R F Lewis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Slow target-directed eye movements in ataxia-telangiectasia
    Richard F Lewis
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:686-91. 2002
  2. ncbi request reprint Frequency-specific mal de debarquement
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Neurology 63:1983-4. 2004
  3. pmc Electrical stimulation of semicircular canal afferents affects the perception of head orientation
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 33:9530-5. 2013
  4. pmc Adaptation of vestibular tone studied with electrical stimulation of semicircular canal afferents
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Assoc Res Otolaryngol 14:331-40. 2013
  5. pmc Spatial and temporal properties of eye movements produced by electrical stimulation of semicircular canal afferents
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Boston, MA, USA
    J Neurophysiol 108:1511-20. 2012
  6. pmc Dynamic tilt thresholds are reduced in vestibular migraine
    Richard F Lewis
    Department of Otology, Harvard Medical School, Boston MA, USA
    J Vestib Res 21:323-30. 2011
  7. pmc Vestibular prosthesis tested in rhesus monkeys
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology at the Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:2277-9. 2011
  8. ncbi request reprint Tilt psychophysics measured in nonhuman primates
    Richard F Lewis
    Department of Otology and Laryngology, Harvard Medical School, Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston MA 02114, USA
    Ann N Y Acad Sci 1039:294-305. 2005
  9. ncbi request reprint Images in clinical medicine. Abnormal eye movements associated with unilateral loss of vestibular function
    Richard F Lewis
    Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 355:e26. 2006
  10. pmc Roll tilt psychophysics in rhesus monkeys during vestibular and visual stimulation
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 100:140-53. 2008

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Slow target-directed eye movements in ataxia-telangiectasia
    Richard F Lewis
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:686-91. 2002
    ..To analyze the slow eye movements that shift the direction of gaze in patients with ataxia-telangiectasia (A-T)...
  2. ncbi request reprint Frequency-specific mal de debarquement
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Neurology 63:1983-4. 2004
  3. pmc Electrical stimulation of semicircular canal afferents affects the perception of head orientation
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 33:9530-5. 2013
    ....
  4. pmc Adaptation of vestibular tone studied with electrical stimulation of semicircular canal afferents
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Assoc Res Otolaryngol 14:331-40. 2013
    ....
  5. pmc Spatial and temporal properties of eye movements produced by electrical stimulation of semicircular canal afferents
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Boston, MA, USA
    J Neurophysiol 108:1511-20. 2012
    ..Furthermore, the presence of gravity-dependent effects (dumping, spatial orientation) despite an absence of low-frequency augmentation of the eVOR has not been previously described in any experimental preparation...
  6. pmc Dynamic tilt thresholds are reduced in vestibular migraine
    Richard F Lewis
    Department of Otology, Harvard Medical School, Boston MA, USA
    J Vestib Res 21:323-30. 2011
    ..These results suggest that patients with vestibular migraine may have enhanced perceptual sensitivity (e.g. increased signal-to-noise ratio) for head motions that dynamically modulate canal and otolith inputs together...
  7. pmc Vestibular prosthesis tested in rhesus monkeys
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology at the Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:2277-9. 2011
    ....
  8. ncbi request reprint Tilt psychophysics measured in nonhuman primates
    Richard F Lewis
    Department of Otology and Laryngology, Harvard Medical School, Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston MA 02114, USA
    Ann N Y Acad Sci 1039:294-305. 2005
    ..This new methodology sets the stage for innovative experimental approaches that will help to elucidate the neural mechanisms underlying the perception of spatial orientation...
  9. ncbi request reprint Images in clinical medicine. Abnormal eye movements associated with unilateral loss of vestibular function
    Richard F Lewis
    Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 355:e26. 2006
  10. pmc Roll tilt psychophysics in rhesus monkeys during vestibular and visual stimulation
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 100:140-53. 2008
    ....
  11. pmc Vestibuloocular reflex adaptation investigated with chronic motion-modulated electrical stimulation of semicircular canal afferents
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston MA 02114, USA
    J Neurophysiol 103:1066-79. 2010
    ..These results demonstrate that the brain can adaptively modify the gain, axis, and symmetry of the VOR when provided with chronic motion-modulated electrical stimulation by a canal prosthesis...
  12. ncbi request reprint Context-dependent adaptation of visually-guided arm movements and vestibular eye movements: role of the cerebellum
    Richard F Lewis
    Department of Otolaryngology and Neurology, Harvard Medical School, Boston, MA 02114, USA
    Cerebellum 2:123-30. 2003
    ..The potential function of the cerebellum in context-dependent adaptation remains uncertain, but the data reviewed below suggest that it may play a fundamental role in this process...
  13. ncbi request reprint Cerebellar lesions impair context-dependent adaptation of reaching movements in primates
    R F Lewis
    Department of Otolaryngology and Neurology, Harvard Medical School, 243 Charles St Boston, MA 02114, USA
    Exp Brain Res 138:263-7. 2001
    ....
  14. ncbi request reprint Oculomotor function in the rhesus monkey after deafferentation of the extraocular muscles
    R F Lewis
    Department of Otolaryngology, Harvard Medical School, Boston, MA, USA
    Exp Brain Res 141:349-58. 2001
    ....
  15. ncbi request reprint Vestibular adaptation studied with a prosthetic semicircular canal
    Richard F Lewis
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Vestib Res 12:87-94. 2002
    ..The results provided by this pilot study suggest that it may be feasible to study central adaptation by chronically modifying the afferent vestibular cue with a prosthetic semicircular canal...
  16. ncbi request reprint Vergence-dependent adaptation of the vestibulo-ocular reflex
    Richard F Lewis
    Department of Otolaryngology and Neurology, Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    Exp Brain Res 152:335-40. 2003
    ..The results demonstrate that subjects can learn to use vergence angle as the contextual cue that retrieves adaptive changes in the angular VOR...
  17. ncbi request reprint Comparison of diameter and perimeter methods for tumor volume calculation
    A G Sorensen
    MGH NMR Center and Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Clin Oncol 19:551-7. 2001
    ..We sought to compare the common method of using orthogonal diameters to estimate lesion volume (the diameter method) with a computer-assisted planimetric technique (the perimeter method)...
  18. ncbi request reprint Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease
    G J Harris
    Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Brain 122:1667-78. 1999
    ..The current study suggests that quantitative assessment of basal ganglia may provide a means to track early signs of decline in individuals with the Huntington's disease gene mutation prior to clinical onset...
  19. ncbi request reprint Hypoperfusion of the cerebellum and aging effects on cerebral cortex blood flow in abstinent alcoholics: a SPECT study
    G J Harris
    Department of Psychiatry, Tufts University School of Medicine, Boston 02114, USA
    Alcohol Clin Exp Res 23:1219-27. 1999
    ..This study evaluated hypotheses concerning alcoholism, aging, and the relationship between cerebral hypoperfusion and residual deficits in the functioning of cerebellar and neocortical brain systems...
  20. ncbi request reprint Chronic vestibulo-ocular reflexes evoked by a vestibular prosthesis
    Daniel M Merfeld
    Jenks Vestibular Physiology Lab, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 54:1005-15. 2007
    ..This suggests that long-term functional replacement of absent vestibular function is feasible...
  21. ncbi request reprint Acclimation to chronic constant-rate peripheral stimulation provided by a vestibular prosthesis
    Daniel M Merfeld
    Jenks Vestibular Physiology Lab, Massachusetts Eye and Ear Infirmary, Room 421, 243 Charles Street, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 53:2362-72. 2006
    ..In fact, after many such off-to-on or on-to-off transitions, little nystagmus was evoked by turning the stimulation on or off. These findings show that the brain acclimates to constant-rate stimulation...
  22. pmc Potential solutions to several vestibular challenges facing clinicians
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Vestib Res 20:71-7. 2010
    ..While electrical stimulation is a standard means of stimulation, optical stimulation is also being investigated as a way to improve prosthetic stimulation specificity...
  23. ncbi request reprint Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism
    C C Streeter
    Department of Psychiatry 116A, Outpatient Clinic, Boston National Institute on Drug Abuse Veterans Administration Medication Development Research Unit, MA 02114, USA
    Psychiatry Res 82:69-82. 1998
    ..The location and rate of alprazolam-induced rCBV changes differed between FH + and FH - subjects. These changes may be related to the increased mood enhancement found in subjects genetically predisposed to alcoholism...

Research Grants7

  1. Vestibular Prosthesis Tested in a Vestibulopathic Model
    Richard Lewis; Fiscal Year: 2009
    ..Successful completion of this task would significantly improve the quality of life for a large number of people who suffer from the debilitating symptoms produced by disorders of the balance portion of the inner ear. ..
  2. Vestibular Prosthesis Tested in a Vestibulopathic Model
    Richard F Lewis; Fiscal Year: 2010
    ..Successful completion of this task would significantly improve the quality of life for a large number of people who suffer from the debilitating symptoms produced by disorders of the balance portion of the inner ear. ..
  3. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2007
    ....
  4. Vestibular Prosthesis Tested in a Vestibulopathic Model
    Richard Lewis; Fiscal Year: 2009
    ..Successful completion of this task would significantly improve the quality of life for a large number of people who suffer from the debilitating symptoms produced by disorders of the balance portion of the inner ear. ..