Research Topics
Genomes and Genes
| Peter LibbySummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Role of inflammation in atherosclerosis associated with rheumatoid arthritisPeter Libby
Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Med 121:S21-31. 2008....
CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1Andreas Zirlik
Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 115:1571-80. 2007..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...- Mechanisms of plaque stabilization with statinsPeter Libby
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Cardiol 91:4B-8B. 2003..However, data suggest that statin-induced alterations in the function of small G proteins may contribute to the anti-inflammatory and antithrombotic actions of statins in clinical practice... 
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosisMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02124, USA
JACC Cardiovasc Imaging 2:1213-22. 2009....- Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in miceJiusong Sun
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 117:3359-68. 2007.... - Leukocyte integrin Mac-1 promotes acute cardiac allograft rejectionKoichi Shimizu
Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 117:1997-2008. 2008.... - Molecular imaging of innate immune cell function in transplant rejectionThomas Christen
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 119:1925-32. 2009..Yet, which macrophage functions may provide useful markers for detecting parenchymal rejection remains uncertain... - Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null miceGalina K Sukhova
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass, USA
Circ Res 96:368-75. 2005..These findings demonstrate directly the importance of cysteine protease/protease inhibitor balance in dysregulated arterial integrity and remodeling during experimental atherogenesis... - Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaquesFabrice Schneider
Donald W Reynolds Cardiovascular Clinical Research Center and Fondation Leducq Transatlantic Network on Atherothrombosis, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 117:931-9. 2008..Although in vitro results suggest collagenase activity for membrane-bound matrix metalloproteinase type 1 (MMP-14), in vivo evidence for such a function in atherosclerosis remains scant... - CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosisRené R S Packard
Leducq Center for Cardiovascular Research and Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ Res 103:965-73. 2008..In particular, DCs remain functional antigen-presenting cells and maintain their ability to prime CD4(+) T cells even when cholesterol-loaded... - Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in preventionPaul M Ridker
Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circ Cardiovasc Qual Outcomes 2:616-23. 2009..However, whether the absolute risk reduction among such individuals justifies wide application of statin therapy in primary prevention is a controversial issue with broad policy and public health implications... - Adiponectin inhibits allograft rejection in murine cardiac transplantationYoshihisa Okamoto
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Transplantation 88:879-83. 2009..This study investigated whether adiponectin modulates allograft rejection in major histocompatibility complex class II-mismatched cardiac transplants... - HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trialPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Lancet 376:333-9. 2010..We addressed, using the JUPITER trial cohort, whether this association remains when LDL-cholesterol concentrations are reduced to the very low ranges with high-dose statin treatment... - Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) StudyScott Kinlay
Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA
Circulation 110:386-91. 2004..Early statin therapy after acute coronary syndromes counters the risk associated with elevated sCD40L... - Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesityViviane Zorzanelli Rocha
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA, 02115, USA
Circ Res 103:467-76. 2008..These results indicate a role for T cells and IFNgamma, a prototypical T-helper 1 cytokine, in regulation of the inflammatory response that accompanies obesity... - Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cellsKikuo Isoda
Donald W. Reynolds Cardiovascular Clinical Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 26:611-7. 2006..The novel anti-inflammatory actions of metformin may explain in part the apparent clinical reduction by metformin of cardiovascular events not fully attributable to its hypoglycemic action... - Rosuvastatin to prevent vascular events in men and women with elevated C-reactive proteinPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 359:2195-207. 2008.... - Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trialPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lancet 373:1175-82. 2009..8 mmol/L (<70 mg/dL). However, the benefit of lowering both LDL cholesterol and hsCRP after the start of statin therapy is controversial. We prospectively tested this hypothesis... - Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic miceStephanie Schulte
Cardiovascular Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, NRB 730J, Boston, MA 02115, USA
Am J Pathol 177:456-63. 2010.... - Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statinsKoichi Shimizu
The Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 108:2113-20. 2003..These results indicate that statins can affect arterial biology and inflammation independently of their effects on cholesterol metabolism... - Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activationManabu Minami
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Biol Chem 283:9692-703. 2008..Thus, PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation... - Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesisStephanie Schulte
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 172:1500-8. 2008..The results presented here illustrate how genetically determined modifiers of both immune and inflammatory responses can modulate atherogenesis independently of lipid levels... - A randomized trial of rosuvastatin in the prevention of venous thromboembolismRobert J Glynn
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 360:1851-61. 2009..Observational studies have yielded variable estimates of the effect of statin therapy on the risk of venous thromboembolism, and evidence from randomized trials is lacking... - Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesisFlorian Leuschner
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston, MA 02114, USA
J Exp Med 209:123-37. 2012..We also detected rapid Mo kinetics in mice with stroke. These findings expand our knowledge of Mo/MΦ flux in acute inflammation and provide the groundwork for novel anti-inflammatory strategies for treating heart failure... - High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosisKunio Morishige
Donald W Reynolds Cardiovascular Clinical Research Center at Harvard Medical School, Boston, MA, USA
Circulation 122:1707-15. 2010..Macrophage imaging may serve as a biomarker to identify subclinical inflamed lesions, to predict future risk, and to aid in the assessment of novel therapies... - Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensorFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
Circulation 115:2292-8. 2007..To assess better the biology of CatK activity in vivo, we developed a novel near-infrared fluorescence (NIRF) probe for imaging of CatK and evaluated it in mouse and human atherosclerosis... - Cathepsin L activity controls adipogenesis and glucose toleranceMin Yang
Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Cell Biol 9:970-7. 2007..Increased levels of CatL in obese and diabetic patients suggest that this protease is a novel target for these metabolic disorders... - Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaquesYoshihiro Fukumoto
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 110:1953-9. 2004..However, no direct in vivo evidence links collagenases with the regulation of collagen content in atherosclerotic plaques... - Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin IIJun o Deguchi
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lab Invest 89:315-26. 2009..Optical analysis further indicated altered collagen fiber orientation in the adventitia of Col(R/R)/apoE(-/-) mice. These results demonstrate that collagen content regulates aortic biomechanical properties and influences AAA formation... - Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomographyEduardo J Folco
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 58:603-14. 2011.... - Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formationEva H C Tang
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 31:261-9. 2011..To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow-derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo... - Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortasKoichi Shimizu
The Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 114:300-8. 2004..The findings establish important regulatory roles for a Th1/Th2 cytokine balance in modulating matrix remodeling and have important implications for the pathophysiology of AAAs and arteriosclerosis... - Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient miceJie Hong Pan
Department of Medicine, University of California San Francisco, Calif, USA
Circulation 109:3149-53. 2004..Therefore, we investigated whether deficiency of MIF modulates atherosclerotic lesion formation and composition in low-density lipoprotein receptor-deficient (LDLr-/-) mice... - Identification of splenic reservoir monocytes and their deployment to inflammatory sitesFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Science 325:612-6. 2009..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation... - TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cellsAndreas Zirlik
Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 27:1101-7. 2007..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis... - Effect of a cleavage-resistant collagen mutation on left ventricular remodelingMerry L Lindsey
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
Circ Res 93:238-45. 2003..We were not able to detect collagen cleavage fragments, and could not, therefore, rule out the possibility of collagen cleavage at additional sites... - Myocardial infarction accelerates atherosclerosisPartha Dutta
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 487:325-9. 2012..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression... - Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejectionKoichi Shimizu
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB7, Boston, MA 02115, USA
Circulation 124:2920-32. 2011..This study investigated the role of MRP-8/14 in cardiac allograft rejection using MRP-14(-/-) mice that lack MRP-8/14 complexes... - Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin KYu Sun
Department of Medicine, Columbia University, New York, NY 10032, USA
Circ Res 104:455-65. 2009.... - Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in miceJiusong Sun
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 122:808-20. 2010..Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist atherogenesis... - Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout miceShiro Kitamoto
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 115:2065-75. 2007..Increased expression of the elastinolytic and collagenolytic enzyme cathepsin L (Cat L) in human atherosclerotic lesions suggests its participation in these processes, a hypothesis tested here in mice... - CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial diseaseKoichi Shimizu
Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 120:1800-13. 2009.... - Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cellsAkio Kawakami
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Circulation 114:681-7. 2006..Therefore, apoCIII-rich VLDL may contribute directly to atherogenesis by activating ECs and recruiting monocytes to them... - Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL studyScott Kinlay
Cardiovascular Division, Veterans Affairs Boston Healthcare System, West Roxbury, Mass, USA
Arterioscler Thromb Vasc Biol 28:142-7. 2008..We measured markers of inflammation in the MIRACL study, a randomized trial of atorvastatin versus placebo in acute coronary syndromes, to assess the relationship of inflammation to stroke... - Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaquesClaudio Vinegoni
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
Sci Transl Med 3:84ra45. 2011..The atheroma-targeting capability of ICG has the potential to accelerate the clinical development of NIRF molecular imaging of high-risk plaques in humans... - Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cellsAlexandra Krettek
Brigham and Womens Hospital, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
Am J Pathol 165:1571-81. 2004.... - Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosisThibaut Quillard
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 31:2464-72. 2011..This study tested the hypothesis that selective matrix metalloproteinase-13 (MMP-13) collagenase inhibition increases collagen content in already established and nascent mouse atheromas... - Inflammation in atherosclerosis: transition from theory to practicePeter Libby
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ J 74:213-20. 2010..Inflammation is thus moving from a theoretical concept to a tool that provides practical clinical utility in risk assessment and targeting of therapy... - Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesisYoshihisa Okamoto
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circ Res 102:218-25. 2008..This study establishes that low levels of adiponectin associated with obesity, the metabolic syndrome, and diabetes favor T-lymphocyte recruitment and contribute to adaptive immune response during atherogenesis... - Mast cells promote atherosclerosis by releasing proinflammatory cytokinesJiusong Sun
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cardiovascular Medicine NRB 7, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 13:719-24. 2007..These observations establish direct participation of mast cells and mast cell-derived IL-6 and IFN-gamma in mouse atherogenesis and provide new mechanistic insight into the pathogenesis of this common disease... - Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosisFarouc A Jaffer
MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
Circulation 118:1802-9. 2008..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization... - Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10Eduardo J Folco
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 284:25569-75. 2009..These results suggest that adiponectin triggers a multifaceted response in human macrophages by inducing the expression of various anti-inflammatory proteins that act at different levels in concert to suppress macrophage activation... - Critical role of mast cell chymase in mouse abdominal aortic aneurysm formationJiusong Sun
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Circulation 120:973-82. 2009..Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown... - Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formationJie Zhang
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circ Res 108:1316-27. 2011..Tryptase is the most abundant MC granule protein and participates in MC activation, protease maturation, leukocyte recruitment, and angiogenesis-all processes critical to AAA pathogenesis... - Atherosclerotic plaque inflammation: the final frontier?Masanori Aikawa
Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Can J Cardiol 20:631-4. 2004 - Inflammation and cellular immune responses in abdominal aortic aneurysmsKoichi Shimizu
The Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 26:987-94. 2006.... - The vascular biology of atherosclerosis and imaging targetsPeter Libby
Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, Boston, Massachusetts, USA
J Nucl Med 51:33S-37S. 2010..The goals for the years to come must include translation of the experimental work to visualization of these appealing biologic targets in humans... - Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesionsEva H C Tang
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB741, Boston, MA 02115, USA
Cardiovasc Res 89:234-43. 2011..Thus, activation of EP4 may constitute an endogenous anti-inflammatory pathway. This study investigated the role of EP4 in atherosclerosis in vivo, and particularly its impact on inflammation... - High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL studyScott Kinlay
Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
Circulation 108:1560-6. 2003..Although statins reduce inflammatory markers in asymptomatic adults or in patients with stable angina, the effect of statins on the markedly heightened inflammation in patients with acute coronary syndromes is unknown... - Neutrophil elastase in human atherosclerotic plaques: production by macrophagesClare M Dollery
Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, EBRC 307, Boston, Mass 02115, USA
Circulation 107:2829-36. 2003..NE can digest elastin, fibrillar and nonfibrillar collagens, and other ECM components in addition to its ability to modify lipoproteins and modulate cytokine and MMP activity... - Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cellsUwe Schonbeck
Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 106:2888-93. 2002.... - Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trialDavid A Morrow
Thrombolysis in Myocardial Infarction Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 155:49-55. 2008..Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals but have not been assessed with respect to prognosis in patients with acute coronary syndrome... - Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient miceGalina K Sukhova
the Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 111:897-906. 2003..CatS(-/-)LDLR(-/-) monocytes showed impaired subendothelial basement membrane transmigration, and aortas from CatS(-/-)LDLR(-/-) mice had preserved elastic laminae. These findings establish a pivotal role for Cat S in atherogenesis... - Obesity, inflammation, and atherosclerosisViviane Z Rocha
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Nat Rev Cardiol 6:399-409. 2009..Our current appreciation of the similarities between obesity and atherosclerosis has already fostered innovations for the diagnosis, prognosis, and prevention of these two conditions... - Wild-type but not interferon-gamma-deficient T cells induce graft arterial disease in the absence of B cellsYutaka Furukawa
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, USA
Cardiovasc Res 63:347-56. 2004..CONCLUSIONS: T cells, even in the absence of B cells, suffice to induce GAD, and T cell-derived IFN-gamma plays a critical role in GAD pathogenesis... - Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cellsUdo Bavendiek
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
Arterioscler Thromb Vasc Biol 25:1244-9. 2005.... - Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regressionSotirios Tsimikas
Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, USA
Arterioscler Thromb Vasc Biol 27:175-81. 2007..We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression... - Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarctionMerry L Lindsey
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 105:753-8. 2002.... - Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient miceRuth Maron
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 106:1708-15. 2002..CONCLUSIONS: Our results demonstrate that nasal vaccination with HSP reduces the inflammatory process associated with atherosclerosis and provides a new immunologic approach for the treatment of atherosclerosis... - Diabetes and atherosclerosis: epidemiology, pathophysiology, and managementJoshua A Beckman
Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
JAMA 287:2570-81. 2002..CONCLUSIONS: Since most patients with diabetes die from complications of atherosclerosis, they should receive intensive preventive interventions proven to reduce their cardiovascular risk... - Influence of Helicobacter pylori infection during atherogenesis in vivo in miceFrancois Mach
Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ Res 90:E1-4. 2002..The full text of this article is available at http://www.circresaha.org... - Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy andDavid Xiao Ming Zhao
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Immunol 169:1556-60. 2002..This chemokine pathway may serve as a monitor and target for novel therapies to prevent CAV and rejection... - Innate and adaptive immunity in atherosclerosisRené R S Packard
Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 7, Boston, MA 02115, USA
Semin Immunopathol 31:5-22. 2009..This review retraces leukocyte subsets involved in innate and adaptive immunity and their contributions to atherogenesis... - Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivoJun o Deguchi
Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, Boston, Massachusetts, USA
Circulation 114:55-62. 2006..Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications... - Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hostsYutaka Furukawa
Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 160:1077-87. 2002..Although prolonged cold ischemia can initiate mild GAD in isografts by transiently enhancing antigen non-specific inflammatory responses, it does not significantly augment subsequent alloresponses... - Inflammatory markers are useful risk assessment toolsPeter Libby
Brigham and Women's Hospital, and Harvard Medical School, Boston, USA
Am J Manag Care . 2003 - Effects of statins in reducing thrombotic risk and modulating plaque vulnerabilityPeter Libby
Harvard Medical School and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Clin Cardiol 26:I11-4. 2003..Rupture of the fibrous cap causes most fatal coronary thrombosis... - Tumor necrosis factor receptor -1 and -2 double deficiency reduces graft arterial disease in murine cardiac allograftsJun-Ichi Suzuki
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Am J Transplant 3:968-76. 2003..We conclude that both p55 and p75 signals on donor vascular wall cells are involved in the development of GAD, and either TNFR is capable of mediating a response that will culminate in GAD... - Macrophage migration inhibitory factor is associated with aneurysmal expansionJie-Hong Pan
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California-San Francisco, 90 Medical Center Way, San Francisco, CA 94143, USA
J Vasc Surg 37:628-35. 2003.... - Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesisSeigo Sugiyama
Leducq Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
Arterioscler Thromb Vasc Biol 24:1309-14. 2004..These results show that MPO-positive macrophage-derived HOCl in the subendothelium of atheromata may participate in ACS by promoting superficial erosion and increasing thrombogenicity... - Soluble CD40L: risk prediction after acute coronary syndromesNerea Varo
Donald W. Reynolds Cardiovascular Clinical Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 108:1049-52. 2003..Notably, combined assessment of sCD40L with cTnI complements prognostic information for death and MI... - Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosisMatthias Nahrendorf
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
Circulation 114:1504-11. 2006..This clinically translatable agent could noninvasively detect inflammation in early, subclinical atherosclerosis... - Inflammation and atherosclerosis: role of C-reactive protein in risk assessmentPeter Libby
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Am J Med 116:9S-16S. 2004..Thus, medical practitioners are ushering in an era in which the biology of inflammation in atherosclerosis will find its way into clinical application... - Cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-asociated cells: implications for persistent Chlamydophila pneumoniae infectionJessica B Sakash
Vascular Research Division Department of Pathology and Leducq Center for Cardiovascular Research, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Infect Immun 70:3959-61. 2002..Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that organism in atherosclerosis... - Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)Paul M Ridker
Center for Cardiovascular Disease Prevention, Boston, Massachusetts, USA
Am J Cardiol 106:204-9. 2010..In conclusion, as the absolute risk increased with increasing hs-CRP, the absolute risk reduction associated with rosuvastatin within JUPITER was also greatest among those with the greatest entry hs-CRP levels... - Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinedionesNerea Varo
Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, Mass 02115, USA
Circulation 107:2664-9. 2003..This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation... - Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?Uwe Schonbeck
Leducq Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 109:II18-26. 2004..This overview addresses the controversy by reviewing in vitro and in vivo evidence regarding statins as antiinflammatory agents... - Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive proteinPaul M Ridker
JUPITER Coordinating Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 100:1659-64. 2007..In conclusion, as 20 mg of rosuvastatin can reduce LDL cholesterol by up to 50%, JUPITER will also provide crucial safety data for several thousand patients who should achieve LDL cholesterol levels<50 mg/dl on a long-term basis... - Essential role for Smad3 in regulating MCP-1 expression and vascular inflammationMark W Feinberg
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circ Res 94:601-8. 2004.... - Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonistsPeter Libby
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Cardiol 99:27B-40B. 2007.... - Inflammation in atherosclerosisPeter Libby
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 420:868-74. 2002..Identifying the triggers for inflammation and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets... - The multiple facets of the fat tissueViviane Zorzanelli Rocha
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Thyroid 18:175-83. 2008..Recently, inflammation within the obese adipose tissue has surfaced as another important link of obesity to its undesirable metabolic consequences... - PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosisNikolaus Marx
Department of Internal Medicine II, University of Ulm, Ulm, Germany
Circ Res 90:703-10. 2002.... - Atherosclerosis: the new viewPeter Libby
Brigham and Women's Hospital, USA
Sci Am 286:46-55. 2002 - Innate and adaptive immunity in the pathogenesis of atherosclerosisGoran K Hansson
Center for Molecular Medicine and Department of Medicine, Karolinska Institute, Stockholm, Sweden Goran Hansson cmm ki se
Circ Res 91:281-91. 2002..As we fill in the molecular details, new potential targets for therapies will doubtless emerge... - Stabilization of atherosclerotic plaques: new mechanisms and clinical targetsPeter Libby
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:1257-62. 2002 - C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitroNikolaus Marx
Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
Arterioscler Thromb Vasc Biol 24:540-5. 2004..This study tested the hypothesis that C-peptide might participate in atherogenesis in these patients... - The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approachMasanori Aikawa
Donald W. Reynolds Cardiovascular Clinical Research Centers, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Cardiovasc Pathol 13:125-38. 2004 - Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiologyDavid P Faxon
Circulation 109:2617-25. 2004 - Lysosomal cysteine proteases in atherosclerosisJian Liu
Department of Molecular and Cell Biology, School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
Arterioscler Thromb Vasc Biol 24:1359-66. 2004.... - The forgotten majority: unfinished business in cardiovascular risk reductionPeter Libby
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 46:1225-8. 2005..Thus, physicians must continue to educate their patients regarding an optimal balance of drug therapy and personal behavior...