Peter Libby

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Role of inflammation in atherosclerosis associated with rheumatoid arthritis
    Peter Libby
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Med 121:S21-31. 2008
  2. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  3. ncbi request reprint Mechanisms of plaque stabilization with statins
    Peter Libby
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 91:4B-8B. 2003
  4. pmc 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02124, USA
    JACC Cardiovasc Imaging 2:1213-22. 2009
  5. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
  6. pmc Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection
    Koichi Shimizu
    Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:1997-2008. 2008
  7. pmc Molecular imaging of innate immune cell function in transplant rejection
    Thomas Christen
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 119:1925-32. 2009
  8. ncbi request reprint Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice
    Galina K Sukhova
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass, USA
    Circ Res 96:368-75. 2005
  9. pmc Adiponectin inhibits allograft rejection in murine cardiac transplantation
    Yoshihisa Okamoto
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 88:879-83. 2009
  10. doi request reprint Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 2:616-23. 2009

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. doi request reprint Role of inflammation in atherosclerosis associated with rheumatoid arthritis
    Peter Libby
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Med 121:S21-31. 2008
    ....
  2. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  3. ncbi request reprint Mechanisms of plaque stabilization with statins
    Peter Libby
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 91:4B-8B. 2003
    ..However, data suggest that statin-induced alterations in the function of small G proteins may contribute to the anti-inflammatory and antithrombotic actions of statins in clinical practice...
  4. pmc 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02124, USA
    JACC Cardiovasc Imaging 2:1213-22. 2009
    ....
  5. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
    ....
  6. pmc Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection
    Koichi Shimizu
    Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:1997-2008. 2008
    ....
  7. pmc Molecular imaging of innate immune cell function in transplant rejection
    Thomas Christen
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 119:1925-32. 2009
    ..Yet, which macrophage functions may provide useful markers for detecting parenchymal rejection remains uncertain...
  8. ncbi request reprint Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice
    Galina K Sukhova
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass, USA
    Circ Res 96:368-75. 2005
    ..These findings demonstrate directly the importance of cysteine protease/protease inhibitor balance in dysregulated arterial integrity and remodeling during experimental atherogenesis...
  9. pmc Adiponectin inhibits allograft rejection in murine cardiac transplantation
    Yoshihisa Okamoto
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 88:879-83. 2009
    ..This study investigated whether adiponectin modulates allograft rejection in major histocompatibility complex class II-mismatched cardiac transplants...
  10. doi request reprint Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 2:616-23. 2009
    ..However, whether the absolute risk reduction among such individuals justifies wide application of statin therapy in primary prevention is a controversial issue with broad policy and public health implications...
  11. doi request reprint HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Lancet 376:333-9. 2010
    ..We addressed, using the JUPITER trial cohort, whether this association remains when LDL-cholesterol concentrations are reduced to the very low ranges with high-dose statin treatment...
  12. doi request reprint Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques
    Fabrice Schneider
    Donald W Reynolds Cardiovascular Clinical Research Center and Fondation Leducq Transatlantic Network on Atherothrombosis, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:931-9. 2008
    ..Although in vitro results suggest collagenase activity for membrane-bound matrix metalloproteinase type 1 (MMP-14), in vivo evidence for such a function in atherosclerosis remains scant...
  13. ncbi request reprint Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:386-91. 2004
    ..Statins inhibit CD40L signaling in vitro, but there are no prospective studies of statins and sCD40L in acute coronary syndromes...
  14. pmc CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis
    René R S Packard
    Leducq Center for Cardiovascular Research and Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:965-73. 2008
    ..In particular, DCs remain functional antigen-presenting cells and maintain their ability to prime CD4(+) T cells even when cholesterol-loaded...
  15. pmc Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts
    Takuya Ueno
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 6:568-73. 2013
    ..Macrophages predominate among the inflammatory cells in rejecting allografts. These innate immune cells, in addition to allospecific T cells, can damage cardiomyocytes directly...
  16. pmc Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity
    Viviane Zorzanelli Rocha
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA, 02115, USA
    Circ Res 103:467-76. 2008
    ..These results indicate a role for T cells and IFNgamma, a prototypical T-helper 1 cytokine, in regulation of the inflammatory response that accompanies obesity...
  17. doi request reprint Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 373:1175-82. 2009
    ..8 mmol/L (<70 mg/dL). However, the benefit of lowering both LDL cholesterol and hsCRP after the start of statin therapy is controversial. We prospectively tested this hypothesis...
  18. ncbi request reprint Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins
    Koichi Shimizu
    The Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 108:2113-20. 2003
    ..This study tested the hypothesis that statins can suppress GAD by cholesterol-independent pathways...
  19. doi request reprint Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  20. pmc Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice
    Stephanie Schulte
    Cardiovascular Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, NRB 730J, Boston, MA 02115, USA
    Am J Pathol 177:456-63. 2010
    ....
  21. ncbi request reprint Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells
    Kikuo Isoda
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:611-7. 2006
    ..Therefore, this study examined the potential action of metformin as an inhibitor of pro-inflammatory responses in human vascular smooth muscle cells (SMCs), macrophages (Mphis), and endothelial cells (ECs)...
  22. ncbi request reprint Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques
    Yoshihiro Fukumoto
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:1953-9. 2004
    ..However, no direct in vivo evidence links collagenases with the regulation of collagen content in atherosclerotic plaques...
  23. pmc Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress
    Konstantinos C Koskinas
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 33:1494-504. 2013
    ..This study tested the hypothesis that coronary regions exposed to low endothelial shear stress (ESS) favor subsequent development of collagen-poor, thin-capped plaques...
  24. pmc Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
    Manabu Minami
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 283:9692-703. 2008
    ..Thus, PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation...
  25. pmc A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 360:1851-61. 2009
    ..Observational studies have yielded variable estimates of the effect of statin therapy on the risk of venous thromboembolism, and evidence from randomized trials is lacking...
  26. pmc Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis
    Stephanie Schulte
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 172:1500-8. 2008
    ..The results presented here illustrate how genetically determined modifiers of both immune and inflammatory responses can modulate atherogenesis independently of lipid levels...
  27. pmc Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study
    Payman Zamani
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    J Am Heart Assoc 2:e003103. 2013
    ..We assessed 8 inflammatory and vascular biomarkers and the risk of death and recurrent nonfatal cardiovascular events in the 16 weeks after an acute coronary syndrome...
  28. pmc Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston, MA 02114, USA
    J Exp Med 209:123-37. 2012
    ..We also detected rapid Mo kinetics in mice with stroke. These findings expand our knowledge of Mo/MΦ flux in acute inflammation and provide the groundwork for novel anti-inflammatory strategies for treating heart failure...
  29. pmc Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II
    Jun o Deguchi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lab Invest 89:315-26. 2009
    ..Optical analysis further indicated altered collagen fiber orientation in the adventitia of Col(R/R)/apoE(-/-) mice. These results demonstrate that collagen content regulates aortic biomechanical properties and influences AAA formation...
  30. ncbi request reprint Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
    Circulation 115:2292-8. 2007
    ..To assess better the biology of CatK activity in vivo, we developed a novel near-infrared fluorescence (NIRF) probe for imaging of CatK and evaluated it in mouse and human atherosclerosis...
  31. pmc High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis
    Kunio Morishige
    Donald W Reynolds Cardiovascular Clinical Research Center at Harvard Medical School, Boston, MA, USA
    Circulation 122:1707-15. 2010
    ..Macrophage imaging may serve as a biomarker to identify subclinical inflamed lesions, to predict future risk, and to aid in the assessment of novel therapies...
  32. doi request reprint Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography
    Eduardo J Folco
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 58:603-14. 2011
    ....
  33. ncbi request reprint Cathepsin L activity controls adipogenesis and glucose tolerance
    Min Yang
    Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 9:970-7. 2007
    ..Increased levels of CatL in obese and diabetic patients suggest that this protease is a novel target for these metabolic disorders...
  34. pmc Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation
    Eva H C Tang
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 31:261-9. 2011
    ..To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow-derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo...
  35. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    ..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation...
  36. ncbi request reprint TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    ..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis...
  37. pmc Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
    Koichi Shimizu
    The Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:300-8. 2004
    ..The findings establish important regulatory roles for a Th1/Th2 cytokine balance in modulating matrix remodeling and have important implications for the pathophysiology of AAAs and arteriosclerosis...
  38. ncbi request reprint Effect of a cleavage-resistant collagen mutation on left ventricular remodeling
    Merry L Lindsey
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circ Res 93:238-45. 2003
    ..We were not able to detect collagen cleavage fragments, and could not, therefore, rule out the possibility of collagen cleavage at additional sites...
  39. pmc Myocardial infarction accelerates atherosclerosis
    Partha Dutta
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 487:325-9. 2012
    ..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression...
  40. pmc Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection
    Koichi Shimizu
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB7, Boston, MA 02115, USA
    Circulation 124:2920-32. 2011
    ..This study investigated the role of MRP-8/14 in cardiac allograft rejection using MRP-14(-/-) mice that lack MRP-8/14 complexes...
  41. ncbi request reprint Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Healthcare System, West Roxbury, Mass, USA
    Arterioscler Thromb Vasc Biol 28:142-7. 2008
    ..We measured markers of inflammation in the MIRACL study, a randomized trial of atorvastatin versus placebo in acute coronary syndromes, to assess the relationship of inflammation to stroke...
  42. pmc Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 122:808-20. 2010
    ..Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD74-deficient mice have reduced numbers of active T cells and resist atherogenesis...
  43. pmc Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques
    Claudio Vinegoni
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 3:84ra45. 2011
    ..The atheroma-targeting capability of ICG has the potential to accelerate the clinical development of NIRF molecular imaging of high-risk plaques in humans...
  44. pmc Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K
    Yu Sun
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 104:455-65. 2009
    ....
  45. ncbi request reprint Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells
    Akio Kawakami
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 114:681-7. 2006
    ..We recently reported that apoCIII has a proinflammatory effect on human monocytes. In this study, we looked for a direct effect of apoCIII on EC expression of adhesion molecules, leading to monocytic cell adhesion...
  46. pmc CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease
    Koichi Shimizu
    Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 120:1800-13. 2009
    ....
  47. pmc Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells
    Alexandra Krettek
    Brigham and Womens Hospital, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
    Am J Pathol 165:1571-81. 2004
    ....
  48. ncbi request reprint Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jie Hong Pan
    Department of Medicine, University of California San Francisco, Calif, USA
    Circulation 109:3149-53. 2004
    ..Therefore, we investigated whether deficiency of MIF modulates atherosclerotic lesion formation and composition in low-density lipoprotein receptor-deficient (LDLr-/-) mice...
  49. ncbi request reprint Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice
    Shiro Kitamoto
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 115:2065-75. 2007
    ..Increased expression of the elastinolytic and collagenolytic enzyme cathepsin L (Cat L) in human atherosclerotic lesions suggests its participation in these processes, a hypothesis tested here in mice...
  50. pmc Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis
    Thibaut Quillard
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 31:2464-72. 2011
    ..This study tested the hypothesis that selective matrix metalloproteinase-13 (MMP-13) collagenase inhibition increases collagen content in already established and nascent mouse atheromas...
  51. ncbi request reprint Mast cells promote atherosclerosis by releasing proinflammatory cytokines
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cardiovascular Medicine NRB 7, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 13:719-24. 2007
    ..These observations establish direct participation of mast cells and mast cell-derived IL-6 and IFN-gamma in mouse atherogenesis and provide new mechanistic insight into the pathogenesis of this common disease...
  52. ncbi request reprint Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis
    Yoshihisa Okamoto
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 102:218-25. 2008
    ..This study establishes that low levels of adiponectin associated with obesity, the metabolic syndrome, and diabetes favor T-lymphocyte recruitment and contribute to adaptive immune response during atherogenesis...
  53. ncbi request reprint Inflammation in atherosclerosis: transition from theory to practice
    Peter Libby
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ J 74:213-20. 2010
    ..Inflammation is thus moving from a theoretical concept to a tool that provides practical clinical utility in risk assessment and targeting of therapy...
  54. pmc Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis
    Farouc A Jaffer
    MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
    Circulation 118:1802-9. 2008
    ..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization...
  55. pmc Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circulation 120:973-82. 2009
    ..Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown...
  56. pmc Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10
    Eduardo J Folco
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:25569-75. 2009
    ..These results suggest that adiponectin triggers a multifaceted response in human macrophages by inducing the expression of various anti-inflammatory proteins that act at different levels in concert to suppress macrophage activation...
  57. pmc Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions
    Clinton S Robbins
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Boston, MA 02114, USA
    Circulation 125:364-74. 2012
    ..Here, we hypothesized that the bone marrow outsources the production of Ly-6C(high) monocytes during atherosclerosis...
  58. pmc Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation
    Jie Zhang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circ Res 108:1316-27. 2011
    ..Tryptase is the most abundant MC granule protein and participates in MC activation, protease maturation, leukocyte recruitment, and angiogenesis-all processes critical to AAA pathogenesis...
  59. pmc Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions
    Eva H C Tang
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB741, Boston, MA 02115, USA
    Cardiovasc Res 89:234-43. 2011
    ..Thus, activation of EP4 may constitute an endogenous anti-inflammatory pathway. This study investigated the role of EP4 in atherosclerosis in vivo, and particularly its impact on inflammation...
  60. ncbi request reprint High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1560-6. 2003
    ..Although statins reduce inflammatory markers in asymptomatic adults or in patients with stable angina, the effect of statins on the markedly heightened inflammation in patients with acute coronary syndromes is unknown...
  61. pmc Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial
    David A Morrow
    Thrombolysis in Myocardial Infarction Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 155:49-55. 2008
    ..Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals but have not been assessed with respect to prognosis in patients with acute coronary syndrome...
  62. ncbi request reprint Atherosclerotic plaque inflammation: the final frontier?
    Masanori Aikawa
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Can J Cardiol 20:631-4. 2004
  63. ncbi request reprint Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:2888-93. 2002
    ....
  64. doi request reprint The vascular biology of atherosclerosis and imaging targets
    Peter Libby
    Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, Boston, Massachusetts, USA
    J Nucl Med 51:33S-37S. 2010
    ..The goals for the years to come must include translation of the experimental work to visualization of these appealing biologic targets in humans...
  65. ncbi request reprint Neutrophil elastase in human atherosclerotic plaques: production by macrophages
    Clare M Dollery
    Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, EBRC 307, Boston, Mass 02115, USA
    Circulation 107:2829-36. 2003
    ..NE can digest elastin, fibrillar and nonfibrillar collagens, and other ECM components in addition to its ability to modify lipoproteins and modulate cytokine and MMP activity...
  66. ncbi request reprint Inflammation and cellular immune responses in abdominal aortic aneurysms
    Koichi Shimizu
    The Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 26:987-94. 2006
    ....
  67. ncbi request reprint Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, USA
    Arterioscler Thromb Vasc Biol 27:175-81. 2007
    ..We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression...
  68. pmc Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice
    Galina K Sukhova
    the Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:897-906. 2003
    ..CatS(-/-)LDLR(-/-) monocytes showed impaired subendothelial basement membrane transmigration, and aortas from CatS(-/-)LDLR(-/-) mice had preserved elastic laminae. These findings establish a pivotal role for Cat S in atherogenesis...
  69. ncbi request reprint Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells
    Udo Bavendiek
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
    Arterioscler Thromb Vasc Biol 25:1244-9. 2005
    ....
  70. doi request reprint Obesity, inflammation, and atherosclerosis
    Viviane Z Rocha
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Cardiol 6:399-409. 2009
    ..Our current appreciation of the similarities between obesity and atherosclerosis has already fostered innovations for the diagnosis, prognosis, and prevention of these two conditions...
  71. ncbi request reprint Wild-type but not interferon-gamma-deficient T cells induce graft arterial disease in the absence of B cells
    Yutaka Furukawa
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, USA
    Cardiovasc Res 63:347-56. 2004
    ..This study investigated whether T cells can induce GAD in the absence of humoral alloresponses and whether activated macrophages or other host cell types can substitute as sources of IFN-gamma in GAD...
  72. ncbi request reprint Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice
    Ruth Maron
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 106:1708-15. 2002
    ..Mucosal administration of autoantigens decreases organ-specific inflammation and disease in several models of autoimmunity (diabetes, arthritis, and encephalomyelitis) and is also being tested in human clinical trials...
  73. ncbi request reprint Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction
    Merry L Lindsey
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 105:753-8. 2002
    ..However, it is not clear if selective MMP inhibition strategies will be effective or if MMP inhibition will impair angiogenesis after MI...
  74. ncbi request reprint Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
    Joshua A Beckman
    Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JAMA 287:2570-81. 2002
    ..Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused...
  75. pmc Innate and adaptive immunity in atherosclerosis
    René R S Packard
    Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 7, Boston, MA 02115, USA
    Semin Immunopathol 31:5-22. 2009
    ..This review retraces leukocyte subsets involved in innate and adaptive immunity and their contributions to atherogenesis...
  76. ncbi request reprint Tumor necrosis factor receptor -1 and -2 double deficiency reduces graft arterial disease in murine cardiac allografts
    Jun ichi Suzuki
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 3:968-76. 2003
    ..We conclude that both p55 and p75 signals on donor vascular wall cells are involved in the development of GAD, and either TNFR is capable of mediating a response that will culminate in GAD...
  77. ncbi request reprint Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo
    Jun o Deguchi
    Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 114:55-62. 2006
    ..Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications...
  78. ncbi request reprint Macrophage migration inhibitory factor is associated with aneurysmal expansion
    Jie Hong Pan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 90 Medical Center Way, San Francisco, CA 94143, USA
    J Vasc Surg 37:628-35. 2003
    ..The correlation and contribution of MIF to these human diseases remain unknown, although a recent rabbit study showed expression of this cytokine in atherosclerotic lesions...
  79. pmc Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts
    Yutaka Furukawa
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 160:1077-87. 2002
    ..Although prolonged cold ischemia can initiate mild GAD in isografts by transiently enhancing antigen non-specific inflammatory responses, it does not significantly augment subsequent alloresponses...
  80. ncbi request reprint Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and
    David Xiao Ming Zhao
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 169:1556-60. 2002
    ..This chemokine pathway may serve as a monitor and target for novel therapies to prevent CAV and rejection...
  81. ncbi request reprint Inflammatory markers are useful risk assessment tools
    Peter Libby
    Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    Am J Manag Care . 2003
  82. ncbi request reprint Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis
    Seigo Sugiyama
    Leducq Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arterioscler Thromb Vasc Biol 24:1309-14. 2004
    ..Superficial erosion of coronary plaques due to endothelial loss causes acute coronary syndromes (ACS). Macrophages at erosive sites of human coronary atheroma present myeloperoxidase (MPO), an enzyme that produces hypochlorous acid (HOCl)...
  83. ncbi request reprint Effects of statins in reducing thrombotic risk and modulating plaque vulnerability
    Peter Libby
    Harvard Medical School and Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Cardiol 26:I11-4. 2003
    ..Rupture of the fibrous cap causes most fatal coronary thrombosis...
  84. ncbi request reprint Influence of Helicobacter pylori infection during atherogenesis in vivo in mice
    Francois Mach
    Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 90:E1-4. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  85. pmc Cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-asociated cells: implications for persistent Chlamydophila pneumoniae infection
    Jessica B Sakash
    Vascular Research Division Department of Pathology and Leducq Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Immun 70:3959-61. 2002
    ..Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that organism in atherosclerosis...
  86. ncbi request reprint Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones
    Nerea Varo
    Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, Mass 02115, USA
    Circulation 107:2664-9. 2003
    ..This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation...
  87. ncbi request reprint Soluble CD40L: risk prediction after acute coronary syndromes
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 108:1049-52. 2003
    ..This study tested the hypothesis that plasma sCD40L, alone or in combination with troponin (cTnI) or C-reactive protein (CRP), may identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events...
  88. ncbi request reprint Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 109:II18-26. 2004
    ..This overview addresses the controversy by reviewing in vitro and in vivo evidence regarding statins as antiinflammatory agents...
  89. ncbi request reprint Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein
    Paul M Ridker
    JUPITER Coordinating Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1659-64. 2007
    ..In conclusion, as 20 mg of rosuvastatin can reduce LDL cholesterol by up to 50%, JUPITER will also provide crucial safety data for several thousand patients who should achieve LDL cholesterol levels<50 mg/dl on a long-term basis...
  90. ncbi request reprint Inflammation and atherosclerosis: role of C-reactive protein in risk assessment
    Peter Libby
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Med 116:9S-16S. 2004
    ..Thus, medical practitioners are ushering in an era in which the biology of inflammation in atherosclerosis will find its way into clinical application...
  91. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  92. doi request reprint Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts, USA
    Am J Cardiol 106:204-9. 2010
    ..In conclusion, as the absolute risk increased with increasing hs-CRP, the absolute risk reduction associated with rosuvastatin within JUPITER was also greatest among those with the greatest entry hs-CRP levels...
  93. ncbi request reprint Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation
    Mark W Feinberg
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Res 94:601-8. 2004
    ....
  94. ncbi request reprint Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists
    Peter Libby
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 99:27B-40B. 2007
    ....
  95. ncbi request reprint CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group
    Sidney C Smith
    Circulation 110:e550-3. 2004
  96. ncbi request reprint The forgotten majority: unfinished business in cardiovascular risk reduction
    Peter Libby
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 46:1225-8. 2005
    ..Thus, physicians must continue to educate their patients regarding an optimal balance of drug therapy and personal behavior...
  97. ncbi request reprint Fat fuels the flame: triglyceride-rich lipoproteins and arterial inflammation
    Peter Libby
    Circ Res 100:299-301. 2007
  98. ncbi request reprint Atherosclerosis: disease biology affecting the coronary vasculature
    Peter Libby
    Harvard Medical School and Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 98:3Q-9Q. 2006
    ..Treatment of vulnerable patients should include measures to stabilize plaques and to lessen the thrombotic consequences of plaque disruptions...
  99. ncbi request reprint PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis
    Nikolaus Marx
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Circ Res 90:703-10. 2002
    ....
  100. ncbi request reprint Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events
    Aileen M Healy
    Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
    Circulation 113:2278-84. 2006
    ..Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events...
  101. ncbi request reprint Vitamin C, collagen, and cracks in the plaque
    Peter Libby
    Circulation 105:1396-8. 2002