Research Topics
| Robert LenkinskiSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Interaction of gadolinium-based MR contrast agents with choline: implications for MR spectroscopy (MRS) of the breastRobert E Lenkinski
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 61:1286-92. 2009..Therefore, we recommend the use of the neutral chelates in MRI/MRS studies of the breast...- Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjectsJay S Reidler
Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Pain 13:450-8. 2012..These results suggest that existing pain therapies involving DNIC may be enhanced through combination with noninvasive brain stimulation... - Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognitionValerie Byrnes
Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Hepatol 56:549-56. 2012..We aimed to evaluate the effect of pegylated interferon/ribavirin (PIFN/R) and HCV clearance on cerebral metabolism, and neuropsychological performance... 
Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathyRachel Katz-Brull
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Neurology 63:897-900. 2004..Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression...- Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificityRobert H Paul
Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
J Neuropsychiatry Clin Neurosci 19:283-92. 2007..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy... - Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: mapping tumor invasion of the prostate capsuleSandra M Gaston
Department of Surgery, Division of Urology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Med 11:95-101. 2005.... - An automated algorithm for combining multivoxel MRS data acquired with phased-array coilsNimrod Maril
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Magn Reson Imaging 21:317-22. 2005..8, due to sampling of the ventricles in the center of the sample. CONCLUSION: The method described in this report provides a means for employing phased-array coils in MRS with the same advantages as those found in MRI... - On-resonance low B1 pulses for imaging of the effects of PARACEST agentsElena Vinogradov
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
J Magn Reson 176:54-63. 2005..It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy)... - Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial resultsB Nicolas Bloch
Department of Radiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
Radiology 245:176-85. 2007.... - Prostate postbrachytherapy seed distribution: comparison of high-resolution, contrast-enhanced, T1- and T2-weighted endorectal magnetic resonance imaging versus computed tomography: initial experienceB Nicolas Bloch
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Int J Radiat Oncol Biol Phys 69:70-8. 2007.... - 3T MR of the prostate: reducing susceptibility gradients by inflating the endorectal coil with a barium sulfate suspensionYael Rosen
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 57:898-904. 2007.... - Limits on activation-induced temperature and metabolic changes in the human primary visual cortexRachel Katz-Brull
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 56:348-55. 2006..Limits on Lac concentration changes were too weak to constrain theories of the metabolic use of elevated Glc consumption during stimulation, and emphasize the challenges of measuring even large Lac changes accompanying stimulation... - MR imaging of the prostate at 3 Tesla: comparison of an external phased-array coil to imaging with an endorectal coil at 1.5 TeslaJacob Sosna
Department of Radiology and Urology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Acad Radiol 11:857-62. 2004..5-T imaging. These findings suggest that additional options are now available for magnetic resonance imaging of the prostate gland... - 3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1)B Nicolas Bloch
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA, USA
Acad Radiol 11:863-7. 2004..5T has gained acceptance for pretherapeutic staging of prostate cancer. The aim of this study was to evaluate the potential clinical utility of combined pelvic phased-array and endorectal coils at 3T... - Fast imaging of phosphocreatine in the normal human myocardium using a three-dimensional RARE pulse sequence at 4 TeslaRobert L Greenman
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 15:467-72. 2002..To investigate the use of a three-dimensional rapid acquisition with relaxation enhancement (RARE) pulse sequence for direct acquisition of phosphocreatine (PCr) images of the human myocardium... - A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysisPatricia Lani Lee
NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
J Magn Reson Imaging 17:625-33. 2003.... - Determinations of prostate volume at 3-Tesla using an external phased array coil: comparison to pathologic specimensJacob Sosna
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Acad Radiol 10:846-53. 2003..652 and 0.86, respectively. CONCLUSIONS: Surface coil prostate imaging at 3-Tesla provides undistorted images for volume assessment and in vivo volume determinations very close to ex vivo imaging volume determinations... - MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivoElena Vinogradov
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 58:650-5. 2007..The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo... - PARACEST agents: modulating MRI contrast via water proton exchangeShanrong Zhang
Department of Chemistry, University of Texas at Dallas, P.O. Box 830688, Richardson, Texas 75083-0688, USA
Acc Chem Res 36:783-90. 2003.... - Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite bindingF Caseiro Alves
Department of Radiology, Faculty of Medicine and Hospital Service of Imageology, University of Coimbra, Coimbra, Portugal
Invest Radiol 38:750-60. 2003..These data suggest a novel strategy for creating highly sensitive, switchable MRI contrast agents... - Optimal breathing protocol for dynamic contrast-enhanced MRI of solitary pulmonary nodules at 3TAya Kino
Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Eur J Radiol 64:397-400. 2007..This breathing maneuver makes it possible to analyze SPN with DCE-MRI while making use of the advantages of a higher magnetic field in conjunction... - Body MR imaging at 3.0 T: understanding the opportunities and challengesMara M Barth
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Radiographics 27:1445-62; discussion 1462-4. 2007..0-T MR imaging systems are complicated by additional safety hazards unique to high-field-strength magnets. These aspects of 3.0-T body imaging represent current challenges and opportunities for radiology practice... 
Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampusMarc G Weisskopf
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
Environ Health Perspect 115:519-23. 2007..Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans...- Recent advances in magnetic resonance neurospectroscopyYael Rosen
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Neurotherapeutics 4:330-45. 2007..Finally, we speculate about some of the potential technical developments, either in progress or in the future, that may lead to improvements in the performance of proton MRS... - Nephrogenic systemic fibrosis: a chemical perspectiveNeil M Rofsky
Radiology 247:608-12. 2008 - Sodium MRI of the human kidney at 3 TeslaNimrod Maril
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 56:1229-34. 2006..Water deprivation (12 hr) induced a significant increase of 25% (P < 0.05) in this gradient. Based on these results, we suggest that sodium MRI can serve as a valuable noninvasive method for functional imaging of the human kidney... - Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesionsRachel Katz-Brull
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Natl Cancer Inst 94:1197-203. 2002..The method is likely to provide even better results with technologic advances in breast MRS that lead to the improved detection of the composite choline signal... - MR imaging of sodium in the human brain with a fast three-dimensional gradient-recalled-echo sequence at 4 TDavid B Clayton
Department of Radiology, University of Pennsylvania, Philadelphia, USA
Acad Radiol 10:358-65. 2003..CONCLUSION: The MR imaging protocol used in this study provided acceptable visualization of sodium in the whole brain in a tolerable total acquisition time of 15 minutes... - Breathhold abdominal and thoracic proton MR spectroscopy at 3TRachel Katz-Brull
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 50:461-7. 2003..These spectra exhibited a resonance at 3.2 ppm attributed to the trimethylamine moiety of choline metabolites. The results of this study suggest a practical strategy for implementation of (1)H-MRS in the body... - Dynamic contrast-enhanced MR studiesRobert E Lenkinski
Acad Radiol 10:961-2. 2003 - Frame-by-frame PRESS 1H-MRS of the brain at 3 T: the effects of physiological motionRachel Katz-Brull
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 51:184-7. 2004..In a motionless phantom, smaller phase and frequency variations were detected in water-suppressed acquisitions. However, the end effects of physiological motion on PRESS 1H-MRS of the brain at 3 T were negligible... - Radiofrequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor modelMuneeb Ahmed
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Radiology 230:761-7. 2004..Predominance of tissue-specific characteristics will likely result in site-specific differences in RF-induced coagulation necrosis... - Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopyRachel Katz-Brull
Dept. of Radiology, Beth Israel Deaconess Medical Ctr, 330 Brookline Ave, Boston, MA 02215, USA
Am J Physiol Renal Physiol 288:F637-41. 2005..The ability to detect renal metabolic shifts noninvasively may improve the specificity of preoperative renal tissue characterization and may provide a new modality for treatment monitoring... - High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3TElena Vinogradov
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
J Magn Reson Imaging 22:302-6. 2005..The pilot results presented here pave the way for imaging the anterior visual pathway in patients with MS... - Radiofrequency ablation: importance of background tissue electrical conductivity--an agar phantom and computer modeling studyStephanie A Solazzo
Minimally-Invasive Tumor Therapy Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Radiology 236:495-502. 2005..99-1.00) were established. CONCLUSION: These results demonstrate the strong relationship between background tissue conductivity and RF heating and further explain electrical phenomena that occur in a two-compartment system... - Strategies for shimming the breastNimrod Maril
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 54:1139-45. 2005..Since many clinical scanners do not have either higher-order shim or automated higher shimming algorithms that work in the presence of fat, the suggested combination provides an effective means to correct inhomogeneities in the breast... - Interrater reliability in assessing quality of diagnostic accuracy studies using the QUADAS tool. A preliminary assessmentWilliam Hollingworth
Department of Radiology, Box 359960, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
Acad Radiol 13:803-10. 2006..We used data from a systematic review of magnetic resonance spectroscopy (MRS) in the characterization of suspected brain tumors to provide a preliminary evaluation of the inter-rater reliability of QUADAS... - Localized proton spectroscopy without water suppression: removal of gradient induced frequency modulations by modulus signal selectionHacene Serrai
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Magn Reson 154:53-9. 2002..The corrected spectra can then be fit accurately. This is confirmed by the results obtained from both the relative and the absolute metabolites concentrations in phantoms and in vivo...
Research Grants
- Multivoxel MRS of Human Breast Cancer at 3T.Robert Lenkinski; Fiscal Year: 2006..We will determine the cost-effectiveness of MRS in the overall work-up of breast cancer. ..
- PARACEST Agents: Optimization for Human MR ImagingRobert Lenkinski; Fiscal Year: 2007..Thomas Dixon and lleana Hancu (Project Leaders, GEGRC) are both experts in NMR and MR imaging. Robert Lenkinski (PI, BIDMC) is an NMR spectroscopist with expertise both in lanthanide agents and MR imaging...
- PARACEST Agents: Optimization for Human MR ImagingRobert E Lenkinski; Fiscal Year: 2010..Thomas Dixon and Ileana Hancu (Project Leaders, GEGRC) are both experts in NMR and MR imaging. Robert Lenkinski (PI, BIDMC) is an NMR spectroscopist with expertise both in lanthanide agents and MR imaging...