Research Topics
| Stephanie C LicataSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigmStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neuroimage 70:211-22. 2013....- A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 TStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 203:819-29. 2009..A great deal is known about the behavioral effects of this drug in humans and laboratory animals, but little is known about zolpidem's specific effects on neurochemistry in vivo... - A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot studyStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Eur J Pharmacol 598:64-7. 2008..Thus, a therapeutic dose of zolpidem may have limited potential for misuse among females who have no experience with drugs of abuse... - Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyondStephanie C Licata
McLean Hospital Harvard Medical School, Behavioral Psychopharmacology Research Laboratory, 115 Mill Street, Belmont, MA 02478, United States
Pharmacol Biochem Behav 90:74-89. 2008..This review examines the behavioral determinants of the abuse and dependence liability of benzodiazepine-type drugs. Moreover, the pharmacological and putative biochemical basis of the abuse-related behavior is discussed... - Modest abuse-related subjective effects of zolpidem in drug-naive volunteersStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, Neuroimaging Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Behav Pharmacol 22:160-6. 2011.... - Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulationStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont MA 02478, USA
Prog Neuropsychopharmacol Biol Psychiatry 35:1645-52. 2011.... - Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteersStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
J Addict Med 5:57-64. 2011..We demonstrated previously that citicoline, a compound used to repair neuronal damage in stroke and brain injury, is safe in cocaine-abusing volunteers... - Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addictionStephanie C Licata
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
Ann N Y Acad Sci 1187:148-71. 2010.... - Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypesStephanie C Licata
Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
Neuropharmacology 58:357-64. 2010..These data suggest that efficacy at alpha2, alpha3, and/or alpha5 subunit-containing GABA(A) receptors likely are sufficient for engendering BZ-like discriminative stimulus effects... - Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeysStephanie C Licata
McLean Hospital Harvard Medical School, Belmont, MA, USA
Psychopharmacology (Berl) 203:539-46. 2009..Benzodiazepines (BZs) are effective anxiolytics and hypnotics, but their use is limited by unwanted side effects, such as motor impairment... 
Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptorsJames K Rowlett
Harvard Medical School, New England Primate Research Center, Box 9102, One Pine Hill Drive Southborough, MA, 01772 9102, USA
Psychopharmacology (Berl) 184:201-11. 2006..We established a conflict procedure with rhesus monkeys in order to examine the role of GABAA receptors in the anxiolytic-like effects of BZs...- Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedureBradford D Fischer
Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, Massachusetts 01772 9102, USA
Neuropharmacology 59:612-8. 2010..These behavioral effects suggest that the anxiolytic and rate-reducing effects of GABA(A) receptor positive modulators are dependent on their relative efficacy and affinity at different GABA(A) receptor subtypes... - Self-administration of bretazenil under progressive-ratio schedules: behavioral economic analysis of the role intrinsic efficacy plays in the reinforcing effects of benzodiazepinesStephanie C Licata
McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 113:157-64. 2011..These findings raise the possibility that degree of intrinsic efficacy of a benzodiazepine agonist may not be predictive of relative reinforcing effectiveness... 
Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 TeslaJ Eric Jensen
McLean Hospital, Belmont, MA 02478, USA
NMR Biomed 22:762-9. 2009..These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction...- The acute and late CNS glutamine response to benzodiazepine challenge: a pilot pharmacokinetic study using proton magnetic resonance spectroscopyMichael E Henry
Caritas St Elizabeth s Medical Center, Department of Psychiatry, Boston, MA 02135, USA
Psychiatry Res 184:171-6. 2010..An increase in Gln/Cr at 1 h post-BZ is consistent with a functionally synergistic relationship between Glu/Gln and GABA in the brain. It also suggests that MRS may have sufficient sensitivity to detect acute drug effects... - Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shellStephanie C Licata
Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
Brain Res 1012:119-26. 2004..These data indicate that dopamine synthesis is not altered by cocaine administration... - Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-Stephanie C Licata
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
J Pharmacol Exp Ther 313:1118-25. 2005..Moreover, a compound with reduced efficacy at alpha(1) GABA(A) and/or alpha(5) GABA(A) receptors may lack some of the motor and subjective effects associated with conventional BZs... - Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signalsYunjie Tong
McLean Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
J Biomed Opt 17:106004. 2012.... - Repeated administration of AMPA or a metabotropic glutamate receptor agonist into the rat ventral tegmental area augments the subsequent behavioral hyperactivity induced by cocaineJustin M Dunn
Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA, 02118, USA
Psychopharmacology (Berl) 179:172-80. 2005..The present findings also suggest that glutamate agonist-induced activation of CaM-KII in the VTA plays a critical role in the behavioral and neuronal plasticity induced by repeated cocaine injections... - Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in ratsStephanie C Licata
Department of Pharmacology, Laboratory of Neuropsychopharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Eur J Neurosci 19:405-14. 2004.... - The roles of calcium/calmodulin-dependent and Ras/mitogen-activated protein kinases in the development of psychostimulant-induced behavioral sensitizationStephanie C Licata
Laboratory of Neuropsychopharmacology, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurochem 85:14-22. 2003....
Research Grants
- Role of Calcium in Cocaine-Induced SensitizationSTEPHANIE LICATA; Fiscal Year: 2002..Second, rats will receive either acute or repeated cocaine and relative abundance of either calmodulin or CaMKII will be measured in the VTA and substantia nigra using immunolabeling techniques. ..
- Abuse of benzodiazepine/heroin combinationsSTEPHANIE LICATA; Fiscal Year: 2006..Together, these studies will determine how hard the animal is willing to work for this drug combination, and to what extent do the alpha 1 and alpha 2 subunits of the GABAA receptor contribute to this behavior? ..
- fMRI Studies Investigating the Choice Effects of Sedative/HypnoticsSTEPHANIE LICATA; Fiscal Year: 2007..These studies will contribute to the overarching goals of the field, which has been focused on determining how BZs mediate their behavioral effects in an effort to separate the clinically useful effects from their abuse potential. ..