Research Topics
| K R LeeSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Human papillomaviruses, expression of p16, and early endocervical glandular neoplasiaLutz Riethdorf
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Hum Pathol 33:899-904. 2002..Because endometrial glandular epithelia may also express p16, the diagnostic application of p16 immunohistochemistry to cytological samples is uncertain...- The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 casesKenneth R Lee
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Surg Pathol 27:281-92. 2003..Careful gross evaluation is also important with special attention paid to the external surface of the ovarian tumor(s) to detect abnormalities that have the features of surface implants on microscopic evaluation... - Early invasive adenocarcinoma of the cervixK R Lee
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Cancer 89:1048-55. 2000..Adenocarcinoma of the cervix is increasing in frequency. There is a dearth of specific detail concerning the histomorphology, histogenesis, and associated findings in early invasive cervical adenocarcinoma... - Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'K R Lee
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Surg Pathol 24:1447-64. 2000..Adequate and sometimes extensive sampling of mucinous ovarian tumors, the appendix and the peritoneum in cases of "pseudomyxoma peritonei" is necessary to achieve an accurate diagnosis and prognosis... - Stage IA1 cervical adenocarcinoma: definition and treatmentJ O Schorge
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Obstet Gynecol 93:219-22. 1999.... - Early cervical adenocarcinoma: selection criteria for radical surgeryJ O Schorge
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
Obstet Gynecol 94:386-90. 1999..To identify selection criteria for radical surgery in early cervical adenocarcinoma based on pretreatment clinical stage and correlation with high-risk surgical-pathologic factors... - Pathologic findings in eight cases of ovarian serous borderline tumors, three with foci of serous carcinoma, that preceded death or morbidity from invasive carcinomaK R Lee
Women's and Perinatal Division, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Int J Gynecol Pathol 20:329-34. 2001..The carcinomas may be preceded or accompanied by noninvasive-appearing micropapillary foci in the peritoneum in some cases, but micropapillary foci in the ovarian tumors are infrequent and not a necessary antecedent... - k-ras mutation may be an early event in mucinous ovarian tumorigenesisA P Garrett
Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, USA
Int J Gynecol Pathol 20:244-51. 2001..k-ras mutations, when they occur, are likely early genetic changes but may not alone be sufficient for malignant transformation of ovarian epithelium... - Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 casesJ F Krane
Division of Cytology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer 93:8-15. 2001..Papanicolaou smear sensitivity for cervical adenocarcinoma (CVCA) is not well established. Also uncertain are the relative contributions to falsely negative diagnoses of sampling, screening, and interpretive errors... - Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AISAgnieszka Witkiewicz
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 29:1609-14. 2005..Superficial AIS should be suspected in endocervical columnar epithelium with segmental nuclear hyperchromasia with mitotic activity, and confirmed by biomarker staining (p16 and Mib-1) if the pathologist is uncertain of the diagnosis... - Type-specific HPV testing as a predictor of high-grade squamous intraepithelial lesion outcome after cytologic abnormalitiesFabiola Medeiros
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02130, USA
J Low Genit Tract Dis 9:154-9. 2005..HPV 53 merits designation as a high-risk HPV based only [corrected] on the proportion of CIN 2,3 in follow-up biopsy... - Dynamics of human papillomavirus infection between biopsy and excision of cervical intraepithelial neoplasia: results from the ZYC101a protocolChristopher P Crum
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusettsm USA
J Infect Dis 189:1348-54. 2004..Little is known about the dynamics of human papillomavirus (HPV) during the follow-up of cervical intraepithelial neoplasia (CIN) 2/3 after biopsy... - Atypical glandular cells of undetermined significance. Outcome predictions based on human papillomavirus testingJeffrey F Krane
Divisions of Women's and Perinatal Pathology and Cytology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA
Am J Clin Pathol 121:87-92. 2004..However, noncervical or other HPV-negative glandular neoplasia must be considered in all patients with AGC, particularly older patients... - Ovarian mucinous and mixed epithelial carcinomas of mullerian (endocervical-like) type: a clinicopathologic analysis of four cases of an uncommon variant associated with endometriosisKenneth R Lee
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 22:42-51. 2003..To better understand their clinicopathologic features and pathogenesis, this uncommon variant should be separated from the usual type in future studies of mucinous carcinomas of the ovary... - Symposium part 4: Should pathologists diagnose endocervical preneoplastic lesions "less than" adenocarcinoma in situ?: CounterpointKenneth R Lee
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 22:22-4. 2003..An opinion is offered favoring the latter approach... - Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparationsJonathan L Hecht
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Cancer 96:1-4. 2002..027% of all cases using TPs and in 0.025% of all cases using CPs. CONCLUSIONS: The use of TPs may increase the diagnostic specificity of AGUS for a high-grade precursor lesion or carcinoma... - Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomasColleen M Feltmate
Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Cancer Res 11:7651-7. 2005..The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin... - Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical studyDiego H Castrillon
Women's and Perinatal Pathology Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 21:4-10. 2002..EMA positivity was present in all 30 EMCAs and in 26 of 29 (90%) CCAs. We conclude that VIM and CEA are useful immunohistochemical markers in distinguishing EMCAs and CCAs, but CK7, CK20, and EMA are not useful in this distinction... 
Histologic and immunohistochemical decision-making in endometrial adenocarcinomaLesley Lomo
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 21:937-42. 2008..Because p53 is an important marker for endometrial adenocarcinoma outcome, and cannot be predicted in advance in indeterminate cases, p53 immunostaining should be employed in cases with observer disagreement in a binary system...