Jianxue Li

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Tissue plasminogen activator regulates Purkinje neuron development and survival
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 110:E2410-9. 2013
  2. doi request reprint Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 68:45-60. 2010
  3. pmc Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7847-52. 2006
  4. ncbi request reprint Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:7839-48. 2006
  5. ncbi request reprint Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice
    Richard L Sidman
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Res 1140:195-204. 2007
  6. ncbi request reprint Unique glycerophospholipid signature in retinal stem cells correlates with enzymatic functions of diverse long-chain acyl-CoA synthetases
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 25:2864-73. 2007
  7. doi request reprint Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis
    Yang D Teng
    Departments of Neurosurgery and PM and R, Brigham and Women s Hospital, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 4:165ra164. 2012
  8. pmc Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 175:209-15. 2006
  9. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
  10. pmc Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research
    Yang D Teng
    Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Curr Neuropharmacol 9:574-85. 2011

Detail Information

Publications10

  1. pmc Tissue plasminogen activator regulates Purkinje neuron development and survival
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 110:E2410-9. 2013
    ..In sum, excess tPA/plasmin, through separate downstream molecular mechanisms, regulates postnatal PN dendritogenesis, synaptogenesis, mitochondrial structure and function, and selective PN viability. ..
  2. doi request reprint Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuron 68:45-60. 2010
    ..These findings provide insight into Nna1's role in neuronal development and why its absence renders Purkinje cells more vulnerable...
  3. pmc Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7847-52. 2006
    ..We thus propose a molecular pathway by which the excessive tPA in nr cerebellum mediates PN degeneration...
  4. ncbi request reprint Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:7839-48. 2006
    ..This report demonstrates for the first time that NSCs can rescue imperiled host neurons by rectifying their gene expression, elevating somatic stem cell therapeutic potential beyond solely cell replacement strategy...
  5. ncbi request reprint Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice
    Richard L Sidman
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Res 1140:195-204. 2007
    ..However, though Purkinje cell rescue has been achieved with NSCs in some other disease models, loss of Purkinje neurons and decline in rotorod performance were still present in injected ASMKO mice...
  6. ncbi request reprint Unique glycerophospholipid signature in retinal stem cells correlates with enzymatic functions of diverse long-chain acyl-CoA synthetases
    Jianxue Li
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 25:2864-73. 2007
    ..These novel findings suggest that LACS-associated GPL signature and cell membrane fluidity may participate in regulating proliferation versus differentiation in RSCs and, perhaps, other types of stem cells...
  7. doi request reprint Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis
    Yang D Teng
    Departments of Neurosurgery and PM and R, Brigham and Women s Hospital, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 4:165ra164. 2012
    ..We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases...
  8. pmc Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 175:209-15. 2006
    ..These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity...
  9. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
  10. pmc Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research
    Yang D Teng
    Division of SCI Research, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Curr Neuropharmacol 9:574-85. 2011
    ..We suggest that embracing this view of the "multipotency" of the SCs is pivotal for correctly, efficiently, and optimally exploiting stem cell biology for therapeutic applications, including reconstitution of a dysfunctional CNS...