Dan Levy

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Mast cell degranulation activates a pain pathway underlying migraine headache
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 130:166-76. 2007
  2. pmc Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat
    Xianghong Arakaki
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 N, El Molino Avenue, Pasadena, CA, 91101, USA
    Fluids Barriers CNS 10:14. 2013
  3. doi request reprint Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Pain Headache Rep 16:270-7. 2012
  4. pmc Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess, Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Behav Immun 26:311-7. 2012
  5. ncbi request reprint Migraine pain, meningeal inflammation, and mast cells
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E CLS639, Boston, MA 02215, USA
    Curr Pain Headache Rep 13:237-40. 2009
  6. ncbi request reprint Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 58:698-705. 2005
  7. ncbi request reprint Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade
    Dan Levy
    Headache Research Laboratory, Dept of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institutes of Medicine, Room 801, 77 Avenue Louis Pasteur, Boston MA 02115, USA
    J Neurophysiol 92:766-72. 2004
  8. pmc Sensitization of meningeal nociceptors: inhibition by naproxen
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 27:917-22. 2008
  9. pmc Activation of central trigeminovascular neurons by cortical spreading depression
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 69:855-65. 2011
  10. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011

Collaborators

  • Rami Burstein
  • Andrew M Strassman
  • Jun Zhao
  • Rodrigo Noseda
  • Xichun Zhang
  • Xi Chun Zhang
  • Vanessa Kainz
  • Moshe Jakubowski
  • Xianghong Arakaki
  • Tanner Boes
  • Michael G Harrington
  • Brian Armstrong
  • Jiarong Chiang
  • Alfred N Fonteh
  • Paige McCleary
  • Linus Kuo
  • Matthew Techy
  • Zahid Bajwa
  • Beth Collins
  • Itay Goor-Aryeh

Detail Information

Publications28

  1. pmc Mast cell degranulation activates a pain pathway underlying migraine headache
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 130:166-76. 2007
    ..Our findings provide evidence linking dural mast cell degranulation to prolonged activation of the trigeminal pain pathway believed to underlie intracranial headaches such as that of migraine...
  2. pmc Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat
    Xianghong Arakaki
    Molecular Neurology Program, Huntington Medical Research Institutes, 99 N, El Molino Avenue, Pasadena, CA, 91101, USA
    Fluids Barriers CNS 10:14. 2013
    ..Since Na,K-ATPase isoforms have different locations and physiological roles, our objective was to establish which alpha isoforms are present at sites where sodium homeostasis is disrupted...
  3. doi request reprint Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Pain Headache Rep 16:270-7. 2012
    ....
  4. pmc Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess, Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Brain Behav Immun 26:311-7. 2012
    ..Our data further suggest that MC activation may lead to widespread tactile pain hypersensitivity...
  5. ncbi request reprint Migraine pain, meningeal inflammation, and mast cells
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E CLS639, Boston, MA 02215, USA
    Curr Pain Headache Rep 13:237-40. 2009
    ..This review examines the evidence linking meningeal mast cells to migraine and highlights current experimental data implicating these immune cells as potent modulators of meningeal nociceptors' activity and the genesis of migraine pain...
  6. ncbi request reprint Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 58:698-705. 2005
    ..The results of this study suggest that CGRP effects in the meninges, including meningeal vasodilatation, are not sufficient to activate or sensitize meningeal nociceptors...
  7. ncbi request reprint Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade
    Dan Levy
    Headache Research Laboratory, Dept of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institutes of Medicine, Room 801, 77 Avenue Louis Pasteur, Boston MA 02115, USA
    J Neurophysiol 92:766-72. 2004
    ..Our results also implicate cGMP in mediating the inhibitory effect of NO...
  8. pmc Sensitization of meningeal nociceptors: inhibition by naproxen
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 27:917-22. 2008
    ..The findings suggest that local COX activity in the dura could mediate the peripheral sensitization that underlies migraine headache...
  9. pmc Activation of central trigeminovascular neurons by cortical spreading depression
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 69:855-65. 2011
    ....
  10. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011
    ....
  11. pmc Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators
    Xi Chun Zhang
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 856, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Pharmacol Exp Ther 322:806-12. 2007
    ..We propose that dural mast cells could promote headache by releasing 5-HT, PGI(2), and histamine...
  12. ncbi request reprint Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 830, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Pain 115:21-8. 2005
    ....
  13. pmc Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors
    Xichun Zhang
    Departments of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Neurol 73:741-50. 2013
    ....
  14. pmc Local action of the proinflammatory cytokines IL-1β and IL-6 on intracranial meningeal nociceptors
    Xichun Zhang
    Department of Anesthesia, Critical Care and Pain Medicine, Israel Medical Center and Harvard Medical School, USA
    Cephalalgia 32:66-72. 2012
    ..An increase in the level of these cytokines in jugular venous blood has been reported during migraine attacks, suggesting their potential involvement in mediating the intracranial headache of migraine...
  15. pmc Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 30:8807-14. 2010
    ..We suggest that migraine with aura is initiated by waves of CSD that lead up to delayed activation of the trigeminovascular pathway...
  16. ncbi request reprint The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons
    Andrew M Strassman
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Neuroreport 15:1409-12. 2004
    ..The excitatory effect on dural afferent discharge might underlie the initial worsening of the headache that can occur following sumatriptan administration, prior to the subsequent onset of headache relief...
  17. pmc Localization of COX-1 and COX-2 in the intracranial dura mater of the rat
    Xi Chun Zhang
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
    Neurosci Lett 452:33-6. 2009
    ..The findings suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater...
  18. ncbi request reprint Response properties of dural nociceptors in relation to headache
    Andrew M Strassman
    Dept of Anesthesia, DA 717, Beth Israel Deaconess Med Ctr, 330 Brookline Ave, Boston, MA 02215, USA
    J Neurophysiol 95:1298-306. 2006
    ....
  19. ncbi request reprint Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors
    Moshe Jakubowski
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Headache 45:850-61. 2005
    ..To determine whether delayed infusion of COX1/COX2 inhibitors (ketorolac, indomethacin) will stop migraine in allodynic patients, and suppress ongoing sensitization in central trigeminovascular neurons in the rat...
  20. ncbi request reprint Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura
    Dan Levy
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215
    J Neurophysiol 88:3021-31. 2002
    ..These differences in mechanical response properties may be related in part to differences in membrane currents involved in impulse generation that have been described in subpopulations of dorsal root ganglion cells...
  21. ncbi request reprint Axon diameters and intradural trajectories of the dural innervation in the rat
    Andrew M Strassman
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 473:364-76. 2004
    ..e., > 5 microm)...
  22. ncbi request reprint A critical view on the role of migraine triggers in the genesis of migraine pain
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Headache 49:953-7. 2009
    ....
  23. ncbi request reprint Mast cell involvement in the pathophysiology of migraine headache: A hypothesis
    Dan Levy
    Department of Anesthesia and Critical Care, Headache Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Headache 46:S13-8. 2006
    ..Further studies are needed to test directly the nature of mast cell involvement in the pathogenesis of migraine headache...
  24. pmc Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells
    Tanner Boes
    Beth Israel Deaconess Medical Center and Harvard Medical School, USA
    Cephalalgia 32:924-31. 2012
    ..The present study thus tested the hypothesis that sex and ovarian hormones influence the density and phenotypic makeup of dural MCs...
  25. ncbi request reprint Migraine pain and nociceptor activation--where do we stand?
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Headache 50:909-16. 2010
    ..The paper further examines the potential future use of established human models of migraine for addressing the origin of migraine headache...
  26. pmc Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists
    Dan Levy
    Departments of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:4274-9. 2004
    ..We therefore suggest that the analgesic action of triptan can be attained specifically in the absence, but not in the presence, of central sensitization...
  27. pmc The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior
    Jun Zhao
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Pain 155:1392-400. 2014
    ..Targeting calvarial periosteal afferents may be effective in ameliorating these headaches. ..
  28. doi request reprint Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
    Dan Levy
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 29:350-61. 2008
    ..Thus, our data demonstrate that modification of a transcription coactivator, namely the DNA damage-induced phosphorylation of Yap1 by c-Abl, influences the specificity of target gene activation...

Research Grants4

  1. Mast Cells: Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2007
    ..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. [unreadable] [unreadable] [unreadable]..
  2. Mast Cells: Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2004
    ..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. ..
  3. Mast Cells: a Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2005
    ..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. ..
  4. Mast Cells: a Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2006
    ..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. [unreadable] [unreadable] [unreadable]..