Ross Lazarus

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Creating reusable tools from scripts: the Galaxy Tool Factory
    Ross Lazarus
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
    Bioinformatics 28:3139-40. 2012
  2. pmc Using automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection
    R Lazarus
    Chanming Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    BMC Public Health 1:9. 2001
  3. pmc Genetic adaptation of the antibacterial human innate immunity network
    Ferran Casals
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 11:202. 2011
  4. pmc Distributed data processing for public health surveillance
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Public Health 6:235. 2006
  5. ncbi Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 190:9-25. 2002
  6. ncbi Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genomics 81:85-91. 2003
  7. ncbi TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    Ross Lazarus
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 170:594-600. 2004
  8. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
  9. ncbi Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
  10. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004

Detail Information

Publications73

  1. pmc Creating reusable tools from scripts: the Galaxy Tool Factory
    Ross Lazarus
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
    Bioinformatics 28:3139-40. 2012
    ..New tools can be written to extend Galaxy, and these can be shared using public Galaxy Tool Shed (GTS) repositories, but converting even simple scripts into tools requires effort from a skilled developer...
  2. pmc Using automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection
    R Lazarus
    Chanming Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    BMC Public Health 1:9. 2001
    ..Knowledge of disease patterns in real time may also help clinicians to manage patients, and assist health plan administrators in allocating resources efficiently...
  3. pmc Genetic adaptation of the antibacterial human innate immunity network
    Ferran Casals
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 11:202. 2011
    ..The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection...
  4. pmc Distributed data processing for public health surveillance
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Public Health 6:235. 2006
    ....
  5. ncbi Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 190:9-25. 2002
    ..These and other factors must be taken into account in the design and analysis of disease association studies...
  6. ncbi Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genomics 81:85-91. 2003
    ..This study suggests that there is substantial diversity in human TLR9, possibly associated with asthma in Europeans but not African Americans. No association was detected with three other diseases potentially related to innate immunity...
  7. ncbi TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    Ross Lazarus
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 170:594-600. 2004
    ..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk...
  8. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  9. ncbi Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
    ..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness...
  10. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  11. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  12. pmc Integrating clinical practice and public health surveillance using electronic medical record systems
    Michael Klompas
    Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Am J Public Health 102:S325-32. 2012
    ..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments...
  13. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    ..IL12B may be an important asthma gene...
  14. pmc Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009
    ..Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma...
  15. pmc Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
    ..The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively...
  16. pmc Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pharmacogenet Genomics 18:733-7. 2008
    ..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted...
  17. ncbi Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer
    Yen Ching Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1982-9. 2007
    ..We assessed if genetic polymorphisms of this gene cluster were associated with the risk of prostate cancer in a U.S. population...
  18. pmc Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
    Audrey H Poon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacogenet Genomics 18:373-82. 2008
    ..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma...
  19. pmc Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 365:1173-83. 2011
    ..We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids...
  20. pmc A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma
    Sunita Sharma
    Channing Laboratory, Center for Genomic Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:328-36. 2010
    ..Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes...
  21. ncbi ADAM33 polymorphisms and phenotype associations in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1071-8. 2004
    ..However, genetic linkage of asthma phenotypes to chromosome 20p13 (the location of ADAM33) has not been observed in most asthma genome scans, and it is unclear whether these associations with ADAM33 are broadly generalizable...
  22. ncbi Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups
    Ross Lazarus
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 80:223-8. 2002
    ..No SNP caused amino acid changes. Differences in pairwise linkage-disequilibrium (LD) patterns and in SNP and haplotype frequency distributions among the three populations may be of potential importance for disease association studies...
  23. pmc Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Med Genet 12:26. 2011
    ..We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts...
  24. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  25. ncbi FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1285-91. 2007
    ..Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations...
  26. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...
  27. pmc Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 182:605-13. 2010
    ..Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q...
  28. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
    ..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14...
  29. pmc Syndromic surveillance using minimum transfer of identifiable data: the example of the National Bioterrorism Syndromic Surveillance Demonstration Program
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Urban Health 80:i25-31. 2003
    ..If successful, this system will allow any organization with appropriate data to contribute vital information to public health syndromic surveillance systems while preserving individuals' privacy to the greatest extent possible...
  30. ncbi Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program
    Edwin K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 112:870-6. 2003
    ..Beta2-adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies...
  31. ncbi Association of vitamin D receptor gene polymorphisms with childhood and adult asthma
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1057-65. 2004
    ..These results suggest that VDR influences asthma and allergy susceptibility in a complex manner...
  32. ncbi Eotaxin polymorphisms and serum total IgE levels in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:298-305. 2006
    ..Family-based association studies of CCL11 genetic variants have not been reported to date...
  33. pmc Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Thorax 62:224-30. 2007
    ..A study was undertaken to identify genomic regions containing susceptibility loci for pulmonary function and bronchodilator responsiveness (BDR) in Costa Ricans...
  34. pmc Genetic determinants of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:476. 2006
  35. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
    ..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association...
  36. ncbi Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1449-56. 2002
    ..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility...
  37. pmc IL1B polymorphisms modulate cystic fibrosis lung disease
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Pulmonol 44:580-93. 2009
    ....
  38. pmc Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
    Amy Murphy
    Channing Laboratory, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 19:4745-57. 2010
    ..Population-based integrative genetic approaches can help identify such variation and enhance our understanding of the genetic basis of complex traits...
  39. ncbi Lung function in type 2 diabetes: the Normative Aging Study
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Med 99:1583-90. 2005
    ..We conducted this analysis to determine whether diabetic subjects have different rates of lung function change compared with non-diabetic subjects...
  40. pmc Instrumenting the health care enterprise for discovery research in the genomic era
    Shawn Murphy
    Informatics, Partners HealthCare Systems, Boston, Massachusetts 02115, USA
    Genome Res 19:1675-81. 2009
    ..Even for rare diseases caused by rare, highly penetrant mutations such as Huntington disease (N = 102) and autism (N = 756), these capabilities are also of interest...
  41. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    ..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
  42. pmc Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes
    Jen hwa Chu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    BMC Syst Biol 5:89. 2011
    ..Though numerous methods have been proposed and successfully implemented to develop these networks, there are no formal methods for comparing differences in network connectivity patterns as a function of phenotypic trait...
  43. pmc Real-time surveillance for tuberculosis using electronic health record data from an ambulatory practice in eastern Massachusetts
    Michael S Calderwood
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Public Health Rep 125:843-50. 2010
    ..We report on the development and validation of a TB detection algorithm for EHR data followed by implementation in a live surveillance and reporting system...
  44. pmc Electronic Support for Public Health: validated case finding and reporting for notifiable diseases using electronic medical data
    Ross Lazarus
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    J Am Med Inform Assoc 16:18-24. 2009
    ..Source code for this highly interoperable application is freely available under an approved open-source license at http://esphealth.org...
  45. ncbi Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 12:1973-9. 2003
    ..Fine mapping efforts for these loci are warranted...
  46. ncbi A new multimarker test for family-based association studies
    Cyril S Rakovski
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Genet Epidemiol 31:9-17. 2007
    ..We confirm the conclusions of our study with an application to Alzheimer's disease data...
  47. pmc Platform dependence of inference on gene-wise and gene-set involvement in human lung development
    Rose Du
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Bioinformatics 10:189. 2009
    ..0 and the Illumina HumanRef-8 v2 Expression Bead Chips, for comparability in a biological system in which changes may be subtle, namely fetal lung tissue as a function of gestational age...
  48. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
    ..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR...
  49. ncbi Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer
    Yen Ching Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Res 65:11771-8. 2005
    ..02). Two common haplotypes were statistically significantly associated with altered risk of prostate cancer. Inherited polymorphisms of the innate immune gene TLR4 are associated with risk of prostate cancer...
  50. doi Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative phosphorylation in adult male rat offspring
    Celine Latouche
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Nutr 144:237-44. 2014
    ..These data indicate that maternal overnutrition, even in the absence of prepregnancy obesity, can promote metabolic dysregulation and predispose offspring to type 2 diabetes. ..
  51. pmc Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance
    W Katherine Yih
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA
    Public Health Rep 129:55-63. 2014
    ..We compared an electronic health record-based influenza-like illness (ILI) surveillance system with manual sentinel surveillance and virologic data to evaluate the utility of the automated system for routine ILI surveillance...
  52. ncbi GGtools: analysis of genetics of gene expression in bioconductor
    Vincent J Carey
    Channing Laboratory, Brigham and Women s Hospital, 75 Francis Street, Boston 02115, USA
    Bioinformatics 23:522-3. 2007
    ..Illustration with a HapMap+expression dataset is provided. Availability: Package GGtools is part of Bioconductor 1.9 (http://bioconductor.org). Open source with Artistic License...
  53. doi Integrating clinical practice and public health surveillance using electronic medical record systems
    Michael Klompas
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Department of Population Medicine, Boston, Massachusetts 02215, USA
    Am J Prev Med 42:S154-62. 2012
    ..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments...
  54. ncbi A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism
    Ken Kleinman
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA 02215 3920, USA
    Am J Epidemiol 159:217-24. 2004
    ..The authors argue that there is great value in using the geographic data...
  55. pmc Minimal haplotype tagging
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 100:9900-5. 2003
    ..This result seems to provide further evidence that a severe bottleneck occurred during the founding of Europe and the conjectured "Out of Africa" event...
  56. ncbi Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
    ....
  57. pmc Automated detection and classification of type 1 versus type 2 diabetes using electronic health record data
    Michael Klompas
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
    Diabetes Care 36:914-21. 2013
    ..To create surveillance algorithms to detect diabetes and classify type 1 versus type 2 diabetes using structured electronic health record (EHR) data...
  58. pmc Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system
    Qing T Zeng
    Decision Systems Group, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Inform Decis Mak 6:30. 2006
    ..The text descriptions in electronic medical records are a rich source of information. We have developed a Health Information Text Extraction (HITEx) tool and used it to extract key findings for a research study on airways disease...
  59. pmc Use of automated ambulatory-care encounter records for detection of acute illness clusters, including potential bioterrorism events
    Ross Lazarus
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 8:753-60. 2002
    ..This system complements emergency room- and hospital-based surveillance by adding the capacity to rapidly identify clusters of illness, including potential bioterrorism events...
  60. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP...
  61. ncbi Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levels
    Piotr Kozlowski
    Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Hum Genet 70:574-86. 2006
    ....
  62. doi A pipeline for the identification and characterization of chromatin modifications derived from ChIP-Seq datasets
    Antony Kaspi
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Biochimie 94:2353-9. 2012
    ..We provide an overview of best-practise approaches with background information and considerations of integrative analysis from ChIP-Seq experiments...
  63. pmc Motif analysis in DNAse hypersensitivity regions uncovers distal cis elements associated with gene expression
    Mark Ziemann
    Epigenetics in Human Health and Disease Laboratory Epigenomics Profiling Facility, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Bioinformation 9:212-5. 2013
    ..AVAILABILITY: The DHC-MEGE shell script can be obtained from Sourceforge https://sourceforge.net/projects/dhcmege/ and the generated GMT file is attached as supplementary data...
  64. ncbi Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations
    Piotr Kozlowski
    Genetics Laboratory, Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Genet 121:389-400. 2007
    ..We conclude that large deletions in TSC1 and TSC2 account for about 0.5 and 6% of mutations seen in TSC patients, respectively, and MLPA is a highly sensitive and accurate detection method, including for mosaicism...
  65. doi Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care
    Jeffrey S Brown
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 48:S45-51. 2010
    ....
  66. pmc A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
    Giulio Genovese
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 78:698-704. 2010
    ..Further studies will be required to establish which variants are causally related to kidney disease, what mutations caused the selective sweep, and to ultimately determine if these are the same...
  67. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  68. ncbi Pathologic outcome of laparoscopic and open radical prostatectomy
    Douglas M Dahl
    Department of Urology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Urology 68:1253-6. 2006
    ..To compare the clinicopathologic data of 286 laparoscopic radical prostatectomies (LRPs) and 714 open radical prostatectomies (RRPs) performed at the Massachusetts General Hospital from 2001 to 2005...
  69. pmc On the replication of genetic associations: timing can be everything!
    Jessica Lasky-Su
    SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Hum Genet 82:849-58. 2008
    ..If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed...
  70. ncbi Balancing selection is the main force shaping the evolution of innate immunity genes
    Anna Ferrer-Admetlla
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
    J Immunol 181:1315-22. 2008
    ..However, we also describe evidence from African populations, which may reflect parallel or long-term selective forces acting in different geographic areas...
  71. pmc Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillance
    Michael Klompas
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2626. 2008
    ..We describe the development and implementation of an algorithm for prospective surveillance of patients with acute hepatitis B using electronic medical record data...
  72. ncbi IgG subclass specific antibody response to periodontopathic organisms in HIV-positive patients
    Stephen C H Yeung
    Faculty of Dentistry, University of Sydney, Sydney, New South Wales, Australia
    J Periodontol 73:1444-50. 2002
    ....
  73. ncbi Is smoking an indirect risk factor for the development of ulcerative colitis? An age- and sex-matched case-control study
    Ned Abraham
    Department of Colorectal Surgery, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia
    J Gastroenterol Hepatol 18:139-46. 2003
    ..It has been suggested that smoking protects against the development of ulcerative colitis (UC). Evidence is mainly driven from the way data from a multitude of case-control studies have been interpreted...

Research Grants5

  1. BIOINFORMATICS CENTER FOR INNATE IMMUNITY PGA
    Ross Lazarus; Fiscal Year: 2004
    ..abstract_text> ..
  2. A Genetic Association Research Statistical Framework
    Ross Lazarus; Fiscal Year: 2006
    ..Developed in the context of airways disease, the software will be immediately and directly applicable to genetic research in other common, complex disorders. ..
  3. A Genetic Association Research Statistical Framework
    Ross Lazarus; Fiscal Year: 2007
    ..Developed in the context of airways disease, the software will be immediately and directly applicable to genetic research in other common, complex disorders. ..
  4. Electronic Support for Public Health - Vaccine Adverse Event Reporting System
    Ross Lazarus; Fiscal Year: 2007
    ....