JAMES KUANG JAN LIAO

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Rho kinase (ROCK) inhibitors
    James K Liao
    The Vascular Medicine Research Unit, Brigham and Women s Hospital, Cambridge 02139 and Harvard Medical School, Boston, Massachusetts, USA
    J Cardiovasc Pharmacol 50:17-24. 2007
  2. pmc Does it matter whether or not a lipid-lowering agent inhibits Rho kinase?
    James K Liao
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Room 275, Cambridge, MA 02139, USA
    Curr Atheroscler Rep 9:384-8. 2007
  3. pmc FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2
    Ryuji Okamoto
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02139, USA
    FASEB J 27:1439-49. 2013
  4. pmc Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol
    James K Liao
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    Am J Cardiol 96:24F-33F. 2005
  5. pmc Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
    James K Liao
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 65 Landsdowne St, Rm 275, Cambridge, MA 02139, USA
    Circulation 115:1615-21. 2007
  6. pmc Safety and efficacy of statins in Asians
    James K Liao
    Brigham and Women s Hospital, Cambridge, Massachusetts Harvard Medical School, Cambridge, Massachusetts, USA
    Am J Cardiol 99:410-4. 2007
  7. ncbi request reprint Clinical implications for statin pleiotropy
    James K Liao
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    Curr Opin Lipidol 16:624-9. 2005
  8. pmc Statin therapy for cardiac hypertrophy and heart failure
    James K Liao
    Vascular Medicine Research, Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    J Investig Med 52:248-53. 2004
  9. pmc Pleiotropic effects of statins
    James K Liao
    Vascular Medicine Research, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    Annu Rev Pharmacol Toxicol 45:89-118. 2005
  10. pmc Fine-tuning the angiogenic response to vascular endothelial growth factor
    James K Liao
    Vascular Medicine Research Unit, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 103:229-30. 2008

Research Grants

  1. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2009
  2. Activation of eNOS by Steroid Hormones
    James Liao; Fiscal Year: 2006
  3. Novel Signaling Pathways in Ischemic Stroke
    JAMES KUANG JAN LIAO; Fiscal Year: 2010
  4. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2007
  5. Role of PI3-Kinase in Estrogen-induced eNOS Activation
    James Liao; Fiscal Year: 2007
  6. Lipoproteins Effect on G Protein Function
    James Liao; Fiscal Year: 2007
  7. ROCK and Obesity
    JAMES KUANG JAN LIAO; Fiscal Year: 2010
  8. Lipoproteins Effect on G Protein Function
    JAMES KUANG JAN LIAO; Fiscal Year: 2010
  9. LIPOPROTEINS EFFECTS ON G PROTEIN FUNCTION
    James Liao; Fiscal Year: 1999
  10. Lipoproteins Effects on G-Protein Function
    James Liao; Fiscal Year: 2004

Collaborators

Detail Information

Publications65

  1. pmc Rho kinase (ROCK) inhibitors
    James K Liao
    The Vascular Medicine Research Unit, Brigham and Women s Hospital, Cambridge 02139 and Harvard Medical School, Boston, Massachusetts, USA
    J Cardiovasc Pharmacol 50:17-24. 2007
    ....
  2. pmc Does it matter whether or not a lipid-lowering agent inhibits Rho kinase?
    James K Liao
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Room 275, Cambridge, MA 02139, USA
    Curr Atheroscler Rep 9:384-8. 2007
    ..This review attempts to make the case that, in addition to lipid lowering, inhibition of ROCK contributes to some of the benefits of statin therapy in patients with cardiovascular disease...
  3. pmc FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2
    Ryuji Okamoto
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02139, USA
    FASEB J 27:1439-49. 2013
    ....
  4. pmc Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol
    James K Liao
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    Am J Cardiol 96:24F-33F. 2005
    ....
  5. pmc Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
    James K Liao
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 65 Landsdowne St, Rm 275, Cambridge, MA 02139, USA
    Circulation 115:1615-21. 2007
    ....
  6. pmc Safety and efficacy of statins in Asians
    James K Liao
    Brigham and Women s Hospital, Cambridge, Massachusetts Harvard Medical School, Cambridge, Massachusetts, USA
    Am J Cardiol 99:410-4. 2007
    ..In conclusion, prescribing lower starting doses of statins in Asians appears warranted while research on this subject continues...
  7. ncbi request reprint Clinical implications for statin pleiotropy
    James K Liao
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    Curr Opin Lipidol 16:624-9. 2005
    ..However, the overall benefits observed with statins appear to occur much earlier and to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering...
  8. pmc Statin therapy for cardiac hypertrophy and heart failure
    James K Liao
    Vascular Medicine Research, Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    J Investig Med 52:248-53. 2004
    ..Because these effects of statins occur independently of cholesterol lowering, statins may have therapeutic benefits in nonhyperlipidemic patients with cardiac hypertrophy and heart failure...
  9. pmc Pleiotropic effects of statins
    James K Liao
    Vascular Medicine Research, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    Annu Rev Pharmacol Toxicol 45:89-118. 2005
    ..In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins...
  10. pmc Fine-tuning the angiogenic response to vascular endothelial growth factor
    James K Liao
    Vascular Medicine Research Unit, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 103:229-30. 2008
  11. ncbi request reprint Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinase
    J K Liao
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Biochem Soc Trans 31:66-70. 2003
    ....
  12. ncbi request reprint Statins and ischemic stroke
    James K Liao
    Vascular Medicine Research, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    Atheroscler Suppl 3:21-5. 2002
    ..In particular, the ability of statins to decrease the incidence of ischemic stroke highlights some of their non-cholesterol effects since serum cholesterol levels are poorly correlated with the risk for ischemic stroke...
  13. pmc Isoprenoids as mediators of the biological effects of statins
    James K Liao
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    J Clin Invest 110:285-8. 2002
  14. ncbi request reprint Beyond lipid lowering: the role of statins in vascular protection
    James K Liao
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Room 275, Cambridge, MA 02139, USA
    Int J Cardiol 86:5-18. 2002
    ....
  15. pmc Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection
    Yoshiyuki Rikitake
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 36:2251-7. 2005
    ..However, it is unknown whether inhibition of ROCK can attenuate ischemia-induced endothelial dysfunction and tissue damage in vivo...
  16. pmc Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis
    Koh Kawasaki
    Vascular Medicine Research Unit, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:5726-37. 2003
    ..These findings indicate that NO promotes endothelial cell migration and neovascularization via cGMP-dependent activation of PI3 kinase and suggest that this pathway is important in mediating NO-induced angiogenesis...
  17. ncbi request reprint Endothelium-dependent effects of statins
    Sebastian Wolfrum
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
    Arterioscler Thromb Vasc Biol 23:729-36. 2003
    ..Thus, the endothelium-dependent effects of statins are thought to contribute to many of the beneficial effects of statin therapy in cardiovascular disease...
  18. pmc ROCKs as therapeutic targets in cardiovascular diseases
    Yoshiyuki Rikitake
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Expert Rev Cardiovasc Ther 3:441-51. 2005
    ..This review will focus on the potential role of ROCKs in cellular functions and discuss the prospects of ROCK inhibitors as emerging therapy for cardiovascular diseases...
  19. pmc Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia
    Minoru Asahi
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    J Cereb Blood Flow Metab 25:722-9. 2005
    ..These results suggest that statins protect against stroke by multiple mechanisms involving both eNOS and tPA. The involvement of each pathway may be revealed depending on the choice of experimental stroke model...
  20. pmc Rho GTPases, statins, and nitric oxide
    Yoshiyuki Rikitake
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 97:1232-5. 2005
    ..The regulation of eNOS by Rho GTPases, therefore, may be an important mechanism underlying the cardiovascular protective effect of statins...
  21. pmc Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms
    Hwa Kyoung Shin
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:998-1009. 2007
    ..Therefore, rapid nontranscriptional upregulation of eNOS activity by small molecule inhibitors of Rho-kinase may be a viable therapeutic approach in acute stroke...
  22. pmc Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 95:217-23. 2004
    ..These findings implicate a potential role for statin therapy to restore endothelial function and thereby investigate vascular disease in cigarette smokers...
  23. pmc Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection
    Hyung Hwan Kim
    Vascular Medicine Research Unit, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Cereb Blood Flow Metab 28:1285-93. 2008
    ..These findings indicate that statin and DP exert additive NO-dependent vascular effects and suggest that the combination of statin and DP has greater benefits in stroke protection than statin alone through vascular protection...
  24. pmc Long-term statin use and psychological well-being
    Yinong Young-Xu
    Lown Cardiovascular Research Foundation, Brookline, Massachusetts 02446, USA
    J Am Coll Cardiol 42:690-7. 2003
    ..We sought to study the effect of long-term statin use on psychometric measures in an adult population with underlying coronary artery disease (CAD)...
  25. pmc Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection
    Naoki Sawada
    Cardiovascular Institute, Beth Israel Deaconess Medical Center, Center for Life Sciences, Boston, MA 02115, USA
    Expert Rev Neurother 9:1171-86. 2009
    ..This review discusses the emerging therapeutic opportunities to target neurovascular signaling beyond the BBB, with special emphasis on the novel role of endothelial Rac1 in stroke protection...
  26. ncbi request reprint Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase
    Masao Takemoto
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
    Circulation 106:57-62. 2002
    ..The mechanism by which hypoxia decreases eNOS expression is not known but may involve Rho-kinase-induced actin cytoskeletal changes in vascular endothelial cells...
  27. pmc Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease
    Anju Nohria
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circ Res 99:1426-32. 2006
    ..Inhibition of the Rho/Rho kinase pathway should provide a useful strategy to restore NO bioavailability in humans with atherosclerosis...
  28. ncbi request reprint Pleiotropic effects of statins. - Basic research and clinical perspectives -
    Qian Zhou
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Circ J 74:818-26. 2010
    ....
  29. pmc Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy
    Qian Zhou
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    Curr Pharm Des 15:467-78. 2009
    ..This review provides an update of statin-mediated vascular effects beyond cholesterol lowering and highlights recent findings from bench to bedside to support the concept of statin pleiotropy...
  30. pmc Translational therapeutics of dipyridamole
    Hyung Hwan Kim
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 28:s39-42. 2008
    ..These platelet and nonplatelet actions of DP may contribute to some of its therapeutic benefits in vascular disease...
  31. pmc Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
    Florian P Limbourg
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 110:1729-38. 2002
    ..These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF...
  32. pmc Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells
    Yoshiyuki Rikitake
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:3261-8. 2005
    ..The induction of PAI-1 expression by hyperglycemia involves oxidative stress and protein kinase C (PKC). However, the mechanism by which hyperglycemia increases PAI-1 expression is unknown...
  33. pmc A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms
    Hironori Nakagami
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Ann Med 35:398-403. 2003
    ..Overall, these pleiotropic effects of statins will give new insights into the process of cardiac hypertrophy...
  34. pmc Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase
    Jianxin Sun
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 24:2238-44. 2004
    ..Because angiogenesis is important for tumor growth, we hypothesize that inhibition of angiogenesis by 17-AAG may mediate some of its antitumor effects...
  35. pmc Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice
    Yoshiyuki Rikitake
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, USA
    Circulation 112:2959-65. 2005
    ..To determine the specific role of ROCK1 in the development of cardiac hypertrophy, we generated ROCK1(+/-) haploinsufficient mice and determined whether cardiac hypertrophy and remodeling are decreased in these mice...
  36. pmc Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation
    Ping Yen Liu
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Circulation 119:131-8. 2009
    ....
  37. pmc RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis
    Brad A Bryan
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    FASEB J 24:3186-95. 2010
    ....
  38. pmc Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1
    Naoki Sawada
    Vascular Medicine Research, Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Circ Res 103:360-8. 2008
    ..Therapeutic strategies to enhance Rac1 function, therefore, may be important for preventing endothelial dysfunction...
  39. ncbi request reprint Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants
    Michael Grimm
    Vascular Medicine Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Masachusetts 02115, USA
    J Biol Chem 277:26460-7. 2002
    ..These results indicate that NO and antioxidants may attenuate vascular inflammation by antagonizing the effects of intracellular reactive oxygen species generation by IFN-gamma, which is necessary for MHC-II gene transcription...
  40. pmc Isoprenoid metabolism and the pleiotropic effects of statins
    Ulrich Laufs
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Curr Atheroscler Rep 5:372-8. 2003
  41. ncbi request reprint Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells
    Tommaso Simoncini
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass, USA
    Arterioscler Thromb Vasc Biol 23:198-203. 2003
    ..Because PI3K is mainly a cytoplasmic complex, we studied the cellular site of interaction between this enzyme and ERalpha, and we dissected the molecular mechanisms that mediate this interaction...
  42. pmc Essential role of endothelial Notch1 in angiogenesis
    Florian P Limbourg
    Vascular Medicine Research Unit, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass, USA
    Circulation 111:1826-32. 2005
    ..Loss of global Notch1 function results in early embryonic lethality, but the cell type responsible for this defect is not known. Here, we identify the endothelium as the primary target tissue affected by Notch1 signaling...
  43. pmc Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection
    Sebastian Wolfrum
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
    Arterioscler Thromb Vasc Biol 24:1842-7. 2004
    ..Rho-kinase activity is increased in cardiovascular diseases and in patients with cardiovascular risk factors. However, it is not known whether inhibition of Rho-kinase could lead to cardiovascular protection and, if so, by what mechanism...
  44. pmc Physiological role of ROCKs in the cardiovascular system
    Kensuke Noma
    Brigham and Women s Hospital, 65 Landsdowne St, Rm 275, Cambridge, MA, USA
    Am J Physiol Cell Physiol 290:C661-8. 2006
    ..Herein we review what is known about the physiological role of ROCKs in the cardiovascular system and speculate about how inhibition of ROCKs could provide cardiovascular benefits...
  45. pmc Statins and myocardial hypertrophy
    Hironori Nakagami
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Coron Artery Dis 15:247-50. 2004
    ....
  46. pmc Critical role of endothelial Notch1 signaling in postnatal angiogenesis
    Kyosuke Takeshita
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Boston, MA, USA
    Circ Res 100:70-8. 2007
    ..These results suggest that Notch1 may be a novel therapeutic target for improving angiogenic response and blood flow recovery in ischemic limbs...
  47. pmc Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells
    Yasushi Mukai
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
    Am J Physiol Heart Circ Physiol 292:H1937-42. 2007
    ..These results suggest that factors that activate the PI3K/Akt pathway in ECs may have therapeutic benefits for atherothrombotic vascular disease...
  48. pmc Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
    Chao Yung Wang
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Trends Mol Med 14:37-44. 2008
    ..Here, we review data from recent clinical trials that support the concept of statin pleiotropy and provide a rationale for their clinical importance...
  49. pmc Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel
    Jianxin Sun
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13108-13. 2002
    ..Theses results indicate that the interaction between a voltage-dependent membrane channel and eNOS may be important for regulating eNOS activity...
  50. pmc Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR
    Chao Yung Wang
    Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Sci Signal 2:ra11. 2009
    ..These findings indicate that long-term activation of Akt-mTOR signaling links diet-induced obesity with vascular senescence and cardiovascular disease...
  51. pmc Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event
    Ron Rawlings
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 103:437-41. 2009
    ..In conclusion, these findings provide direct clinical evidence that statins, at clinically relevant doses, could differentially inhibit ROCK activity and improve endothelial function by cholesterol-independent mechanism...
  52. pmc Statins inhibit Rho kinase activity in patients with atherosclerosis
    Anju Nohria
    Brigham and Women s Hospital, Boston, MA, USA
    Atherosclerosis 205:517-21. 2009
    ..In experimental settings, statins inhibit ROCK and reverse vascular dysfunctions in atherosclerosis, independent of cholesterol reduction. It is not known whether statins inhibit ROCK activity in humans with atherosclerosis...
  53. pmc Nontranscriptional actions of the glucocorticoid receptor
    Florian P Limbourg
    Vascular Medicine Research, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    J Mol Med (Berl) 81:168-74. 2003
    ..This novel pathway of steroid hormone action protects against ischemic injury by augmenting blood flow and decreasing vascular inflammation...
  54. pmc Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt
    Yasushi Mukai
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 116:334-43. 2006
    ..These results suggest that enhancing endothelial Akt activity alone could have therapeutic benefits after vascular injury...
  55. pmc Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen
    Minoru Satoh
    Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 115:3197-204. 2007
    ..We hypothesize that estrogen prevents cardiomyocyte apoptosis and the development of CHF...
  56. pmc Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
    Ali Hafezi-Moghadam
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:473-9. 2002
    ..The rapid activation of eNOS by the non-nuclear actions of GR, therefore, represents an important cardiovascular protective effect of acute high-dose corticosteroid therapy...
  57. pmc Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy
    Koichi Node
    Cardiovascular Division, Department of Medicine, Saga University School of Medicine, 5 1 1 Nabeshima, Saga, 849 8501 Japan
    Circulation 108:839-43. 2003
    ..We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure...
  58. pmc Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction
    Yuxin Li
    Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Circulation 123:866-76. 2011
    ..Notch receptors mediate binary cell fate determination and may regulate the function of BM-derived cells. However, it is not known whether Notch1 signaling in BM-derived cells mediates cardiac repair after myocardial injury...
  59. doi request reprint NF-κB and innate immunity in ischemic stroke
    Olivier A Harari
    Vascular Medicine Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1207:32-40. 2010
    ..Here, we review the relationship between NF-κB and ischemic stroke, its role in the neurovascular unit, and discuss some animal models that suggest that this relationship is causal...
  60. pmc Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
    Partha S Biswas
    Department of Medicine, Columbia University, New York, New York, USA
    J Clin Invest 120:3280-95. 2010
    ....
  61. ncbi request reprint Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids
    Jianxin Sun
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02139, USA
    Circ Res 90:1020-7. 2002
    ..These findings indicate that EETs possess antimigratory effects on SMCs through the cAMP-PKA pathway and suggest that CYP epoxygenase-derived eicosanoids may play important roles in vascular disease and remodeling...
  62. pmc Increased leukocyte ROCK activity in patients after acute ischemic stroke
    Steven K Feske
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Brain Res 1257:89-93. 2009
    ..Inhibition of ROCK leads to decreased infarct size in animal models of ischemic stroke. This study tests the hypothesis that ROCK activity increases during the acute phase of ischemic stroke...
  63. pmc Inhibition of MHC II gene transcription by nitric oxide and antioxidants
    Olivier Harari
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Room 275, Cambridge, Massachusetts 02139, USA
    Curr Pharm Des 10:893-8. 2004
    ..Nitric oxide and antioxidants attenuate this class II induction through negative effects on the induction of class II transactivator protein expression and on the binding of transcription factor NF-Y to the class II promoter...
  64. pmc Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular disease
    Karen J Ho
    The Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Cambridge, MA 02139, USA
    Mol Interv 2:219-28. 2002
    ..Thus, a greater understanding of ER function and regulation may lead to the development of highly specific therapeutics that mediate the prevention and treatment of cardiovascular diseases...
  65. pmc Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2
    Chao Yung Wang
    Brigham and Women s Hospital, 65 Landsdowne St, Room 275, Cambridge, MA 02139, USA
    Circulation 118:2166-73. 2008
    ..We hypothesize that endothelial dysfunction in Per2 mutant (Per2(m/m)) mice is mediated in part by increased vascular senescence and impaired endothelial progenitor cell (EPC) function...

Research Grants29

  1. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2009
    ..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
  2. Activation of eNOS by Steroid Hormones
    James Liao; Fiscal Year: 2006
    ....
  3. Novel Signaling Pathways in Ischemic Stroke
    JAMES KUANG JAN LIAO; Fiscal Year: 2010
    ..This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in platelets as a potential therapeutic target for preventing and treating ischemic strokes. ..
  4. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2007
    ..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
  5. Role of PI3-Kinase in Estrogen-induced eNOS Activation
    James Liao; Fiscal Year: 2007
    ..These results may explain some of the actions of selective estrogen receptor modulators (SERMs) and provide a therapeutic basis for using estrogens in cardiovascular disease. ..
  6. Lipoproteins Effect on G Protein Function
    James Liao; Fiscal Year: 2007
    ....
  7. ROCK and Obesity
    JAMES KUANG JAN LIAO; Fiscal Year: 2010
    ..This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in fat tissues and skeletal muscle as a potential therapeutic target for preventing and treating diet-induced obesity. ..
  8. Lipoproteins Effect on G Protein Function
    JAMES KUANG JAN LIAO; Fiscal Year: 2010
    ....
  9. LIPOPROTEINS EFFECTS ON G PROTEIN FUNCTION
    James Liao; Fiscal Year: 1999
    ..This may ultimately lead to therapeutic modalities which can restore vascular function through enhancing G-protein interaction with its receptors and effectors. ..
  10. Lipoproteins Effects on G-Protein Function
    James Liao; Fiscal Year: 2004
    ..These proposed studies will hopefully provide greater insights into how lipoproteins cause endothelial dysfunction. ..