Jeff W Lichtman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
  2. ncbi request reprint Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo
    Y Albert Pan
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 23:11479-88. 2003
  3. pmc Ome sweet ome: what can the genome tell us about the connectome?
    Jeff W Lichtman
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 18:346-53. 2008
  4. pmc Semi-automated reconstruction of neural processes from large numbers of fluorescence images
    Ju Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e5655. 2009
  5. ncbi request reprint Imaging the neuromuscular junction over the past centuries
    Ju Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Sheng Li Xue Bao 59:683-96. 2007
  6. pmc A technicolour approach to the connectome
    Jeff W Lichtman
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 9:417-22. 2008
  7. ncbi request reprint Fluorescence microscopy
    Jeff W Lichtman
    Department of Molecular and Cell Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Methods 2:910-9. 2005
  8. ncbi request reprint Translational neuroscience during the Second World War
    Jeff W Lichtman
    Harvard University, USA
    J Exp Biol 209:3485-7. 2006
  9. doi request reprint The big and the small: challenges of imaging the brain's circuits
    Jeff W Lichtman
    Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Science 334:618-23. 2011
  10. doi request reprint Pervasive synaptic branch removal in the mammalian neuromuscular system at birth
    Juan C Tapia
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 74:816-29. 2012

Collaborators

Detail Information

Publications58

  1. ncbi request reprint In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
    ..These results suggest that time-lapse imaging of spinal cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration...
  2. ncbi request reprint Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo
    Y Albert Pan
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 23:11479-88. 2003
    ..Because neuropathy is the major dose-limiting side effect of vincristine, we propose that its efficacy could be enhanced by coadministration of FK506 analogs that are neuroactive but not immunosuppressive...
  3. pmc Ome sweet ome: what can the genome tell us about the connectome?
    Jeff W Lichtman
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 18:346-53. 2008
    ..Remarkably similar objections were voiced when the Human Genome Project, now widely viewed as a success, was first proposed. We revisit that controversy to ask if it holds any lessons for proposals to map the connectome...
  4. pmc Semi-automated reconstruction of neural processes from large numbers of fluorescence images
    Ju Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e5655. 2009
    ..5 mm per hour. We found an error rate in the automatic tracing mode of approximately 1 error per 250 um of axonal length. We demonstrated the capacity of the program by reconstructing the connectome of motor axons in a small mouse muscle...
  5. ncbi request reprint Imaging the neuromuscular junction over the past centuries
    Ju Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Sheng Li Xue Bao 59:683-96. 2007
    ..In this paper we review the historical development of research on some key aspects of the NMJ, including its structure, nicotinic acetylcholine receptor distribution, the process of synaptic vesicle release, and its development...
  6. pmc A technicolour approach to the connectome
    Jeff W Lichtman
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 9:417-22. 2008
    ..Here we review recent advances in this area, along with some of the opportunities that these advances present and the obstacles that remain...
  7. ncbi request reprint Fluorescence microscopy
    Jeff W Lichtman
    Department of Molecular and Cell Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Methods 2:910-9. 2005
    ..This review attempts to provide a framework for understanding excitation of and emission by fluorophores, the way fluorescence microscopes work, and some of the ways fluorescence can be optimized...
  8. ncbi request reprint Translational neuroscience during the Second World War
    Jeff W Lichtman
    Harvard University, USA
    J Exp Biol 209:3485-7. 2006
  9. doi request reprint The big and the small: challenges of imaging the brain's circuits
    Jeff W Lichtman
    Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Science 334:618-23. 2011
    ..These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain...
  10. doi request reprint Pervasive synaptic branch removal in the mammalian neuromuscular system at birth
    Juan C Tapia
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 74:816-29. 2012
    ..Analogous changes in connectivity may occur in the CNS...
  11. pmc Lysosomal activity associated with developmental axon pruning
    Jae W Song
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 28:8993-9001. 2008
    ..We propose that lysosomal activity is a central feature of synapse elimination. Moreover, staining for lysosomal activity may serve as a marker for regions of the developing nervous system undergoing axon pruning...
  12. pmc Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
    Gregorio Valdez
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:14863-8. 2010
    ..These results demonstrate a critical effect of aging on synaptic structure and provide evidence that interventions capable of extending health span and lifespan can partially reverse these age-related synaptic changes...
  13. ncbi request reprint Improved tools for the Brainbow toolbox
    Dawen Cai
    Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 10:540-7. 2013
    ..We also provide technical advice about how best to image Brainbow-expressing tissue...
  14. ncbi request reprint Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
    Jean Livet
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 450:56-62. 2007
    ..The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale...
  15. doi request reprint Chapter 11: Imaging fluorescent mice in vivo using confocal microscopy
    Stephen G Turney
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Methods Cell Biol 89:309-27. 2008
    ....
  16. pmc Terminal Schwann cells participate in neuromuscular synapse remodeling during reinnervation following nerve injury
    Hyuno Kang
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Texas 78712, Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, and Department of Biology, Texas A and M University, College Station, Texas 77843
    J Neurosci 34:6323-33. 2014
    ..These observations show that SCs participate actively in the remodeling of neuromuscular synapses following nerve injury by their guidance of axonal reinnervation. ..
  17. pmc Agrin and synaptic laminin are required to maintain adult neuromuscular junctions
    Melanie A Samuel
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e46663. 2012
    ..Together, these results demonstrate that pre- and post-synaptic organizers actively function to maintain the structure and function of adult NMJs...
  18. pmc Shared resistance to aging and ALS in neuromuscular junctions of specific muscles
    Gregorio Valdez
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e34640. 2012
    ..Together, these results reveal novel structural, regional and molecular parallels between aging and ALS...
  19. pmc Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo
    Corey M McCann
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 11:807-15. 2008
    ..Therefore, neurotransmitter receptor dynamism associated with rapid changes in synaptic efficacy precedes long-lasting structural changes in synaptic connectivity...
  20. ncbi request reprint Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex
    Giulio Srubek Tomassy
    Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 344:319-24. 2014
    ..Our data indicate that the profile of longitudinal distribution of myelin is an integral feature of neuronal identity and may have evolved as a strategy to modulate long-distance communication in the neocortex. ..
  21. pmc The interscutularis muscle connectome
    Ju Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 7:e32. 2009
    ..This variability may arise from the dominant role of synaptic competition in establishing the final circuit...
  22. doi request reprint Motor axon regeneration and muscle reinnervation in young adult and aged animals
    Hyuno Kang
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138
    J Neurosci 33:19480-91. 2013
    ..These results imply that facilitating clearance of axon debris might be a good target for the treatment of nerve injury in the aged. ..
  23. pmc Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish
    Y Albert Pan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 140:2835-46. 2013
    ..The Zebrabow tool set presented here provides a resource for next-generation color-based anatomical and lineage analyses in zebrafish...
  24. ncbi request reprint Imaging axonal transport of mitochondria in vivo
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Methods 4:559-61. 2007
    ..We show that axon damage and recovery lead to early and sustained changes in anterograde and retrograde transport. In vivo imaging of mitochondria will be a useful tool to analyze this essential organelle...
  25. pmc Seeing circuits assemble
    Jeff W Lichtman
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 60:441-8. 2008
    ..e., neurons, glia, and progenitors) that inhabit brains. New tools will certainly be needed if we wish to monitor the myriad cooperative and competitive interactions at play in the cellular society that builds brains...
  26. pmc Reversing the outcome of synapse elimination at developing neuromuscular junctions in vivo: evidence for synaptic competition and its mechanism
    Stephen G Turney
    Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 10:e1001352. 2012
    ..These results demonstrate competition at the synaptic level and enable us to provide a conceptual framework for understanding this form of synaptic plasticity...
  27. pmc In vivo imaging of presynaptic terminals and postsynaptic sites in the mouse submandibular ganglion
    Corey M McCann
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Dev Neurobiol 68:760-70. 2008
    ..The submandibular ganglion is an ideal site to study the formation, elimination, and maintenance of synaptic connections between neurons in vivo...
  28. pmc It's lonely at the top: winning climbing fibers ascend dendrites solo
    Ryan W Draft
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 63:6-8. 2009
    ..In this issue of Neuron, Hashimoto et al. show that, by the time climbing fibers ascend the dendrites, the winner and losers are already decided...
  29. pmc Controlling the orientation and synaptic differentiation of myotubes with micropatterned substrates
    Jacinthe Gingras
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Biophys J 97:2771-9. 2009
    ..Our results represent what we believe is a new approach for musculoskeletal tissue engineering, and our model sheds light on mechanisms of myotube alignment in vivo...
  30. ncbi request reprint Rapid synapse elimination after postsynaptic protein synthesis inhibition in vivo
    Corey M McCann
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 27:6064-7. 2007
    ....
  31. pmc Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:11088-93. 2005
    ..Similar interactions between neurotransmitters and synaptic organizing molecules may operate at synapses in the central nervous system...
  32. ncbi request reprint Axon branch removal at developing synapses by axosome shedding
    Derron L Bishop
    Department of Molecular and Cellular and Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 44:651-61. 2004
    ..After this engulfment, the axosome's contents mix with the cytoplasm of the glial cell. Axosome shedding might underlie other forms of axon loss and may provide a pathway for interactions between axons and glia...
  33. pmc Developmental bias in cleavage-stage mouse blastomeres
    Inna Tabansky
    The Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 23:21-31. 2013
    ..To determine whether blastomere allocation to the two earliest lineages is random, we developed and utilized a recombination-mediated, noninvasive combinatorial fluorescent labeling method for embryonic lineage tracing...
  34. pmc High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy
    Juan Carlos Tapia
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Protoc 7:193-206. 2012
    ..This protocol takes 7-15 d to prepare resin-embedded tissue, cut sections and produce serial section images...
  35. pmc Super-resolution laser scanning microscopy through spatiotemporal modulation
    Ju Lu
    Department of Molecular and Cellular Biology, Center for Brain Science, Department of Chemistry and Chemical Biology, Harvard University, USA
    Nano Lett 9:3883-9. 2009
    ..When combined with multiphoton excitation, both schemes can image thick samples with three-dimensional optical sectioning and much improved resolution...
  36. pmc Mouse transgenic lines that selectively label type I, type IIa, and types IIX+B skeletal muscle fibers
    Joe V Chakkalakal
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, Massachusetts
    Genesis 50:50-8. 2012
    ..We demonstrate their use for motor unit reconstruction and live imaging of nerve-dependent alterations in fiber type. genesis 50:50-58, 2012. © 2011 Wiley Periodicals, Inc...
  37. ncbi request reprint Peptide tags for labeling membrane proteins in live cells with multiple fluorophores
    Corey M McCann
    Harvard University, Cambridge, MA, USA
    Biotechniques 38:945-52. 2005
    ....
  38. ncbi request reprint Silicon-vacancy color centers in nanodiamonds: cathodoluminescence imaging markers in the near infrared
    Huiliang Zhang
    Department of Physics, Harvard University, Cambridge, MA, 02138, USA
    Small 10:1908-13. 2014
    ..CL emission intensity from negative charge-state Si-V centers is greatly enhanced by increasing the nitrogen concentration during nanodiamond growth. ..
  39. pmc Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling
    Dmitry Shvartsman
    1 School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA 2 Wyss Institute for Biologically Inspired Engineering, Cambridge, Massachusetts, USA
    Mol Ther 22:1243-53. 2014
    ....
  40. ncbi request reprint LTP: perils and progress
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts, 02454, USA
    Nat Rev Neurosci 4:926-9. 2003
  41. pmc Improved tools for the Brainbow toolbox
    Dawen Cai
    1 Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA 2 Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 10:540-7. 2013
    ..We also provide technical advice about how best to image Brainbow-expressing tissue. ..
  42. pmc Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors
    Cristina Borselli
    Wyss Institute, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:3287-92. 2010
    ..These results support the utility of simultaneously targeting distinct aspects of the regenerative process...
  43. ncbi request reprint Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition
    Mario Buffelli
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid, St Louis, Missouri 63110, USA
    Nature 424:430-4. 2003
    ..Here we use a genetic method to selectively inhibit neurotransmission from one of two inputs to a single target cell. We show that more powerful inputs are strongly favoured competitors during synapse elimination...
  44. ncbi request reprint Pre-existing pathways promote precise projection patterns
    Quyen T Nguyen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Neurosci 5:861-7. 2002
    ..These results suggest that nonspecific guidance cues can be sufficient to generate specific synaptic circuitry...
  45. ncbi request reprint Repulsive force based snake model to segment and track neuronal axons in 3D microscopy image stacks
    Hongmin Cai
    Center for Bioinformatics, Harvard Center for Neurodegeneration and Repair, and Department of Radiology, Brigham and Women s Hospital, Boston, MA 02114, USA
    Neuroimage 32:1608-20. 2006
    ..Individual axons can then be extracted based on the segmentation results. The utility and performance of the method are demonstrated using 3D axonal images obtained from transgenic mice that express fluorescent protein...
  46. ncbi request reprint Watching the neuromuscular junction
    Jeff W Lichtman
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    J Neurocytol 32:767-75. 2003
    ..The development, maturation, stability, remodeling and regeneration of neuromuscular junctions and motor units can then be assessed over intervals ranging from seconds to months...
  47. ncbi request reprint The rise of the 'projectome'
    Narayanan Kasthuri
    Nat Methods 4:307-8. 2007
  48. ncbi request reprint Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase
    Thomas Misgeld
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 36:635-48. 2002
    ..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
  49. ncbi request reprint In vivo time-lapse imaging of synaptic takeover associated with naturally occurring synapse elimination
    Mark K Walsh
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 37:67-73. 2003
    ..These results show synaptic competition is not always monotonic and that one axon's contraction in synaptic area is associated with another axon's expansion...
  50. pmc Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions
    R Mark Grady
    Dept of Pediatrics, Washington University School of Medicine, Pediatric Research Bldg, St Louis, MO 63110, USA
    J Cell Biol 160:741-52. 2003
    ..More generally, alphaDB may play multiple roles in muscle by means of differential distribution of isoforms with distinct signaling or structural properties...
  51. ncbi request reprint A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
    Anneliese M Schaefer
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Comp Neurol 490:209-19. 2005
    ..Identification of factors that protect "compensatory" motor neurons from degenerative changes may provide new targets for therapeutic intervention...
  52. ncbi request reprint Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion
    Wen Biao Gan
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid, Box 8108, St Louis, Missouri 63110, USA
    Nat Neurosci 6:956-60. 2003
    ..The long-term stability of synaptic patterns could provide a structural basis for the persistence of memory in the adult nervous system...
  53. ncbi request reprint Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands
    Mohammed Akaaboune
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuron 34:865-76. 2002
    ..These results demonstrate remarkable molecular dynamism underlying macroscopic stability of the postsynaptic membrane, and establish alpha-dystrobrevin as a key control point for regulation of mobility and turnover...
  54. ncbi request reprint The role of neuronal identity in synaptic competition
    Narayanan Kasthuri
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 424:426-30. 2003
    ..An accompanying paper tests the idea that the amount of neurotransmitter released is this global resource...
  55. ncbi request reprint Age-associated synapse elimination in mouse parasympathetic ganglia
    Jay S Coggan
    Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurobiol 60:214-26. 2004
    ..These results demonstrate primary, age-associated synapse elimination with functional consequences that cannot be explained by pre- or postsynaptic cell death...
  56. pmc Nerve-independent formation of a topologically complex postsynaptic apparatus
    Terrance T Kummer
    Dept of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Cell Biol 164:1077-87. 2004
    ..These results reveal the sequence of steps by which a topologically complex domain forms on a cell and suggest an unexpected nerve-independent role for the postsynaptic cell in generating this topological complexity...
  57. pmc Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific
    Timm Schubert
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Neurophysiol 100:304-16. 2008
    ..Our data suggest that presynaptic modulation of glutamate transmission from bipolar cells matures rapidly and is differentially coordinated for GABAergic and glycinergic synapses onto distinct bipolar cell subclasses...

Research Grants33

  1. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff W Lichtman; Fiscal Year: 2010
    ..abstract_text> ..
  2. Cellular and Molecular Analysis of Defects at Aging Neuromuscular Synapses
    Jeff Lichtman; Fiscal Year: 2009
    ..Together, these studies will provide insights into age-related neural defects that may not only provide ways to ameliorate sarcopenia but also be generally applicable to the nervous system. ..
  3. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2009
    ..abstract_text> ..
  4. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2001
    ..Because learning disorders and memory impairments are common but at present almost entirely without rational treatment, the kind of basic information this proposal aims to provide concerning how synapses change is likely to be useful. ..
  5. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2000
    ..Because learning disorders and memory impairments are common but at present almost entirely without rational treatment, the kind of basic information this proposal aims to provide concerning how synapses change is likely to be useful. ..
  6. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 1999
    ..Because learning disorders and memory impairments are common but at present almost entirely without rational treatment, the kind of basic information this proposal aims to provide concerning how synapses change is likely to be useful. ..
  7. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2003
    ..It is hoped that these experiments will provide essential and fundamental insights into the cell biological phenomena that regulate synapse number and distribution in the nervous system. ..
  8. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2004
    ..It is hoped that these experiments will provide essential and fundamental insights into the cell biological phenomena that regulate synapse number and distribution in the nervous system. ..
  9. Confocal/Multiphoton Microscope
    Jeff Lichtman; Fiscal Year: 2004
    ..It will be available to other members of the Neuroscience community at Washington University, particularly for exploring and developing new optical imaging tools. ..
  10. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2004
    ..It is hoped that these experiments will provide essential and fundamental insights into the cell biological phenomena that regulate synapse number and distribution in the nervous system. ..
  11. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2006
    ..It is hoped that these experiments will provide essential and fundamental insights into the cell biological phenomena that regulate synapse number and distribution in the nervous system. ..
  12. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 1990
    ..As such, understanding the biological basis of this phenomenon is fundamental to an understanding of brain maturation and function...
  13. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2002
    ..It is hoped that these experiments will provide essential and fundamental insights into the cell biological phenomena that regulate synapse number and distribution in the nervous system. ..
  14. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 1993
    ..As such, understanding the biological basis of this phenomenon is fundamental to an understanding of brain maturation and function...
  15. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 1991
    ..As such, understanding the biological basis of this phenomenon is fundamental to an understanding of brain maturation and function...
  16. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2007
    ..abstract_text> ..
  17. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2007
    ....
  18. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 2005
    ..It is hoped that these experiments will provide essential and fundamental insights into the cell biological phenomena that regulate synapse number and distribution in the nervous system. ..
  19. COMPETITION BETWEEN AXONS AT THE NEUROMUSCULAR JUNCTION
    Jeff Lichtman; Fiscal Year: 1992
    ..As such, understanding the biological basis of this phenomenon is fundamental to an understanding of brain maturation and function...
  20. Cellular and Molecular Analysis of Defects at Aging Neuromuscular Synapses
    Joshua R Sanes; Fiscal Year: 2010
    ..Together, these studies will provide insights into age-related neural defects that may not only provide ways to ameliorate sarcopenia but also be generally applicable to the nervous system. ..