Affiliation: Harvard University
Liao G, Nayak S, Regueiro J, Berger S, Detre C, Romero X, et al
. GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int Immunol. 2010;22:259-70 pubmed publisher
..IX and reduced the anticoagulation factors. We conclude that GITR engagement enhances Treg proliferation both in vitro and in vivo and that Fc-GITR-L may be a useful tool for in vivo tolerance induction. ..
Liao G, Detre C, Berger S, Engel P, de Waal Malefyt R, Herzog R, et al
. Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice. Gastroenterology. 2012;142:582-591.e8 pubmed publisher
..GITR instead appears to control dendritic cell and monocyte development; in its absence, mice develop aggravated chronic enterocolitis via an imbalance of colitogenic Th1 cells and Treg cells. ..
Liao G, van Driel B, Magelky E, O Keeffe M, de Waal Malefyt R, Engel P, et al
. Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine. FASEB J. 2014;28:474-84 pubmed publisher
..We conclude that GITR-L regulates the number of proinflammatory macrophages in sites of inflammation by controlling the egress of monocytes from the splenic reservoir. ..
O Keeffe M, Song J, Liao G, De Calisto J, Halibozek P, Mora J, et al
. SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine. Gastroenterology. 2015;148:991-1001.e4 pubmed publisher
..Signaling via SLAMF4 controls expansion of cytotoxic CD8Î±Î²(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine. ..