Gongxian Liao


Affiliation: Harvard University
Country: USA


  1. Liao G, Nayak S, Regueiro J, Berger S, Detre C, Romero X, et al. GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int Immunol. 2010;22:259-70 pubmed publisher
    ..IX and reduced the anticoagulation factors. We conclude that GITR engagement enhances Treg proliferation both in vitro and in vivo and that Fc-GITR-L may be a useful tool for in vivo tolerance induction. ..
  2. Liao G, Detre C, Berger S, Engel P, de Waal Malefyt R, Herzog R, et al. Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice. Gastroenterology. 2012;142:582-591.e8 pubmed publisher
    ..GITR instead appears to control dendritic cell and monocyte development; in its absence, mice develop aggravated chronic enterocolitis via an imbalance of colitogenic Th1 cells and Treg cells. ..
  3. Liao G, van Driel B, Magelky E, O Keeffe M, de Waal Malefyt R, Engel P, et al. Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine. FASEB J. 2014;28:474-84 pubmed publisher
    ..We conclude that GITR-L regulates the number of proinflammatory macrophages in sites of inflammation by controlling the egress of monocytes from the splenic reservoir. ..
  4. O Keeffe M, Song J, Liao G, De Calisto J, Halibozek P, Mora J, et al. SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine. Gastroenterology. 2015;148:991-1001.e4 pubmed publisher
    ..Signaling via SLAMF4 controls expansion of cytotoxic CD8αβ(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine. ..