Elena Levantini

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element
    Elena Levantini
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Center for Life Science, Boston, MA, USA
    EMBO J 30:4059-70. 2011
  2. pmc Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia
    Hong Zhang
    Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cancer Cell 24:575-88. 2013
  3. pmc C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence
    Min Ye
    Harvard Stem Cell Institute, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nat Cell Biol 15:385-94. 2013
  4. pmc CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture
    Yakov Peter
    Department of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Tissue Eng Regen Med 7:572-83. 2013
  5. pmc Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells
    Robert S Welner
    Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 27:671-81. 2015
  6. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
  7. pmc Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
    Florence C Guibal
    Center for Life Sciences, Harvard Medical School, Boston, MA, USA
    Blood 114:5415-25. 2009
  8. pmc Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice
    Daniela S Bassères
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 26:1109-23. 2006
  9. pmc CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma
    Yi Cai
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 10:e0120647. 2015
  10. pmc Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization
    Yakov Peter
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Carcinog 48:488-97. 2009

Collaborators

Detail Information

Publications12

  1. pmc RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element
    Elena Levantini
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Center for Life Science, Boston, MA, USA
    EMBO J 30:4059-70. 2011
    ..Overall, our in vivo data provide novel evidence about the role of RUNX1 in mediating interactions between distal and proximal elements of the HSC gene CD34...
  2. pmc Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia
    Hong Zhang
    Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cancer Cell 24:575-88. 2013
    ..Our data demonstrate that Sox4 overexpression resulting from C/EBPα inactivation contributes to the development of leukemia with a distinct LIC phenotype. ..
  3. pmc C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence
    Min Ye
    Harvard Stem Cell Institute, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nat Cell Biol 15:385-94. 2013
    ..Mechanistically we identified N-Myc as a downstream target of C/EBPa, and loss of C/EBPa resulted in de-repression of N-Myc. Our data establish C/EBPa as a central determinant in the switch from fetal to adult HSCs...
  4. pmc CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture
    Yakov Peter
    Department of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Tissue Eng Regen Med 7:572-83. 2013
    ....
  5. pmc Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells
    Robert S Welner
    Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 27:671-81. 2015
    ..Compatible results were obtained when human CML were cultured with normal human hematopoietic progenitor cells. Furthermore, neutralization of IL-6 prevented these changes and treated the disease. ..
  6. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells...
  7. pmc Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
    Florence C Guibal
    Center for Life Sciences, Harvard Medical School, Boston, MA, USA
    Blood 114:5415-25. 2009
    ..Our findings provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can initiate and propagate the disease...
  8. pmc Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice
    Daniela S Bassères
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 26:1109-23. 2006
    ..Furthermore, this study indicates that exploring the C/EBPalpha pathway might have therapeutic benefits for patients with respiratory distress syndromes...
  9. pmc CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma
    Yi Cai
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 10:e0120647. 2015
    ..Taken together, our data suggest that C/EBPβ is dispensable for development of lung adenocarcinoma. ..
  10. pmc Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization
    Yakov Peter
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Carcinog 48:488-97. 2009
    ..Understanding the influence of EGF on A549 cell permeability and reorganization will help shed light on NSCLC tumor colonization and contribute to the development of novel anti-cancer treatments...
  11. ncbi Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice
    Shigeto Kubo
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, and Ireland Cancer Center, University Hospitals of Cleveland Case Western Reserve University, OH, USA
    Magn Reson Med 56:698-703. 2006
    ..This promising method is noninvasive and has the potential to eventually replace invasive histopathology because it obviates the need to kill groups of animals at multiple time points...
  12. ncbi Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
    Pu Zhang
    Harvard Institutes of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 21:853-63. 2004
    ..Therefore, C/EBP alpha is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity...