D A Leffler

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The interaction between eating disorders and celiac disease: an exploration of 10 cases
    Daniel A Leffler
    The Celiac Center, Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana, Boston, MA 02215, USA
    Eur J Gastroenterol Hepatol 19:251-5. 2007
  2. ncbi request reprint Etiologies and predictors of diagnosis in nonresponsive celiac disease
    Daniel A Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 5:445-50. 2007
  3. pmc Factors that influence adherence to a gluten-free diet in adults with celiac disease
    Daniel A Leffler
    Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Dig Dis Sci 53:1573-81. 2008
  4. pmc Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease
    Daniel Leffler
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Gut 62:996-1004. 2013
  5. pmc The Oslo definitions for coeliac disease and related terms
    Jonas F Ludvigsson
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Gut 62:43-52. 2013
  6. pmc A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge
    Daniel A Leffler
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Gastroenterol 107:1554-62. 2012
  7. doi request reprint Adenoma detection rates vary minimally with time of day and case rank: a prospective study of 2139 first screening colonoscopies
    Daniel A Leffler
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Gastrointest Endosc 75:554-60. 2012
  8. doi request reprint Treatment of Clostridium difficile-associated disease
    Daniel A Leffler
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 136:1899-912. 2009
  9. doi request reprint A validated disease-specific symptom index for adults with celiac disease
    Daniel A Leffler
    Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 7:1328-34, 1334.e1-3. 2009
  10. pmc Celiac disease diagnosis and management: a 46-year-old woman with anemia
    Daniel Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    JAMA 306:1582-92. 2011

Detail Information

Publications27

  1. ncbi request reprint The interaction between eating disorders and celiac disease: an exploration of 10 cases
    Daniel A Leffler
    The Celiac Center, Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana, Boston, MA 02215, USA
    Eur J Gastroenterol Hepatol 19:251-5. 2007
    ..Our findings suggest that clinicians treating patients with eating disorders or celiac disease should be aware of both conditions to provide optimum care...
  2. ncbi request reprint Etiologies and predictors of diagnosis in nonresponsive celiac disease
    Daniel A Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 5:445-50. 2007
    ..The aim of this study was to determine the common etiologies of NRCD in a tertiary referral center...
  3. pmc Factors that influence adherence to a gluten-free diet in adults with celiac disease
    Daniel A Leffler
    Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Dig Dis Sci 53:1573-81. 2008
    ..The purpose of this study was to determine factors influencing gluten-free diet adherence in adults with celiac disease...
  4. pmc Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease
    Daniel Leffler
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Gut 62:996-1004. 2013
    ..Lack of data regarding the kinetics of responses to gluten is a limitation in clinical practice and research when GC is performed...
  5. pmc The Oslo definitions for coeliac disease and related terms
    Jonas F Ludvigsson
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Gut 62:43-52. 2013
    ..The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten...
  6. pmc A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge
    Daniel A Leffler
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Gastroenterol 107:1554-62. 2012
    ..The aim of this study was to evaluate the efficacy and tolerability of larazotide acetate in protecting against gluten-induced intestinal permeability and gastrointestinal symptom severity in patients with celiac disease...
  7. doi request reprint Adenoma detection rates vary minimally with time of day and case rank: a prospective study of 2139 first screening colonoscopies
    Daniel A Leffler
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Gastrointest Endosc 75:554-60. 2012
    ..Adenoma detection rate is an important measure of colonoscopy quality; however, factors including procedure order that contribute to adenoma detection are incompletely understood...
  8. doi request reprint Treatment of Clostridium difficile-associated disease
    Daniel A Leffler
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 136:1899-912. 2009
    ..Failure to develop specific antibody response has recently been identified as a critical factor in recurrence. The review discusses the different management strategies for initial and recurrent symptomatic C difficile infections...
  9. doi request reprint A validated disease-specific symptom index for adults with celiac disease
    Daniel A Leffler
    Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 7:1328-34, 1334.e1-3. 2009
    ..Although the incidence of celiac disease (CD) is increasing, studies have been hampered by the lack of validated outcome measures. We sought to create a disease-specific Celiac Symptom Index (CSI) to reliably assess relevant symptoms...
  10. pmc Celiac disease diagnosis and management: a 46-year-old woman with anemia
    Daniel Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    JAMA 306:1582-92. 2011
    ..In addition, a gluten-free diet is highly burdensome and can profoundly affect patients and their families. For these reasons, care of individuals with celiac disease requires prompt diagnosis and ongoing multidisciplinary management...
  11. doi request reprint An alerting system improves adherence to follow-up recommendations from colonoscopy examinations
    Daniel A Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Gastroenterology 140:1166-1173.e1-3. 2011
    ..We tested the effectiveness of a novel follow-up system for patients due for surveillance colonoscopy examinations...
  12. doi request reprint The incidence and cost of unexpected hospital use after scheduled outpatient endoscopy
    Daniel A Leffler
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 170:1752-7. 2010
    ..Data on complications of gastrointestinal endoscopic procedures are limited. We evaluated prospectively the incidence and cost of hospital visits resulting from outpatient endoscopy...
  13. doi request reprint Update on serologic testing in celiac disease
    Daniel A Leffler
    Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Gastroenterol 105:2520-4. 2010
    ..We discuss the need to develop tests for CD activity in order to assess the efficacy of upcoming nondietary therapies...
  14. doi request reprint A simple validated gluten-free diet adherence survey for adults with celiac disease
    Daniel A Leffler
    Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 7:530-6, 536.e1-2. 2009
    ..The aim of this study was to develop a valid and reliable Celiac Dietary Adherence Test (CDAT)...
  15. ncbi request reprint A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac disease
    D A Leffler
    The Celiac Center, Beth Israel Deaconess Medical Center, Department of Gastroenterology, Boston, MA 02215, USA
    Aliment Pharmacol Ther 26:1227-35. 2007
    ..The only accepted treatment for coeliac disease is lifelong adherence to a strict gluten-free diet (GFD). Individuals' ability to adhere to the GFD varies, but systematic studies guiding the assessment of adherence are currently lacking...
  16. doi request reprint Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study
    C P Kelly
    Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Aliment Pharmacol Ther 37:252-62. 2013
    ..Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and associated sequelae...
  17. doi request reprint Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet
    T A Kabbani
    Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Aliment Pharmacol Ther 35:723-9. 2012
    ..Coeliac disease is increasingly diagnosed and weight changes are common after adoption of a gluten-free diet (GFD), however data on body mass index (BMI) changes are limited...
  18. doi request reprint Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection
    Mary Y Hu
    Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 136:1206-14. 2009
    ..This study aimed to develop a prediction rule for recurrent CDI using the above derivation cohort and prospectively evaluate the performance of this rule in an independent validation cohort...
  19. ncbi request reprint Celiac disease: diagnosis, autoimmune mechanisms and treatment
    Brian M Gill
    Clinical Fellow in Internal Medicine, Beth Israel Deaconess Medical Center, Dana 501330, Brookline Ave, Boston, MA 02130, USA
    Expert Rev Clin Immunol 3:763-72. 2007
    ....
  20. ncbi request reprint Using medical students to enhance curricular integration of cross-cultural content
    Helen M Shields
    Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Kaohsiung J Med Sci 25:493-502. 2009
    ..Our study underscores the fundamental link between teachers and students as partners in curricular development...
  21. doi request reprint Integration of racial, cultural, ethnic, and socioeconomic factors into a gastrointestinal pathophysiology course
    Helen M Shields
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 7:279-84. 2009
    ....
  22. doi request reprint Psychological correlates of gluten-free diet adherence in adults with celiac disease
    Jessica B Edwards George
    Department of Gastroenterology, Beth Israel Deaconess Medical Center BIDMC, The Celiac Center, Harvard Medical School, Northeastern University, Boston, MA02215 5491, USA
    J Clin Gastroenterol 43:301-6. 2009
    ..To determine whether personality traits and psychological characteristics are related to gluten-free diet (GFD) adherence in an adult population diagnosed with celiac disease (CD)...
  23. ncbi request reprint A faculty development program to train tutors to be discussion leaders rather than facilitators
    Helen M Shields
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Acad Med 82:486-92. 2007
    ..The purpose of this study was to learn what difference this new approach made...
  24. doi request reprint Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practice
    K Pallav
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Aliment Pharmacol Ther 35:380-90. 2012
    ..Duodenal villous atrophy (DVA) is a key diagnostic finding in coeliac disease (CD). However, the differential diagnosis for this finding is broad...
  25. doi request reprint Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis
    Brian Hyett
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Gastroenterology 137:445-52. 2009
    ..The aim of this study was to evaluate the prognostic value of gastric emptying studies on the morbidity associated with diabetic gastroparesis...
  26. pmc Celiac crisis is a rare but serious complication of celiac disease in adults
    Shailaja Jamma
    Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 8:587-90. 2010
    ..To improve awareness of this condition and to facilitate diagnosis, we reviewed cases of celiac crisis to identify presenting features, formulate diagnostic criteria, and develop treatment strategies...
  27. ncbi request reprint Update on the evaluation and diagnosis of celiac disease
    Daniel A Leffler
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Curr Opin Allergy Clin Immunol 6:191-6. 2006
    ..Understanding the risk factors, clinical presentations and diagnostic modalities is necessary to identify and treat patients with this commonly misdiagnosed disorder...