Ann Hwee Lee

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:7448-59. 2003
  2. pmc The role of CREB-H transcription factor in triglyceride metabolism
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Curr Opin Lipidol 23:141-6. 2012
  3. pmc Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:8885-90. 2011
  4. pmc Regulation of hepatic lipogenesis by the transcription factor XBP1
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 320:1492-6. 2008
  5. pmc Intersection of the unfolded protein response and hepatic lipid metabolism
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Cell Mol Life Sci 66:2835-50. 2009
  6. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
  7. pmc Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice
    Jae Seon So
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 16:487-99. 2012
  8. ncbi Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    Claudio Hetz
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Science 312:572-6. 2006
  9. pmc Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Proc Natl Acad Sci U S A 100:9946-51. 2003
  10. pmc XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    EMBO J 24:4368-80. 2005

Collaborators

Detail Information

Publications27

  1. pmc XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:7448-59. 2003
    ..Further, our observations suggest the existence of additional, as-yet-unknown, key regulators of the UPR...
  2. pmc The role of CREB-H transcription factor in triglyceride metabolism
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Curr Opin Lipidol 23:141-6. 2012
    ..Cyclic-AMP-responsive-element-binding protein H (CREB-H) is a transcription factor that is highly and selectively expressed in liver and small intestine. Here I summarize recent findings on the role of CREB-H in lipid metabolism...
  3. pmc Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:8885-90. 2011
    ..These results demonstrate that IRE1α has dual and opposing roles in β-cells, and that a precisely regulated feedback circuit involving IRE1α and its product XBP1s is required to achieve optimal insulin secretion and glucose control...
  4. pmc Regulation of hepatic lipogenesis by the transcription factor XBP1
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 320:1492-6. 2008
    ..This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias...
  5. pmc Intersection of the unfolded protein response and hepatic lipid metabolism
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Cell Mol Life Sci 66:2835-50. 2009
    ....
  6. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
    ..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
  7. pmc Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice
    Jae Seon So
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 16:487-99. 2012
    ..Ablation of XBP1 ameliorated hepatosteatosis, liver damage, and hypercholesterolemia in dyslipidemic animal models, suggesting that direct targeting of either IRE1α or XBP1 might be a feasible strategy to treat dyslipidemias...
  8. ncbi Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    Claudio Hetz
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Science 312:572-6. 2006
    ..Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR...
  9. pmc Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Proc Natl Acad Sci U S A 100:9946-51. 2003
    ..Identification of compounds that target the activity of IRE1 alpha/XBP-1 may yield novel therapies for the treatment of multiple myeloma and other malignancies that rely on an intact UPR...
  10. pmc XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    EMBO J 24:4368-80. 2005
    ..These data lead us to propose that XBP-1 is both necessary and sufficient for the full biogenesis of the secretory machinery in exocrine cells...
  11. ncbi Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health 651 Huntington Avenue, Boston, Massachusetts 02115 6017, USA
    Nat Immunol 4:321-9. 2003
    ..We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR...
  12. pmc From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis
    Laurie H Glimcher
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1173:E2-9. 2009
    ....
  13. ncbi The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Immunol Rev 194:29-38. 2003
    ..Additionally, XBP-1 plays an important role in the regulation of interleukin-6 production, a cytokine essential for plasma cell survival...
  14. pmc Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:757-62. 2008
    ....
  15. pmc TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    Fabio Martinon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Immunol 11:411-8. 2010
    ..Our findings identify an unsuspected critical function for XBP1 in mammalian host defenses...
  16. pmc IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
    Kyu Yeon Hur
    Deartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 209:307-18. 2012
    ..Our study reveals an unexpected function of RIDD in drug metabolism...
  17. pmc XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
    Derrick J Todd
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 206:2151-9. 2009
    ..Finally, we show that memory B cells develop normally in XBP1(CD19) mice, demonstrating that XBP1-mediated functions occur independently of any memory cell lineage commitment...
  18. pmc The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
    Jung Hoon Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 17:812-5. 2011
    ..We identified multiple nonsynonymous mutations in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hypertriglyceridemia, implying a crucial role for CREB-H in human triglyceride metabolism...
  19. pmc Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells
    Yang Hu
    F M Kirby Neurobiology Center, Children s Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:445-52. 2012
    ....
  20. pmc XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    Arthur Kaser
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cell 134:743-56. 2008
    ..Hence, intestinal inflammation can originate solely from XBP1 abnormalities in IECs, thus linking cell-specific ER stress to the induction of organ-specific inflammation...
  21. pmc The role of adipocyte XBP1 in metabolic regulation during lactation
    Margaret F Gregor
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Rep 3:1430-9. 2013
    ..Moreover, we demonstrate that XBP1 is regulated during lactation and responds to prolactin to alter lipogenic gene expression. These results demonstrate a role for adipocyte-XBP1 in the regulation of lactational metabolism...
  22. doi The endoplasmic reticulum stress response in immunity and autoimmunity
    Derrich J Todd
    Department of Infectious Diseases and Immunology, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:663-74. 2008
    ..This Review focuses on the role of the UPR in the mammalian immune system and how manipulation of this complex signalling pathway may be of therapeutic benefit in human disease...
  23. pmc The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling
    Jin A Cho
    Department of Medicine, Division of GI Cell Biology, Boston Children s Hospital, Boston, MA 02115, USA
    Cell Host Microbe 13:558-69. 2013
    ..We propose IRE1α provides for a generalized mechanism of innate immune surveillance originating within the ER lumen...
  24. ncbi It's a good year for Blimp-1 (and plasma cells)
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Immunity 19:466-8. 2003
  25. pmc Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products
    Boaz Tirosh
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Room 836, Boston MA 02115, USA
    J Virol 79:2768-79. 2005
    ..We conclude that the contribution of the UPR is more pronounced on HC degradation shortly after induction of US11 expression and that US11 is sufficient to induce such a response...
  26. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
    ..Thus, XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells...
  27. ncbi XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
    Lorenzo Romero-Ramirez
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 64:5943-7. 2004
    ..Taken together, these studies directly implicate XBP1 as an essential survival factor for hypoxic stress and tumor growth...