M Charles Liberman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
    J Assoc Res Otolaryngol 10:50-63. 2009
  2. pmc Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea?
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 116:1649-55. 2004
  3. ncbi request reprint Feedback control of the auditory periphery: anti-masking effects of middle ear muscles vs. olivocochlear efferents
    M C Liberman
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, USA
    J Commun Disord 31:471-82; quiz 483; 553. 1998
  4. ncbi request reprint Afferent innervation of outer and inner hair cells is normal in neonatally de-efferented cats
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 423:132-9. 2000
  5. pmc Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice
    Robin E Williamson
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Hear Res 237:57-65. 2008
  6. pmc Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:6751-62. 2010
  7. pmc Slow build-up of cochlear suppression during sustained contralateral noise: central modulation of olivocochlear efferents?
    Erik Larsen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 256:1-10. 2009
  8. pmc Contralateral cochlear effects of ipsilateral damage: no evidence for interaural coupling
    Erik Larsen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States
    Hear Res 260:70-80. 2010
  9. pmc A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction
    Nahid G Robertson
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 17:3426-34. 2008
  10. ncbi request reprint A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 97:3269-78. 2007

Detail Information

Publications71

  1. pmc Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 3096, USA
    J Assoc Res Otolaryngol 10:50-63. 2009
    ..Our results suggest that GABAergic signaling in type II afferent neurons may be required for normal outer hair cell amplifier function at low sound levels and may also modulate outer hair cell responses to high-level sound...
  2. pmc Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea?
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 116:1649-55. 2004
    ....
  3. ncbi request reprint Feedback control of the auditory periphery: anti-masking effects of middle ear muscles vs. olivocochlear efferents
    M C Liberman
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, USA
    J Commun Disord 31:471-82; quiz 483; 553. 1998
    ..It does not improve masked thresholds, but can improve the detectability of small suprathreshold intensity increments. Anti-masking effects of both MEM and MOC systems should be reduced in cases of sensorineural hearing loss...
  4. ncbi request reprint Afferent innervation of outer and inner hair cells is normal in neonatally de-efferented cats
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 423:132-9. 2000
    ..Thus, the postnatal presence of an efferent system is not required for the normal development of cochlear afferent innervation, and the synaptic competition hypothesis is not supported...
  5. pmc Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice
    Robin E Williamson
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Hear Res 237:57-65. 2008
    ..Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds...
  6. pmc Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:6751-62. 2010
    ....
  7. pmc Slow build-up of cochlear suppression during sustained contralateral noise: central modulation of olivocochlear efferents?
    Erik Larsen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 256:1-10. 2009
    ..Results suggest that conventional tests of OC reflex strength may underestimate its magnitude in noisy environments...
  8. pmc Contralateral cochlear effects of ipsilateral damage: no evidence for interaural coupling
    Erik Larsen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States
    Hear Res 260:70-80. 2010
    ..We did, however, find evidence for age-related increases in DPOAE amplitudes as animals mature from 6 to 12weeks and evidence for a slow apical spread of noise-induced threshold shifts, which continues for several days post-exposure...
  9. pmc A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction
    Nahid G Robertson
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 17:3426-34. 2008
    ..This is the only mouse model developed to date where hearing loss begins at such an advanced age, providing an opportunity to study both progressive age-related hearing loss and possible interventional therapies...
  10. ncbi request reprint A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 97:3269-78. 2007
    ....
  11. pmc Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline
    Yevgeniya Sergeyenko
    Department of Audiology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Neurosci 33:13686-94. 2013
    ..Key functional clues to the synaptopathy are available in the neural response; these can be accessed noninvasively, enhancing the possibilities for translation to human clinical characterization. ..
  12. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
    ..This primary neurodegeneration should add to difficulties hearing in noisy environments, and could contribute to tinnitus, hyperacusis, and other perceptual anomalies commonly associated with inner ear damage...
  13. pmc Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons
    Bradley N Buran
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 30:7587-97. 2010
    ....
  14. pmc Influence of supporting cells on neuronal degeneration after hair cell loss
    Mitsuru Sugawara
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 6:136-47. 2005
    ..Results are consistent with the idea that supporting cells participate in the regulation of neuronal survival and neuronal sprouting in the organ of Corti...
  15. pmc Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti
    C Eduardo Corrales
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Neurobiol 66:1489-500. 2006
    ..The regeneration of these neurons shows that neurons differentiated from stem cells have the capacity to grow to a specific target in an animal model of neuronal degeneration...
  16. pmc Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss
    Mingqian Huang
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, Eaton Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, Howard Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    J Neurosci 33:15086-94. 2013
    ....
  17. ncbi request reprint Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear
    Mitsuru Sugawara
    Neurobiology Program, Children s Hospital and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 501:30-7. 2007
    ..These results suggest that NT3 might play a long-term role in the maintenance and functioning of the adult auditory and vestibular systems and that supporting cells are the main source of this factor in the adult...
  18. pmc The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system
    Douglas E Vetter
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:20594-9. 2007
    ..Moreover, alpha10 nAChR subunits are required for normal olivocochlear activity because alpha9 homomeric nAChRs do not support maintenance of normal olivocochlear innervation or function in alpha10(-/-) mutant mice...
  19. pmc Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss
    Jun Yang
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000955. 2010
    ..e., disruption of the PMC. Third, whirlin mutations that ablate the N-terminal PDZ domains lead to Usher syndrome, but non-syndromic hearing loss will result if they are spared...
  20. pmc Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114
    J Comp Neurol 498:403-14. 2006
    ..1997] Hear. Res 108:89-111)...
  21. pmc Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression
    Maria E Gómez-Casati
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17005-10. 2010
    ..These results indicate that vestibular supporting cells contribute in vivo to vestibular synapse formation and that this is mediated by reciprocal signals between sensory neurons and supporting cells involving erbB receptors and BDNF...
  22. pmc Cochlear efferent feedback balances interaural sensitivity
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, Massachusetts 02114, USA
    Nat Neurosci 9:1474-6. 2006
    ..Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space...
  23. pmc Efferent feedback minimizes cochlear neuropathy from moderate noise exposure
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 33:5542-52. 2013
    ....
  24. pmc Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 32:344-55. 2012
    ..In D4 and D5 knock-outs, the increased noise vulnerability was seen only in ABRs, consistent with a role for dopaminergic signaling in minimizing neural damage...
  25. pmc Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurophysiol 97:2930-6. 2007
    ....
  26. pmc Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs
    Ronald K de Venecia
    Department of Otology and Laryngology, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 487:345-60. 2005
    ..We suggest that multipolar cells within the PVCN have the distribution and response characteristics appropriate to be the MOC reflex interneurons...
  27. ncbi request reprint Response properties of single auditory nerve fibers in the mouse
    Annette M Taberner
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    J Neurophysiol 93:557-69. 2005
    ..Phase-locking was seen for tone frequencies <4 kHz. Maximum synchronization indices were lower than those in cat but similar to those found in guinea pig...
  28. ncbi request reprint Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurophysiol 90:2941-9. 2003
    ..This constitutes the most direct evidence to date for a functional role of the lateral OC system in the auditory periphery...
  29. pmc Reciprocal synapses between outer hair cells and their afferent terminals: evidence for a local neural network in the mammalian cochlea
    Fabio A Thiers
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 9:477-89. 2008
    ..This network may mediate local feedback control of, and bidirectional communication among, OHCs throughout the cochlear spiral...
  30. pmc Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury
    Keith N Darrow
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Neurophysiol 97:1775-85. 2007
    ..These findings suggest that the LOC modulates cochlear nerve excitability and protects the cochlea from neural damage in acute acoustic injury...
  31. pmc Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    J Neurophysiol 108:491-500. 2012
    ..Possible alternate pathways are discussed for the source of contra-noise-evoked effects at low ipsilateral levels...
  32. pmc Age-related primary cochlear neuronal degeneration in human temporal bones
    Chadi A Makary
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3006, USA
    J Assoc Res Otolaryngol 12:711-7. 2011
    ..The age-related decline in SGC counts may contribute to the well-known decline in hearing-in-noise performance, and the data will help in interpretation of histopathological findings from temporal bones with known otologic disease...
  33. pmc Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift
    Harrison W Lin
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 12:605-16. 2011
    ....
  34. pmc Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells
    Xiaoqing Liu
    Berman Gund Laboratory for the Study of Retinal Degenerations and Eaton Peabody Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:4413-8. 2007
    ....
  35. ncbi request reprint BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium
    Fuxin Shi
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 26:3016-23. 2007
    ..These data indicate that hES cells can be induced to form sensory neurons that have the potential to treat neural degeneration associated with sensorineural hearing loss...
  36. pmc Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:10315-26. 2006
    ..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear...
  37. pmc Mice lacking adrenergic signaling have normal cochlear responses and normal resistance to acoustic injury but enhanced susceptibility to middle-ear infection
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 11:449-61. 2010
    ..However, adrenergic modulation of olivocochlear efferents does not mediate the protective effect of contralateral cochlear destruction on ipsilateral response to acoustic overexposure...
  38. ncbi request reprint Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis
    Robin E Williamson
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 143:1630-9. 2007
    ..A knockout mouse model for MTAP deficiency was also created and no significant hearing loss was detected in heterozygotes for Mtap. Homozygous Mtap-deficient mice were embryonic lethal...
  39. ncbi request reprint Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurosci 22:10838-46. 2002
    ..These data demonstrate that efferent protection is mediated via the alpha9 nAChR in the outer hair cells and provide direct evidence for a protective role, in vivo, of a member of the nAChR family...
  40. pmc Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses
    Leslie D Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurosci 31:801-8. 2011
    ..2010)...
  41. ncbi request reprint Modulation of cochlear afferent response by the lateral olivocochlear system: activation via electrical stimulation of the inferior colliculus
    J Alan Groff
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
    J Neurophysiol 90:3178-200. 2003
    ..Such a system may be useful in maintaining accurate binaural comparisons necessary for sound localization in the face of slow changes in interaural sensitivity...
  42. pmc Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 109:1525-34. 2013
    ..The suppression remaining in BK nulls was blocked by strychnine, suggesting involvement of α9-/α10-cholinergic receptors, coupled to activation of the remaining SK2 channels...
  43. pmc Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea
    Yael Zilberstein
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci 32:405-10. 2012
    ..These results overturn a long-standing dogma in the study of sensorineural hearing loss and highlight the importance of cochlear supporting cells in neuronal survival in the adult inner ear...
  44. pmc Sound-evoked olivocochlear activation in unanesthetized mice
    Anna R Chambers
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 13:209-17. 2012
    ..These findings demonstrate the utility of the CAS assay in the unanesthetized mouse and highlight the adverse effects of anesthesia when probing the functional status of descending control pathways within the auditory system...
  45. ncbi request reprint Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
    M Charles Liberman
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 419:300-4. 2002
    ....
  46. pmc Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool
    Haobing Wang
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Otol Neurotol 27:452-7. 2006
    ..To develop a three-dimensional virtual model of a human temporal bone based on serial histologic sections...
  47. pmc Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Comp Neurol 455:406-16. 2003
    ....
  48. pmc Eya4-deficient mice are a model for heritable otitis media
    Frederic F S Depreux
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:651-8. 2008
    ..We suggest that some human otitis media susceptibility reflects underlying genetic predisposition in genes like EYA4 that regulate middle ear and eustachian tube anatomy...
  49. ncbi request reprint Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear
    Konstantina Stankovic
    Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:8651-61. 2004
    ....
  50. pmc Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 7:211-7. 2006
    ..Such a pattern is consistent with the observed discrepancy between ABR and OAE threshold shifts. The possible role of thiamine transport in other reported cases of selective inner hair cell loss is considered...
  51. pmc Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig
    S G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 2:268-78. 2001
    ..level functions, and both disappeared after OC section. Although smaller in magnitude, contralateral OC effects were identical to ipsilateral effects in frequency and level dependence and in form...
  52. pmc The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs
    Marie Drottar
    Department of Otolaryngology, Children s Hospital, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Laryngoscope 116:292-6. 2006
    ..The goal of this study was to determine if the antitumor agent sodium butyrate (a histone deacetylase inhibitor) protects against cisplatin ototoxicity when administered systemically...
  53. pmc Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth
    Sharon G Kujawa
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 26:2115-23. 2006
    ..Data suggest that pathologic but sublethal changes initiated by early noise exposure render the inner ears significantly more vulnerable to aging...
  54. ncbi request reprint Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice
    Carlos Rio
    Division of Neuroscience and Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 442:156-62. 2002
    ....
  55. ncbi request reprint A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig
    T S Sridhar
    Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston 02114 3096, USA
    J Neurosci 15:3667-78. 1995
    ..The long time constant of the slow effect compared to the fast effect suggests that it may arise from a distinct intracellular mechanism, possibly mediated by second-messenger systems...
  56. pmc Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates
    Adam C Furman
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Neurophysiol 110:577-86. 2013
    ..A selective loss of high-threshold fibers may contribute to the problems of hearing in noisy environments that characterize the aging auditory system. ..
  57. ncbi request reprint Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction
    Nahid G Robertson
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 15:1071-85. 2006
    ....
  58. pmc Dynamics of noise-induced cellular injury and repair in the mouse cochlea
    Yong Wang
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 3:248-68. 2002
    ..Insights into mechanisms of acute and chronic noise-induced cellular damage are discussed...
  59. ncbi request reprint Restraint stress and protection from acoustic injury in mice
    Yong Wang
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston 02114, USA
    Hear Res 165:96-102. 2002
    ..Results are consistent with the idea that cochlear protective effects may be mediated by stress pathways and that glucocorticoid levels may be an important upstream regulator of these effects...
  60. ncbi request reprint Fast, but not slow, effects of olivocochlear activation are resistant to apamin
    N Yoshida
    Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 85:84-8. 2001
    ..The results suggest that in vivo fast OC effects are dominated by a conductance that is not apamin sensitive...
  61. pmc Effects of anesthesia on efferent-mediated adaptation of the DPOAE
    K P Boyev
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 3:362-73. 2002
    ..These results suggest that previous studies using anesthetized preparations may have underestimated the magnitude of sound-evoked responses in the OC pathway...
  62. ncbi request reprint Dense innervation of Deiters' and Hensen's cells persists after chronic deefferentation of guinea pig cochleas
    F P Fechner
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Comp Neurol 400:299-309. 1998
    ..We speculate that they may be branches of type II afferent fibers to outer hair cells and that a smaller population of OSCFs with different morphology and immunoreactivity may arise from the OC system...
  63. ncbi request reprint Morphometric analysis of age-related changes in the human basilar membrane
    K A Bhatt
    Department of Otology and Laryngology, Harvard Medical School, and Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Ann Otol Rhinol Laryngol 110:1147-53. 2001
    ..Although age-related BM thickening, seen in both groups, could contribute to hearing loss, the extreme basal region, to which the thickening was confined, is not tested in routine audiometry...
  64. ncbi request reprint Selective inner hair cell loss in premature infants and cochlea pathological patterns from neonatal intensive care unit autopsies
    M G Amatuzzi
    Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Otolaryngol Head Neck Surg 127:629-36. 2001
    ..Additional histological patterns suggest more than one cause for neonatal intensive care unit hearing loss. Hair cell loss patterns seem frequently compatible with in utero damage...
  65. pmc Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice
    S Hequembourg
    Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 2:118-29. 2001
    ....
  66. pmc Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system
    E D Abel
    Thyroid Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 104:291-300. 1999
    ..Growth hormone gene expression is marginally reduced. In contrast, TR beta 2-null mice exhibit no evidence of hearing impairment, indicating that TR beta 1 and TR beta 2 subserve divergent roles in the regulation of auditory function...
  67. pmc Orphan glutamate receptor delta1 subunit required for high-frequency hearing
    Jiangang Gao
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 27:4500-12. 2007
    ....
  68. ncbi request reprint Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior
    Douglas E Vetter
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 31:363-9. 2002
    ..These results provide the first example of a function for any peptidergic system in hearing...
  69. pmc Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
    Nobuyuki Shibusawa
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC1027, Chicago, Illinois 60637, USA
    J Clin Invest 112:588-97. 2003
    ..Inner ear development, although not completely normal, can occur in the absence of TR DNA-binding, suggesting that an alternative and perhaps novel thyroid hormone-signaling pathway may mediate these effects...
  70. pmc Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea
    Keiko Hirose
    Department of Otolaryngology and Communicative Disorders, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Assoc Res Otolaryngol 4:339-52. 2003
    ..However, EP loss could contribute to acute threshold shifts that resolve to a PTS. EP recovery despite significant strial degeneration may be partly due to decreased transduction current caused by hair cell damage...
  71. pmc The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery
    Dominik Oliver
    Physiologisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 26:6181-9. 2006
    ..In summary, our results indicate an essential role of IHC BKCa channels for precise timing of high-frequency cochlear signaling as well as a function of BKCa in the primary afferent neuron...