Research Topics
| D A LefflerSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
The interaction between eating disorders and celiac disease: an exploration of 10 casesDaniel A Leffler
The Celiac Center, Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana, Boston, MA 02215, USA
Eur J Gastroenterol Hepatol 19:251-5. 2007..Our findings suggest that clinicians treating patients with eating disorders or celiac disease should be aware of both conditions to provide optimum care...
The Oslo definitions for coeliac disease and related termsJonas F Ludvigsson
Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Gut 62:43-52. 2013..The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten...
A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challengeDaniel A Leffler
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Gastroenterol 107:1554-62. 2012..The aim of this study was to evaluate the efficacy and tolerability of larazotide acetate in protecting against gluten-induced intestinal permeability and gastrointestinal symptom severity in patients with celiac disease...
Adenoma detection rates vary minimally with time of day and case rank: a prospective study of 2139 first screening colonoscopiesDaniel A Leffler
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Gastrointest Endosc 75:554-60. 2012..Adenoma detection rate is an important measure of colonoscopy quality; however, factors including procedure order that contribute to adenoma detection are incompletely understood...
Etiologies and predictors of diagnosis in nonresponsive celiac diseaseDaniel A Leffler
Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 5:445-50. 2007..The aim of this study was to determine the common etiologies of NRCD in a tertiary referral center...
A validated disease-specific symptom index for adults with celiac diseaseDaniel A Leffler
Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 7:1328-34, 1334.e1-3. 2009..Although the incidence of celiac disease (CD) is increasing, studies have been hampered by the lack of validated outcome measures. We sought to create a disease-specific Celiac Symptom Index (CSI) to reliably assess relevant symptoms...
Treatment of Clostridium difficile-associated diseaseDaniel A Leffler
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Gastroenterology 136:1899-912. 2009..Failure to develop specific antibody response has recently been identified as a critical factor in recurrence. The review discusses the different management strategies for initial and recurrent symptomatic C difficile infections...
A simple validated gluten-free diet adherence survey for adults with celiac diseaseDaniel A Leffler
Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 7:530-6, 536.e1-2. 2009..The aim of this study was to develop a valid and reliable Celiac Dietary Adherence Test (CDAT)...
The incidence and cost of unexpected hospital use after scheduled outpatient endoscopyDaniel A Leffler
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Intern Med 170:1752-7. 2010..Data on complications of gastrointestinal endoscopic procedures are limited. We evaluated prospectively the incidence and cost of hospital visits resulting from outpatient endoscopy...
An alerting system improves adherence to follow-up recommendations from colonoscopy examinationsDaniel A Leffler
Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Gastroenterology 140:1166-1173.e1-3. 2011..We tested the effectiveness of a novel follow-up system for patients due for surveillance colonoscopy examinations...
Factors that influence adherence to a gluten-free diet in adults with celiac diseaseDaniel A Leffler
Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Dig Dis Sci 53:1573-81. 2008..The purpose of this study was to determine factors influencing gluten-free diet adherence in adults with celiac disease...
A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac diseaseD A Leffler
The Celiac Center, Beth Israel Deaconess Medical Center, Department of Gastroenterology, Boston, MA 02215, USA
Aliment Pharmacol Ther 26:1227-35. 2007..The only accepted treatment for coeliac disease is lifelong adherence to a strict gluten-free diet (GFD). Individuals' ability to adhere to the GFD varies, but systematic studies guiding the assessment of adherence are currently lacking...
Celiac disease diagnosis and management: a 46-year-old woman with anemiaDaniel Leffler
Department of Gastroenterology, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
JAMA 306:1582-92. 2011..In addition, a gluten-free diet is highly burdensome and can profoundly affect patients and their families. For these reasons, care of individuals with celiac disease requires prompt diagnosis and ongoing multidisciplinary management...
Update on serologic testing in celiac diseaseDaniel A Leffler
Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Gastroenterol 105:2520-4. 2010..We discuss the need to develop tests for CD activity in order to assess the efficacy of upcoming nondietary therapies...
Body mass index and the risk of obesity in coeliac disease treated with the gluten-free dietT A Kabbani
Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Aliment Pharmacol Ther 35:723-9. 2012..Coeliac disease is increasingly diagnosed and weight changes are common after adoption of a gluten-free diet (GFD), however data on body mass index (BMI) changes are limited...
Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infectionMary Y Hu
Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Gastroenterology 136:1206-14. 2009..This study aimed to develop a prediction rule for recurrent CDI using the above derivation cohort and prospectively evaluate the performance of this rule in an independent validation cohort...
Celiac disease: diagnosis, autoimmune mechanisms and treatmentBrian M Gill
Clinical Fellow in Internal Medicine, Beth Israel Deaconess Medical Center, Dana 501330, Brookline Ave, Boston, MA 02130, USA
Expert Rev Clin Immunol 3:763-72. 2007....
Integration of racial, cultural, ethnic, and socioeconomic factors into a gastrointestinal pathophysiology courseHelen M Shields
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 7:279-84. 2009....
Psychological correlates of gluten-free diet adherence in adults with celiac diseaseJessica B Edwards George
Department of Gastroenterology, Beth Israel Deaconess Medical Center BIDMC, The Celiac Center, Harvard Medical School, Northeastern University, Boston, MA02215 5491, USA
J Clin Gastroenterol 43:301-6. 2009..To determine whether personality traits and psychological characteristics are related to gluten-free diet (GFD) adherence in an adult population diagnosed with celiac disease (CD)...
A faculty development program to train tutors to be discussion leaders rather than facilitatorsHelen M Shields
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Acad Med 82:486-92. 2007..The purpose of this study was to learn what difference this new approach made...
Using medical students to enhance curricular integration of cross-cultural contentHelen M Shields
Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Kaohsiung J Med Sci 25:493-502. 2009..Our study underscores the fundamental link between teachers and students as partners in curricular development...
Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled studyC P Kelly
Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Aliment Pharmacol Ther 37:252-62. 2013..Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and associated sequelae...
Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practiceK Pallav
Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA
Aliment Pharmacol Ther 35:380-90. 2012..Duodenal villous atrophy (DVA) is a key diagnostic finding in coeliac disease (CD). However, the differential diagnosis for this finding is broad...
Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesisBrian Hyett
Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
Gastroenterology 137:445-52. 2009..The aim of this study was to evaluate the prognostic value of gastric emptying studies on the morbidity associated with diabetic gastroparesis...
Celiac crisis is a rare but serious complication of celiac disease in adultsShailaja Jamma
Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 8:587-90. 2010..To improve awareness of this condition and to facilitate diagnosis, we reviewed cases of celiac crisis to identify presenting features, formulate diagnostic criteria, and develop treatment strategies...
Update on the evaluation and diagnosis of celiac diseaseDaniel A Leffler
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Curr Opin Allergy Clin Immunol 6:191-6. 2006..However, case finding in individuals with risk factors for celiac disease is recommended. Further study is necessary to define diagnostic algorithms and target populations likely to benefit from testing...
