Stephanie C Licata

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuroimage 70:211-22. 2013
  2. pmc A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Eur J Pharmacol 598:64-7. 2008
  3. pmc Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Addict Med 5:57-64. 2011
  4. pmc Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont MA 02478, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1645-52. 2011
  5. pmc Modest abuse-related subjective effects of zolpidem in drug-naive volunteers
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, Neuroimaging Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Behav Pharmacol 22:160-6. 2011
  6. pmc Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1187:148-71. 2010
  7. pmc Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond
    Stephanie C Licata
    McLean Hospital Harvard Medical School, Behavioral Psychopharmacology Research Laboratory, 115 Mill Street, Belmont, MA 02478, United States
    Pharmacol Biochem Behav 90:74-89. 2008
  8. pmc A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 T
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 203:819-29. 2009
  9. pmc Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Neuropharmacology 58:357-64. 2010
  10. pmc Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys
    Stephanie C Licata
    McLean Hospital Harvard Medical School, Belmont, MA, USA
    Psychopharmacology (Berl) 203:539-46. 2009

Research Grants

Detail Information

Publications23

  1. pmc The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuroimage 70:211-22. 2013
    ....
  2. pmc A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Eur J Pharmacol 598:64-7. 2008
    ..Thus, a therapeutic dose of zolpidem may have limited potential for misuse among females who have no experience with drugs of abuse...
  3. pmc Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Addict Med 5:57-64. 2011
    ..We demonstrated previously that citicoline, a compound used to repair neuronal damage in stroke and brain injury, is safe in cocaine-abusing volunteers...
  4. pmc Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont MA 02478, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1645-52. 2011
    ....
  5. pmc Modest abuse-related subjective effects of zolpidem in drug-naive volunteers
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, Neuroimaging Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Behav Pharmacol 22:160-6. 2011
    ....
  6. pmc Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1187:148-71. 2010
    ....
  7. pmc Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond
    Stephanie C Licata
    McLean Hospital Harvard Medical School, Behavioral Psychopharmacology Research Laboratory, 115 Mill Street, Belmont, MA 02478, United States
    Pharmacol Biochem Behav 90:74-89. 2008
    ..This review examines the behavioral determinants of the abuse and dependence liability of benzodiazepine-type drugs. Moreover, the pharmacological and putative biochemical basis of the abuse-related behavior is discussed...
  8. pmc A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 T
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 203:819-29. 2009
    ..A great deal is known about the behavioral effects of this drug in humans and laboratory animals, but little is known about zolpidem's specific effects on neurochemistry in vivo...
  9. pmc Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Neuropharmacology 58:357-64. 2010
    ..These data suggest that efficacy at alpha2, alpha3, and/or alpha5 subunit-containing GABA(A) receptors likely are sufficient for engendering BZ-like discriminative stimulus effects...
  10. pmc Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys
    Stephanie C Licata
    McLean Hospital Harvard Medical School, Belmont, MA, USA
    Psychopharmacology (Berl) 203:539-46. 2009
    ..Benzodiazepines (BZs) are effective anxiolytics and hypnotics, but their use is limited by unwanted side effects, such as motor impairment...
  11. ncbi request reprint Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Box 9102, One Pine Hill Drive Southborough, MA, 01772 9102, USA
    Psychopharmacology (Berl) 184:201-11. 2006
    ..We established a conflict procedure with rhesus monkeys in order to examine the role of GABAA receptors in the anxiolytic-like effects of BZs...
  12. pmc Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, Massachusetts 01772 9102, USA
    Neuropharmacology 59:612-8. 2010
    ..These behavioral effects suggest that the anxiolytic and rate-reducing effects of GABA(A) receptor positive modulators are dependent on their relative efficacy and affinity at different GABA(A) receptor subtypes...
  13. doi request reprint Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
    J Eric Jensen
    McLean Hospital, Belmont, MA 02478, USA
    NMR Biomed 22:762-9. 2009
    ..These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction...
  14. pmc Self-administration of bretazenil under progressive-ratio schedules: behavioral economic analysis of the role intrinsic efficacy plays in the reinforcing effects of benzodiazepines
    Stephanie C Licata
    McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 113:157-64. 2011
    ..These findings raise the possibility that degree of intrinsic efficacy of a benzodiazepine agonist may not be predictive of relative reinforcing effectiveness...
  15. pmc Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment
    Stephanie C Licata
    McLean Hospital, Belmont, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e84806. 2013
    ..Future work should examine the interaction between ZP and DNA as the cause for altered gene expression in the HIP, given that BZs can enter the nucleus and intercalate into DNA directly. ..
  16. pmc Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks
    Yunjie Tong
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuroimage 76:202-15. 2013
    ....
  17. ncbi request reprint The acute and late CNS glutamine response to benzodiazepine challenge: a pilot pharmacokinetic study using proton magnetic resonance spectroscopy
    Michael E Henry
    Caritas St Elizabeth s Medical Center, Department of Psychiatry, Boston, MA 02135, USA
    Psychiatry Res 184:171-6. 2010
    ..An increase in Gln/Cr at 1 h post-BZ is consistent with a functionally synergistic relationship between Glu/Gln and GABA in the brain. It also suggests that MRS may have sufficient sensitivity to detect acute drug effects...
  18. ncbi request reprint Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shell
    Stephanie C Licata
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Brain Res 1012:119-26. 2004
    ..These data indicate that dopamine synthesis is not altered by cocaine administration...
  19. ncbi request reprint Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 313:1118-25. 2005
    ..Moreover, a compound with reduced efficacy at alpha(1) GABA(A) and/or alpha(5) GABA(A) receptors may lack some of the motor and subjective effects associated with conventional BZs...
  20. pmc Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals
    Yunjie Tong
    McLean Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Biomed Opt 17:106004. 2012
    ....
  21. ncbi request reprint Repeated administration of AMPA or a metabotropic glutamate receptor agonist into the rat ventral tegmental area augments the subsequent behavioral hyperactivity induced by cocaine
    Justin M Dunn
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA, 02118, USA
    Psychopharmacology (Berl) 179:172-80. 2005
    ..Glutamate receptors and their related second messengers in the ventral tegmental area (VTA) are known to play critical roles in the initiation of behavioral sensitization to cocaine...
  22. ncbi request reprint Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in rats
    Stephanie C Licata
    Department of Pharmacology, Laboratory of Neuropsychopharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Eur J Neurosci 19:405-14. 2004
    ....
  23. ncbi request reprint The roles of calcium/calmodulin-dependent and Ras/mitogen-activated protein kinases in the development of psychostimulant-induced behavioral sensitization
    Stephanie C Licata
    Laboratory of Neuropsychopharmacology, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 85:14-22. 2003
    ....

Research Grants4

  1. Role of Calcium in Cocaine-Induced Sensitization
    STEPHANIE LICATA; Fiscal Year: 2002
    ..Second, rats will receive either acute or repeated cocaine and relative abundance of either calmodulin or CaMKII will be measured in the VTA and substantia nigra using immunolabeling techniques. ..
  2. Abuse of benzodiazepine/heroin combinations
    STEPHANIE LICATA; Fiscal Year: 2006
    ..Together, these studies will determine how hard the animal is willing to work for this drug combination, and to what extent do the alpha 1 and alpha 2 subunits of the GABAA receptor contribute to this behavior? ..
  3. fMRI Studies Investigating the Choice Effects of Sedative/Hypnotics
    STEPHANIE LICATA; Fiscal Year: 2007
    ..These studies will contribute to the overarching goals of the field, which has been focused on determining how BZs mediate their behavioral effects in an effort to separate the clinically useful effects from their abuse potential. ..