K R Lee

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia
    Lutz Riethdorf
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 33:899-904. 2002
  2. ncbi request reprint The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases
    Kenneth R Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 27:281-92. 2003
  3. ncbi request reprint Early invasive adenocarcinoma of the cervix
    K R Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer 89:1048-55. 2000
  4. ncbi request reprint Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'
    K R Lee
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 24:1447-64. 2000
  5. ncbi request reprint Stage IA1 cervical adenocarcinoma: definition and treatment
    J O Schorge
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 93:219-22. 1999
  6. ncbi request reprint Early cervical adenocarcinoma: selection criteria for radical surgery
    J O Schorge
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
    Obstet Gynecol 94:386-90. 1999
  7. ncbi request reprint Pathologic findings in eight cases of ovarian serous borderline tumors, three with foci of serous carcinoma, that preceded death or morbidity from invasive carcinoma
    K R Lee
    Women's and Perinatal Division, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
    Int J Gynecol Pathol 20:329-34. 2001
  8. ncbi request reprint k-ras mutation may be an early event in mucinous ovarian tumorigenesis
    A P Garrett
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, USA
    Int J Gynecol Pathol 20:244-51. 2001
  9. ncbi request reprint Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases
    J F Krane
    Division of Cytology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 93:8-15. 2001
  10. ncbi request reprint Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AIS
    Agnieszka Witkiewicz
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:1609-14. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia
    Lutz Riethdorf
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 33:899-904. 2002
    ..Because endometrial glandular epithelia may also express p16, the diagnostic application of p16 immunohistochemistry to cytological samples is uncertain...
  2. ncbi request reprint The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases
    Kenneth R Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 27:281-92. 2003
    ..Careful gross evaluation is also important with special attention paid to the external surface of the ovarian tumor(s) to detect abnormalities that have the features of surface implants on microscopic evaluation...
  3. ncbi request reprint Early invasive adenocarcinoma of the cervix
    K R Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer 89:1048-55. 2000
    ..Adenocarcinoma of the cervix is increasing in frequency. There is a dearth of specific detail concerning the histomorphology, histogenesis, and associated findings in early invasive cervical adenocarcinoma...
  4. ncbi request reprint Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'
    K R Lee
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 24:1447-64. 2000
    ..Adequate and sometimes extensive sampling of mucinous ovarian tumors, the appendix and the peritoneum in cases of "pseudomyxoma peritonei" is necessary to achieve an accurate diagnosis and prognosis...
  5. ncbi request reprint Stage IA1 cervical adenocarcinoma: definition and treatment
    J O Schorge
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 93:219-22. 1999
    ....
  6. ncbi request reprint Early cervical adenocarcinoma: selection criteria for radical surgery
    J O Schorge
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
    Obstet Gynecol 94:386-90. 1999
    ..To identify selection criteria for radical surgery in early cervical adenocarcinoma based on pretreatment clinical stage and correlation with high-risk surgical-pathologic factors...
  7. ncbi request reprint Pathologic findings in eight cases of ovarian serous borderline tumors, three with foci of serous carcinoma, that preceded death or morbidity from invasive carcinoma
    K R Lee
    Women's and Perinatal Division, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
    Int J Gynecol Pathol 20:329-34. 2001
    ..The carcinomas may be preceded or accompanied by noninvasive-appearing micropapillary foci in the peritoneum in some cases, but micropapillary foci in the ovarian tumors are infrequent and not a necessary antecedent...
  8. ncbi request reprint k-ras mutation may be an early event in mucinous ovarian tumorigenesis
    A P Garrett
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, USA
    Int J Gynecol Pathol 20:244-51. 2001
    ..k-ras mutations, when they occur, are likely early genetic changes but may not alone be sufficient for malignant transformation of ovarian epithelium...
  9. ncbi request reprint Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases
    J F Krane
    Division of Cytology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 93:8-15. 2001
    ..Papanicolaou smear sensitivity for cervical adenocarcinoma (CVCA) is not well established. Also uncertain are the relative contributions to falsely negative diagnoses of sampling, screening, and interpretive errors...
  10. ncbi request reprint Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AIS
    Agnieszka Witkiewicz
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:1609-14. 2005
    ..Superficial AIS should be suspected in endocervical columnar epithelium with segmental nuclear hyperchromasia with mitotic activity, and confirmed by biomarker staining (p16 and Mib-1) if the pathologist is uncertain of the diagnosis...
  11. ncbi request reprint Type-specific HPV testing as a predictor of high-grade squamous intraepithelial lesion outcome after cytologic abnormalities
    Fabiola Medeiros
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02130, USA
    J Low Genit Tract Dis 9:154-9. 2005
    ..This study addressed whether type-specific HPV testing predicts risk of biopsy outcome of high-grade cervical intraepithelial neoplasia (CIN 2,3)...
  12. ncbi request reprint Dynamics of human papillomavirus infection between biopsy and excision of cervical intraepithelial neoplasia: results from the ZYC101a protocol
    Christopher P Crum
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusettsm USA
    J Infect Dis 189:1348-54. 2004
    ..Little is known about the dynamics of human papillomavirus (HPV) during the follow-up of cervical intraepithelial neoplasia (CIN) 2/3 after biopsy...
  13. ncbi request reprint Atypical glandular cells of undetermined significance. Outcome predictions based on human papillomavirus testing
    Jeffrey F Krane
    Divisions of Women s and Perinatal Pathology and Cytology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Pathol 121:87-92. 2004
    ..However, noncervical or other HPV-negative glandular neoplasia must be considered in all patients with AGC, particularly older patients...
  14. ncbi request reprint Ovarian mucinous and mixed epithelial carcinomas of mullerian (endocervical-like) type: a clinicopathologic analysis of four cases of an uncommon variant associated with endometriosis
    Kenneth R Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 22:42-51. 2003
    ..To better understand their clinicopathologic features and pathogenesis, this uncommon variant should be separated from the usual type in future studies of mucinous carcinomas of the ovary...
  15. ncbi request reprint Symposium part 4: Should pathologists diagnose endocervical preneoplastic lesions "less than" adenocarcinoma in situ?: Counterpoint
    Kenneth R Lee
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 22:22-4. 2003
    ..An opinion is offered favoring the latter approach...
  16. ncbi request reprint Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations
    Jonathan L Hecht
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 96:1-4. 2002
    ..The authors compared outcomes after AGUS interpreted in TP specimens and conventional smear preparations (CPs)...
  17. ncbi request reprint Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas
    Colleen M Feltmate
    Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Cancer Res 11:7651-7. 2005
    ..The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin...
  18. ncbi request reprint Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study
    Diego H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 21:4-10. 2002
    ..EMA positivity was present in all 30 EMCAs and in 26 of 29 (90%) CCAs. We conclude that VIM and CEA are useful immunohistochemical markers in distinguishing EMCAs and CCAs, but CK7, CK20, and EMA are not useful in this distinction...
  19. doi request reprint Histologic and immunohistochemical decision-making in endometrial adenocarcinoma
    Lesley Lomo
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 21:937-42. 2008
    ..Because p53 is an important marker for endometrial adenocarcinoma outcome, and cannot be predicted in advance in indeterminate cases, p53 immunostaining should be employed in cases with observer disagreement in a binary system...