Bernardo Lemos

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Rates of divergence in gene expression profiles of primates, mice, and flies: stabilizing selection and variability among functional categories
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 59:126-37. 2005
  2. ncbi Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 319:91-3. 2008
  3. ncbi Regulatory evolution across the protein interaction network
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Genet 36:1059-60. 2004
  4. ncbi Phylogenetic footprinting reveals extensive conservation of Sonic Hedgehog (SHH) regulatory elements
    Bernardo Lemos
    Department of Genetics, Universidade Federal do Rio de Janeiro, Brazil
    Genomics 84:511-23. 2004
  5. ncbi Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, USA
    Mol Biol Evol 22:1345-54. 2005
  6. ncbi The Opossum genome reveals further evidence for regulatory evolution in mammalian diversification
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Divinity Avenue, Cambridge, MA 02138, USA
    Genome Biol 8:223. 2007
  7. ncbi Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:15826-31. 2010
  8. ncbi Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:14471-6. 2008
  9. ncbi Genetic properties influencing the evolvability of gene expression
    Christian R Landry
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 317:118-21. 2007
  10. ncbi Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila
    Jun Zhou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:9941-6. 2012

Detail Information

Publications15

  1. ncbi Rates of divergence in gene expression profiles of primates, mice, and flies: stabilizing selection and variability among functional categories
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 59:126-37. 2005
    ..Finally, we argue that differences in mRNA levels of the magnitudes observed herein could be explained by a remarkably small number of generations of directional selection...
  2. ncbi Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 319:91-3. 2008
    ..Functionally, they affect microtubule stability, lipid and mitochondrial metabolism, and the thermal sensitivity of spermatogenesis. Our findings provide a mechanism for adaptive phenotypic variation associated with the Y chromosome...
  3. ncbi Regulatory evolution across the protein interaction network
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Genet 36:1059-60. 2004
    ..Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionarily coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies...
  4. ncbi Phylogenetic footprinting reveals extensive conservation of Sonic Hedgehog (SHH) regulatory elements
    Bernardo Lemos
    Department of Genetics, Universidade Federal do Rio de Janeiro, Brazil
    Genomics 84:511-23. 2004
    ..The relevance of these findings with respect to regulation of SHH expression during normal and pathologic development is discussed...
  5. ncbi Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, USA
    Mol Biol Evol 22:1345-54. 2005
    ....
  6. ncbi The Opossum genome reveals further evidence for regulatory evolution in mammalian diversification
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Divinity Avenue, Cambridge, MA 02138, USA
    Genome Biol 8:223. 2007
    ....
  7. ncbi Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:15826-31. 2010
    ....
  8. ncbi Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:14471-6. 2008
    ..We suggest that widespread regulatory effects of recessive low-frequency homozygous variation may provide a general mechanism mediating disease phenotypes and the genetic load of natural populations...
  9. ncbi Genetic properties influencing the evolvability of gene expression
    Christian R Landry
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 317:118-21. 2007
    ..These results provide a mechanistic basis for gene expression evolvability that can serve as a foundation for realistic models of regulatory evolution...
  10. ncbi Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila
    Jun Zhou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:9941-6. 2012
    ..These results further expand our understanding of the role of the Y chromosome in modulating global gene expression, and suggest a link with modifications of the chromatin state...
  11. ncbi Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes"
    Luciana O Araripe
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    BMC Evol Biol 10:385. 2010
    ..In the current work we used marked P-element insertions as dominant markers to efficiently locate one genetic factor causing a severe reduction in fertility in hybrid males of Drosophila simulans and D. mauritiana...
  12. ncbi Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila
    Timothy B Sackton
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:17046-51. 2011
    ....
  13. ncbi Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster
    Jun Zhou
    Department of Organismic and Evolutionary Biology, Harvard University, USA
    Genome Biol Evol 3:1014-24. 2011
    ..Dosage-sensitive CNVs that are upregulated and downregulated coincide with copy-number increases and decreases. Our results help clarify the relation between CNV dosage and gene expression in the D. melanogaster genome...
  14. ncbi Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster
    Pan Pan Jiang
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 186:109-18. 2010
    ....
  15. ncbi The lowest diploid number (2n = 16) yet found in any primate: Callicebus lugens (Humboldt, 1811)
    Cibele R Bonvicino
    Division of Genetics, Instituto Nacional de Cancer, Praça da Cruz Vermelha 23, 6o andar, 20230 130 Rio de Haneiro, Brazil
    Folia Primatol (Basel) 74:141-9. 2003
    ..lugens has the lowest diploid chromosome number of the primate order (2n = 16). Comparisons with other congeneric species clearly supported the proposition that C. lugens is karyotypically similar to others of the torquatus group...