbi request reprint Sparse current source estimation for MEG using loose orientation constraints
    Wei Tang Chang
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Hum Brain Mapp 34:2190-201. 2013
    ..The proposed ℓ(1) LOC method appears useful for incorporating anatomical information about the source orientations into sparse source estimation of MEG data...
  35. ncbi request reprint MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortex
    Jyrki Ahveninen
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, CNY149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 35:577-82. 2007
    ..Anatomically constrained spectral imaging displays the cortical loci of drug effects on oscillatory brain activity, providing a novel tool for human pharmacological neuroimaging...
  36. doi request reprint Improving the spatial resolution of magnetic resonance inverse imaging via the blipped-CAIPI acquisition scheme
    Wei Tang Chang
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA, USA Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 91:401-11. 2014
    ..With the improved spatial resolution, especially in subcortical regions, bInI can be a useful fMRI tool for obtaining high spatiotemporal information for clinical and cognitive neuroscience studies. ..
  37. pmc Multidimensionally encoded magnetic resonance imaging
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 70:86-96. 2013
    ..Results show that MDE MRI with a higher dimensional encoding space can reconstruct images more efficiently and with a smaller reconstruction error when the k-space sampling distribution and the number of samples are controlled...
  38. pmc Effective cerebral connectivity during silent speech reading revealed by functional magnetic resonance imaging
    Ying Hua Chu
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e80265. 2013
    ..The direct functional connection from pFG to MFG/FP and feedback connection from MFG/FP to pSTG/S and IFG support the hypothesis of prefrontal speech motor areas influencing auditory speech processing in pSTG/S via an efference copy. ..
  39. pmc Parallel input makes the brain run faster
    Tommi Raij
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 40:1792-7. 2008
    ..This arrangement could also allow very early top-down modulation of the bottom-up stream of sensory information...
  40. pmc Task-modulated "what" and "where" pathways in human auditory cortex
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, CNY 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:14608-13. 2006
    ..This finding suggests that selective-attention effects are feature-specific in the human nonprimary auditory cortex and that they arise from enhanced tuning of receptive fields of task-relevant neuronal populations...
  41. ncbi request reprint Degenerate mode birdcage volume coil for sensitivity-encoded imaging
    Fa Hsuan Lin
    Havard MIT Division of Health Sciences and Technology, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:1107-11. 2003
    ..5 T. The maximal 2-fold acceleration in this dual-mode degenerate birdcage coil offers the potential to extend SENSE-type image reconstruction methods to applications demanding uniform whole brain coverage...
  42. pmc Lexical influences on speech perception: a Granger causality analysis of MEG and EEG source estimates
    David W Gow
    Neuropsychology Laboratory, Massachusetts General Hospital, 175 Cambridge St, CPZ S340, Boston, MA 02114, USA
    Neuroimage 43:614-23. 2008
    ....
  43. pmc Stimulus-induced Rotary Saturation (SIRS): a potential method for the detection of neuronal currents with MRI
    Thomas Witzel
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, USA
    Neuroimage 42:1357-65. 2008
    ..Magn. Reson. Med. 50, 40-49], but is potentially less encumbered by temporal and spatial cancellation effects...
  44. doi request reprint Mitigate B1+ inhomogeneity using spatially selective radiofrequency excitation with generalized spatial encoding magnetic fields
    Yi Cheng Hsu
    Department of Mathematics, National Taiwan University, Taipei, Taiwan Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Espoo, Finland
    Magn Reson Med 71:1458-69. 2014
    ..High-field magnetic resonance imaging (MRI) has the challenge of inhomogeneous B(1)(+), and consequently inhomogeneous flip angle distribution, which causes spatially dependent contrast and makes clinical diagnosis difficult...
  45. pmc Enhanced spontaneous oscillations in the supplementary motor area are associated with sleep-dependent offline learning of finger-tapping motor-sequence task
    Masako Tamaki
    Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, USA
    J Neurosci 33:13894-902. 2013
    ..The consolidation may arise along with possible reorganization of a larger-scale cortical network that involves the SMA and cortical regions outside the motor regions, including prefrontal and parietal regions. ..
  46. pmc Suppressing multi-channel ultra-low-field MRI measurement noise using data consistency and image sparsity
    Fa Hsuan Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e61652. 2013
    ..Simulations and experimental data using 47 SQUID sensors demonstrate the effectiveness of this data consistency constraint and sparsity prior in ULF-MRI reconstruction...
  47. ncbi request reprint A wavelet-based approximation of surface coil sensitivity profiles for correction of image intensity inhomogeneity and parallel imaging reconstruction
    Fa Hsuan Lin
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
    Hum Brain Mapp 19:96-111. 2003
    ..The results, using bi-orthogonal Daubechies 97 wavelets and other members in this family, are evaluated for T1-weighted and T2-weighted brain imaging...
  48. ncbi request reprint Parallel imaging reconstruction using automatic regularization
    Fa Hsuan Lin
    Division of Health Sciences and Technology, Harvard Medical School MIT, Cambridge, Massachusetts, USA
    Magn Reson Med 51:559-67. 2004
    ..47 to 0.80 in twofold sensitivity encoding (SENSE) acceleration. In vivo anatomical images from an eight-channel system show an averaged g-factor reduction of 1.22 to 0.84 in 2.67-fold acceleration...
  49. ncbi request reprint Accelerated short-TE 3D proton echo-planar spectroscopic imaging using 2D-SENSE with a 32-channel array coil
    Ricardo Otazo
    Electrical and Computer Engineering Department, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Magn Reson Med 58:1107-16. 2007
    ..The short acquisition time makes the method suitable for volumetric metabolite mapping in clinical studies...

Research Grants2