K S Lee

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi MR urography versus retrograde pyelography/ureteroscopy for the exclusion of upper urinary tract malignancy
    K S Lee
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Clin Radiol 65:185-92. 2010
  2. ncbi Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 17:3408-17. 1997
  3. ncbi Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 95:9301-6. 1998
  4. ncbi Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 15:7143-51. 1995
  5. ncbi Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA
    F Niiya
    Laboratory of Cell Biology, National Cancer Institute, NIH Bldg 37, 37 Convent Drive, Bethesda, MD 20892 4256, USA
    Oncogene 25:827-37. 2006
  6. ncbi Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development
    J K Kim
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Shinlim Dong, Seoul 151 742, Republic of Korea
    Mol Cell Biol 21:7787-95. 2001
  7. ncbi A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis
    S Song
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 152:451-69. 2001
  8. ncbi Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures
    S Song
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:286-98. 2000
  9. ncbi Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog
    K S Lee
    Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205
    Mol Cell Biol 12:172-82. 1992
  10. ncbi The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity
    K S Lee
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, Maryland 21205
    J Biol Chem 269:19725-30. 1994

Collaborators

Detail Information

Publications25

  1. ncbi MR urography versus retrograde pyelography/ureteroscopy for the exclusion of upper urinary tract malignancy
    K S Lee
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Clin Radiol 65:185-92. 2010
    ..To evaluate the diagnostic performance of magnetic resonance urography (MRU) versus retrograde pyelography and/or ureteroscopy (RPU) in the detection of upper urinary tract neoplasms...
  2. ncbi Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 17:3408-17. 1997
    ..It appears that the C terminus of Plk is not required for the observed cell cycle influence but may be important for polarized cell growth and septal structure formation...
  3. ncbi Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 95:9301-6. 1998
    ..Our data provide evidence that the polo-box plays a critical role in Plk function, likely by directing its subcellular localization...
  4. ncbi Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 15:7143-51. 1995
    ..In addition, CHO1/MKLP-1 appears to interact with Plk in vivo and to be phosphorylated by Plk-associated kinase activity in vitro...
  5. ncbi Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA
    F Niiya
    Laboratory of Cell Biology, National Cancer Institute, NIH Bldg 37, 37 Convent Drive, Bethesda, MD 20892 4256, USA
    Oncogene 25:827-37. 2006
    ..These results suggest that ECT2 is regulated by Cdk1 and Plk1 in concert...
  6. ncbi Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development
    J K Kim
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Shinlim Dong, Seoul 151 742, Republic of Korea
    Mol Cell Biol 21:7787-95. 2001
    ..Our findings demonstrate that Srg3 is essential for early embryogenesis and plays an important role in the brain development of mice...
  7. ncbi A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis
    S Song
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 152:451-69. 2001
    ..Thus, we propose that Cdc5 may coordinate mitotic exit with cytokinesis by participating in both anaphase promoting complex activation and a polo-box-dependent cytokinetic pathway...
  8. ncbi Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures
    S Song
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:286-98. 2000
    ..These data provide evidence that the polo box is required to direct Cdc5 to specific subcellular locations and induce or organize cytokinetic structures...
  9. ncbi Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog
    K S Lee
    Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205
    Mol Cell Biol 12:172-82. 1992
    ..This region may serve as a hinge between domains whose interaction is regulated by PKC1...
  10. ncbi The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity
    K S Lee
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, Maryland 21205
    J Biol Chem 269:19725-30. 1994
    ..These results indicate that PLB1 is principally responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol...
  11. ncbi A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:5843-53. 1993
    ..Genetic interactions between BCK2 and other pathway components suggested that BCK2 functions on a common pathway branch with PPZ1 and PPZ2...
  12. ncbi Analysis of the structure and expression fo the TFIIB gene in Drosophila melanogaster
    K S Lee
    Department and Institute of Genetic Engineering, Kyung Hee University, Suwon, Korea
    Mol Cells 7:374-9. 1997
    ..Within this minimal promoter region, the upstream regulatory element responsible for the stimulation of gene expression may exist in the DNA fragment between -698 (PsfI) and -351 (StuI)...
  13. ncbi Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase
    T Hara
    Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 25:566-78. 2006
    ..Therefore, ECT2 activity might be regulated by the phosphorylation status of T341. We propose that T341 phosphorylation by Cyclin B/Cdk1 could be a trigger for further activation of ECT2...
  14. ncbi Effects of uwhangchungsimwon on cell viability, proliferation, and gene expression of human neuronal cell line IMR32
    K Song
    Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Am J Chin Med 29:445-58. 2001
    ..Taken together, our data suggest that the pharmacoclinical effects of UC might be derived in part from its negative regulation of cell proliferation and apoptosis through the transcriptional control of related genes...
  15. ncbi A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:3067-75. 1993
    ....
  16. ncbi Internalization of mammalian fluorescent cellular prion protein and N-terminal deletion mutants in living cells
    K S Lee
    Ludwig Institute for Cancer Research, , Rua Antonio Prudente, , Brazil
    J Neurochem 79:79-87. 2001
    ..Our data suggest that GFP-PrP(c) can be used to follow constitutive and induced PrP(c) traffic in living cells...
  17. ncbi Molecular cloning and functional expression of bovine brain GABA transaminase
    S G Jeon
    Department of Genetic Engineering, Hallym University, Chunchon, Korea
    Mol Cells 12:91-6. 2001
    ..coli using the pGEX bacterial- expression vector system. The overexpressed GABA-T was enzymatically active after purification, and it had very similar kinetic parameters when compared with those of other mammalian GABA-Ts...
  18. ncbi Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds
    E I Hwang
    Antibiotics Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon, Korea
    Planta Med 67:501-4. 2001
    ..The inhibition appears to be selective for chitin synthase II, as they did not appreciably inhibit chitin synthase III...
  19. ncbi Intimate relationship between TGF-beta/BMP signaling and runt domain transcription factor, PEBP2/CBF
    S C Bae
    Department of Biochemistry, School of Medicine, and Medical Research Institute, Chungbuk National University, Cheongju, Korea
    J Bone Joint Surg Am 83:S48-55. 2001
    ..CONCLUSIONS: Both TGF-beta and BMP activate transcription of RUNX2, which is sufficient to inhibit myogenesis. To induce osteogenesis, BMP-induced RUNX2 must cooperate with BMP-activated Smads...
  20. ncbi MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C
    K Irie
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Mol Cell Biol 13:3076-83. 1993
    ..Genetic epistasis experiments indicated that the site of action for MKK1 and MKK2 is between BCK1 and MPK1...
  21. ncbi Dual transcriptional regulation of the Escherichia coli phosphate-starvation-inducible psiE gene of the phosphate regulon by PhoB and the cyclic AMP (cAMP)-cAMP receptor protein complex
    S K Kim
    Research Center for Biomedicinal Resources Bio Med RRC, Paichai University, Taejon 302 735, Korea
    J Bacteriol 182:5596-9. 2000
    ..These results, together with measurements of the in vivo psiE promoter activity under various conditions, show that expression of the psiE gene is under direct positive and negative control by PhoB and cAMP-CRP, respectively...
  22. ncbi A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae
    P Chen
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, MD 21205
    Mol Gen Genet 236:443-7. 1993
    ..The YPK1 gene was mapped to the left arm of chromosome XI and YPK2 was mapped to the right arm of chromosome XIII...
  23. ncbi Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)
    M E Shuck
    Department of Cell Biology and Inflammation Research, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan 49007, USA
    J Biol Chem 272:586-93. 1997
    ..Co-expression of Kir1.3 with either Kir1.1 or Kir1.2 reduced currents resulting from expression of these inward-rectifier subunits alone, consistent with a dominant negative influence on Kir1.1 and Kir1.2 expression...
  24. ncbi Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit
    J W Kim
    Molecular and Cellular Biology Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
    Biochem Mol Biol Int 43:669-75. 1997
    ..The expression level of the 0.7 kb mRNA in heart, skeletal muscle, and brain was higher than in other organs. Human MLRQ cDNA could cross-hybridize with the genomic DNAs from various species...
  25. ncbi Isolation of cDNA clones encoding human histone macroH2A1 subtypes
    Y Lee
    Molecular and Cellular Biology Research Group, Korea Research Institute of Bioscience and Biotechnology, Taejon, South Korea
    Biochim Biophys Acta 1399:73-7. 1998
    ..Northern blot analysis showed that the macroH2A1.1 and macroH2A1.2 subtypes were expressed as mRNA species with a size of 1.5 and 4.4 kb, respectively. They were expressed in all human tissues examined...