Ofer Levy

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation
    Katheryn E Nathe
    Department of Medicine, Children s Hospital Boston, Massachusetts, USA
    Pediatr Res 72:203-11. 2012
  2. pmc The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes
    David J Dowling
    Department of Medicine, Division of Infectious Diseases, Boston Children s Hospital, Boston, Massachusetts, USA
    PLoS ONE 8:e58164. 2013
  3. pmc Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine
    Matthew Pettengill
    From the Department of Medicine, Division of Infectious Diseases, Boston Children s Hospital, Boston, Massachusetts 02115
    J Biol Chem 288:27315-26. 2013
  4. pmc A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses
    Kenny D Kronforst
    Newborn Medicine, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e43897. 2012
  5. pmc TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia
    Tobias Strunk
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    PLoS ONE 5:e10111. 2010
  6. pmc Neonatal host defense against Staphylococcal infections
    Melanie R Power Coombs
    Pathology, Dalhousie University, Halifax, NS, Canada
    Clin Dev Immunol 2013:826303. 2013
  7. ncbi request reprint Immune response to vaccine adjuvants during the first year of life
    Ofer Levy
    Boston Children s Hospital and Harvard Medical School, Boston, MA, USA
    Vaccine 31:2500-5. 2013
  8. ncbi request reprint Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Endotoxin Res 11:113-6. 2005
  9. doi request reprint Development of newborn and infant vaccines
    Guzman Sanchez-Schmitz
    Children s Hospital Boston, Boston, MA 02115, USA
    Sci Transl Med 3:90ps27. 2011
  10. ncbi request reprint Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848
    Ofer Levy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 173:4627-34. 2004

Detail Information

Publications45

  1. pmc Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation
    Katheryn E Nathe
    Department of Medicine, Children s Hospital Boston, Massachusetts, USA
    Pediatr Res 72:203-11. 2012
    ..We characterized innate immune activation in TAs of mechanically ventilated neonates...
  2. pmc The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes
    David J Dowling
    Department of Medicine, Division of Infectious Diseases, Boston Children s Hospital, Boston, Massachusetts, USA
    PLoS ONE 8:e58164. 2013
    ..Effects of VTX-294 and R-848 in combination with monophosphoryl lipid A (MPLA; TLR4) were also assessed...
  3. pmc Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine
    Matthew Pettengill
    From the Department of Medicine, Division of Infectious Diseases, Boston Children s Hospital, Boston, Massachusetts 02115
    J Biol Chem 288:27315-26. 2013
    ..Targeted manipulation of purine-metabolizing enzymes may benefit this vulnerable population. ..
  4. pmc A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses
    Kenny D Kronforst
    Newborn Medicine, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e43897. 2012
    ..This novel model can now be used to characterize immune ontogeny, evaluate infection biomarkers, and assess preventative and therapeutic modalities...
  5. pmc TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia
    Tobias Strunk
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    PLoS ONE 5:e10111. 2010
    ..The role of TLR2 in responses of primary blood leukocytes to live SE and in clearance of SE bacteremia, the most common clinical manifestation of SE infection, is unknown...
  6. pmc Neonatal host defense against Staphylococcal infections
    Melanie R Power Coombs
    Pathology, Dalhousie University, Halifax, NS, Canada
    Clin Dev Immunol 2013:826303. 2013
    ..Characterization of distinct aspects of the neonatal immune response is defining novel approaches to enhance host defense to prevent and/or treat staphylococcal infection in this vulnerable population. ..
  7. ncbi request reprint Immune response to vaccine adjuvants during the first year of life
    Ofer Levy
    Boston Children s Hospital and Harvard Medical School, Boston, MA, USA
    Vaccine 31:2500-5. 2013
    ..Herein, we discuss the potential implications of innate immune ontogeny for the activity of adjuvants contained in licensed infant vaccines, as well as future directions for rational design of adjuvanted vaccines for this age group...
  8. ncbi request reprint Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Endotoxin Res 11:113-6. 2005
    ..Definition of the mechanisms underlying distinct neonatal immunity promises to identify novel ways to prevent and treat infection in this relatively high-risk population...
  9. doi request reprint Development of newborn and infant vaccines
    Guzman Sanchez-Schmitz
    Children s Hospital Boston, Boston, MA 02115, USA
    Sci Transl Med 3:90ps27. 2011
    ..Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants...
  10. ncbi request reprint Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848
    Ofer Levy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 173:4627-34. 2004
    ..Conversely, relative preservation of responses to R-848 may present unique opportunities for augmenting innate and acquired immunity in the human newborn...
  11. pmc The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn
    Ofer Levy
    Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    J Immunol 177:1956-66. 2006
    ..We conclude that the distinct adenosine system of newborns polarizes TLR-mediated cytokine production during the perinatal period and may thereby modulate their innate and adaptive immune responses...
  12. ncbi request reprint Innate immunity of the newborn: basic mechanisms and clinical correlates
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Immunol 7:379-90. 2007
    ..This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population...
  13. pmc Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital Boston, Boston, MA 02115, USA
    Blood 108:1284-90. 2006
    ..We conclude that TLR8 agonists are uniquely efficacious in activating costimulatory responses in neonatal APCs and suggest that these agents are promising candidate adjuvants for enhancing immune responses in human newborns...
  14. doi request reprint Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation
    Tobias Strunk
    University of Western Australia Centre for Neonatal Research and Education, Perth, Western Australia, Australia
    Pediatr Res 72:10-8. 2012
    ..We hypothesized that the innate immune responses to SE in preterm infants are impaired in a gestational age (GA)-dependent manner...
  15. ncbi request reprint Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death
    Eva C Guinan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Sci Transl Med 3:110ra118. 2011
    ....
  16. pmc Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways
    Victoria J Philbin
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston, Boston, Mass Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 130:195-204.e9. 2012
    ....
  17. ncbi request reprint Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates
    Katheryn E Nathe
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatr Res 66:191-6. 2009
    ..TA extracellular BPI, LBP, and sCD14 were positively correlated. TAs from intubated neonates demonstrate endotoxin accumulation and mobilization of endotoxin-directed innate immunity, potentially contributing to pulmonary inflammation...
  18. ncbi request reprint Neonatal immune responses to coagulase-negative staphylococci
    Tobias Strunk
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Curr Opin Infect Dis 20:370-5. 2007
    ..This review summarizes current knowledge on the human immune response to coagulase-negative staphylococci, with particular emphasis on the neonatal innate immune system...
  19. doi request reprint Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy
    Christine D Palmer
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Biochem Soc Trans 39:994-9. 2011
    ....
  20. pmc 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli
    Christine D Palmer
    Children s Hospital Boston, Boston, MA 02115, USA
    J Leukoc Biol 90:459-70. 2011
    ..coli in an LPS- and TLR4-dependent manner, such that this Rv could promote resolution of GNB/LPS-driven inflammation by reducing m proinflammatory responses to isolated LPS and increasing m responses important for clearance of infection...
  21. ncbi request reprint Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Leukoc Biol 76:909-25. 2004
    ..From a clinical perspective, congeners of several of the APP have been developed as potential therapeutic agents and have entered clinical trials with some evidence of benefit...
  22. doi request reprint Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis
    Tobias Strunk
    School of Paediatrics and Child Health, University of Western Australia, Subiaco
    Innate Immun 17:508-16. 2011
    ..The effects of the bacterial preparation method on the activation of innate signalling pathways by the common opportunistic pathogen Staphylococcus epidermidis (SE) are unknown...
  23. pmc Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Immun 71:6344-53. 2003
    ....
  24. pmc Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease
    Amit Srivastava
    Division of Infectious Diseases, Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Infect Immun 75:342-9. 2007
    ..We have thus discovered a novel interaction between pneumococcus and rBPI21, a potent antimicrobial peptide previously considered to target only gram-negative bacteria...
  25. doi request reprint Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency
    Sung Yun Pai
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:1113-1118.e1. 2008
    ..Boys with X-linked ectodermal dysplasia and immunodeficiency caused by mutations of nuclear factor-kappaB essential modulator have defects in innate and adaptive immunity, and some have colitis...
  26. doi request reprint Novel vaccines: bridging research, development and production
    Alicia Demirjian
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    Expert Rev Vaccines 7:1321-4. 2008
    ....
  27. ncbi request reprint Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities
    Melanie R Power Coombs
    Department of Medicine Infectious Diseases, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Expert Rev Anti Infect Ther 9:261-9. 2011
    ..Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection...
  28. ncbi request reprint Therapeutic potential of the bactericidal/permeability-increasing protein
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital of Boston, MA, USA
    Expert Opin Investig Drugs 11:159-67. 2002
    ..Identification and evaluation of additional disease entities characterised by Gram-negative bacteraemia and/or endotoxaemia as possible targets for BPI therapy continues...
  29. ncbi request reprint Neonatal babesiosis: case report and review of the literature
    Leanne M Fox
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA
    Pediatr Infect Dis J 25:169-73. 2006
    ..Of neonatal babesiosis reported in the literature, 9 other cases are reviewed, including 6 that were transfusion-associated, 2 congenital and 2 tick transmitted...
  30. ncbi request reprint Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein
    Geraldine Canny
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 290:G557-67. 2006
    ..Taken together, these data confirm the transcriptional regulation of BPI in intestinal epithelia and provide insight into the relevance of BPI as an anti-infective molecule at intestinal surfaces...
  31. ncbi request reprint Genetic screening for susceptibility to infection in the NICU setting
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatr Res 55:546-8. 2004
  32. pmc Safety and efficacy of neonatal vaccination
    Alicia Demirjian
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston, Boston, MA 02115, USA
    Eur J Immunol 39:36-46. 2009
    ..This review focuses on safety and efficacy of neonatal vaccination in humans as well as recent research employing novel approaches to enhance the efficacy of neonatal vaccination...
  33. ncbi request reprint Impaired innate immunity at birth: deficiency of bactericidal/permeability-increasing protein (BPI) in the neutrophils of newborns
    Ofer Levy
    Division of Infectious Diseases, Children s Hospital and Channing Research Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Res 51:667-9. 2002
  34. ncbi request reprint Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils
    Ofer Levy
    Division of Infectious Diseases, General Clinical Research Center, and Medicine, Children s Hospital, Boston, Massachusetts, USA
    Transplantation 73:1522-6. 2002
    ..To assess potential qualitative defects in neutrophil function in patients undergoing BMT, we measured neutrophil content of the antimicrobial (poly)peptides BPI and defensins...
  35. pmc Developmental biology of the innate immune response: implications for neonatal and infant vaccine development
    Victoria Jane Philbin
    Department of Medicine, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 65:98R-105R. 2009
    ..This review summarizes recent developments in the field of innate immunity emphasizing developmental expression in the fetus, newborn, and infant and its implications for the design of more effective neonatal and infant vaccines...
  36. ncbi request reprint Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation
    Ofer Levy
    Dicision of Infectious Diseases, The Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Infect Dis J 22:978-81. 2003
    ..Our aim was to gain insight into the potential role of endotoxin and endotoxin-induced acute phase proteins in children undergoing SCT...
  37. ncbi request reprint Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells
    Ofer Levy
    Division Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 188:948-53. 2003
    ....
  38. ncbi request reprint Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia
    Jordan S Orange
    Division of Immunology, Children s Hospital of Philadelphia, PA, USA
    J Allergy Clin Immunol 114:650-6. 2004
    ..Male subjects with these mutant NEMO molecules have an X-linked syndrome known as ectodermal dysplasia with immunodeficiency, which is characterized by severe infections, with herpesviruses, bacteria, and mycobacterial susceptibility...
  39. pmc Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
    Cheng Lung Ku
    Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
    J Exp Med 204:2407-22. 2007
    ..Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria...
  40. pmc Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI
    Marcelo Gonzalez
    IFREMER, Centre National de la Recherche Scientifique, Universite Montpellier 2, Unité Mixte de Recherche 5119, Ecosystèmes Lagunaires, Place E Bataillon, CC80, 34095 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 104:17759-64. 2007
    ..To our knowledge, this is the first characterization of a BPI in an invertebrate...
  41. pmc Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists
    James L Wynn
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610 0286, USA
    Blood 112:1750-8. 2008
    ..These benefits were independent of the adaptive immune system and type I interferon signaling. Improving innate immune function with select TLR agonists may be a useful strategy to prevent neonatal sepsis mortality...
  42. ncbi request reprint Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo
    Donatella F Angelone
    Catholic University of the Sacred Heart, Rome, Italy
    Pediatr Res 60:205-9. 2006
    ..A high ratio of stimulus-induced IL-6/TNF-alpha production is likely to profoundly modulate both innate and adaptive immune responses in the human newborn...
  43. pmc Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia
    Geraldine Canny
    Department of Veterinary Physiology, University College of Dublin, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 99:3902-7. 2002
    ..These studies identify a previously unappreciated "molecular shield" for protection of mucosal surfaces against Gram-negative bacteria and their endotoxin...
  44. ncbi request reprint TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs
    Analía V Ezernitchi
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Immunol 177:4763-72. 2006
    ..Such an environment is anticipated to limit the success of immunotherapeutic strategies based on vaccination and T cell transfer, which are currently under investigation for immunotherapy of cancer...
  45. ncbi request reprint Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function
    Tsufit Gonen-Gross
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 171:1343-51. 2003
    ..These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells...

Research Grants7

  1. Determinants of Innate Immunity to Group B Streptococci
    Ofer Levy; Fiscal Year: 2005
    ..abstract_text> ..
  2. Adenosine Shapes Neonatal Toll-like Receptor Function
    Ofer Levy; Fiscal Year: 2006
    ..As a whole, these studies will deepen our understanding of how the unique physiology of the human newborn fundamentally alters innate immunity at birth. ..
  3. Adenosine Shapes Neonatal Toll-like Receptor Function
    Ofer Levy; Fiscal Year: 2007
    ..As a whole, these studies will deepen our understanding of how the unique physiology of the human newborn fundamentally alters innate immunity at birth. ..
  4. Adenosine Shapes Neonatal Toll-like Receptor Function
    Ofer Levy; Fiscal Year: 2009
    ..As a whole, these studies will deepen our understanding of how the unique physiology of the human newborn fundamentally alters innate immunity at birth. ..
  5. Adenosine Shapes Neonatal Toll-like Receptor Function
    Ofer Levy; Fiscal Year: 2010
    ..As a whole, these studies will deepen our understanding of how the unique physiology of the human newborn fundamentally alters innate immunity at birth. ..
  6. Adenosine Shapes Neonatal Toll-like Receptor Function
    Ofer Levy; Fiscal Year: 2010
    ..As a whole, these studies will deepen our understanding of how the unique physiology of the human newborn fundamentally alters innate immunity at birth. ..