Janice M LaPlante

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The cation channel mucolipin-1 is a bifunctional protein that facilitates membrane remodeling via its serine lipase domain
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Exp Cell Res 317:691-705. 2011
  2. ncbi request reprint Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 322:1384-91. 2004
  3. ncbi request reprint Lysosomal exocytosis is impaired in mucolipidosis type IV
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mol Genet Metab 89:339-48. 2006
  4. doi request reprint Chaperone-mediated autophagy is defective in mucolipidosis type IV
    Bhuvarahamurthy Venugopal
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Cell Physiol 219:344-53. 2009
  5. ncbi request reprint Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    FEBS Lett 532:183-7. 2002

Collaborators

Detail Information

Publications5

  1. pmc The cation channel mucolipin-1 is a bifunctional protein that facilitates membrane remodeling via its serine lipase domain
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Exp Cell Res 317:691-705. 2011
    ..MLN1 is absent or mutated in patients with mucolipidosis IV (MLIV), a lysosomal disorder with devastating neurological and other consequences. This study provides potential insight into the pathophysiology of MLIV...
  2. ncbi request reprint Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 322:1384-91. 2004
    ....
  3. ncbi request reprint Lysosomal exocytosis is impaired in mucolipidosis type IV
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mol Genet Metab 89:339-48. 2006
    ..Further, we show that transfection with wild type MLN1 cDNA rescues exocytosis, suggesting the possibility of treatments based on the restoration of this crucial cellular function...
  4. doi request reprint Chaperone-mediated autophagy is defective in mucolipidosis type IV
    Bhuvarahamurthy Venugopal
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Cell Physiol 219:344-53. 2009
    ..It is also possible that TRPML1 channel activity may be required for CMA. Understanding the role of TRPML1 in CMA will undoubtedly help to characterize the pathogenesis of MLIV...
  5. ncbi request reprint Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    FEBS Lett 532:183-7. 2002
    ..With its Ca(2+) permeability and modulation by [Ca(2+)], MLN1 could play a major role in Ca(2+) transport regulating lysosomal exocytosis and potentially other phenomena related to the trafficking of late endosomes and lysosomes...