R T Lee

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Matrix metalloproteinase inhibition and the prevention of heart failure
    R T Lee
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA, USA
    Trends Cardiovasc Med 11:202-5. 2001
  2. ncbi Mechanical strain induces specific changes in the synthesis and organization of proteoglycans by vascular smooth muscle cells
    R T Lee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    J Biol Chem 276:13847-51. 2001
  3. ncbi Receptor-based differences in human aortic smooth muscle cell membrane stiffness
    H Huang
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA
    Hypertension 38:1158-61. 2001
  4. ncbi Cell stiffness and receptors: evidence for cytoskeletal subnetworks
    Hayden Huang
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts, USA
    Am J Physiol Cell Physiol 288:C72-80. 2005
  5. ncbi Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension
    H Sakamoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:109-14. 2001
  6. ncbi Regulation of cardiomyocyte mechanotransduction by the cardiac cycle
    K Yamamoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 103:1459-64. 2001
  7. ncbi Electrophysiological characterization of murine myocardial ischemia and infarction
    J Gehrmann
    Department of Cardiology, Children's Hospital, Boston, MA 02115, USA
    Basic Res Cardiol 96:237-50. 2001
  8. ncbi Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice
    M Scherrer-Crosbie
    Cardiology Division, Cardiovascular Research Center, Department of Medicine, Boston, Massachusetts, USA
    Circulation 104:1286-91. 2001
  9. ncbi Macrophages and atherosclerotic plaque stability
    P Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Lipidol 7:330-5. 1996
  10. ncbi Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial
    M A Pfeffer
    Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:2643-51. 1997

Collaborators

Detail Information

Publications87

  1. ncbi Matrix metalloproteinase inhibition and the prevention of heart failure
    R T Lee
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA, USA
    Trends Cardiovasc Med 11:202-5. 2001
    ..However, the crucial question of whether MMP inhibition benefits long-term left ventricular function and survival should be answered...
  2. ncbi Mechanical strain induces specific changes in the synthesis and organization of proteoglycans by vascular smooth muscle cells
    R T Lee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    J Biol Chem 276:13847-51. 2001
    ..These data demonstrate that mechanical deformation increases specific vascular smooth muscle cell proteoglycan synthesis and aggregation, indicating a highly coordinated extracellular matrix response to biomechanical stimulation...
  3. ncbi Receptor-based differences in human aortic smooth muscle cell membrane stiffness
    H Huang
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA
    Hypertension 38:1158-61. 2001
    ..001). Mechanical characteristics of vascular smooth muscle cells depend on the receptor by which the stress is applied, with integrin-based linkages demonstrating cell-stiffening behavior...
  4. ncbi Cell stiffness and receptors: evidence for cytoskeletal subnetworks
    Hayden Huang
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts, USA
    Am J Physiol Cell Physiol 288:C72-80. 2005
    ....
  5. ncbi Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension
    H Sakamoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:109-14. 2001
    ..7+/-4.7% for animals on standard chow; P<0.001). CONCLUSIONS: Biomechanical strain induces SRA expression by monocyte/macrophages, suggesting a novel mechanism for promotion of atherosclerosis in hypertensive patients...
  6. ncbi Regulation of cardiomyocyte mechanotransduction by the cardiac cycle
    K Yamamoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 103:1459-64. 2001
    ....
  7. ncbi Electrophysiological characterization of murine myocardial ischemia and infarction
    J Gehrmann
    Department of Cardiology, Children's Hospital, Boston, MA 02115, USA
    Basic Res Cardiol 96:237-50. 2001
    ..The limitations of directly extrapolating murine cardiac electrophysiology data to conditions in humans need to be considered...
  8. ncbi Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice
    M Scherrer-Crosbie
    Cardiology Division, Cardiovascular Research Center, Department of Medicine, Boston, Massachusetts, USA
    Circulation 104:1286-91. 2001
    ..Conclusions- These results suggest that the presence of NOS3 limits LV dysfunction and remodeling in a murine model of MI by an afterload-independent mechanism, in part by decreasing myocyte hypertrophy in the remote myocardium...
  9. ncbi Macrophages and atherosclerotic plaque stability
    P Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Lipidol 7:330-5. 1996
    ..We hypothesize that lipid-lowering reduces clinical events, as shown in recent trials, by stabilizing lesions in part by reversing some of the maladaptive functions of macrophages described above...
  10. ncbi Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial
    M A Pfeffer
    Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:2643-51. 1997
    ..Although ACE inhibitor therapy has been shown to reduce mortality in patients with acute myocardial infarction (MI), the optimal dose and the timing of its initiation have not been determined...
  11. ncbi Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist
    R T Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:5084-8. 1997
    ..This pathophysiologic mechanism may play a role in the anatomic localization of some inflammatory skin diseases, such as psoriasis, which occurs more commonly in locations where the dermis is subjected to repetitive stretch or trauma...
  12. ncbi MRI of rabbit atherosclerosis in response to dietary cholesterol lowering
    M V McConnell
    Noninvasive Laboratory, Vascular Medicine, Atherosclerosis Unit, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 19:1956-9. 1999
    ..Plaque progression was seen with maintenance of high-cholesterol diet. MRI is a promising noninvasive technology for directly imaging atherosclerosis and its response to therapeutic interventions...
  13. ncbi Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture
    R T Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass
    Arterioscler Thromb Vasc Biol 16:1070-3. 1996
    ..Degradation and weakening of the collagenous extracellular matrix at these critical high-stress regions may play a role in the pathogenesis of plaque rupture and acute ischemic syndromes...
  14. ncbi Force-induced focal adhesion translocation: effects of force amplitude and frequency
    P J Mack
    Department of Mechanical Enginnering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Physiol Cell Physiol 287:C954-62. 2004
    ..These results highlight the mutual importance of force transmission and biochemical signaling in focal adhesion mechanotransduction...
  15. ncbi Molecular biology of atherosclerosis
    P Libby
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Cardiol 62:S23-9. 1997
    ..Rather than attempting a comprehensive overview, we will focus primarily on selected examples where new information sheds light on potential molecular mechanisms underlying these pathologic processes...
  16. pmc Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:7616-21. 2003
    ..Hence, CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1...
  17. ncbi Usefulness of transthoracic echocardiography as a tool for risk stratification of patients undergoing major noncardiac surgery
    L E Rohde
    Partners Community HealthCare Inc, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02199, USA
    Am J Cardiol 87:505-9. 2001
    ..In conclusion, preoperative TTE before noncardiac surgery can provide independent information about the risk of postoperative cardiac complications in selected patients...
  18. ncbi The impact of calcification on the biomechanical stability of atherosclerotic plaques
    H Huang
    MassachusettsInstitute of Technology, Cambridge, MA, USA
    Circulation 103:1051-6. 2001
    ..In contrast to lipid pools, which dramatically increase stresses, calcification does not seem to decrease the mechanical stability of the coronary atheroma...
  19. ncbi Vascular mechanics for the cardiologist
    R T Lee
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge
    J Am Coll Cardiol 23:1289-95. 1994
    ..Approaches to measuring vessel wall stiffness and the mechanical basis for vascular catastrophes are introduced...
  20. ncbi Quantitative measurements of active and passive mechanical properties of adult cardiac myocytes
    J Lammerding
    Cardiovascular Division, Partners Research Facility, Rm 280, 65 Landsdowne St, Cambridge, MA 02139, USA
    IEEE Eng Med Biol Mag 22:124-7. 2003
  21. ncbi Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival
    R S Agrawal
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Gene Ther 11:962-9. 2004
    ..This concept of preinjury delivery and 'pre-emptive' gene therapy via the expression of a secreted protein that renders paracrine therapeutic action can be an effective strategy for organ protection against future injury...
  22. ncbi Characterization of the atherosclerotic carotid bifurcation using MRI, finite element modeling, and histology
    M R Kaazempur-Mofrad
    Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Biomed Eng 32:932-46. 2004
    ..These trends agree with hypotheses in the literature, which are based on ex vivo and in vitro experimental studies...
  23. ncbi Plaque stabilization: the role of lipid lowering
    R T Lee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Cardiol 74:S11-5. 2000
    ....
  24. pmc Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
    B K McConnell
    Department of Genetics, Howard Hughes Medical Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1235-44. 1999
    ..We also propose that mice bearing homozygous familial hypertrophic cardiomyopathy-causing mutations may provide useful tools for predicting the severity of disease that these mutations will cause in humans...
  25. ncbi Blood pressure and inflammation in apparently healthy men
    C U Chae
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hypertension 38:399-403. 2001
    ..These data suggest that increased blood pressure may be a stimulus for inflammation and that this is a possible mechanism underlying the well-established role of hypertension as a risk factor for atherosclerotic disease...
  26. pmc Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    A Ducharme
    Cardiovascular Division, Department of Medicine, and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:55-62. 2000
    ..The decrease in collagen accumulation and the enhanced expression of other MMPs suggest that MMP-9 plays a prominent role in extracellular matrix remodeling after MI...
  27. pmc Cystatin C deficiency in human atherosclerosis and aortic aneurysms
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1191-7. 1999
    ..The findings highlight a potentially important role for imbalance between cysteine proteases and cystatin C in arterial wall remodeling and establish that cystatin C deficiency occurs in vascular disease...
  28. ncbi Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151
    R L Yauch
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:9230-8. 2000
    ..Finally, we demonstrated that both NH(2)- and COOH-terminal domains of CD151 are located on the inside of the plasma membrane, thus confirming a long suspected model of TM4SF protein topology...
  29. ncbi Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction
    Merry L Lindsey
    Division of Cardiothoracic Surgery Research, Rm 629, Strom Thurmond Research Bldg, 770 MUSC Complex, Medical Univ of South Carolina, 114 Doughty St, PO Box 250778, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 290:H232-9. 2006
    ..Thus targeted strategies to inhibit MMP-9 early post-MI will likely not impair the angiogenic response...
  30. pmc Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells
    Jan Lammerding
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 170:781-91. 2005
    ....
  31. ncbi The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C deficient cells
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Novartis Found Symp 264:264-73; discussion 273-8. 2005
    ..Individual mutations in the lamin A/C gene could potentially selectively interfere with any of these functions, explaining the tissue-specific effects observed in the laminopathies...
  32. ncbi Self-assembling short oligopeptides and the promotion of angiogenesis
    Daria A Narmoneva
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02139, USA
    Biomaterials 26:4837-46. 2005
    ..Since these peptides can be modified in many ways, they may be uniquely valuable in regeneration of vascularized tissues...
  33. ncbi Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload
    Jun Yoshioka
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 101:1328-38. 2007
    ..These results support the emerging concept that the function of Txnip is not as a simple thioredoxin inhibitor but as a metabolic control protein...
  34. pmc Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells
    Michael E Davis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Circulation 111:442-50. 2005
    ..We hypothesized that a novel approach to promote vascularization would be to create injectable microenvironments within the myocardium that recruit endothelial cells and promote their survival and organization...
  35. ncbi A model for mechanotransduction in cardiac muscle: effects of extracellular matrix deformation on autocrine signaling
    Ivan V Maly
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Ann Biomed Eng 32:1319-35. 2004
    ..These predictions point to the potential capabilities of the EGFR autocrine signaling circuit in mechanotransduction and suggest a new perspective on the cardiac hypertrophic response...
  36. ncbi Macrophage-mediated cardiac fibrosis
    P Christian Schulze
    Circ Res 95:552-3. 2004
  37. doi Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 117:1936-44. 2008
    ....
  38. pmc Mechanical control of tissue morphogenesis
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 103:234-43. 2008
    ..Insights into the mechanisms linking mechanical forces to cell and tissue differentiation pathways are important for understanding many congenital diseases and for developing regenerative medicine strategies...
  39. pmc Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors
    Valerie L R M Verstraeten
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 7:383-93. 2008
    ....
  40. ncbi Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production
    William A Chutkow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 283:2397-406. 2008
    ..While available thioredoxin is not changed in Txnip-null mice, the effects of Txnip on glucose homeostasis are abolished by a single cysteine mutation that inhibits binding to thioredoxin...
  41. pmc IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
    Shoji Sanada
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:1538-49. 2007
    ..IL-33 may have therapeutic potential for beneficially regulating the myocardial response to overload...
  42. ncbi Cell nuclei spin in the absence of lamin b1
    Julie Y Ji
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Biol Chem 282:20015-26. 2007
    ..These findings demonstrate that lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton...
  43. ncbi Role of thioredoxin in cell growth through interactions with signaling molecules
    Jun Yoshioka
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Antioxid Redox Signal 8:2143-51. 2006
    ..In this review, we focus on the structure of thioredoxin and its functional regulation of cell growth through the interactions with signaling molecules...
  44. pmc FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction
    Felix B Engel
    Department of Pediatrics, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:15546-51. 2006
    ..Our data indicate that FGF1 and p38 MAP kinase, proteins involved in cardiomyocyte proliferation and angiogenesis during development, may be delivered therapeutically to enhance cardiac regeneration...
  45. ncbi Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 26:2666-72. 2006
    ..We show the NO-dependent transcriptional regulation of the antioxidative thioredoxin system...
  46. ncbi Lamins A and C but not lamin B1 regulate nuclear mechanics
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 281:25768-80. 2006
    ..Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness...
  47. pmc The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 281:21884-91. 2006
    ..These data suggest that Txnip is a target of reduced thioredoxin and provide insight into the potential role of Txnip as a redox-sensitive signaling protein...
  48. pmc Prelamin A and lamin A appear to be dispensable in the nuclear lamina
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    J Clin Invest 116:743-52. 2006
    ..These studies suggest a new therapeutic strategy for treating progeria and other lamin A diseases...
  49. pmc Endothelial-cardiomyocyte interactions in cardiac development and repair
    Patrick C H Hsieh
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 68:51-66. 2006
    ....
  50. pmc Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells
    Hideyuki Yamawaki
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Clin Invest 115:733-8. 2005
    ..The data suggest that TXNIP and TRX are key components of biomechanical signal transduction and establish them as potentially novel regulators of TNF signaling and inflammation in ECs...
  51. pmc Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration
    Daria A Narmoneva
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Circulation 110:962-8. 2004
    ..This study tested the hypothesis that endothelial cells (ECs) promote CM survival and enhance spatial organization in a 3-dimensional configuration...
  52. pmc Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
    Koichi Shimizu
    The Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:300-8. 2004
    ..The findings establish important regulatory roles for a Th1/Th2 cytokine balance in modulating matrix remodeling and have important implications for the pathophysiology of AAAs and arteriosclerosis...
  53. ncbi Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formation
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02139, USA
    Circ Res 93:1210-7. 2003
    ..These findings suggest that the induction of iex-1 represents a novel negative biomechanical feedback mechanism limiting the vascular response to injury...
  54. pmc A three-dimensional viscoelastic model for cell deformation with experimental verification
    Helene Karcher
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 85:3336-49. 2003
    ..Modulation of cell height has little effect on the results, provided the monolayer is >5 micro m thick. NIH 3T3 fibroblasts exhibited a viscoelastic timescale of approximately 1 s and a shear modulus of approximately 1000 Pa...
  55. ncbi Effect of a cleavage-resistant collagen mutation on left ventricular remodeling
    Merry L Lindsey
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circ Res 93:238-45. 2003
    ..We were not able to detect collagen cleavage fragments, and could not, therefore, rule out the possibility of collagen cleavage at additional sites...
  56. ncbi Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction
    Stefan Frantz
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, MA 02115, Boston, USA
    J Mol Cell Cardiol 35:685-94. 2003
    ....
  57. pmc Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction
    Ellen O Weinberg
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Mass 02139, USA
    Circulation 106:2961-6. 2002
    ..We identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized that ST2 participates in the acute myocardial response to stress and injury...
  58. ncbi Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Res 91:689-95. 2002
    ..These data also demonstrate that activation of the reductase TRX plays a pivotal role in the redox-dependent proliferation of SMCs...
  59. ncbi Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin
    Yanlin Wang
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:26496-500. 2002
    ....
  60. ncbi Identification of IEX-1 as a biomechanically controlled nuclear factor-kappaB target gene that inhibits cardiomyocyte hypertrophy
    Gilles W De Keulenaer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts, USA
    Circ Res 90:690-6. 2002
    ....
  61. ncbi Identification of mechanically induced genes in human monocytic cells by DNA microarrays
    Ruri Ohki
    Department of Cardiology, Jichi Medical School, Minamikawachi Machi, Tochigi, Japan
    J Hypertens 20:685-91. 2002
    ..Although macrophages may be subjected to excess mechanical stress in these diseases, the way in which biomechanical forces affect macrophage function remains incompletely defined...
  62. ncbi Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction
    Merry L Lindsey
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 105:753-8. 2002
    ..However, it is not clear if selective MMP inhibition strategies will be effective or if MMP inhibition will impair angiogenesis after MI...
  63. pmc Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Clin Invest 113:370-8. 2004
    ..These findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation...
  64. ncbi Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02115, USA
    Atherosclerosis 175:91-4. 2004
    ..If confirmed in other cohorts, these data support the emerging hypothesis that eotaxin participates in atherosclerosis...
  65. ncbi Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 279:30369-74. 2004
    ..These studies implicate reduced thioredoxin activity through interaction with Txnip as an important mechanism for vascular oxidative stress in diabetes mellitus...
  66. ncbi Cell mechanics and mechanotransduction: pathways, probes, and physiology
    Hayden Huang
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Am J Physiol Cell Physiol 287:C1-11. 2004
    ....
  67. ncbi Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity
    Jun Yoshioka
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 109:2581-6. 2004
    ..Because thioredoxin is a major intracellular antioxidant and can also regulate redox-dependent transcription, we explored the role of thioredoxin activity in mechanically overloaded cardiomyocytes in vitro and in vivo...
  68. ncbi Ask the doctor. I've been told that I have an abnormal T wave. Should I be worried about this? How will it affect my heart health?
    Richard T Lee
    Harv Heart Lett 14:8. 2004
  69. ncbi Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes
    Yanlin Wang
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Partners Research Facility, 65 Lansdowne Street, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 283:H533-9. 2002
    ....
  70. pmc Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
    Patrick C H Hsieh
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Med 13:970-4. 2007
    ..5% in areas bordering a myocardial infarction, 76.6% in areas away from a myocardial infarction, and 75.7% in hearts subjected to pressure overload, indicating that stem cells or precursor cells had refreshed the cardiomyocytes...
  71. ncbi Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction
    Vincent F M Segers
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 116:1683-92. 2007
    ..However, SDF-1 is cleaved by exopeptidases and matrix metalloproteinase-2, generating a neurotoxin implicated in some forms of dementia...
  72. ncbi Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion
    Ellen O Weinberg
    Cardiovascular Division, Brigham and Women s Hospital, 65 Landsdowne St, Cambridge, MA 02139, USA
    Am J Physiol Heart Circ Physiol 288:H1802-9. 2005
    ....
  73. pmc Engineering insulin-like growth factor-1 for local delivery
    Tomotake Tokunou
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 22:1886-93. 2008
    ..These data show that the strategy of engineering a "long-distance" growth factor like IGF-1 for local delivery may be useful for tissue repair and minimizing systemic effects...
  74. ncbi Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells
    George C Cheng
    Joint Center for Radiation Therapy, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Exp Cell Res 300:297-307. 2004
    ....
  75. ncbi Pathophysiology of atherosclerotic plaque development and rupture: an overview
    Luis E P Rohde
    Hospital de Clinicas de Porto Alegre, Medical Post Graduation Program, Medical School of Rio Grande do Sul Federal University, Porto Alegre, Brazil
    Semin Vasc Med 3:347-54. 2003
    ..This article reviews basic pathophysiologic aspects of atherosclerotic plaque development and rupture to provide the necessary background for understanding the crucial role of inflammation in acute coronary syndromes...
  76. pmc TXNIP regulates peripheral glucose metabolism in humans
    Hemang Parikh
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS Med 4:e158. 2007
    ..Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure...
  77. pmc Thioredoxins, mitochondria, and hypertension
    Parth Patwari
    Partners Research Facility, 65 Landsdowne St, Rm 280, Cambridge, MA 02139, USA
    Am J Pathol 170:805-8. 2007
    ....
  78. ncbi Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction
    P Christian Schulze
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 97:418-26. 2005
    ....
  79. ncbi Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells
    Daihiko Hakuno
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 280:39534-44. 2005
    ..These data indicate that FAK is a key regulator of cardiogenesis in mouse ES cells and that FAK signaling within embryoid bodies can direct stem cell lineage commitment...
  80. pmc Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF
    Jun Yoshioka
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Proc Natl Acad Sci U S A 102:10622-7. 2005
    ..These findings demonstrate how cells can coordinate remodeling with their immediate neighboring cells with highly localized extracellular EGF signaling...
  81. pmc Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers
    Patrick C H Hsieh
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 116:237-48. 2006
    ..Furthermore, this study shows that injectable nanofibers allow precise and sustained delivery of proteins to the myocardium with potential therapeutic benefits...
  82. pmc Custom design of the cardiac microenvironment with biomaterials
    Michael E Davis
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Circ Res 97:8-15. 2005
    ..Thus, new rationally-designed biomaterials no longer simply coexist with tissues, but can provide precision bioactive control of the microenvironment that may be required for cardiac regeneration and repair...
  83. ncbi Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction
    Masahisa Shimpo
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 109:2186-90. 2004
    ..Serum levels of ST2 are associated with prognosis in nonischemic heart failure, but the predictive value of ST2 in patients with acute myocardial infarction is unknown...
  84. ncbi Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
    Tomosaburo Takahashi
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 107:1912-6. 2003
    ..In appropriate culture conditions, ES cells can differentiate into specialized cells, including cardiac myocytes, but the efficiency is typically low and the process is incompletely understood...
  85. ncbi Identification of serum soluble ST2 receptor as a novel heart failure biomarker
    Ellen O Weinberg
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 107:721-6. 2003
    ..This study tested the hypothesis that soluble ST2 levels in the serum of patients with severe chronic heart failure are increased in patients with neurohormonal activation...
  86. ncbi Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload
    Ellen O Weinberg
    Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Genomics 12:113-27. 2003
    ..Moreover, sex modifies these responses. Furthermore, these studies have uncovered several novel and potentially important genes that are regulated in response to overload and may open unrecognized avenues for further functional analysis...
  87. ncbi Ask the doctor. I had a blood test for CRP that came back at 1.9, which my doctor said was on the high side. I had it checked again a few weeks later and it was under 1. What does this mean? Should I have it checked again?
    Richard T Lee
    Harv Heart Lett 16:8. 2005