S Lelas

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines
    S Lelas
    Division of Behavioral Biology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
    Exp Clin Psychopharmacol 8:294-311. 2000
  2. ncbi request reprint Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs
    S Lelas
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 154:96-104. 2001
  3. ncbi request reprint Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam
    S Lelas
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 158:181-9. 2001
  4. ncbi request reprint Transduction of the discriminative stimulus effects of zolpidem by GABA(A)/alpha1 receptors
    J K Rowlett
    New England Regional Primate Research Center, Harvard Medical School, Box 9102, One Pine Hill Drive, Southborough, MA, USA
    Eur J Pharmacol 406:R9-R10. 2000

Collaborators

  • J K Rowlett
  • R D Spealman

Detail Information

Publications4

  1. ncbi request reprint Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines
    S Lelas
    Division of Behavioral Biology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
    Exp Clin Psychopharmacol 8:294-311. 2000
    ..In addition, data from many drug discrimination studies suggest that the conventional BZ agonist chlordiazepoxide may have reduced intrinsic efficacy compared with other BZ agonists...
  2. ncbi request reprint Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs
    S Lelas
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 154:96-104. 2001
    ..Triazolam is a high-efficacy benzodiazepine (BZ) agonist, which might be hypothesized to engender highly pharmacologically specific discriminative stimulus (DS) effects and distinguish among BZ agonists with different intrinsic efficacy...
  3. ncbi request reprint Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam
    S Lelas
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 158:181-9. 2001
    ..The discriminative stimulus (DS) effects of chlordiazepoxide (CDP) differ from those of other typical benzodiazepine (BZ) agonists in that CDP does not always occasion full substitution for a BZ agonist DS...
  4. ncbi request reprint Transduction of the discriminative stimulus effects of zolpidem by GABA(A)/alpha1 receptors
    J K Rowlett
    New England Regional Primate Research Center, Harvard Medical School, Box 9102, One Pine Hill Drive, Southborough, MA, USA
    Eur J Pharmacol 406:R9-R10. 2000
    ..These findings offer the first evidence for a selective role of GABA(A)/alpha1 receptors in the interoceptive effects of high doses of zolpidem...