Yi Li

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Testing the correlation for clustered categorical and censored discrete time-to-event data when covariates are measured without/with errors
    Yi Li
    Department of Biostatistics, Harvard School of Public Health, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biometrics 59:25-35. 2003
  2. pmc Comparing trends in cancer rates across overlapping regions
    Yi Li
    Harvard School of Public Health and Dana Farber Cancer Institute
    Biometrics 64:1280-6. 2008
  3. ncbi request reprint Modeling spatial survival data using semiparametric frailty models
    Yi Li
    Department of Biostatistics, Harvard School of Public Health and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biometrics 58:287-97. 2002
  4. pmc An age-stratified poisson model for comparing trends in cancer rates across overlapping regions
    Yi Li
    Department of Biostatistics, Harvard University and Dana Farber Cancer Institute, 44 Binney Street, LW211 Boston, MA 02115, USA
    Biom J 50:608-19. 2008
  5. ncbi request reprint A nonparametric comparison of conditional distributions with nonnegligible cure fractions
    Yi Li
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Lifetime Data Anal 11:367-87. 2005
  6. pmc Estimating subject-specific dependent competing risk profile with censored event time observations
    Yi Li
    Department of Biostatistics, Harvard University, Boston, Massachusetts 02115, USA
    Biometrics 67:427-35. 2011
  7. ncbi request reprint Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure
    Chu Ling Yu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 164:200-7. 2006
  8. pmc Swallowing function following postchemoradiotherapy neck dissection: review of findings and analysis of contributing factors
    Claudia I Chapuy
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 145:428-34. 2011
  9. doi request reprint Neck dissection after chemoradiotherapy: timing and complications
    Laura A Goguen
    Division of Otolaryngology, Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 136:1071-7. 2010
  10. doi request reprint Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer
    Robert Haddad
    Head and Neck Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Cancer 115:4514-23. 2009

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Testing the correlation for clustered categorical and censored discrete time-to-event data when covariates are measured without/with errors
    Yi Li
    Department of Biostatistics, Harvard School of Public Health, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biometrics 59:25-35. 2003
    ..The asymptotic properties of the proposed tests are studied. We illustrate these tests by analyzing two data sets and evaluate their performance with simulations...
  2. pmc Comparing trends in cancer rates across overlapping regions
    Yi Li
    Harvard School of Public Health and Dana Farber Cancer Institute
    Biometrics 64:1280-6. 2008
    ..The proposed test will be important for the SEER * STAT software, maintained by the NCI, for the analysis of the SEER data...
  3. ncbi request reprint Modeling spatial survival data using semiparametric frailty models
    Yi Li
    Department of Biostatistics, Harvard School of Public Health and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biometrics 58:287-97. 2002
    ..Different spatial covariance structures are explored in simulations and the proposed methods are applied to the East Boston Asthma Study to detect prognostic factors leading to childhood asthma...
  4. pmc An age-stratified poisson model for comparing trends in cancer rates across overlapping regions
    Yi Li
    Department of Biostatistics, Harvard University and Dana Farber Cancer Institute, 44 Binney Street, LW211 Boston, MA 02115, USA
    Biom J 50:608-19. 2008
    ....
  5. ncbi request reprint A nonparametric comparison of conditional distributions with nonnegligible cure fractions
    Yi Li
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Lifetime Data Anal 11:367-87. 2005
    ..The algorithms can be easily implemented for data analysis and significantly reduce computing time compared to the bootstrap approach. For illustrative purposes, we apply the proposed test to a published clinical trial...
  6. pmc Estimating subject-specific dependent competing risk profile with censored event time observations
    Yi Li
    Department of Biostatistics, Harvard University, Boston, Massachusetts 02115, USA
    Biometrics 67:427-35. 2011
    ..The primary endpoint for this study was the time to prostate cancer death, but had two types of dependent competing events, one from cardiovascular death and the other from death of other causes...
  7. ncbi request reprint Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure
    Chu Ling Yu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 164:200-7. 2006
    ..54 (95 percent confidence interval: 1.14, 2.09). This study illustrates the utility of geographic information system tools for providing refined exposure estimates for residential exposure to petrochemical pollution...
  8. pmc Swallowing function following postchemoradiotherapy neck dissection: review of findings and analysis of contributing factors
    Claudia I Chapuy
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 145:428-34. 2011
    ..This study assesses swallowing function following chemoradiotherapy and neck dissection in head and neck cancer patients and investigates clinical, treatment, and neck dissection factors associated with dysphagia...
  9. doi request reprint Neck dissection after chemoradiotherapy: timing and complications
    Laura A Goguen
    Division of Otolaryngology, Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 136:1071-7. 2010
    ....
  10. doi request reprint Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer
    Robert Haddad
    Head and Neck Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Cancer 115:4514-23. 2009
    ....
  11. pmc A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan
    Yau Chang Kuo
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 20:57-65. 2009
    ..This study investigated the association between green tea consumption and leukemia...
  12. doi request reprint Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy
    Hale B Caglar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 72:1110-8. 2008
    ..To evaluate early swallowing after intensity-modulated radiotherapy for head and neck squamous cell carcinoma and determine factors correlating with aspiration and/or stricture...
  13. pmc Survival analysis with error-prone time-varying covariates: a risk set calibration approach
    Xiaomei Liao
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 67:50-8. 2011
    ..The method was applied to a study of diet and cancer from Harvard's Health Professionals Follow-up Study (HPFS)...
  14. doi request reprint Do men make informed decisions about prostate cancer screening? Baseline results from the "take the wheel" trial
    Jennifer D Allen
    Center for Community Based Research, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Med Decis Making 31:108-20. 2011
    ..Psychosocial and demographic correlates of IDM were also assessed...
  15. ncbi request reprint Spatial cluster detection for censored outcome data
    Andrea J Cook
    Department of Biostatistics, University of Washington, Seattle, Washington 98105, USA
    Biometrics 63:540-9. 2007
    ....
  16. ncbi request reprint Rate of pathologic complete responses to docetaxel, cisplatin, and fluorouracil induction chemotherapy in patients with squamous cell carcinoma of the head and neck
    Robert Haddad
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Mass, USA
    Arch Otolaryngol Head Neck Surg 132:678-81. 2006
    ..To report the rate of pathological complete response after induction chemotherapy with the docetaxel, cisplatin, and fluorouracil (TPF) combination...
  17. doi request reprint A pilot surrogate endpoint biomarker study of celecoxib in oral premalignant lesions
    Lori J Wirth
    Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 1:339-48. 2008
    ..Treatment with celecoxib in subjects with OPLs favorably modulates the primary mediator of cyclooxygenase-2 activity, PGE(2), after 12 weeks...
  18. pmc Assessing the relationship between work-family conflict and smoking
    Candace C Nelson
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Public Health 102:1767-72. 2012
    ..We examined the relationship between smoking and work-family conflict among a sample of New England long-term-care facility workers...
  19. pmc Allocation of household responsibilities influences change in dietary behavior
    Candace C Nelson
    Harvard School of Public Health, Department of Society, Human Development and Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Soc Sci Med 73:1517-24. 2011
    ....
  20. ncbi request reprint Effects of unmeasured heterogeneity in the linear transformation model for censored data
    Bin Zhang
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Lifetime Data Anal 12:191-203. 2006
    ..Numerical studies under a proportional odds model show that the loss of efficiency and the loss of power can be substantial when the heterogeneity, as embodied by a frailty, is ignored...
  21. doi request reprint Parental decision making about the HPV vaccine
    Jennifer D Allen
    Dana Farber Cancer Institute, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:2187-98. 2010
    ..Prophylactic human papillomavirus (HPV) vaccines are available, but uptake is suboptimal. Information on factors influencing parental decisions regarding vaccination will facilitate the development of successful interventions...
  22. ncbi request reprint Examining the need for neck dissection in the era of chemoradiation therapy for advanced head and neck cancer
    Laura A Goguen
    Division of Otolaryngology, Department of Surgery, Brigham and Women s Hospital and the Dana Farber Cancer Institute, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 132:526-31. 2006
    ....
  23. pmc Ultrasound and MRI of fetuses with ventriculomegaly: can cortical development be used to predict postnatal outcome?
    Yi Li
    Harvard Medical School, Boston, MA, USA
    AJR Am J Roentgenol 196:1457-67. 2011
    ....
  24. pmc Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia
    Chen Yu Liu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 29:984-90. 2008
    ..In conclusion, this study suggests that AKR1C3 polymorphisms may be important predictive markers for childhood leukemia susceptibility...
  25. ncbi request reprint HPV16 transmission between a couple with HPV-related head and neck cancer
    Robert Haddad
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Oral Oncol 44:812-5. 2008
    ..An uncommon signal variant nucleotide was identified in both genomes that is not present in the HPV16R. These tumors likely represent transmission between the couple...
  26. pmc MassBuilt: effectiveness of an apprenticeship site-based smoking cessation intervention for unionized building trades workers
    Cassandra A Okechukwu
    Robert Wood Johnson Health and Society Scholars Program, University of California San Francisco and Berkeley, 3333 California St, Suite 465, San Francisco, CA 94709 0844, USA
    Cancer Causes Control 20:887-94. 2009
    ..Blue-collar workers are difficult to reach and less likely to successfully quit smoking. The objective of this study was to test a training site-based smoking cessation intervention...
  27. pmc Racial/ethnic variations in associations between socioeconomic factors and tooth loss
    Monik Jimenez
    Harvard School of Public Health, Boston, MA, USA
    Community Dent Oral Epidemiol 37:267-75. 2009
    ..To compare the associations between socioeconomic factors and tooth loss among White, Black, and Mexican-American people...
  28. pmc Neighborhood safety, socioeconomic status, and physical activity in older adults
    Reginald D Tucker-Seeley
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Prev Med 37:207-13. 2009
    ..Yet, the moderating influence of various measures of SES on the association between perceived neighborhood safety and leisure-time physical activity (LTPA) among older adults remains unknown...
  29. ncbi request reprint Results of a union-based smoking cessation intervention for apprentice iron workers (United States)
    Elizabeth M Barbeau
    Centre for Community Based, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Causes Control 17:53-61. 2006
    ..Effective smoking cessation interventions among blue-collar workers are needed to address growing class-based disparities...
  30. pmc The association of workplace hazards and smoking in a U.S. multiethnic working-class population
    Cassandra A Okechukwu
    Robert Wood Johnson Health and Society Scholars Program, University of California San Francisco and Berkeley, San Francisco, CA 94709 0844, USA
    Public Health Rep 125:225-33. 2010
    ..g., dust, chemicals, noise, and ergonomic strain) and social (e.g., abuse, sexual harassment, and racial discrimination) workplace hazards in a sample of U.S. multiethnic working-class adults...
  31. pmc Prospective associations between measures of adiposity and periodontal disease
    Monik Jimenez
    Brigham and Women s Hospital, Division of Preventive Medicine, Boston, MA, USA
    Obesity (Silver Spring) 20:1718-25. 2012
    ..54). The associations of BMI and WC were significant even among nondiabetics and never smokers. Given the high prevalence of overweight, obesity, and periodontal disease this association may be of substantial public health importance...
  32. pmc Lifecourse socioeconomic circumstances and multimorbidity among older adults
    Reginald D Tucker-Seeley
    Center for Community Based Research, Dana Farber Cancer Institute, Boston, MA, 02215 USA
    BMC Public Health 11:313. 2011
    ..In this study we investigate the association among childhood financial hardship, lifetime earnings, and multimorbidity...
  33. pmc Testing hypothesized psychosocial mediators: lessons learned in the MassBUILT study
    Cassandra A Okechukwu
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA, USA
    Health Educ Behav 38:404-11. 2011
    ..The variables examined were important but were not mediators of the MassBUILT intervention and this could have contributed to the significant relapse in smoking among study participants...
  34. pmc Financial hardship and mortality among older adults using the 1996-2004 Health and Retirement Study
    Reginald D Tucker-Seeley
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA, USA
    Ann Epidemiol 19:850-7. 2009
    ..We investigated the effect of financial hardship on mortality risk in a community-dwelling sample of adults 50 years of age and olderin the United States...
  35. pmc Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study
    Chen Yu Liu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    BMC Cancer 9:15. 2009
    ..This study investigated whether consumed cured/smoked meat and fish, the major dietary resource for exposure to nitrites and nitrosamines, is associated with childhood acute leukemia...
  36. ncbi request reprint The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power
    Yi Li
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 58:232-6. 2002
    ..Further, there may be a substantial loss of power in the presence of the frailty with or without an interaction with treatment...
  37. doi request reprint Multiple health behavior clusters among female college students
    Lisa Quintiliani
    Center for Community Based Research, Dana Farber Cancer Institute, Boston, USA
    Patient Educ Couns 79:134-7. 2010
    ..To examine prevalence of multiple unhealthful behaviors and detect clusters of unhealthful behaviors among college women...
  38. doi request reprint A randomized trial of a computer-tailored decision aid to improve prostate cancer screening decisions: results from the take the wheel trial
    Jennifer D Allen
    Dana Farber Cancer Institute, Harvard MedicalSchool, School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:2172-86. 2010
    ..To evaluate a decision aid (DA) designed to promote informed decision making for prostate cancer screening...
  39. pmc Magnetic resonance volumetric assessments of brains in fetuses with ventriculomegaly correlated to outcomes
    Danielle B Pier
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Ultrasound Med 30:595-603. 2011
    ....
  40. ncbi request reprint Optimal weight functions for marginal proportional hazards analysis of clustered failure time data
    Robert J Gray
    Department of Biostatistical Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Lifetime Data Anal 8:5-19. 2002
    ....
  41. ncbi request reprint Swallowing dysfunction after chemoradiation for advanced squamous cell carcinoma of the head and neck
    Tamar Kotz
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Head Neck 26:365-72. 2004
    ..Swallowing dysfunction is a common side effect of chemoradiation...
  42. doi request reprint Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment
    Valentina Nardi
    Departments of Pathology and Medicine, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Clin Cancer Res 19:480-90. 2013
    ..We investigated whether genotyping analysis could detect novel tumor-specific mutations that would help direct SDC patient treatment using targeted agents...
  43. ncbi request reprint Prospective phase II trial of PFL-induction chemotherapy followed by definitive local treatment for advanced squamous cell carcinoma of the head and neck: 10-year follow-up
    Phillip M Devlin
    Department of Radiation Oncology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Clin Oncol 27:369-75. 2004
    ..An organ preservation approach for patients with advanced SCCHN who demonstrated PS CR to chemotherapy demonstrated a trend to improved overall survival...
  44. ncbi request reprint No association between residential exposure to petrochemicals and brain tumor risk
    Chu Ling Yu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:3007-9. 2005
  45. ncbi request reprint Outcome of elderly patients with recurrent or metastatic head and neck cancer treated with cisplatin-based chemotherapy
    Athanassios Argiris
    Feinberg School of Medicine, Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    J Clin Oncol 22:262-8. 2004
    ..To evaluate the outcome of elderly patients with head and neck cancer undergoing palliative chemotherapy...
  46. ncbi request reprint Analysis of clustered and interval censored data from a community-based study in asthma
    Scarlett L Bellamy
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, 629 Blockley Hall 423 Guardian Drive, Philadelphia, PA 19103, USA
    Stat Med 23:3607-21. 2004
    ..We also discuss a score test to make inferences about the magnitude and significance of over-dispersion in clustered data settings. These methods will be illustrated using data from the East Boston Asthma Study...
  47. ncbi request reprint Locally recurrent, previously irradiated head and neck cancer: concurrent re-irradiation and chemotherapy, or chemotherapy alone?
    Stuart J Wong
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Oncol 24:2653-8. 2006
    ....
  48. ncbi request reprint Prognostic factors and long-term survivorship in patients with recurrent or metastatic carcinoma of the head and neck
    Athanassios Argiris
    Division of Hematology Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
    Cancer 101:2222-9. 2004
    ....
  49. pmc Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows
    Yi Li
    Genome Institute of Singapore, Genome, Singapore, 138672, Republic of Singapore
    Am J Hum Genet 80:705-15. 2007
    ....
  50. ncbi request reprint Phase II evaluation of 96-hour paclitaxel infusion in advanced (recurrent or metastatic) squamous cell carcinoma of the head and neck (E3395): a trial of the Eastern Cooperative Oncology Group
    Corey J Langer
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Invest 22:823-31. 2004
    ..Protracted exposure to paclitaxel may overcome resistance observed by using shorter infusions. Therefore we sought to evaluate paclitaxel by 96-hour infusion in both treatment-naïve and previously treated patients with SCCHN...
  51. ncbi request reprint Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology Group
    Michael K Gibson
    Department of Medical Oncology, Sidney Kimmell Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    J Clin Oncol 23:3562-7. 2005
    ....
  52. ncbi request reprint An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer
    David J Adelstein
    Cleveland Clinic Foundation, Department of Hematology and Medical Oncology, Ohio 44195, USA
    J Clin Oncol 21:92-8. 2003
    ..The Head and Neck Intergroup conducted a phase III randomized trial to test the benefit of adding chemotherapy to radiation in patients with unresectable squamous cell head and neck cancer...
  53. ncbi request reprint Bayesian automatic relevance determination algorithms for classifying gene expression data
    Yi Li
    Department of Engineering Mathematics, University of Bristol, Bristol, BS8 1TR, UK Microsoft Research, 7 J J Thomson Avenue, Cambridge, CB3 0FD, UK
    Bioinformatics 18:1332-9. 2002
    ..We investigate two new Bayesian classification algorithms incorporating feature selection. These algorithms are applied to the classification of gene expression data derived from cDNA microarrays...
  54. pmc Computational optical biopsy
    Yi Li
    Department of Mathematics, University of Iowa, Iowa City, IA 52242, USA
    Biomed Eng Online 4:36. 2005
    ....
  55. ncbi request reprint Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma
    Liang Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China
    World J Gastroenterol 11:4478-83. 2005
    ..mAb 3G11 was conjugated to an antitumor antibiotic lidamycin (LDM). The antitumor activity of 3G11-LDM conjugate against colon carcinoma was investigated in mice...
  56. ncbi request reprint Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations
    Xiaomei Zhang
    Breast Center, Baylor College of Medicine, One Baylor Plaza, N1210 03, Houston, TX 77030, USA
    Oncogene 24:4220-31. 2005
    ..This is a first report of a mouse model of antiestrogen-resistant ER-positive breast cancers, and could provide a powerful tool to study the molecular mechanisms that control antiestrogen resistance...
  57. ncbi request reprint Constructing plasma protein binding model based on a combination of cluster analysis and 4D-fingerprint molecular similarity analyses
    Jianzhong Liu
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
    Bioorg Med Chem 14:611-21. 2006
    ..Moreover, these three IPE/IPE type similarity measures are very similar to one another for the particular training and test sets investigated. The 4D-fingerprints have relatively high predictivity for this particular dataset...
  58. ncbi request reprint [G6PD Gene Mutations in Shui people in Sandu of Guizhou]
    Jin Xiu
    Key Laboratory of Molecular Biology, Guiyang Medical College, Guiyang 550004, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:147-50. 2005
    ..In conclusion: 1376 G-->T, 1388 G-->A, 95 A-->G mutations are the common G6PD mutations in Shui people in Sandu of Guizhou. The results indicates that different national minorities of Chinese may originated from a common ancestor...
  59. ncbi request reprint Stem/progenitor cells in mouse mammary gland development and breast cancer
    Yi Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 10:17-24. 2005
    ..Thus, the heterogeneity of different breast cancers may reflect the activation of different oncogenic pathways, different cellular targets in which these genetic changes occur, or both...
  60. ncbi request reprint Constructing optimum blood brain barrier QSAR models using a combination of 4D-molecular similarity measures and cluster analysis
    Dahua Pan
    Laboratory of Molecular Modeling and Design M C 781, College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    J Chem Inf Comput Sci 44:2083-98. 2004
    ..Partitioning compounds into chemically similar classes is essential to constructing predictive blood-brain barrier penetration models embedding the corresponding key physiochemical properties of a given chemical class...
  61. ncbi request reprint [Influence of P-glycoprotein expression on chemotherapeutic response of metastatic breast carcinoma]
    En xiao Li
    Department of Medical Oncology, First Hospital of Xi an Jiaotong University, Xi an 710061, P R China
    Ai Zheng 21:430-2. 2002
    ..The current study was designed to investigate the role of P-gp expression and its clinical value of chemotherapy for the patients with different metastatic sites of this carcinoma...
  62. ncbi request reprint [Clinical and pathological features of borderline ovarian tumors]
    Yi Li
    Department of Gynecologic Oncology Center, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Fu Chan Ke Za Zhi 38:81-4. 2003
    ..To study the relationship between clinical pathological factors and prognosis...
  63. ncbi request reprint Analysis and optimization of structure-based virtual screening protocols. 2. Examination of docked ligand orientation sampling methodology: mapping a pharmacophore for success
    Andrew C Good
    Bristol Myers Squibb, P O Box 5100, Wallingford, CT 06492, USA
    J Mol Graph Model 22:31-40. 2003
    ..The difference in results when comparing chemotype with compound hit rates is also highlighted...
  64. ncbi request reprint In silico ADME/Tox: why models fail
    Terry R Stouch
    Department of Macromolecular Structure, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
    J Comput Aided Mol Des 17:83-92. 2003
    ..We make recommendations to providers of models regarding the development, description, and use of models as well as the data and information that are important to understanding a model's quality and scope of use...
  65. ncbi request reprint Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma
    Bingtao Hao
    Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Cancer Res 64:4378-84. 2004
    ..The results suggest that the polymorphisms in five BER genes may be associated with the susceptibility to ESCC in a Chinese population...
  66. ncbi request reprint Determinants of cardiac electrophysiological properties in mice
    Gregory O Appleton
    Section of Cardiology, Department of Medicine, and The DeBakey Heart Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Interv Card Electrophysiol 11:5-14. 2004
    ..However, little is known regarding the impact of experimental conditions or model selection on the outcome of EP studies in mice...
  67. ncbi request reprint Uniqueness theorems in bioluminescence tomography
    Ge Wang
    Bioluminescence Tomography Laboratory, Departments of Radiology, Biomedical Engineering, and Mathematics, University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 31:2289-99. 2004
    ..For better readability, the exact conditions for and rigorous proofs of the theorems are given in the Appendices. Further research directions are also discussed...
  68. ncbi request reprint The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neuroimaging Clin N Am 15:803-26, x. 2005
    ..The last section describes problems encountered in the differential diagnosis...
  69. ncbi request reprint Prediction of aqueous solubility of organic compounds using a quantitative structure-property relationship
    Xue Qing Chen
    Discovery Pharmaceutics, L12 09, Preclinical Candidate Optimization, Bristol Myers Squibb Pharmaceutical Research Institute, Lawrenceville, New Jersey 08543, USA
    J Pharm Sci 91:1838-52. 2002
    ..84 and rms = 0.86 log unit). The present model can serve as a tool for medicinal chemists to guide their early synthetic efforts in arriving at appropriate analogs...
  70. ncbi request reprint Prediction of plasma protein binding of drugs using Kier-Hall valence connectivity indices and 4D-fingerprint molecular similarity analyses
    Jianzhong Liu
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA
    J Comput Aided Mol Des 19:567-83. 2005
    ..Both the Kier-Hall valence connectivity indices similarity measures and the 4D-fingerprints have nearly same predictivity for this particular dataset...
  71. ncbi request reprint Effective algorithms for tag SNP selection
    Tie Fei Liu
    School of Computing, National University of Singapore and Institute of Bioengineering and Nanotechnology, Singapore
    J Bioinform Comput Biol 3:1089-106. 2005
    ..Experiments show that TSSA can find the optimal solutions for medium-sized problems in reasonable time, while TSSD can handle very large problems and report approximate solutions very close to the optimal ones...
  72. ncbi request reprint Wnt signaling, stem cells, and the cellular origin of breast cancer
    Charlotta Lindvall
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Stem Cell Rev 3:157-68. 2007
    ....
  73. pmc Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study
    Kristjana Einarsdóttir
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Nobels vag 12a, 171 77 Solna, Sweden
    Breast Cancer Res 8:R67. 2006
    ..However, whether common variation in these genes has a role in the development of breast cancer or breast cancer survival in humans is still not clear...
  74. ncbi request reprint One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke
    Li Hong Shen
    Department of Neurology, Henry Ford Hospital, E and R 3056, Detroit, MI 48202, USA
    Stroke 38:2150-6. 2007
    ..We sought to evaluate the long-term effects of bone marrow stromal cell (BMSC) treatment on retired breeder rats with stroke...
  75. pmc Is congenital syphilis really congenital syphilis?
    Yi Li
    Department of Obstetrics and Gynecology, School of Medicine, Wayne State University, Detroit, MI 48235, USA
    Infect Dis Obstet Gynecol 2006:81629. 2006
    ..A health department reporting program that includes more diligent neonatal followup would allow for a more accurate representation of this public health concern...
  76. ncbi request reprint Clinical analysis of salivary gland tumor cases in West China in past 50 years
    Long Jiang Li
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, PR China
    Oral Oncol 44:187-92. 2008
    ..The parotid gland and palate were the most common locations of salivary gland tumors. Pleomorphic adenoma and mucoepidermoid carcinoma were the most frequent benign and malignant tumors, respectively...
  77. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  78. ncbi request reprint The epidemiology of non-traumatic prehospital sudden death in Macau
    Houli Wang
    Department of Emergency Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, PR China
    Resuscitation 74:222-6. 2007
    ..To understand the epidemiology of non-traumatic prehospital sudden death (NPSD) in Macau, and to discuss potential diseases related to NPSD...
  79. ncbi request reprint RCAS-TVA in the mammary gland: an in vivo oncogene screen and a high fidelity model for breast transformation?
    Zhijun Du
    Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Cycle 6:823-6. 2007
    ..Finally, this approach may provide an opportunity to target oncogenes into mammary cells at different differentiation stages, providing a tool to study the relationship between cell origin and cancer phenotype...
  80. ncbi request reprint Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk
    Kristjana Einarsdóttir
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 171 77 Stockholm, Sweden
    Hum Mol Genet 16:154-64. 2007
    ..In conclusion, it is possible that common variants in the ATM and CHEK2 genes, in interaction with oestrogen-related exposures, are involved in endometrial cancer aetiology...
  81. ncbi request reprint New developments and novel therapeutic perspectives for vitamin C
    Yi Li
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Nutr 137:2171-84. 2007
    ..Several animal models that could be utilized to address unresolved questions regarding the feasibility of vitamin C therapy are also discussed...
  82. ncbi request reprint The pilot study of anti-tumor effects versus immunosuppression of Staphylococcal Enterotoxin C
    Ke Ge Jie
    State Key Laboratory of Pathogen and Biosecurity, The Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
    Cancer Biol Ther 6:1584-91. 2007
    ..Molecular mechanism underlying these findings warrants further intensive investigation...
  83. pmc High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines
    Yangbing Zhao
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5845-54. 2007
    ..Although the biological activity of these two relatively low-affinity TCRs was comparable to wild-type reactivity in CD8(+) T cells, introduction of these TCR dramatically increased the reactivity of CD4(+) T cells to tumor cell lines...
  84. ncbi request reprint Effect of sock on biomechanical responses of foot during walking
    Xiao Qun Dai
    Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China
    Clin Biomech (Bristol, Avon) 21:314-21. 2006
    ..This study aimed at investigating the effect of wearing socks with different frictional properties on plantar shear, which is a possible mechanical risk factor of foot lesion development...
  85. doi request reprint No association between epidermal growth factor and epidermal growth factor receptor polymorphisms and nasopharyngeal carcinoma
    Lin Bo Gao
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
    Cancer Genet Cytogenet 185:69-73. 2008
    ..67-1.23). Further studies are still needed to explore the complicated interaction between environmental factors and EGF +61 G/A and EGFR +2073 A/T polymorphisms in the risk of NPC, particularly in ethnically different populations...
  86. ncbi request reprint Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 33:210-21. 2006
    ..This study was designed to examine the utility of visual inspection of medial temporal lobe (MTL) metabolism in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using FDG-PET scans...
  87. pmc Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors
    Stefan K Siwko
    Breast Center, Baylor College of Medicine, Houston, TX, 77030 USA
    Neoplasia 10:653-62, 1 p following 662. 2008
    ..This work demonstrates the first use of a lentiviral vector to introduce oncogenes for modeling cancer in mice, and this vector system may be especially suitable for introducing genetic alterations into quiescent cells in vivo...
  88. doi request reprint Script-independent text line segmentation in freestyle handwritten documents
    Yi Li
    Language and Media Processing Laboratory, Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742, USA
    IEEE Trans Pattern Anal Mach Intell 30:1313-29. 2008
    ..Further experiments show the proposed algorithm is robust to scale change, rotation, and noise...
  89. ncbi request reprint A multicentral randomized control study on clinical acupuncture treatment of Bell's palsy
    Fanrong Liang
    The College of Acupuncture and Massage, Chengdu University of Traditional Chinese Medicine, Sichuan 610075, China
    J Tradit Chin Med 26:3-7. 2006
    ..To confirm the clinical therapeutic effects of acupuncture and moxibustion on Bell's palsy...
  90. pmc ESR1 and EGF genetic variation in relation to breast cancer risk and survival
    Kristjana Einarsdóttir
    Centre for Health Services Research, School of Population Health, University of Western Australia, 6009 Crawley, Perth, Western Australia
    Breast Cancer Res 10:R15. 2008
    ..We sought to determine if common genetic variation in the ESR1 and EGF genes affects breast cancer risk, tumour characteristics or breast cancer survival...
  91. ncbi request reprint Wnt-1 is dominant over neu in specifying mammary tumor expression profiles
    Shixia Huang
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Technol Cancer Res Treat 5:565-71. 2006
    ..These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles...
  92. pmc Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides
    Yi Li
    Department of Chemistry, Wichita State University, Wichita, KS 67260, USA
    Bioorg Med Chem 16:692-8. 2008
    ..The results of these studies demonstrate that exploitation of differences in the S' subsites of HNE and PR 3 can lead to highly selective inhibitors of HNE...
  93. ncbi request reprint Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort
    Yi Li
    National Laboratory of Medical Molecular Biology, Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, PR China
    Diabetes Metab Res Rev 23:455-61. 2007
    ..The purpose of the present study was to study the potential association of CDC2L2 variations with type 2 diabetes (T2D)...

Research Grants7

  1. Community-Based Studies in Cancer and Environment
    Yi Li; Fiscal Year: 2006
    ..abstract_text> ..
  2. Community-Based Studies in Cancer and Environment
    Yi Li; Fiscal Year: 2009
    ..abstract_text> ..
  3. Community-Based Studies in Cancer and Environment
    Yi Li; Fiscal Year: 2010
    ..abstract_text> ..