JEANNIE LEE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Regulation of X-chromosome counting by Tsix and Xite sequences
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School Boston, MA 02114, USA
    Science 309:768-71. 2005
  2. pmc X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
    Eda Yildirim
    Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Nat Struct Mol Biol 19:56-61. 2012
  3. pmc Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain
    Montserrat C Anguera
    Howard Hughes Medical Institute, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002248. 2011
  4. doi request reprint X-inactivation, imprinting, and long noncoding RNAs in health and disease
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 152:1308-23. 2013
  5. doi request reprint Epigenetic regulation by long noncoding RNAs
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02138, USA
    Science 338:1435-9. 2012
  6. pmc Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient
    Janice Y Ahn
    Department of Molecular Biology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School Boston, MA 02114 USA
    BMC Dev Biol 10:90. 2010
  7. pmc Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:3836-41. 1999
  8. pmc Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 23:1831-42. 2009
  9. pmc The X as model for RNA's niche in epigenomic regulation
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 2:a003749. 2010
  10. ncbi request reprint Tsix, a gene antisense to Xist at the X-inactivation centre
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Nat Genet 21:400-4. 1999

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Regulation of X-chromosome counting by Tsix and Xite sequences
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School Boston, MA 02114, USA
    Science 309:768-71. 2005
    ..The mutations affect XX and XY cells differently, demonstrating that counting and choice are regulated not by one "blocking factor," but by both a "blocking" and a "competence" factor...
  2. pmc X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
    Eda Yildirim
    Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Nat Struct Mol Biol 19:56-61. 2012
    ..Thus, Xa upregulation involves combined increases of active histone marks and Pol II occupancy, without invoking X-specific dependencies between chromatin states and transcription...
  3. pmc Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain
    Montserrat C Anguera
    Howard Hughes Medical Institute, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002248. 2011
    ..Combined, our study indicates that Tsx performs general functions in multiple cell types and links the noncoding locus to stem and germ cell development, learning, and behavior in mammals...
  4. doi request reprint X-inactivation, imprinting, and long noncoding RNAs in health and disease
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 152:1308-23. 2013
    ..Here, we review recent advances in basic biology, the connections to disease, and preview potential therapeutic strategies for future development...
  5. doi request reprint Epigenetic regulation by long noncoding RNAs
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02138, USA
    Science 338:1435-9. 2012
    ....
  6. pmc Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient
    Janice Y Ahn
    Department of Molecular Biology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School Boston, MA 02114 USA
    BMC Dev Biol 10:90. 2010
    ..Here, we investigate if different methods of cell differentiation and use of all -trans retinoic acid (RA) could be causative factors and how they might impact Xist expression...
  7. pmc Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:3836-41. 1999
    ..Analysis of multiple Xic constructs and insertion sites indicated that long-range Xic effects can be generalized to different autosomes, thereby supporting the feasibility of a Tg-based approach for studying X inactivation...
  8. pmc Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 23:1831-42. 2009
    ..These properties imply that long noncoding transcripts may ultimately rival small RNAs and proteins in their versatility as epigenetic regulators, particularly for locus- and allele-specific control...
  9. pmc The X as model for RNA's niche in epigenomic regulation
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 2:a003749. 2010
    ..Thus, like their small RNA cousins, long ncRNAs may emerge as versatile and powerful regulators of the epigenome...
  10. ncbi request reprint Tsix, a gene antisense to Xist at the X-inactivation centre
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Nat Genet 21:400-4. 1999
    ..Tsix is not found on the inactive X once cells enter the X-inactivation pathway. Tsix has features suggesting a role in regulating the early steps of X inactivation, but not the silencing step...
  11. ncbi request reprint Targeted mutagenesis of Tsix leads to nonrandom X inactivation
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02115, USA
    Cell 99:47-57. 1999
    ..Therefore, counting, choice, and silencing are genetically separable. Contrasting effects in XX and XY cells argue that negative and positive factors are involved in choosing active and inactive Xs...
  12. ncbi request reprint Disruption of imprinted X inactivation by parent-of-origin effects at Tsix
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Cell 103:17-27. 2000
    ..These results highlight differences between imprinted and random X inactivation but show that Tsix regulates both. We propose that an imprinting center lies within Tsix...
  13. doi request reprint Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Mol Cell Biol 12:815-26. 2011
    ....
  14. ncbi request reprint Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein
    Na Xu
    Howard Hughes Medical Institute Department of Molecular Biology, Massachusetts General Hospital Department of Genetics, Harvard Medical School Boston, Massachusetts 02114, USA
    Nat Genet 39:1390-6. 2007
    ..The kinetics suggest a pairing half-life of <1 h. We propose that pairing requires Ctcf binding and co-transcriptional activity of Tsix and Xite...
  15. pmc Two-step imprinted X inactivation: repeat versus genic silencing in the mouse
    Satoshi H Namekawa
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Mol Cell Biol 30:3187-205. 2010
    ..Our model incorporates aspects of the so-called classical, de novo, and preinactivation hypotheses and suggests that Xist RNA functions relatively late during preimplantation mouse development...
  16. ncbi request reprint Xite, X-inactivation intergenic transcription elements that regulate the probability of choice
    Yuya Ogawa
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Mol Cell 11:731-43. 2003
    ..We propose that allele-specific Xite action promotes Tsix asymmetry and generates X chromosome inequality. Therefore, Xite is a candidate for the Xce, the classical modifier of XCI ratios...
  17. ncbi request reprint Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos
    Khanh D Huynh
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 426:857-62. 2003
    ..We propose that imprinted X inactivation results from inheritance of a pre-inactivated X chromosome from the paternal germ line...
  18. ncbi request reprint Transient homologous chromosome pairing marks the onset of X inactivation
    Na Xu
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School Boston, MA 02114, USA
    Science 311:1149-52. 2006
    ..Thus, Tsix and Xite function both in cis and in trans. We propose that Tsix and Xite regulate counting and mutually exclusive choice through X-X pairing...
  19. ncbi request reprint CTCF, a candidate trans-acting factor for X-inactivation choice
    Wendy Chao
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Science 295:345-7. 2002
    ..In vitro binding is reduced by CpG methylation and abolished by including non-CpG methylation. We postulate that Tsix and CTCF together establish a regulatable epigenetic switch for X-inactivation...
  20. ncbi request reprint Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice
    Shinwa Shibata
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Biol 14:1747-54. 2004
    ..We conclude that the processed antisense RNA does not act alone and that Tsix function specifically requires antiparallel transcription through Xist. A mechanism of transcription-based feedback regulation is proposed...
  21. ncbi request reprint The DXPas34 repeat regulates random and imprinted X inactivation
    Dena E Cohen
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Dev Cell 12:57-71. 2007
    ..Intriguingly, sequence analysis suggests that DXPas34 could potentially have descended from an ancient retrotransposon. We hypothesize that DXPas34 was acquired by Tsix to regulate antisense function...
  22. pmc New twists in X-chromosome inactivation
    Jennifer A Erwin
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
    Curr Opin Cell Biol 20:349-55. 2008
    ..These findings have impacted our understanding of general gene regulation and are discussed herein...
  23. pmc Telomeric RNAs mark sex chromosomes in stem cells
    Li Feng Zhang
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114 and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114
    Genetics 182:685-98. 2009
    ..Furthermore, RNA accumulation increases in Dicer-deficient stem cells, suggesting direct or indirect links to RNAi. We propose that telomeric RNAs are tied to cell differentiation and may be used to mark pluripotency and disease...
  24. doi request reprint X chromosome dosage compensation: how mammals keep the balance
    Bernhard Payer
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Genet 42:733-72. 2008
    ..Here, we review various facets of the ever-expanding field of mammalian dosage compensation and discuss its evolutionary, developmental, and mechanistic components...
  25. ncbi request reprint Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Genet 32:195-200. 2002
    ....
  26. pmc Functional intergenic transcription: a case study of the X-inactivation centre
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Philos Trans R Soc Lond B Biol Sci 358:1417-23; discussion 1423. 2003
    ..It seems likely that intergenic transcription will turn out to be a widespread phenomenon in mammals and that, more importantly, it will emerge as a significant regulatory mechanism for the expression of coding sequences...
  27. ncbi request reprint Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting?
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Curr Biol 13:R242-54. 2003
    ..I propose that imprinting was first fixed on the X chromosome for XCI and subsequently acquired by autosomes...
  28. ncbi request reprint Characterization and quantitation of differential Tsix transcripts: implications for Tsix function
    Shinwa Shibata
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Hum Mol Genet 12:125-36. 2003
    ..9 kb region of complementarity between sense and antisense RNAs. Implications for Tsix's possible mechanisms of action are discussed...
  29. ncbi request reprint Is X-chromosome inactivation a homology effect?
    Jeannie T Lee
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, and Massachusetts General Hospital, Boston 02114, USA
    Adv Genet 46:25-48. 2002
  30. ncbi request reprint X-chromosome inactivation and the search for chromosome-wide silencers
    Dena E Cohen
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Genet Dev 12:219-24. 2002
    ..As none of the silencing proteins identified so far is unique to X chromosome inactivation, the specificity must partly reside in Xist RNA whose spread along the X orchestrates general silencing factors for this specific task...
  31. ncbi request reprint Sex chromosome inactivation: the importance of pairing
    Jeannie T Lee
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Biol 15:R249-52. 2005
    ..Why and how does this happen? The answer apparently lies in whether a chromosome finds a pairing partner. Similar mechanisms in mold and worms reveal a surprising and recurrent theme throughout evolution...
  32. pmc Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation
    Nicholas Stavropoulos
    Howard Hughes Medical Institute, Boston, MA 02114, USA
    Mol Cell Biol 25:2757-69. 2005
    ..Characterization of these enhancers will facilitate the identification of trans-acting regulatory factors for X chromosome counting and choice...
  33. pmc X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells
    Susana S Silva
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:4820-5. 2008
    ..We conclude that hESC lines are subject to dynamic epigenetic reprogramming ex vivo. Given that XCI and cell differentiation are tightly linked, we consider implications for hESC pluripotency and differentiation potential...
  34. ncbi request reprint Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Mol Cell 25:43-56. 2007
    ..Yy1 and Ctcf associate through specific protein-protein interactions and together transactivate Tsix. We propose that the Ctcf-Yy1-Tsix complex functions as a key component of the X chromosome binary switch...
  35. pmc Intersection of the RNA interference and X-inactivation pathways
    Yuya Ogawa
    Department of Molecular Biology, Massachusetts General Hospital and Howard Hughes Medical Institute, Boston, MA 02114, USA
    Science 320:1336-41. 2008
    ..The defects are partially rescued by truncating Tsix. Thus, XCI and RNAi intersect, down-regulating Xist on Xa and spreading silencing on Xi...
  36. ncbi request reprint A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization
    Bryan K Sun
    Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, 02114, USA
    Mol Cell 21:617-28. 2006
    ..This state persists through XCI establishment and "reverts" to a euchromatic state during XCI maintenance. We have therefore identified chromatin marks that preempt and predict asymmetric Xist expression...
  37. ncbi request reprint The search for a marsupial XIC reveals a break with vertebrate synteny
    Lance S Davidow
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Chromosome Res 15:137-46. 2007
    ..The latter argues that marsupial XCI does not require XIST and opens the search for alternative mechanisms of dosage compensation...
  38. ncbi request reprint Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing
    Li Feng Zhang
    Howard Hughes Medical Institute, Boston, MA 02114 USA
    Cell 129:693-706. 2007
    ..We propose that the Xi must continuously visit the perinucleolar compartment to maintain its epigenetic state. These data raise a mechanism by which chromatin states can be replicated by spatial and temporal separation in the nucleus...
  39. pmc Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    Jing Zhao
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Science 322:750-6. 2008
    ..Likewise, PRC2 deficiency compromises Xist up-regulation. Therefore, RepA, together with PRC2, is required for the initiation and spread of XCI. We conclude that a ncRNA cofactor recruits Polycomb complexes to their target locus...
  40. pmc Mapping of DNA replication origins to noncoding genes of the X-inactivation center
    Rebecca K Rowntree
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 26:3707-17. 2006
    ..Location and/or activity of ORIs appear to be modulated by removal of specific Xic elements. These data provide a foundation for testing potential relationships between DNA replication and epigenetic regulation in future studies...
  41. ncbi request reprint Postmeiotic sex chromatin in the male germline of mice
    Satoshi H Namekawa
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 16:660-7. 2006
    ..We conclude that chromosome-wide X silencing continues from meiosis to the end of spermiogenesis, and we discuss implications for proposed mechanisms of imprinted X-inactivation...
  42. pmc Characterization of two Mst1-deficient mouse models
    Montserrat C Anguera
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Dev Dyn 237:3424-34. 2008
    ..Thus, a mutation in Mst1 alone does not affect survival. Our results set the stage for identification of the lethal second-site mutation that is paradoxically favored for transmission...
  43. pmc The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Nature 460:128-32. 2009
    ..Thus, we have identified the first trans-factor that regulates counting, and ascribed new functions to Oct4 during X-chromosome reprogramming...
  44. pmc Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice
    Rebecca Maxfield Boumil
    Department of Molecular Biology, Howard Hughes Medical Institute, Massachusetts General Hospital, Simches 6 624, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 26:2109-17. 2006
    ..The discovery of DMDs in CTCF sites draws further parallels between X-inactivation and autosomal imprinting...
  45. pmc Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Cell 16:425-38. 2009
    ..Approximately 30% of human HCCs show low Yap1(Ser127) phosphorylation and a majority exhibit loss of cleaved, activated Mst1. Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC...
  46. ncbi request reprint X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny
    Khanh D Huynh
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Genet 6:410-8. 2005
    ..Here, we propose that X-chromosome inactivation and imprinting might have evolved from an ancient genome-defence mechanism that silences unpaired DNA...
  47. pmc Characterization of X-chromosome inactivation status in human pluripotent stem cells
    Jennifer A Erwin
    Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2010
    ..Because the different steps of XCI are some of the first epigenetic changes to take place in differentiating hESC, analysis of the XCI state provides a first indication of an hESC culture's overall health...
  48. pmc Sex chromosome silencing in the marsupial male germ line
    Satoshi H Namekawa
    Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:9730-5. 2007
    ..These results reveal a common gametogenic program in two diverse clades of mammals and support the idea that male germ-line silencing may have provided an ancestral form of mammalian dosage compensation...
  49. pmc The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation
    Di Tian
    Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:390-403. 2010
    ..Furthermore, ΔJpx is rescued by truncating Tsix, indicating an antagonistic relationship between the ncRNAs. We conclude that Xist is controlled by two RNA-based switches: Tsix for Xa and Jpx for Xi...
  50. ncbi request reprint Molecular biology: Complicity of gene and pseudogene
    Jeannie T Lee
    Nature 423:26-8. 2003
  51. ncbi request reprint X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation
    Laura P O'Neill
    Chromatin and Gene Expression Group, Anatomy Department, University of Birmingham Medical School, Birmingham B15 2TT, UK
    Hum Mol Genet 12:1783-90. 2003
    ..We suggest that the mark forms part of a chromatin-based mechanism that restricts X-inactivation to cells with more than one X chromosome...
  52. ncbi request reprint Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Development 133:4203-10. 2006
    ..Our findings establish a model for how epigenetic gene silencing by non-coding RNA may depend on distance from the non-coding RNA and on lineage and differentiation specific factors...
  53. pmc A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis
    Shinseog Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e62. 2007
    ..In addition, because it is found in all branches of mammals, but not in other vertebrates, Dmrt7 may shed light on evolution of meiosis and of sex chromatin...
  54. pmc Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes
    Hong Lin
    Chromatin and Gene Expression Group, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    PLoS Biol 5:e326. 2007
    ....
  55. pmc Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus
    Anders M Lindroth
    Division of Nutritional Sciences, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000145. 2008
    ..These data reveal the previously unknown antagonism between H3K27 and DNA methylation and identify a means by which epigenetic states may change during disease and development...
  56. ncbi request reprint Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...

Research Grants19

  1. Polycomb complexes targeted to specific loci by non-coding RNA co-factors
    Jeannie T Lee; Fiscal Year: 2010
    ....
  2. Regulation of X-Chromosome Inactivation and Imprinting by Non-coding Elements
    Jeannie T Lee; Fiscal Year: 2010
    ..It will also enhance our understanding of basic biological processes, especially those involving chromosome dynamics, ncRNA regulation, and transgenerational inheritance. ..
  3. GENETIC ANALYSIS OF THE X-CHROMOSOME INACTIVATION CENTER
    JEANNIE LEE; Fiscal Year: 1999
    ..Once required Xic subregions and Xist domains are uncovered, effort will be directed towards cloning of essential elements and isolation of interacting factors. ..
  4. Regulation of X-Chromosome Inactivation and Imprinting by Non-coding Elements
    JEANNIE LEE; Fiscal Year: 2009
    ..It will also enhance our understanding of basic biological processes, especially those involving chromosome dynamics, ncRNA regulation, and transgenerational inheritance. ..
  5. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2007
    ..abstract_text> ..
  6. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2006
    ..Information gained from the research program will also have significant impact on human genetics, cancer, and animal cloning, as well as on the basic biology of chromosomes, chromatin structure, and transcriptional regulation. ..
  7. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2007
    ..Information gained from the research program will also have significant impact on human genetics, cancer, and animal cloning, as well as on the basic biology of chromosomes, chromatin structure, and transcriptional regulation. ..
  8. Regulation of X-Chromosome Inactivation and Imprinting by Non-coding Elements
    JEANNIE LEE; Fiscal Year: 2009
    ..It will also enhance our understanding of basic biological processes, especially those involving chromosome dynamics, ncRNA regulation, and transgenerational inheritance. ..
  9. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2005
    ..Information gained from the research program will also have significant impact on human genetics, cancer, and animal cloning, as well as on the basic biology of chromosomes, chromatin structure, and transcriptional regulation. ..
  10. GENETIC ANALYSIS OF THE X-CHROMOSOME INACTIVATION CENTER
    JEANNIE LEE; Fiscal Year: 2000
    ..Once required Xic subregions and Xist domains are uncovered, effort will be directed towards cloning of essential elements and isolation of interacting factors. ..
  11. Emerging Mechanisms of Epigenetic Regulation
    JEANNIE LEE; Fiscal Year: 2003
    ..Appreciate the agricultural implications of epigenetics, such as those relating to plant viral defense mechanisms, animal cloning, and imprinting. ..
  12. GENETIC ANALYSIS OF THE X-CHROMOSOME INACTIVATION CENTER
    JEANNIE LEE; Fiscal Year: 2002
    ..Once required Xic subregions and Xist domains are uncovered, effort will be directed towards cloning of essential elements and isolation of interacting factors. ..
  13. GENETIC ANALYSIS OF THE X-CHROMOSOME INACTIVATION CENTER
    JEANNIE LEE; Fiscal Year: 2001
    ..Once required Xic subregions and Xist domains are uncovered, effort will be directed towards cloning of essential elements and isolation of interacting factors. ..
  14. GENETIC ANALYSIS OF THE X-CHROMOSOME INACTIVATION CENTER
    JEANNIE LEE; Fiscal Year: 2003
    ..Once required Xic subregions and Xist domains are uncovered, effort will be directed towards cloning of essential elements and isolation of interacting factors. ..
  15. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2004
    ..Information gained from the research program will also have significant impact on human genetics, cancer, and animal cloning, as well as on the basic biology of chromosomes, chromatin structure, and transcriptional regulation. ..
  16. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2005
    ..Information gained from the research program will also have significant impact on human genetics, cancer, and animal cloning, as well as on the basic biology of chromosomes, chromatin structure, and transcriptional regulation. ..
  17. Regulation of X-Inactivation by Non-Coding RNA Loci
    JEANNIE LEE; Fiscal Year: 2006
    ..Information gained from the research program will also have significant impact on human genetics, cancer, and animal cloning, as well as on the basic biology of chromosomes, chromatin structure, and transcriptional regulation. ..