I Min Lee

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Dairy products, calcium and prostate cancer risk
    K A Koh
    Harvard University, 8 Garden Street, Cambridge, MA 02138, USA
    Br J Cancer 95:1582-5. 2006
  2. pmc Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 380:219-29. 2012
  3. doi request reprint Physical activity and inflammation in a multiethnic cohort of women
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Med Sci Sports Exerc 44:1088-96. 2012
  4. ncbi request reprint Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
  5. pmc No pain, no gain? Thoughts on the Caerphilly study
    I M Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Br J Sports Med 38:4-5. 2004
  6. doi request reprint Physical activity and cardiac protection
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Curr Sports Med Rep 9:214-9. 2010
  7. pmc Physical activity and weight gain prevention
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 303:1173-9. 2010
  8. ncbi request reprint The "weekend warrior" and risk of mortality
    I Min Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 160:636-41. 2004
  9. pmc The built environment and physical activity levels: the Harvard Alumni Health Study
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Prev Med 37:293-8. 2009
  10. ncbi request reprint The importance of walking to public health
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Med Sci Sports Exerc 40:S512-8. 2008

Research Grants

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. pmc Dairy products, calcium and prostate cancer risk
    K A Koh
    Harvard University, 8 Garden Street, Cambridge, MA 02138, USA
    Br J Cancer 95:1582-5. 2006
    ..23 and 0.64, respectively), or calcium supplements was associated with prostate cancer risk (relative risk, 1.05; 95% confidence interval, 0.84-1.31)...
  2. pmc Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 380:219-29. 2012
    ....
  3. doi request reprint Physical activity and inflammation in a multiethnic cohort of women
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Med Sci Sports Exerc 44:1088-96. 2012
    ..The purpose of this study was to examine the associations between physical activity and inflammation assessed at two time points among women of different race/ethnicities...
  4. ncbi request reprint Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
    ..Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons...
  5. pmc No pain, no gain? Thoughts on the Caerphilly study
    I M Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Br J Sports Med 38:4-5. 2004
  6. doi request reprint Physical activity and cardiac protection
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Curr Sports Med Rep 9:214-9. 2010
    ..Among patients with established coronary artery disease, physical activity also reduces all-cause and cardiovascular disease mortality rates...
  7. pmc Physical activity and weight gain prevention
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 303:1173-9. 2010
    ..In 2008, federal guidelines recommended at least 150 minutes per week (7.5 metabolic equivalent [MET] hours per week) of moderate-intensity activity for "substantial health benefits."..
  8. ncbi request reprint The "weekend warrior" and risk of mortality
    I Min Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 160:636-41. 2004
    ..However, among those with no major risk factors, even 1-2 episodes/week generating 1,000 kcal/week or more can postpone mortality...
  9. pmc The built environment and physical activity levels: the Harvard Alumni Health Study
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Prev Med 37:293-8. 2009
    ....
  10. ncbi request reprint The importance of walking to public health
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Med Sci Sports Exerc 40:S512-8. 2008
    ....
  11. ncbi request reprint Physical activity and cancer prevention--data from epidemiologic studies
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Med Sci Sports Exerc 35:1823-7. 2003
    ..The aim of this paper is to examine whether physical activity plays any role in the prevention of cancer...
  12. ncbi request reprint Wife carrying for health
    I Min Lee
    Division of Preventive Medicine, Harvard Medical School, Boston, Mass, USA
    Med J Aust 195:723-5. 2011
    ..To highlight a fun activity--the sport of wife carrying--and to investigate factors associated with better performance...
  13. pmc Physical activity, body weight, and pancreatic cancer mortality
    I M Lee
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Br J Cancer 88:679-83. 2003
    ..00, 0.98, 0.92, and 1.31, respectively) nor BMI (corresponding findings: 1.00, 0.84, 1.08, and 0.99, respectively) significantly predicted pancreatic cancer mortality...
  14. ncbi request reprint A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  15. pmc Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 21:897-908. 2010
    ....
  16. ncbi request reprint Alcohol consumption and breast cancer risk in the Women's Health Study
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Am J Epidemiol 165:667-76. 2007
    ..The findings from this prospective study suggest that moderate alcohol consumption increases breast cancer risk...
  17. pmc Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 104:1562-75. 2012
    ..Folic acid, vitamin B(6), and vitamin B(12) act in concert in the one-carbon metabolism and may protect against colorectal neoplasia. We examined the effect of combined B-vitamin treatment on the occurrence of colorectal adenoma...
  18. pmc Physical activity and survival after cancer diagnosis in men
    I Min Lee
    Division of Preventive Medicine, Harvard Medical School, Boston, MA
    J Phys Act Health 11:85-90. 2014
    ..The number of cancer survivors is increasing rapidly; however, little is known about whether engaging in physical activity after a cancer diagnosis is associated with lower mortality rates in men...
  19. pmc Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer
    Brian M Wolpin
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 105:1027-35. 2013
    ..Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic β-cell dysfunction...
  20. pmc Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women
    Lu Wang
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Arch Intern Med 170:453-61. 2010
    ..Alcohol consumption is a source of energy intake that may contribute to body weight gain and development of obesity. However, previous studies of this relationship have been limited, with inconsistent results...
  21. ncbi request reprint Dietary glycemic load and risk of colorectal cancer in the Women's Health Study
    Susan Higginbotham
    Department of Epidemiology, University of California at Los Angeles, USA
    J Natl Cancer Inst 96:229-33. 2004
    ..09, 95% CI = 1.13 to 3.87; P(trend) =.08) were also statistically significantly associated with increased risk. Thus, our data indicate that a diet with a high dietary glycemic load may increase the risk of colorectal cancer in women...
  22. ncbi request reprint Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  23. ncbi request reprint Total magnesium intake and colorectal cancer incidence in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 15:2006-9. 2006
  24. pmc Plasma homocysteine and cysteine and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 70:2397-405. 2010
    ..The increased risk of breast cancer associated with high cysteine levels warrants further investigation...
  25. ncbi request reprint Intakes of calcium and vitamin D and risk of colorectal cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 161:755-64. 2005
    ..Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk...
  26. ncbi request reprint The joint effects of physical activity and body mass index on coronary heart disease risk in women
    Amy R Weinstein
    Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Shapiro 1, Atrium Suite, Boston, MA 02215, USA
    Arch Intern Med 168:884-90. 2008
    ..Our objective was to study the combined association of physical activity and body mass index on CHD...
  27. ncbi request reprint Is C-reactive protein specific for vascular disease in women?
    Nader Rifai
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 136:529-33. 2002
    ..C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic individuals. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain...
  28. ncbi request reprint Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
    ..Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer...
  29. pmc Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 89:905-12. 2009
    ..Flavonoids may protect against cancer development through several biological mechanisms. However, epidemiologic studies on dietary flavonoids and cancer risk have yielded inconsistent results...
  30. pmc Colorectal cancer after start of nonsteroidal anti-inflammatory drug use
    TIL STURMER
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Am J Med 119:494-502. 2006
    ....
  31. pmc Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women
    Tariq Ahmad
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:675-80. 2011
    ..Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear...
  32. pmc The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women
    Tariq Ahmad
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 160:1163-9. 2010
    ..However, its association with cardiovascular disease (CVD) in healthy populations and any interaction with physical activity remain unclear...
  33. ncbi request reprint Body mass index and mortality among US male physicians
    Umed A Ajani
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ann Epidemiol 14:731-9. 2004
    ..To assess the relationship between body mass index and mortality in a population homogeneous in educational attainment and socioeconomic status...
  34. ncbi request reprint Androgen receptor polymorphisms and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, 181 Longwood Avenue, Boston, MA 02115, USA
    Int J Cancer 118:1261-8. 2006
    ..supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html)...
  35. ncbi request reprint Dietary glycemic load and breast cancer risk in the Women's Health Study
    Susan Higginbotham
    Department of Epidemiology, UCLA School of Public Health, University of California at Los Angeles UCLA, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 13:65-70. 2004
    ..Prospective studies of a larger sample size and longer duration are warranted to confirm our findings...
  36. pmc Novel breast cancer risk alleles and endometrial cancer risk
    Monica McGrath
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, MA 02115, USA
    Int J Cancer 123:2961-4. 2008
    ..The molecular mechanisms underlying these differences remain to be defined...
  37. pmc Inflammatory plasma markers and pancreatic cancer risk: a prospective study of five U.S. cohorts
    Ying Bao
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:855-61. 2013
    ....
  38. pmc Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial
    Nancy R Cook
    Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 159:77-85. 2013
    ..Recent evidence suggests that daily aspirin use decreases cancer risk, particularly for colorectal cancer, but evidence for alternate-day use is scant...
  39. ncbi request reprint Intakes of calcium and vitamin D and breast cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 167:1050-9. 2007
    ..Animal data suggest the potential anticarcinogenic effects of calcium and vitamin D on breast cancer development. However, epidemiologic data relating calcium and vitamin D levels to breast cancer have been inconclusive...
  40. ncbi request reprint Sex hormone levels and risk of cardiovascular events in postmenopausal women
    Kathryn M Rexrode
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, Mass 02215, USA
    Circulation 108:1688-93. 2003
    ..Despite diffuse effects of sex hormones on the cardiovascular system, few prospective studies have examined the relationship of plasma androgens and estrogens with risk of cardiovascular disease (CVD) in postmenopausal women...
  41. ncbi request reprint Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:783-8. 2007
    ..However, we observed significant associations in some subgroups, which should be evaluated further in other studies because increasing vitamin D intake is an easy preventive measure to adopt...
  42. ncbi request reprint C-reactive protein and risk of breast cancer
    Shumin M Zhang
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    J Natl Cancer Inst 99:890-4. 2007
    ..71 to 1.16; P(trend) = .19; crude incidence rates: 273 versus 305 per 100,000 person-years). Our data suggest that baseline plasma CRP levels are not associated with the increased risk of breast cancer in apparently healthy women...
  43. ncbi request reprint Body mass index and risk of colorectal cancer in women (United States)
    Jennifer Lin
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Cancer Causes Control 15:581-9. 2004
    ..We prospectively investigated the role of BMI in colorectal cancer risk along with the modifying effects of estrogen in a large cohort from the Women's Health Study...
  44. pmc Hemoglobin A1c concentrations and risk of colorectal cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 14:3010-2. 2005
  45. pmc Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
    Gynecol Oncol 117:255-9. 2010
    ..Given the role of estrogens in endometrial carcinogenesis, we hypothesized that genetic variation in StAR and CYP11A1 genes may influence endometrial cancer risk...
  46. pmc Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 163:108-15. 2006
    ..An alternative explanation is that other factors related to dietary intakes of folate and vitamin B(6) account for the inverse associations...
  47. ncbi request reprint Use of oral conjugated estrogen alone and risk of breast cancer
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 165:524-9. 2007
    ..These data, like those from the Women's Health Initiative, show no significant increase in breast cancer risk with use of oral conjugated estrogen alone (0.625 mg/day), but a small increase or decrease in risk cannot be excluded...
  48. ncbi request reprint A prospective study of hemoglobin A1c concentrations and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2869-75. 2006
    ..These data suggest that higher HbA1c concentrations do not seem to increase risk of breast cancer among apparently healthy women...
  49. pmc The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    JoAnn E Manson
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, United States
    Contemp Clin Trials 33:159-71. 2012
    ....
  50. pmc Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry
    Tariq Ahmad
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 4:74-80. 2011
    ..Whether these associations are modified by physical activity, which increases HDL-C levels and reduces the risk of cardiovascular disease, is uncertain...
  51. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
    ..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer...
  52. pmc Telomere length and genetic analyses in population-based studies of endometrial cancer risk
    Jennifer Prescott
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 116:4275-82. 2010
    ..When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic...
  53. pmc Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Nancy A Shadick
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:545-50. 2010
    ..Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorectal adenomas, but no trial has evaluated the role of aspirin in RA prevention...
  54. pmc Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Clin Chem Lab Med 48:259-62. 2010
    ..To date, no prospective epidemiological data are available, particularly in women, on mean leukocyte telomere length as a risk predictor...
  55. pmc Egg consumption and risk of type 2 diabetes in men and women
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:295-300. 2009
    ..This project sought to examine the relation between egg intake and the risk of type 2 diabetes in two large prospective cohorts...
  56. ncbi request reprint Dietary fat and fatty acids and risk of colorectal cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 160:1011-22. 2004
    ..However, intake of fried foods and/or other factors related to their intake may be associated with colorectal cancer development. This finding warrants further examination...
  57. ncbi request reprint Plasma androgen concentrations and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 167:211-8. 2008
    ..bottom, relative risks were 0.65 and 0.70, respectively). Overall, these results do not support a positive association between circulating androgen levels and ovarian cancer risk...
  58. ncbi request reprint Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 295:1412-9. 2006
    ..There are few data directly comparing the effects of physical activity and body weight on cardiovascular biomarkers...
  59. ncbi request reprint Weight change and risk of developing type 2 diabetes
    Yuko Oguma
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Obes Res 13:945-51. 2005
    ..To examine the association between weight change and risk of type 2 diabetes and whether initial weight modifies the association...
  60. ncbi request reprint Oral contraceptives, reproductive factors, and risk of colorectal cancer among women in a prospective cohort study
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 165:794-801. 2007
    ..09). No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer...
  61. ncbi request reprint C-reactive protein in the prediction of rheumatoid arthritis in women
    Nancy A Shadick
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2490-4. 2006
    ..The purpose of this study was to examine whether levels of C-reactive protein (CRP), a sensitive marker of disease activity in rheumatoid arthritis (RA), are associated with increased risk of subsequent RA...
  62. ncbi request reprint Estrogen-progestin replacement therapy and breast cancer risk: the Women's Health Study (United States)
    Juliet V Porch
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Cancer Causes Control 13:847-54. 2002
    ..We therefore examined estrogen-progestin replacement therapy and breast cancer risk in the Women's Health Study...
  63. pmc A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts
    Ying Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 105:95-103. 2013
    ..Although development of pancreatic cancer is associated with states of insulin resistance and chronic inflammation, the mechanistic basis of the associations is poorly understood...
  64. pmc Physical activity and the risk of becoming overweight or obese in middle-aged and older women
    Kathryn A Britton
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:1096-103. 2012
    ..In conclusion, higher amounts of total LTPA should be encouraged to prevent obesity. Among those willing to participate in vigorous LTPA, and for whom such activities are not contraindicated, vigorous LPTA should be encouraged...
  65. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  66. ncbi request reprint Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States)
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Causes Control 16:225-33. 2005
    ..We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study...
  67. pmc Physical activity, body mass index, and diabetes risk in men: a prospective study
    Lydia C Siegel
    Massachusetts Veterans Epidemiology Research and Information Center at the VA Boston Healthcare System, Boston, Mass, USA
    Am J Med 122:1115-21. 2009
    ..We investigated the independent and joint associations between vigorous activity and BMI on diabetes risk in men...
  68. ncbi request reprint Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1691-5. 2007
    ..Overall, our results do not support a positive association between IGF-related proteins and ovarian cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1691-5)...
  69. pmc Migraine and subsequent risk of breast cancer: a prospective cohort study
    Anke C Winter
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Causes Control 24:81-9. 2013
    ..Further prospective studies are warranted to confirm these results. In addition, studies evaluating migraine characteristics (e.g., migraine subtypes and frequency) are lacking...
  70. pmc Vitamin E supplementation and the risk of heart failure in women
    Claudia U Chae
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Heart Fail 5:176-82. 2012
    ..No large clinical trials have addressed the role of antioxidant therapy in the primary prevention of HF...
  71. ncbi request reprint Relationship of physical activity vs body mass index with type 2 diabetes in women
    Amy R Weinstein
    Boston VA Healthcare System, MA, USA
    JAMA 292:1188-94. 2004
    ..Physical inactivity and body mass index (BMI) are established independent risk factors in the development of type 2 diabetes; however, their comparative importance and joint relationship with diabetes are unclear...
  72. pmc Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 116:2110-8. 2007
    ..Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect...
  73. pmc Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 59:1589-95. 2008
    ..Vitamin E supplements may reduce the risk of developing rheumatoid arthritis (RA) through antioxidant effects. Although previous observational studies have investigated this question, no randomized trial data are available...
  74. pmc Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 121:54-8. 2011
    ..Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide polymorphisms (SNPs) in genes HSD17b2 and HSD17b4 may alter the enzyme activity, estradiol levels and risk of disease...
  75. ncbi request reprint Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Diabetes 55:2856-62. 2006
    ..83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women...
  76. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  77. pmc Plasma 25-hydroxyvitamin D and risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 21:82-91. 2012
    ..Laboratory studies suggest that vitamin D may inhibit pancreatic cancer cell growth. However, epidemiologic studies of vitamin D and pancreatic cancer risk have been conflicting...
  78. pmc GSTM1 and GSTT1 copy number variation in population-based studies of endometrial cancer risk
    Stalo Karageorgi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:1447-52. 2011
    ..The associations of GSTM1 and GSTT1 polymorphisms with endometrial cancer risk have been inconsistent...
  79. ncbi request reprint Relative intensity of physical activity and risk of coronary heart disease
    I Min Lee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 107:1110-6. 2003
    ..It is unknown whether moderate-intensity exercise, relative to an individual's capacity, is associated with reduced coronary heart disease (CHD) rates...
  80. ncbi request reprint Development of a risk score for colorectal cancer in men
    Jane A Driver
    The Brigham and Women s Hospital Divisions of Aging, Boston, Mass 02120, USA
    Am J Med 120:257-63. 2007
    ..Colorectal cancer is a common and preventable disease for which screening rates remain unacceptably low...
  81. pmc Metabolic abnormalities and risk for colorectal cancer in the physicians' health study
    TIL STURMER
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 15:2391-7. 2006
    ....
  82. doi request reprint Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Harvard School of Public Health, Boston, Mass, USA harvard edu
    Hypertension 51:1073-9. 2008
    ....
  83. pmc Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pharmacogenet Genomics 19:239-43. 2009
    ..Our data suggest that these UGT polymorphisms do not contribute significantly to endometrial cancer risk...
  84. pmc A 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 17:1136-43. 2008
    ..Human studies have not shown consistent results. We examined the association between intakes of fish and n-3 fatty acids from fish and colorectal cancer risk in men enrolled in the Physicians' Health Study...
  85. ncbi request reprint Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study
    Hillary H Hegener
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 52:2021-7. 2006
    ..No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes...
  86. pmc Physical activity and the risk of incident atrial fibrillation in women
    Brendan M Everett
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 4:321-7. 2011
    ..We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), would reduce the risk of incident atrial fibrillation (AF) in women...
  87. pmc Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circulation 120:237-44. 2009
    ..We examined the association between alcohol and CVD and death in 26 399 women and estimated the proportion of reduced risk of CVD/death explained by a series of intermediate factors...
  88. pmc Prospective study of plasma vitamin B6 and risk of colorectal cancer in men
    Jung Eun Lee
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1197-202. 2009
    ..92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; P(trend) = 0.01), respectively. In conclusion, vitamin B(6) may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers...
  89. pmc Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies
    Shelley S Tworoger
    Channing Laboratory, Boston, MA 02115, USA
    Cancer Res 69:1885-91. 2009
    ..34-1.28), and among women with the Ff or ff genotype the OR was 0.71 (95% CI, 0.43-1.18). Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis...
  90. pmc Dose response between physical activity and risk of coronary heart disease: a meta-analysis
    Jacob Sattelmair
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 124:789-95. 2011
    ..Instead, previous reviews have used qualitative estimates such as low, moderate, and high physical activity...
  91. pmc MDM2 SNP309 is associated with endometrial cancer risk
    Kathryn Terry
    Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:983-6. 2008
    ..87; 95% confidence interval, 1.29-2.73) for endometrial cancer. We observed no association between age at diagnosis and genotype. Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer...
  92. ncbi request reprint Body mass index and risk of Parkinson's disease: a prospective cohort study
    Giancarlo Logroscino
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 166:1186-90. 2007
    ....
  93. pmc Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes
    Luc Djousse
    Division of Aging and Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 93:143-50. 2011
    ..Although dietary omega-3 (n-3) fatty acids may confer some cardiovascular benefits, it is unclear whether these nutrients may also unfavorably affect risk of type 2 diabetes (T2D)...
  94. pmc Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies
    Jung Eun Lee
    Department of Food and Nutrition, Sookmyung Women s University, Seoul, Republic of Korea
    Cancer Prev Res (Phila) 4:735-43. 2011
    ..77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer...
  95. pmc Physical activity and risk of stroke in women
    Jacob R Sattelmair
    MBBS, ScD, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Stroke 41:1243-50. 2010
    ..Physical activity has generally been inversely related to the risk of developing stroke, but details regarding the amount and kinds of activity required are unclear as are associations for specific stroke subtypes...
  96. ncbi request reprint C-reactive protein levels are not associated with increased risk for colorectal cancer in women
    Shumin M Zhang
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts
    Ann Intern Med 142:425-32. 2005
    ..While a recent prospective study observed a positive association between C-reactive protein (CRP), a marker of inflammation, and risk for colon cancer, data testing this hypothesis are sparse...
  97. ncbi request reprint Migraine and coronary heart disease in women and men
    Nancy R Cook
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Headache 42:715-27. 2002
    ..We evaluated migraine as an independent risk factor for subsequent coronary heart disease (CHD) events among women in the Women's Health Study (WHS) and men in the Physicians' Health Study (PHS)...
  98. ncbi request reprint Lack of association between tea and cardiovascular disease in college alumni
    Howard D Sesso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA USA
    Int J Epidemiol 32:527-33. 2003
    ..Epidemiological studies suggest that tea intake, a major dietary source of flavonoids, may be associated with a decreased risk of cardiovascular disease (CVD)...
  99. ncbi request reprint Recreational physical activity during pregnancy and risk of preeclampsia
    Tanya K Sorensen
    Center for Perinatal Studies, Swedish Medical Center, 747 Broadway 4 North, Seattle, WA 98122
    Hypertension 41:1273-80. 2003
    ..These data suggest that regular physical activity, particularly when performed during the year before pregnancy and during early pregnancy, is associated with a reduced risk of preeclampsia...
  100. ncbi request reprint Vitamin E in the prevention of prostate cancer: where are we today?
    I Min Lee
    J Natl Cancer Inst 98:225-7. 2006
  101. ncbi request reprint Past physical activity, current physical activity, and risk of coronary heart disease
    Molly B Conroy
    Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Med Sci Sports Exerc 37:1251-6. 2005
    ..We examined the relationship between 1) physical activity during young adulthood and middle age, and 2) physical activity during each time period and CHD occurring in middle age or older...

Research Grants5

  1. Dairy Products, Calcium, and Risk of Prostate Cancer
    I Min Lee; Fiscal Year: 2004
    ..We also will examine men aged <65, 65-74, and 75+ years. This large database provides a unique and cost-effective opportunity to answer questions of public health importance. ..
  2. Saw Palmetto Use and Risk of Prostate Cancer
    I Min Lee; Fiscal Year: 2004
    ..abstract_text> ..
  3. Risk Factors for Pancreatic Cancer
    I Min Lee; Fiscal Year: 2002
    ..Findings from these analyses will have public health significance for a highly fatal disease. ..
  4. Controversies in Physical Activity and CHD
    I Min Lee; Fiscal Year: 2002
    ..We also will examine CHD risk among men cross-classified by both physical activity and body weight. This proposal, at relatively little cost, will provide important information of public health significance. ..
  5. Urban Sprawl and Physical Activity Levels
    I Min Lee; Fiscal Year: 2006
    ..This study will provide important information for planning or redesigning communities in order to maximize the potential for physical activity and health. ..