Research Topics
Species | JAMES KUANG JAN LIAOSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Rho kinase (ROCK) inhibitorsJames K Liao
The Vascular Medicine Research Unit, Brigham and Women s Hospital, Cambridge 02139 and Harvard Medical School, Boston, Massachusetts, USA
J Cardiovasc Pharmacol 50:17-24. 2007....- Does it matter whether or not a lipid-lowering agent inhibits Rho kinase?James K Liao
Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Room 275, Cambridge, MA 02139, USA
Curr Atheroscler Rep 9:384-8. 2007..This review attempts to make the case that, in addition to lipid lowering, inhibition of ROCK contributes to some of the benefits of statin therapy in patients with cardiovascular disease... - Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?James K Liao
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 65 Landsdowne St, Rm 275, Cambridge, MA 02139, USA
Circulation 115:1615-21. 2007.... - Statin therapy for cardiac hypertrophy and heart failureJames K Liao
Vascular Medicine Research, Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
J Investig Med 52:248-53. 2004..Because these effects of statins occur independently of cholesterol lowering, statins may have therapeutic benefits in nonhyperlipidemic patients with cardiac hypertrophy and heart failure... - Safety and efficacy of statins in AsiansJames K Liao
Brigham and Women s Hospital, Cambridge, Massachusetts Harvard Medical School, Cambridge, Massachusetts, USA
Am J Cardiol 99:410-4. 2007..In conclusion, prescribing lower starting doses of statins in Asians appears warranted while research on this subject continues... - Fine-tuning the angiogenic response to vascular endothelial growth factorJames K Liao
Vascular Medicine Research Unit, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Circ Res 103:229-30. 2008 - Pleiotropic effects of statinsJames K Liao
Vascular Medicine Research, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
Annu Rev Pharmacol Toxicol 45:89-118. 2005..In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins... 
Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinaseJ K Liao
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Biochem Soc Trans 31:66-70. 2003....- Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterolJames K Liao
Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
Am J Cardiol 96:24F-33F. 2005.... - Beyond lipid lowering: the role of statins in vascular protectionJames K Liao
Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Room 275, Cambridge, MA 02139, USA
Int J Cardiol 86:5-18. 2002.... - Statins and ischemic strokeJames K Liao
Vascular Medicine Research, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Atheroscler Suppl 3:21-5. 2002..In particular, the ability of statins to decrease the incidence of ischemic stroke highlights some of their non-cholesterol effects since serum cholesterol levels are poorly correlated with the risk for ischemic stroke... - Isoprenoids as mediators of the biological effects of statinsJames K Liao
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
J Clin Invest 110:285-8. 2002 - Clinical implications for statin pleiotropyJames K Liao
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
Curr Opin Lipidol 16:624-9. 2005..However, the overall benefits observed with statins appear to occur much earlier and to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering... - Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protectionYoshiyuki Rikitake
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Stroke 36:2251-7. 2005..However, it is unknown whether inhibition of ROCK can attenuate ischemia-induced endothelial dysfunction and tissue damage in vivo... - Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesisKoh Kawasaki
Vascular Medicine Research Unit, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 23:5726-37. 2003..These findings indicate that NO promotes endothelial cell migration and neovascularization via cGMP-dependent activation of PI3 kinase and suggest that this pathway is important in mediating NO-induced angiogenesis... - Endothelium-dependent effects of statinsSebastian Wolfrum
Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
Arterioscler Thromb Vasc Biol 23:729-36. 2003..Thus, the endothelium-dependent effects of statins are thought to contribute to many of the beneficial effects of statin therapy in cardiovascular disease... - Protective effects of statins involving both eNOS and tPA in focal cerebral ischemiaMinoru Asahi
Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
J Cereb Blood Flow Metab 25:722-9. 2005..These results suggest that statins protect against stroke by multiple mechanisms involving both eNOS and tPA. The involvement of each pathway may be revealed depending on the choice of experimental stroke model... - Rho GTPases, statins, and nitric oxideYoshiyuki Rikitake
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Circ Res 97:1232-5. 2005..The regulation of eNOS by Rho GTPases, therefore, may be an important mechanism underlying the cardiovascular protective effect of statins... - Rho kinase inhibition improves endothelial function in human subjects with coronary artery diseaseAnju Nohria
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Circ Res 99:1426-32. 2006..Inhibition of the Rho/Rho kinase pathway should provide a useful strategy to restore NO bioavailability in humans with atherosclerosis... - ROCKs as therapeutic targets in cardiovascular diseasesYoshiyuki Rikitake
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Expert Rev Cardiovasc Ther 3:441-51. 2005..This review will focus on the potential role of ROCKs in cellular functions and discuss the prospects of ROCK inhibitors as emerging therapy for cardiovascular diseases... - Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoproteinJoshua A Beckman
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circ Res 95:217-23. 2004..These findings implicate a potential role for statin therapy to restore endothelial function and thereby investigate vascular disease in cigarette smokers... - Long-term statin use and psychological well-beingYinong Young-Xu
Lown Cardiovascular Research Foundation, Brookline, Massachusetts 02446, USA
J Am Coll Cardiol 42:690-7. 2003..We sought to study the effect of long-term statin use on psychometric measures in an adult population with underlying coronary artery disease (CAD)... - Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthaseMasao Takemoto
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
Circulation 106:57-62. 2002..CONCLUSIONS: These results indicate that hypoxia-induced decrease in eNOS expression is mediated by Rho-kinase and suggest that Rho-kinase inhibitors may have therapeutic benefits in patients with hypoxia-induced pulmonary hypertension... - Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protectionNaoki Sawada
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Center for Life Sciences, Boston, MA 02115, USA
Expert Rev Neurother 9:1171-86. 2009..This review discusses the emerging therapeutic opportunities to target neurovascular signaling beyond the BBB, with special emphasis on the novel role of endothelial Rac1 in stroke protection... - Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanismsHwa Kyoung Shin
Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 27:998-1009. 2007..Therefore, rapid nontranscriptional upregulation of eNOS activity by small molecule inhibitors of Rho-kinase may be a viable therapeutic approach in acute stroke... - Additive effects of statin and dipyridamole on cerebral blood flow and stroke protectionHyung Hwan Kim
Vascular Medicine Research Unit, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Cereb Blood Flow Metab 28:1285-93. 2008..These findings indicate that statin and DP exert additive NO-dependent vascular effects and suggest that the combination of statin and DP has greater benefits in stroke protection than statin alone through vascular protection... - Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cellsYoshiyuki Rikitake
Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 111:3261-8. 2005..The induction of PAI-1 expression by hyperglycemia involves oxidative stress and protein kinase C (PKC). However, the mechanism by which hyperglycemia increases PAI-1 expression is unknown... - Pleiotropic effects of statins. - Basic research and clinical perspectives -Qian Zhou
Vascular Medicine Research Unit, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
Circ J 74:818-26. 2010.... - Statins and cardiovascular diseases: from cholesterol lowering to pleiotropyQian Zhou
Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
Curr Pharm Des 15:467-78. 2009..This review provides an update of statin-mediated vascular effects beyond cholesterol lowering and highlights recent findings from bench to bedside to support the concept of statin pleiotropy... - A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanismsHironori Nakagami
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
Ann Med 35:398-403. 2003..Overall, these pleiotropic effects of statins will give new insights into the process of cardiac hypertrophy... - Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroidsFlorian P Limbourg
Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 110:1729-38. 2002..These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF... - Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthaseJianxin Sun
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 24:2238-44. 2004..CONCLUSIONS: These findings indicate that Hsp90 is important not only for Akt and eNOS phosphorylation but also for eNOS gene transcription and suggests that Hsp90 may be a novel target for anti-angiogenic therapy... - Translational therapeutics of dipyridamoleHyung Hwan Kim
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 28:s39-42. 2008..These platelet and nonplatelet actions of DP may contribute to some of its therapeutic benefits in vascular disease... - Critical role of endothelial Notch1 signaling in postnatal angiogenesisKyosuke Takeshita
Vascular Medicine Research Unit, Brigham and Women s Hospital, Boston, MA, USA
Circ Res 100:70-8. 2007..These results suggest that Notch1 may be a novel therapeutic target for improving angiogenic response and blood flow recovery in ischemic limbs... - RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesisBrad A Bryan
Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
FASEB J 24:3186-95. 2010.... - Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cellsYasushi Mukai
Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA
Am J Physiol Heart Circ Physiol 292:H1937-42. 2007..These results suggest that factors that activate the PI3K/Akt pathway in ECs may have therapeutic benefits for atherothrombotic vascular disease... - Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammationPing Yen Liu
Cardiovascular Division, Brigham and Women s Hospital, Cambridge, MA 02139, USA
Circulation 119:131-8. 2009.... - Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1Naoki Sawada
Vascular Medicine Research, Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
Circ Res 103:360-8. 2008..Therapeutic strategies to enhance Rac1 function, therefore, may be important for preventing endothelial dysfunction... - Physiological role of ROCKs in the cardiovascular systemKensuke Noma
Brigham and Women's Hospital, 65 Landsdowne St, Rm. 275, Cambridge, MA, USA
Am J Physiol Cell Physiol 290:C661-8. 2006..Herein we review what is known about the physiological role of ROCKs in the cardiovascular system and speculate about how inhibition of ROCKs could provide cardiovascular benefits... - Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidantsMichael Grimm
Vascular Medicine Unit, Brigham and Women s Hospital and Harvard Medical School, Boston, Masachusetts 02115, USA
J Biol Chem 277:26460-7. 2002..These results indicate that NO and antioxidants may attenuate vascular inflammation by antagonizing the effects of intracellular reactive oxygen species generation by IFN-gamma, which is necessary for MHC-II gene transcription... - Statins and myocardial hypertrophyHironori Nakagami
Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
Coron Artery Dis 15:247-50. 2004.... - Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cellsTommaso Simoncini
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass, USA
Arterioscler Thromb Vasc Biol 23:198-203. 2003..Because PI3K is mainly a cytoplasmic complex, we studied the cellular site of interaction between this enzyme and ERalpha, and we dissected the molecular mechanisms that mediate this interaction... - Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protectionSebastian Wolfrum
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Mass 02139, USA
Arterioscler Thromb Vasc Biol 24:1842-7. 2004..These findings suggest that Rho-kinase may play an important role in mediating the inflammatory response to I/R injury... - Essential role of endothelial Notch1 in angiogenesisFlorian P Limbourg
Vascular Medicine Research Unit, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass, USA
Circulation 111:1826-32. 2005..Loss of global Notch1 function results in early embryonic lethality, but the cell type responsible for this defect is not known. Here, we identify the endothelium as the primary target tissue affected by Notch1 signaling... - Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient miceYoshiyuki Rikitake
Vascular Medicine Research Unit, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, USA
Circulation 112:2959-65. 2005..To determine the specific role of ROCK1 in the development of cardiac hypertrophy, we generated ROCK1(+/-) haploinsufficient mice and determined whether cardiac hypertrophy and remodeling are decreased in these mice... - Isoprenoid metabolism and the pleiotropic effects of statinsUlrich Laufs
Vascular Medicine Research, Brigham and Women's Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
Curr Atheroscler Rep 5:372-8. 2003 - Statins inhibit Rho kinase activity in patients with atherosclerosisAnju Nohria
Brigham and Women s Hospital, Boston, MA, USA
Atherosclerosis 205:517-21. 2009..In experimental settings, statins inhibit ROCK and reverse vascular dysfunctions in atherosclerosis, independent of cholesterol reduction. It is not known whether statins inhibit ROCK activity in humans with atherosclerosis... - Nontranscriptional actions of the glucocorticoid receptorFlorian P Limbourg
Vascular Medicine Research, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
J Mol Med 81:168-74. 2003..This novel pathway of steroid hormone action protects against ischemic injury by augmenting blood flow and decreasing vascular inflammation... - Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTORChao Yung Wang
Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
Sci Signal 2:ra11. 2009..These findings indicate that long-term activation of Akt-mTOR signaling links diet-induced obesity with vascular senescence and cardiovascular disease... - Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathyKoichi Node
Cardiovascular Division, Department of Medicine, Saga University School of Medicine, 5 1 1 Nabeshima, Saga, 849 8501 Japan
Circulation 108:839-43. 2003..We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure... - Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthaseAli Hafezi-Moghadam
The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:473-9. 2002..The rapid activation of eNOS by the non-nuclear actions of GR, therefore, represents an important cardiovascular protective effect of acute high-dose corticosteroid therapy... - Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channelJianxin Sun
Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:13108-13. 2002..Theses results indicate that the interaction between a voltage-dependent membrane channel and eNOS may be important for regulating eNOS activity... - Pleiotropic effects of statin therapy: molecular mechanisms and clinical resultsChao Yung Wang
Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
Trends Mol Med 14:37-44. 2008..Here, we review data from recent clinical trials that support the concept of statin pleiotropy and provide a rationale for their clinical importance... - Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogenMinoru Satoh
Vascular Medicine Research Unit, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
Circulation 115:3197-204. 2007..We hypothesize that estrogen prevents cardiomyocyte apoptosis and the development of CHF... - Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase AktYasushi Mukai
Vascular Medicine Research Unit, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 116:334-43. 2006..These results suggest that enhancing endothelial Akt activity alone could have therapeutic benefits after vascular injury... - Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic eventRon Rawlings
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 103:437-41. 2009..In conclusion, these findings provide direct clinical evidence that statins, at clinically relevant doses, could differentially inhibit ROCK activity and improve endothelial function by cholesterol-independent mechanism... - Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarctionYuxin Li
Brigham and Women s Hospital, Cambridge, MA 02139, USA
Circulation 123:866-76. 2011..Notch receptors mediate binary cell fate determination and may regulate the function of BM-derived cells. However, it is not known whether Notch1 signaling in BM-derived cells mediates cardiac repair after myocardial injury... - Increased leukocyte ROCK activity in patients after acute ischemic strokeSteven K Feske
Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
Brain Res 1257:89-93. 2009..Inhibition of ROCK leads to decreased infarct size in animal models of ischemic stroke. This study tests the hypothesis that ROCK activity increases during the acute phase of ischemic stroke... - Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular diseaseKaren J Ho
The Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Cambridge, MA 02139, USA
Mol Interv 2:219-28. 2002..Thus, a greater understanding of ER function and regulation may lead to the development of highly specific therapeutics that mediate the prevention and treatment of cardiovascular diseases... - Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoidsJianxin Sun
Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02139, USA
Circ Res 90:1020-7. 2002..These findings indicate that EETs possess antimigratory effects on SMCs through the cAMP-PKA pathway and suggest that CYP epoxygenase-derived eicosanoids may play important roles in vascular disease and remodeling... - Inhibition of MHC II gene transcription by nitric oxide and antioxidantsOlivier Harari
Vascular Medicine Research, Brigham and Women's Hospital, 65 Landsdowne Street, Room 275, Cambridge, Massachusetts 02139, USA
Curr Pharm Des 10:893-8. 2004..Nitric oxide and antioxidants attenuate this class II induction through negative effects on the induction of class II transactivator protein expression and on the binding of transcription factor NF-Y to the class II promoter... - Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in micePartha S Biswas
Department of Medicine, Columbia University, New York, New York, USA
J Clin Invest 120:3280-95. 2010.... 
NF-κB and innate immunity in ischemic strokeOlivier A Harari
Vascular Medicine Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann N Y Acad Sci 1207:32-40. 2010..Here, we review the relationship between NF-κB and ischemic stroke, its role in the neurovascular unit, and discuss some animal models that suggest that this relationship is causal...- Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2Chao Yung Wang
Brigham and Women s Hospital, 65 Landsdowne St, Room 275, Cambridge, MA 02139, USA
Circulation 118:2166-73. 2008..We hypothesize that endothelial dysfunction in Per2 mutant (Per2(m/m)) mice is mediated in part by increased vascular senescence and impaired endothelial progenitor cell (EPC) function...
Research Grants
- Endothelial Akt in Vascular InjuryJames Liao; Fiscal Year: 2009..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
- Novel Signaling Pathways in Ischemic StrokeJAMES KUANG JAN LIAO; Fiscal Year: 2010..This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in platelets as a potential therapeutic target for preventing and treating ischemic strokes. ..
- Activation of eNOS by Steroid HormonesJames Liao; Fiscal Year: 2006....
- Endothelial Akt in Vascular InjuryJames Liao; Fiscal Year: 2007..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
- Role of PI3-Kinase in Estrogen-induced eNOS ActivationJames Liao; Fiscal Year: 2007..These results may explain some of the actions of selective estrogen receptor modulators (SERMs) and provide a therapeutic basis for using estrogens in cardiovascular disease. ..
- Lipoproteins Effect on G Protein FunctionJames Liao; Fiscal Year: 2007....
- ROCK and ObesityJAMES KUANG JAN LIAO; Fiscal Year: 2010..This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in fat tissues and skeletal muscle as a potential therapeutic target for preventing and treating diet-induced obesity. ..
- Lipoproteins Effect on G Protein FunctionJAMES KUANG JAN LIAO; Fiscal Year: 2010....
- LIPOPROTEINS EFFECTS ON G PROTEIN FUNCTIONJames Liao; Fiscal Year: 1999..This may ultimately lead to therapeutic modalities which can restore vascular function through enhancing G-protein interaction with its receptors and effectors. ..
- Lipoproteins Effects on G-Protein FunctionJames Liao; Fiscal Year: 2004..These proposed studies will hopefully provide greater insights into how lipoproteins cause endothelial dysfunction. ..