Research Topics
Genomes and Genes
| Ann Hwee LeeSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein responseAnn Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Mol Cell Biol 23:7448-59. 2003..Further, our observations suggest the existence of additional, as-yet-unknown, key regulators of the UPR...- The role of CREB-H transcription factor in triglyceride metabolismAnn Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
Curr Opin Lipidol 23:141-6. 2012..Cyclic-AMP-responsive-element-binding protein H (CREB-H) is a transcription factor that is highly and selectively expressed in liver and small intestine. Here I summarize recent findings on the role of CREB-H in lipid metabolism... - Regulation of hepatic lipogenesis by the transcription factor XBP1Ann Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Science 320:1492-6. 2008..This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias... - Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretionAnn Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:8885-90. 2011..These results demonstrate that IRE1α has dual and opposing roles in β-cells, and that a precisely regulated feedback circuit involving IRE1α and its product XBP1s is required to achieve optimal insulin secretion and glucose control... - Intersection of the unfolded protein response and hepatic lipid metabolismAnn Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
Cell Mol Life Sci 66:2835-50. 2009.... 
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesUmut Ozcan
Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
Science 306:457-61. 2004..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...- Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in miceJae Seon So
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cell Metab 16:487-99. 2012..Ablation of XBP1 ameliorated hepatosteatosis, liver damage, and hypercholesterolemia in dyslipidemic animal models, suggesting that direct targeting of either IRE1α or XBP1 might be a feasible strategy to treat dyslipidemias... - Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaClaudio Hetz
Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
Science 312:572-6. 2006..Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR... - XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsAnn Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
EMBO J 24:4368-80. 2005..These data lead us to propose that XBP-1 is both necessary and sufficient for the full biogenesis of the secretory machinery in exocrine cells... - Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Neal N Iwakoshi
Department of Immunology and Infectious Diseases, Harvard School of Public Health 651 Huntington Avenue, Boston, Massachusetts 02115 6017, USA
Nat Immunol 4:321-9. 2003..We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR... - From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesisLaurie H Glimcher
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
Ann N Y Acad Sci 1173:E2-9. 2009.... - Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesisClaudio Hetz
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:757-62. 2008.... - TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophagesFabio Martinon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Immunol 11:411-8. 2010..Our findings identify an unsuspected critical function for XBP1 in mammalian host defenses... - IRE1α activation protects mice against acetaminophen-induced hepatotoxicityKyu Yeon Hur
Deartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Exp Med 209:307-18. 2012..Our study reveals an unexpected function of RIDD in drug metabolism... - XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell developmentDerrick J Todd
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Exp Med 206:2151-9. 2009..Finally, we show that memory B cells develop normally in XBP1(CD19) mice, demonstrating that XBP1-mediated functions occur independently of any memory cell lineage commitment... - Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsAnn-Hwee Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017, USA
Proc Natl Acad Sci U S A 100:9946-51. 2003..Identification of compounds that target the activity of IRE1 alpha/XBP-1 may yield novel therapies for the treatment of multiple myeloma and other malignancies that rely on an intact UPR... - The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolismJung Hoon Lee
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Med 17:812-5. 2011..We identified multiple nonsynonymous mutations in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hypertriglyceridemia, implying a crucial role for CREB-H in human triglyceride metabolism... - Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cellsYang Hu
F M Kirby Neurobiology Center, Children s Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Neuron 73:445-52. 2012.... - XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseArthur Kaser
Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Cell 134:743-56. 2008..Hence, intestinal inflammation can originate solely from XBP1 abnormalities in IECs, thus linking cell-specific ER stress to the induction of organ-specific inflammation... 
The endoplasmic reticulum stress response in immunity and autoimmunityDerrich J Todd
Department of Infectious Diseases and Immunology, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts 02115, USA
Nat Rev Immunol 8:663-74. 2008..This Review focuses on the role of the UPR in the mammalian immune system and how manipulation of this complex signalling pathway may be of therapeutic benefit in human disease...- The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein responseNeal N Iwakoshi
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017, USA
Immunol Rev 194:29-38. 2003..Additionally, XBP-1 plays an important role in the regulation of interleukin-6 production, a cytokine essential for plasma cell survival... - It's a good year for Blimp-1 (and plasma cells)Neal N Iwakoshi
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Immunity 19:466-8. 2003 - XBP1 is essential for survival under hypoxic conditions and is required for tumor growthLorenzo Romero-Ramirez
Department of Radiation Oncology, Stanford University, Stanford, California 94305-5152, USA
Cancer Res 64:5943-7. 2004..Taken together, these studies directly implicate XBP1 as an essential survival factor for hypoxic stress and tumor growth... - Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex productsBoaz Tirosh
Department of Pathology, Harvard Medical School, 77 Ave. Louis Pasteur, Room 836, Boston MA 02115, USA
J Virol 79:2768-79. 2005..We conclude that the contribution of the UPR is more pronounced on HC degradation shortly after induction of US11 expression and that US11 is sufficient to induce such a response... - XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationA L Shaffer
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Immunity 21:81-93. 2004..Thus, XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells...