Nelson C Lau

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Diverse roles for RNA in gene regulation
    Nelson C Lau
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Genome Biol 6:315. 2005
  2. pmc Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Genome Res 19:1776-85. 2009
  3. doi Analysis of small endogenous RNAs
    Nelson C Lau
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2008
  4. pmc Most Caenorhabditis elegans microRNAs are individually not essential for development or viability
    Eric A Miska
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 3:e215. 2007
  5. ncbi The coming of age for Piwi proteins
    Anita G Seto
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 26:603-9. 2007
  6. ncbi Characterization of the piRNA complex from rat testes
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Science 313:363-7. 2006
  7. ncbi Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects
    Ming Li
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Dev Cell 9:415-22. 2005
  8. ncbi The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans
    Allison L Abbott
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 9:403-14. 2005
  9. ncbi Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lee P Lim
    Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
    Nature 433:769-73. 2005
  10. ncbi Censors of the genome
    Nelson C Lau
    Massachusetts Institute of Technology, USA
    Sci Am 289:34-41. 2003

Collaborators

  • Eric C Lai
  • Eugene Berezikov
  • David Bartel
  • Victor Ambros
  • Robert Kingston
  • Lee P Lim
  • Eric A Miska
  • Allison L Abbott
  • Anita G Seto
  • H Robert Horvitz
  • Ezequiel Alvarez-Saavedra
  • Ming Li
  • Andrew B Hellman
  • Shannon M McGonagle
  • John Castle
  • Andrew Grimson
  • Philip Garrett-Engele
  • Ann E Rougvie
  • Janell M Schelter
  • Matthew W Jones-Rhoades
  • Jason M Johnson
  • Peter S Linsley
  • Earl G Weinstein
  • Aliaa Abdelhakim
  • Soraya Yekta
  • Matthew W Rhoades
  • Christopher B Burge

Detail Information

Publications11

  1. pmc Diverse roles for RNA in gene regulation
    Nelson C Lau
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Genome Biol 6:315. 2005
  2. pmc Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Genome Res 19:1776-85. 2009
    ..These data indicate that the restriction of certain TEs in somatic gonadal cells is largely mediated by a primary piRNA pathway...
  3. doi Analysis of small endogenous RNAs
    Nelson C Lau
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2008
    ..This unit also outlines a cell-based reporter gene assay for assessing the regulatory potential of a microRNA on a candidate mRNA target...
  4. pmc Most Caenorhabditis elegans microRNAs are individually not essential for development or viability
    Eric A Miska
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 3:e215. 2007
    ..This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs...
  5. ncbi The coming of age for Piwi proteins
    Anita G Seto
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 26:603-9. 2007
    ..Here, we highlight the recent progress in understanding Piwi function and the implications for germline and stem cell development...
  6. ncbi Characterization of the piRNA complex from rat testes
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Science 313:363-7. 2006
    ..Piwi has been genetically linked to TGS in flies, and slicer activity cofractionates with the purified complex. These results are consistent with a gene-silencing role for piRC in mammals...
  7. ncbi Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects
    Ming Li
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Dev Cell 9:415-22. 2005
    ..These results suggest that lin-58 alleles disrupt a repressor binding site that restricts the time of miR-48 action in wild-type animals...
  8. ncbi The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans
    Allison L Abbott
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 9:403-14. 2005
    ..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions...
  9. ncbi Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lee P Lim
    Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
    Nature 433:769-73. 2005
    ..Moreover, miR-1 and miR-124, and presumably other tissue-specific miRNAs, seem to downregulate a far greater number of targets than previously appreciated, thereby helping to define tissue-specific gene expression in humans...
  10. ncbi Censors of the genome
    Nelson C Lau
    Massachusetts Institute of Technology, USA
    Sci Am 289:34-41. 2003
  11. pmc The microRNAs of Caenorhabditis elegans
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 17:991-1008. 2003
    ..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species...