Research Topics
| Alan LevitonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Brain damage markers in children. Neurobiological and clinical aspectsA Leviton
Department of Neurology, Children s Hospital, Boston, MA 02115, USA
Acta Paediatr 91:9-13. 2002..Conclusion: We conclude that brain damage markers will increasingly be measured in the blood of newborns and other children at risk of brain damage...- A review of the literature relating caffeine consumption by women to their risk of reproductive hazardsA Leviton
Neuroepidemiology Unit, Children s Hospital, Harvard Medical School, Carnegie 207, 300 Longwood Avenue, Boston, MA 02115 5737, USA
Food Chem Toxicol 40:1271-310. 2002..g. coffee and caffeine consumption). Thus, it seems reasonable to conclude that no convincing evidence has been presented to show that caffeine consumption increases the risk of any reproductive adversity... - Coagulation, inflammation, and the risk of neonatal white matter damageAlan Leviton
Neuroepidemiology Unit, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Res 55:541-5. 2004.... - Methodologic issues in epidemiologic studies of congenital microcephalyAlan Leviton
Department of Neurology, Harvard Medical School and Children s Hospital, Neuroepidemiology Unit, Boston, MA 02115 5724, USA
Early Hum Dev 69:91-105. 2002..We pay particular attention to three concerns: Who is a case? How should cases be classified? To whom should cases be compared?.. - Antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual weekAlan Leviton
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
Early Hum Dev 86:515-21. 2010..Little is known about the antecedents of microcephaly in early childhood among children born at extremely low gestational age... - SNAP-II and SNAPPE-II and the risk of structural and functional brain disorders in extremely low gestational age newborns: the ELGAN studyOlaf Dammann
Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, Mass 02111, USA
Neonatology 97:71-82. 2010..Illness severity measures predict death and illnesses in the newborn. It is unknown how well they predict brain lesions evident on ultrasound scans or neurodevelopmental dysfunctions in preterm infants... - Developmental correlates of head circumference at birth and two years in a cohort of extremely low gestational age newbornsKarl C K Kuban
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, Boston, MA, USA
J Pediatr 155:344-9.e1-3. 2009..To evaluate the developmental correlates of microcephaly evident at birth and at 2 years in a cohort born at extremely low gestational age... - Persistence after birth of systemic inflammation associated with umbilical cord inflammationAlan Leviton
Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
J Reprod Immunol 90:235-43. 2011.... - The Modified Checklist for Autism in Toddlers in extremely low gestational age newborns: individual items associated with motor, cognitive, vision and hearing limitationsRHIANNON J LUYSTER
Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Harvard Medical School, Boston, MA 02215, USA
Paediatr Perinat Epidemiol 25:366-76. 2011..The strong association between impaired sensory or motor function and M-CHAT results among extremely low gestational age children suggests that such impairments might give rise to false positive M-CHAT screening... - Maternal antenatal complications and the risk of neonatal cerebral white matter damage and later cerebral palsy in children born at an extremely low gestational ageThomas F McElrath
Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Epidemiol 170:819-28. 2009.... - Factors associated with small head circumference at birth among infants born before the 28th weekThomas F McElrath
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 203:138.e1-8. 2010..We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns... - The clustering of disorders in infants born before the 28th week of gestationAlan Leviton
Neurology Department, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Acta Paediatr 99:1795-800. 2010..To see whether disorders prevalent in infants born extremely preterm cluster... - Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulationAlan Leviton
Neurology Department, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Cytokine 53:66-73. 2011..We wanted to assess to what extent concentrations of circulating proteins appear to be developmentally regulated, and to what extent such regulation is influenced by intra-uterine inflammation... - Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN StudyAlan Leviton
Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02115, USA
Cytokine 56:392-8. 2011..To explore the relationships between blood gas derangements and blood concentrations of inflammation-related proteins shortly after preterm birth... - Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational ageKarl C K Kuban
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, Boston, Massachusetts, USA
J Child Neurol 24:63-72. 2009..Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality... - The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN studyAlan Leviton
Neuroepidemiology Unit, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Pediatr 158:897-903.e1-5. 2011..To evaluate whether concentrations of inflammation-related proteins are elevated in the blood of preterm newborns who develop cerebral white matter damage... - Histological characteristics of singleton placentas delivered before the 28th week of gestationJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02118, USA
Pathology 40:372-6. 2008..We describe the histological characteristics of 947 singleton placentas from infants born between 23 and 27 weeks gestation... - Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm deliverySunita Trivedi
Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 206:236.e1-8. 2012..Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor... - Does bronchopulmonary dysplasia contribute to the occurrence of cerebral palsy among infants born before 28 weeks of gestation?Linda J Van Marter
Newborn Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Arch Dis Child Fetal Neonatal Ed 96:F20-9. 2011..To evaluate the relationships among cerebral palsy (CP) phenotypes and bronchopulmonary dysplasia (BPD) severity and, in the process, to generate hypotheses regarding causal pathways linking BPD to CP... - Colonization of second-trimester placenta parenchymaAndrew B Onderdonk
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 199:52.e1-52.e10. 2008..The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation... - Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissuesJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Pediatr Dev Pathol 11:15-22. 2008..Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation... - Cluster Analysis of Placental Inflammatory Proteins can Distinguish Preeclampsia from Preterm Labor and Premature Membrane Rupture in Singleton Deliveries Less Than 28?Weeks of GestationJessica M Faupel-Badger
Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD, USA Department of Obstetrics and Gynecology, Brigham and Woman s Hospital, Boston, MA, USA Neuroepidemiology Unit, Children s Hospital of Boston, Boston, MA, USA Department of Pathology, Beth Israel Deaconess Hospital, Boston, MA, USA Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA, USA
Am J Reprod Immunol 66:488-94. 2011..Conclusion? Discriminating protein patterns were elucidated and may serve as a foundation from which to understand the biologic mechanisms underlying these pregnancy complications... - Neonatal bacteremia and retinopathy of prematurity: the ELGAN studyKristi Washburn Tolsma
Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, 800 Washington St, PO Box 854, Boston, MA 02111 1526, USA
Arch Ophthalmol 129:1555-63. 2011..To explore whether early or late and presumed or definite neonatal bacteremia are associated with an increased risk of severe retinopathy of prematurity (ROP)... - Early blood gas abnormalities and the preterm brainAlan Leviton
Neuroepidemiology Unit, Neurology Department, Children s Hospital Boston, and Harvard Medical School, Boston, Massachusetts 02215 5724, USA
Am J Epidemiol 172:907-16. 2010..Findings suggest that individual blood gas derangements do not increase brain damage risk. Rather, the multiple derangements associated with indicators of brain damage might be indicators of immaturity/vulnerability and illness severity... - Microbiologic and histologic characteristics of the extremely preterm infant's placenta predict white matter damage and later cerebral palsy. the ELGAN studyAlan Leviton
Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 67:95-101. 2010..Organism recovery does not seem to be needed for placenta inflammation to predict diparetic CP... - Early cranial ultrasound lesions predict microcephaly at age 2 years in preterm infantsKalpathy S Krishnamoorthy
Department of Neurology Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, Harvard Medical School, Harvard University, Boston, Massachusetts, USA
J Child Neurol 26:188-94. 2011..Focal white-matter lesion (echolucent lesion) and diffuse white-matter damage (ventriculomegaly) predict an increased risk of microcephaly... - Positive screening on the Modified Checklist for Autism in Toddlers (M-CHAT) in extremely low gestational age newbornsKarl C K Kuban
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, Boston, MA 02118, USA
J Pediatr 154:535-540.e1. 2009..To test the hypothesis that children born preterm are more likely to screen positive on the M-CHAT for an autism spectrum disorder... - Interinstitutional variation in prediction of death by SNAP-II and SNAPPE-II among extremely preterm infantsOlaf Dammann
Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts 02111, USA
Pediatrics 124:e1001-6. 2009..Illness severity scores predict death among infants admitted to NICUs. We know of no study limited to a population defined by an extremely low gestational age... - Presumed and definite bacteremia in extremely low gestational age newbornsSonal Patel
Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA
Acta Paediatr 100:36-41. 2011..To explore risk patterns for presumed and definite, early and late neonatal bacteremia... - Placenta microbiology and histology and the risk for severe retinopathy of prematurityMinghua L Chen
Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts 02111 1526, USA
Invest Ophthalmol Vis Sci 52:7052-8. 2011..To test the hypothesis that the presence of bacteria and/or histologic inflammation in the placenta of infants born preterm is associated with an increased risk for severe retinopathy of prematurity (ROP)... - Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newbornsRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics and Gynecology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
MBio 2:e00280-10. 2011..This study provides evidence that microorganisms colonizing the placenta provoke distinctive newborn inflammatory responses and that Lactobacillus may suppress these responses... - Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infantsLinda J Van Marter
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Pediatr 140:171-6. 2002.... - Prolonged latency after preterm premature rupture of membranes: an evaluation of histologic condition and intracranial ultrasonic abnormality in the neonate born at <28 weeks of gestationThomas F McElrath
Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Boston, MA, USA
Am J Obstet Gynecol 189:794-8. 2003..The odds of ultrasonically detectable brain abnormalities, however, did not increase with increasing latency... - Systemic hypotension and white-matter damage in preterm infantsOlaf Dammann
Children s Hospital, Boston, MA 02115, USA
Dev Med Child Neurol 44:82-90. 2002..In sum, these results do not support the hypothesis that systemic hypotension contributes to echolucency among preterm infants... - Antenatal glucocorticoids increase early total thyroxine levels in premature infantsCamilia R Martin
Department of Neonatology, Beth Israel Deaconess Medical Center, Division of Newborn Medicine, Boston, MA 02215, USA
Biol Neonate 87:273-80. 2005..It is standard obstetrical practice to offer antenatal glucocorticoids to pregnant women with threatened preterm delivery. Few studies have investigated the effect of antenatal glucocorticoids on neonatal thyroid function... - Blood protein profiles of infants born before 28 weeks differ by pregnancy complicationThomas F McElrath
Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 204:418.e1-418.e12. 2011..Disorders that lead to preterm delivery influence the fetal inflammatory response... - Reader variability in the use of diagnostic terms to describe white matter lesions seen on cranial scans of severely premature infants: the ELGAN studySjirk Westra
Massachusetts General Hospital, Department of Radiology, Boston, Massachusetts, USA
J Clin Ultrasound 38:409-19. 2010..To evaluate reader variability of white matter lesions seen on cranial sonographic scans of extreme low gestational age neonates (ELGANs)... - Relationships among the concentrations of 25 inflammation-associated proteins during the first postnatal weeks in the blood of infants born before the 28th week of gestationAlan Leviton
Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 5724, USA
Cytokine 57:182-90. 2012..Inflammation appears to be involved in processes leading to organ damage in preterm newborns, yet little is known about the relationships among elevated concentrations of inflammation-associated proteins in the blood of preterm newborns... - Systemic responses of preterm newborns with presumed or documented bacteraemiaAlan Leviton
Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02215 5349, USA
Acta Paediatr 101:355-9. 2012.... - Detection of bacteria in placental tissues obtained from extremely low gestational age neonatesAndrew B Onderdonk
Harvard Medical School and the Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 198:110.e1-7. 2008..The objective of the study was to quantify and identify aerobic and anaerobic bacteria as well as Mycoplasma and Ureaplasma in the chorionic parenchyma... - An algorithm for identifying and classifying cerebral palsy in young childrenKarl C K Kuban
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, Boston, MA, USA
J Pediatr 153:466-72. 2008.... - Nutritional practices and growth velocity in the first month of life in extremely premature infantsCamilia R Martin
Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Pediatrics 124:649-57. 2009.... - Observer variability assessing US scans of the preterm brain: the ELGAN studyKarl Kuban
Division of Pediatric Neurology, Boston University Medical Center, Boston University School of Medicine, Boston, MA, USA
Pediatr Radiol 37:1201-8. 2007..Neurosonography can assist clinicians and can provide researchers with documentation of brain lesions. Unfortunately, we know little about the reliability of sonographically derived diagnoses... - Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA NewbornsJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Pediatr Res 69:68-73. 2011..These results confirm the predictive value of placental histology for the presence or absence of elevated inflammatory response in newborns... - Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremiaCamilia R Martin
Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
J Pediatr 157:751-6.e1. 2010..To evaluate neurodevelopment after necrotizing enterocolitis (NEC) and late bacteremia, alone and together... - Neuregulin-1: a potential endogenous protector in perinatal brain white matter damageOlaf Dammann
Division of Newborn Medicine, Department of Pediatrics, Tufts New England Medical Center, Boston, Mass, USA
Neonatology 93:182-7. 2008..We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention... - Perturbation of gene expression of the chromatin remodeling pathway in premature newborns at risk for bronchopulmonary dysplasiaJennifer Cohen
Children s Hospital, Boston, Division of Newborn Medicine, Boston, Longwood Avenue, Boston, MA 02115, USA
Genome Biol 8:R210. 2007..Sections of umbilical cord were obtained at birth from 20 infants who later developed BPD and from 34 of their peers who did not develop BPD... - Thymus involution and cerebral white matter damage in extremely low gestational age neonatesJoshua David Kuban
Boston University School of Public Health, Boston, Mass, USA
Biol Neonate 90:252-7. 2006..CONCLUSION: These results are consistent with the possibility that early thymus involution and neonatal white matter damage are not independent phenomena and may have common antecedents... - Neuronal damage accompanies perinatal white-matter damageAlan Leviton
Department of Neurology, Children s Hospital Boston, Boston, MA, USA
Trends Neurosci 30:473-8. 2007..Together, these advances support the untested hypothesis that white-matter damage in the preterm newborn is accompanied by the death of neurons as they migrate through the dangerous minefield of white matter undergoing injury... - What explains away the increased risk of histological chorioamnionitis in African-American mothers of very-low-birthweight infants? Developmental Epidemiology Network InvestigatorsO Dammann
Neuroepidemiology Unit, Children s Hospital, Boston, MA 02115, USA
Paediatr Perinat Epidemiol 14:20-9. 2000..We discuss the possibility that this set of confounding variables conveys, in part, the same information as the variable African-American, and also perhaps information about the availability and/or utilisation of prenatal health care... - Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental NetworkL J Van Marter
Children s Hospital, Boston, Massachusetts 02115, USA
Pediatrics 105:1194-201. 2000..To explore the hypothesis that variation in respiratory management among newborn intensive care units (NICUs) explains differences in chronic lung disease (CLD) rates... - Sonographically detected subarachnoid hemorrhage: an independent predictor of neonatal posthemorrhagic hydrocephalus?A R Hansen
Division of Newborn Medicine, Children s Hospital, 300 Longwood Avenue, 02115, Boston, MA, USA
Clin Imaging 24:121-9. 2000..We found that ultrasonographically diagnosed SAH and measurement of ventricular blood volume predict ventriculomegaly and need for VP shunt... - Mediators of fetal inflammation in extremely low gestational age newbornsO Dammann
Neuroepidemiology Unit, CA 505, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Cytokine 13:234-9. 2001..Such studies would also add to our understanding of the possible role of inflammatory mediators in the pathophysiology of the major complications of extreme prematurity... - Growth-restricted premature infants are at increased risk for low thyroxineC R Martin
Department of Neonatology, Beth Israel Deaconess Medical Center, Division of Newborn Medicine, Boston, MA, USA
Early Hum Dev 64:119-28. 2001..To evaluate, in extremely premature infants, the relationship between growth restriction and early total thyroxine levels, and to determine how maternal, prenatal, perinatal and neonatal variables influence the relationship... - Brain damage in preterm newborns: might enhancement of developmentally regulated endogenous protection open a door for prevention?O Dammann
Neuroepidemiology Unit, Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
Pediatrics 104:541-50. 1999..We suggest that research into networks of developmentally regulated endogenous protectors (such as oligotrophins) is necessary to broaden our perspectives in brain injury prevention in preterm newborns... - Reference weights for placentas delivered before the 28th week of gestationJ L Hecht
Beth Israel Deaconess Medical Center, Department of Pathology, 330 Brookline Avenue, Boston, MA 02215, USA
Placenta 28:987-90. 2007..Very few studies have measured the weight of large numbers of placentas delivered before the 28th post-menstrual week... - Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classificationT F McElrath
Division of Maternal Fetal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Epidemiol 168:980-9. 2008..Disorders leading to preterm delivery may be separated into two groups: those associated with intrauterine inflammation and those associated with aberrations of placentation... - Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born pretermOlaf Dammann
Neuroepidemiology Unit, Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, USA
Ment Retard Dev Disabil Res Rev 8:46-50. 2002..We conclude that the relationship between antenatal infection and cognitive limitations deserves much further attention by researchers interested in the prevention of this undesirable outcome of prematurity... - Antenatal glucocorticoid treatment does not reduce chronic lung disease among surviving preterm infantsL J Van Marter
Children's Hospital, Boston, Massachusetts 02115, USA
J Pediatr 138:198-204. 2001.... - The wealth of information conveyed by gestational ageAlan Leviton
Children's Hospital and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
J Pediatr 146:123-7. 2005 - Intraventricular haemorrhage grading scheme: time to abandon?Alan Leviton
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA, USA
Acta Paediatr 96:1254-6. 2007 - Possible strategies to protect the preterm brain against the fetal inflammatory responseO Dammann
Neuroepidemiology Unit, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Dev Med Child Neurol Suppl 86:18-20. 2001..Appropriate observational and experimental studies are needed before clinical interventions can be initiated... - Adult stroke and perinatal brain damage: like grandparent, like grandchild?A Leviton
Neuroepidemiology Unit, Children's Hospital, Boston, MA, USA
Neuropediatrics 33:281-7. 2002..We also describe desirable characteristics of future studies of perinatal brain damage that involve measurements of systemic biomarkers... - What is quality improvement and why should child neurologists care?Alan Leviton
Departments of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
J Child Neurol 27:251-7. 2012.... - The adaptive immune response in neonatal cerebral white matter damageAlan Leviton
Neuroepidemiology Unit, Children s Hospital Boston, 1 Autumn Street, Boston, MA 02215 5349, USA
Ann Neurol 58:821-8. 2005..These include specific recognition of bacterial antigens, specific recognition of autoantigens, polyclonal activation by Toll-like receptors, and bystander activation by cytokines... - Risk of cranial ultrasound abnormalities in very-low-birth-weight infants conceived with assisted reproductive techniquesJane E Stewart
Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Perinatol 22:37-45. 2002..CONCLUSION: VLBW infants conceived with ART do not appear to be at increased risk of cranial ultrasound abnormalities. Likewise, twins and triplets were not at increased risk of these abnormalities... - Topography of cerebral white-matter disease of prematurity studied prospectively in 1607 very-low-birthweight infantsK C Kuban
Department of Pediatrics, New England Medical Center, Boston, MA, USA
J Child Neurol 16:401-8. 2001.... - Do white cells matter in white matter damage?O Dammann
Children's Hospital and Harvard Medical School, Boston, MA, USA
Trends Neurosci 24:320-4. 2001.... - Is periventricular leukomalacia an axonopathy as well as an oligopathy?O Dammann
Neuroepidemiology Unit, Department of Neurology, Children's Hospital, Boston, Massachusetts 02115
Pediatr Res 49:453-7. 2001..We conclude that it is too early to view periventricular leukomalacia exclusively as a consequence of oligodendrocyte damage and/or maldevelopment... - Hypocarbia during the first 24 postnatal hours and white matter echolucencies in newborns < or = 28 weeks gestationO Dammann
Neuroepidemiology Unit, CA 505, Children's Hospital, Boston, Massachusetts 02115, USA
Pediatr Res 49:388-93. 2001..In the multivariable analyses, the association diminished after adjustment with a hypocarbia propensity score (odds ratio = 1.7; 95 % confidence interval, 0.8-3.2) or with potential confounders... - Inflammation, brain damage and visual dysfunction in preterm infantsOlaf Dammann
Perinatal Infectious Disease Epidemiology Unit, Department of Gynecology, Hannover Medical School, OE 6415, 30623 Hannover, Germany
Semin Fetal Neonatal Med 11:363-8. 2006.... - Antenatal mycoplasma infection, the fetal inflammatory response and cerebral white matter damage in very-low-birthweight infantsOlaf Dammann
Hannover Medical School, Germany
Paediatr Perinat Epidemiol 17:49-57. 2003..Our finding that M. hominis in the placenta was associated with a not quite significant threefold risk increase for echolucency deserves further investigation... - Bronchopulmonary dysplasia is not associated with ultrasound-defined cerebral white matter damage in preterm newbornsOlaf Dammann
Department of Obstetrics, Prenatal Medicine and Gynecology, Hannover Medical School, 30623 Hannover, Germany
Pediatr Res 55:319-25. 2004..Confounding does not seem to account for this lack of association between WMD and BPD. In conclusion, our findings do not support the hypothesis that BPD contributes to the occurrence of sonographically defined WMD... - Biomarker epidemiology of cerebral palsyOlaf Dammann
Ann Neurol 55:158-61. 2004 - Lung and brain damage in preterm newborns. Are they related? How? Why?Olaf Dammann
Departments of Obstetrics and Pediatrics, Perinatal Infectious Disease Epidemiology Unit, Hannover Medical School, Hannover, Germany
Biol Neonate 85:305-13. 2004..g. postnatal steroid exposure) that increase the risk for developmental disability in childhood... - Inflammatory brain damage in preterm newborns--dry numbers, wet lab, and causal inferencesOlaf Dammann
Perinatal Infectious Disease Epidemiology Unit, Hannover Medical School, Germany
Early Hum Dev 79:1-15. 2004..We also need more (and more detailed) observational studies clarifying the presumed infection --> inflammation --> WMD sequence before we can initiate intervention trials to reduce the risk of WMD... - Periventricular leukomalacia might not specifically affect cortical magnetoencephalographic response to biological motionOlaf Dammann
Ann Neurol 60:269; author reply 269-70. 2006 - Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcomeOlaf Dammann
Perinatal Infectious Disease Epidemiology Unit, Department of Obstetrics and Pediatrics, OE 6415 Hannover Medical School, 30623 Hannover, Germany
BJOG 112:4-9. 2005..In this paper we discuss the complexities that paediatricians, perinatologists and perinatal epidemiologists face as they try to understand the contributions of factors associated with preterm birth to neonatal and childhood disorders... - Proposed definition and classification of cerebral palsy, April 2005Martin Bax
Division of Paediatrics, Obstetrics and Gynaecology, Imperial College, London, UK
Dev Med Child Neurol 47:571-6. 2005..The Executive Committee presents this revision and welcomes substantive comments about it... - Video and CD-ROM as a training tool for performing neurologic examinations of 1-year-old children in a multicenter epidemiologic studyKarl C K Kuban
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, MA 02118, USA
J Child Neurol 20:829-31. 2005..It provides an effective means to evaluate interobserver variability, offers a route for feedback, and creates an opportunity to reevaluate variability, both immediately and at periodic intervals... - Neurological sequelae in in-vitro fertilisation babiesAlan Leviton
Lancet 360:718; author reply 719. 2002 - Neuroimaging and the prediction of outcomes in preterm infantsOlaf Dammann
N Engl J Med 355:727-9. 2006 - Factors associated with treatment for hypotension in extremely low gestational age newborns during the first postnatal weekMatthew Laughon
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Pediatrics 119:273-80. 2007.... - A report: the definition and classification of cerebral palsy April 2006Peter Rosenbaum
CanChild Centre for Childhood Disability Research, Hamilton, Ontario, Canada
Dev Med Child Neurol Suppl 109:8-14. 2007..The Executive Committee presents this report with the intent of providing a common conceptualization of CP for use by a broad international audience... - Neonatal cranial ultrasound lesions and developmental delays at 2 years of age among extremely low gestational age childrenT MICHAEL O'SHEA
Wake Forest University Health Sciences, Department of Pediatrics, Medical Center Boulevard, Winston Salem, NC 27157, USA
Pediatrics 122:e662-9. 2008..Studies of the relationship between ultrasound images from preterm newborns and developmental delay most often are based on small samples defined by birth weight and exclude infants not testable with standardized assessments...