Robert Lenkinski

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Interaction of gadolinium-based MR contrast agents with choline: implications for MR spectroscopy (MRS) of the breast
    Robert E Lenkinski
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 61:1286-92. 2009
  2. doi request reprint Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects
    Jay S Reidler
    Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Pain 13:450-8. 2012
  3. doi request reprint Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition
    Valerie Byrnes
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 56:549-56. 2012
  4. ncbi request reprint Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 63:897-900. 2004
  5. ncbi request reprint Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
  6. ncbi request reprint Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: mapping tumor invasion of the prostate capsule
    Sandra M Gaston
    Department of Surgery, Division of Urology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 11:95-101. 2005
  7. ncbi request reprint An automated algorithm for combining multivoxel MRS data acquired with phased-array coils
    Nimrod Maril
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Magn Reson Imaging 21:317-22. 2005
  8. ncbi request reprint On-resonance low B1 pulses for imaging of the effects of PARACEST agents
    Elena Vinogradov
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Magn Reson 176:54-63. 2005
  9. ncbi request reprint Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results
    B Nicolas Bloch
    Department of Radiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Radiology 245:176-85. 2007
  10. ncbi request reprint Prostate postbrachytherapy seed distribution: comparison of high-resolution, contrast-enhanced, T1- and T2-weighted endorectal magnetic resonance imaging versus computed tomography: initial experience
    B Nicolas Bloch
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 69:70-8. 2007

Research Grants

  1. Multivoxel MRS of Human Breast Cancer at 3T.
    Robert Lenkinski; Fiscal Year: 2006
  2. PARACEST Agents: Optimization for Human MR Imaging
    Robert Lenkinski; Fiscal Year: 2007
  3. PARACEST Agents: Optimization for Human MR Imaging
    Robert E Lenkinski; Fiscal Year: 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Interaction of gadolinium-based MR contrast agents with choline: implications for MR spectroscopy (MRS) of the breast
    Robert E Lenkinski
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 61:1286-92. 2009
    ..Therefore, we recommend the use of the neutral chelates in MRI/MRS studies of the breast...
  2. doi request reprint Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects
    Jay S Reidler
    Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Pain 13:450-8. 2012
    ..These results suggest that motor cortex modulation may have a greater analgesic effect when combined with bottom-up neuromodulatory mechanisms, presenting new avenues for modulation of pain using noninvasive neuromodulatory approaches...
  3. doi request reprint Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition
    Valerie Byrnes
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 56:549-56. 2012
    ..We aimed to evaluate the effect of pegylated interferon/ribavirin (PIFN/R) and HCV clearance on cerebral metabolism, and neuropsychological performance...
  4. ncbi request reprint Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 63:897-900. 2004
    ..Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression...
  5. ncbi request reprint Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
    ..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
  6. ncbi request reprint Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: mapping tumor invasion of the prostate capsule
    Sandra M Gaston
    Department of Surgery, Division of Urology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 11:95-101. 2005
    ....
  7. ncbi request reprint An automated algorithm for combining multivoxel MRS data acquired with phased-array coils
    Nimrod Maril
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Magn Reson Imaging 21:317-22. 2005
    ..To develop a fully automated algorithm for combining multivoxel magnetic resonance spectroscopy (MRS) data acquired with a phased-array coil...
  8. ncbi request reprint On-resonance low B1 pulses for imaging of the effects of PARACEST agents
    Elena Vinogradov
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Magn Reson 176:54-63. 2005
    ..It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy)...
  9. ncbi request reprint Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results
    B Nicolas Bloch
    Department of Radiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Radiology 245:176-85. 2007
    ....
  10. ncbi request reprint Prostate postbrachytherapy seed distribution: comparison of high-resolution, contrast-enhanced, T1- and T2-weighted endorectal magnetic resonance imaging versus computed tomography: initial experience
    B Nicolas Bloch
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 69:70-8. 2007
    ....
  11. ncbi request reprint 3T MR of the prostate: reducing susceptibility gradients by inflating the endorectal coil with a barium sulfate suspension
    Yael Rosen
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 57:898-904. 2007
    ....
  12. ncbi request reprint Limits on activation-induced temperature and metabolic changes in the human primary visual cortex
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 56:348-55. 2006
    ..Limits on Lac concentration changes were too weak to constrain theories of the metabolic use of elevated Glc consumption during stimulation, and emphasize the challenges of measuring even large Lac changes accompanying stimulation...
  13. ncbi request reprint MR imaging of the prostate at 3 Tesla: comparison of an external phased-array coil to imaging with an endorectal coil at 1.5 Tesla
    Jacob Sosna
    Department of Radiology and Urology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Acad Radiol 11:857-62. 2004
    ..To qualitatively compare the image quality of torso phased-array 3-Tesla (3T) imaging of the prostate with that of endorectal 1.5-Tesla imaging...
  14. ncbi request reprint 3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1)
    B Nicolas Bloch
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA, USA
    Acad Radiol 11:863-7. 2004
    ..5T has gained acceptance for pretherapeutic staging of prostate cancer. The aim of this study was to evaluate the potential clinical utility of combined pelvic phased-array and endorectal coils at 3T...
  15. ncbi request reprint Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 Tesla
    Robert L Greenman
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 15:467-72. 2002
    ..To investigate the use of a three-dimensional rapid acquisition with relaxation enhancement (RARE) pulse sequence for direct acquisition of phosphocreatine (PCr) images of the human myocardium...
  16. ncbi request reprint A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis
    Patricia Lani Lee
    NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
    J Magn Reson Imaging 17:625-33. 2003
    ....
  17. ncbi request reprint Determinations of prostate volume at 3-Tesla using an external phased array coil: comparison to pathologic specimens
    Jacob Sosna
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Acad Radiol 10:846-53. 2003
    ..To compare techniques for measuring in vivo prostate volumes using torso phased-array imaging at 3-Tesla...
  18. ncbi request reprint MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo
    Elena Vinogradov
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 58:650-5. 2007
    ..The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo...
  19. ncbi request reprint PARACEST agents: modulating MRI contrast via water proton exchange
    Shanrong Zhang
    Department of Chemistry, University of Texas at Dallas, P O Box 830688, Richardson, Texas 75083 0688, USA
    Acc Chem Res 36:783-90. 2003
    ....
  20. ncbi request reprint Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding
    F Caseiro Alves
    Department of Radiology, Faculty of Medicine and Hospital Service of Imageology, University of Coimbra, Coimbra, Portugal
    Invest Radiol 38:750-60. 2003
    ..To date, its pharmacokinetics, effects on organ relaxivity, and interaction with hydroxyapatite (HA) has not been described...
  21. ncbi request reprint Optimal breathing protocol for dynamic contrast-enhanced MRI of solitary pulmonary nodules at 3T
    Aya Kino
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Eur J Radiol 64:397-400. 2007
    ..This breathing maneuver makes it possible to analyze SPN with DCE-MRI while making use of the advantages of a higher magnetic field in conjunction...
  22. ncbi request reprint Body MR imaging at 3.0 T: understanding the opportunities and challenges
    Mara M Barth
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Radiographics 27:1445-62; discussion 1462-4. 2007
    ..0-T MR imaging systems are complicated by additional safety hazards unique to high-field-strength magnets. These aspects of 3.0-T body imaging represent current challenges and opportunities for radiology practice...
  23. pmc Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
    Environ Health Perspect 115:519-23. 2007
    ..Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans...
  24. ncbi request reprint Recent advances in magnetic resonance neurospectroscopy
    Yael Rosen
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Neurotherapeutics 4:330-45. 2007
    ..Finally, we speculate about some of the potential technical developments, either in progress or in the future, that may lead to improvements in the performance of proton MRS...
  25. doi request reprint Nephrogenic systemic fibrosis: a chemical perspective
    Neil M Rofsky
    Radiology 247:608-12. 2008
  26. ncbi request reprint Sodium MRI of the human kidney at 3 Tesla
    Nimrod Maril
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 56:1229-34. 2006
    ..Water deprivation (12 hr) induced a significant increase of 25% (P < 0.05) in this gradient. Based on these results, we suggest that sodium MRI can serve as a valuable noninvasive method for functional imaging of the human kidney...
  27. ncbi request reprint Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 94:1197-203. 2002
    ..The method is likely to provide even better results with technologic advances in breast MRS that lead to the improved detection of the composite choline signal...
  28. ncbi request reprint MR imaging of sodium in the human brain with a fast three-dimensional gradient-recalled-echo sequence at 4 T
    David B Clayton
    Department of Radiology, University of Pennsylvania, Philadelphia, USA
    Acad Radiol 10:358-65. 2003
    ....
  29. ncbi request reprint Breathhold abdominal and thoracic proton MR spectroscopy at 3T
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 50:461-7. 2003
    ..These spectra exhibited a resonance at 3.2 ppm attributed to the trimethylamine moiety of choline metabolites. The results of this study suggest a practical strategy for implementation of (1)H-MRS in the body...
  30. ncbi request reprint Dynamic contrast-enhanced MR studies
    Robert E Lenkinski
    Acad Radiol 10:961-2. 2003
  31. ncbi request reprint Frame-by-frame PRESS 1H-MRS of the brain at 3 T: the effects of physiological motion
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 51:184-7. 2004
    ..In a motionless phantom, smaller phase and frequency variations were detected in water-suppressed acquisitions. However, the end effects of physiological motion on PRESS 1H-MRS of the brain at 3 T were negligible...
  32. ncbi request reprint Radiofrequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor model
    Muneeb Ahmed
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Radiology 230:761-7. 2004
    ..Predominance of tissue-specific characteristics will likely result in site-specific differences in RF-induced coagulation necrosis...
  33. ncbi request reprint Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy
    Rachel Katz-Brull
    Dept of Radiology, Beth Israel Deaconess Medical Ctr, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 288:F637-41. 2005
    ..The ability to detect renal metabolic shifts noninvasively may improve the specificity of preoperative renal tissue characterization and may provide a new modality for treatment monitoring...
  34. ncbi request reprint High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T
    Elena Vinogradov
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Magn Reson Imaging 22:302-6. 2005
    ..To evaluate techniques for anatomical and physiological imaging of the intracranial optic nerve (ON), optic chiasm (OC), and optic tract (OT) at 3T with the aim of visualizing axonal damage in multiple sclerosis (MS)...
  35. ncbi request reprint Radiofrequency ablation: importance of background tissue electrical conductivity--an agar phantom and computer modeling study
    Stephanie A Solazzo
    Minimally Invasive Tumor Therapy Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Radiology 236:495-502. 2005
    ....
  36. ncbi request reprint Strategies for shimming the breast
    Nimrod Maril
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 54:1139-45. 2005
    ..Since many clinical scanners do not have either higher-order shim or automated higher shimming algorithms that work in the presence of fat, the suggested combination provides an effective means to correct inhomogeneities in the breast...
  37. ncbi request reprint Interrater reliability in assessing quality of diagnostic accuracy studies using the QUADAS tool. A preliminary assessment
    William Hollingworth
    Department of Radiology, Box 359960, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    Acad Radiol 13:803-10. 2006
    ..We used data from a systematic review of magnetic resonance spectroscopy (MRS) in the characterization of suspected brain tumors to provide a preliminary evaluation of the inter-rater reliability of QUADAS...
  38. ncbi request reprint Localized proton spectroscopy without water suppression: removal of gradient induced frequency modulations by modulus signal selection
    Hacene Serrai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Magn Reson 154:53-9. 2002
    ..The corrected spectra can then be fit accurately. This is confirmed by the results obtained from both the relative and the absolute metabolites concentrations in phantoms and in vivo...

Research Grants7

  1. Multivoxel MRS of Human Breast Cancer at 3T.
    Robert Lenkinski; Fiscal Year: 2006
    ..We will determine the cost-effectiveness of MRS in the overall work-up of breast cancer. ..
  2. PARACEST Agents: Optimization for Human MR Imaging
    Robert Lenkinski; Fiscal Year: 2007
    ..Thomas Dixon and lleana Hancu (Project Leaders, GEGRC) are both experts in NMR and MR imaging. Robert Lenkinski (PI, BIDMC) is an NMR spectroscopist with expertise both in lanthanide agents and MR imaging...
  3. PARACEST Agents: Optimization for Human MR Imaging
    Robert E Lenkinski; Fiscal Year: 2010
    ..Thomas Dixon and Ileana Hancu (Project Leaders, GEGRC) are both experts in NMR and MR imaging. Robert Lenkinski (PI, BIDMC) is an NMR spectroscopist with expertise both in lanthanide agents and MR imaging...