Jan Lammerding

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi Mechanics of the nucleus
    Jan Lammerding
    Brigham and Women s Hospital Harvard Medical School, Cambridge, Massachusetts, USA
    Compr Physiol 1:783-807. 2011
  2. ncbi Lamins A and C but not lamin B1 regulate nuclear mechanics
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 281:25768-80. 2006
  3. pmc Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells
    Jan Lammerding
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 170:781-91. 2005
  4. ncbi Cell nuclei spin in the absence of lamin b1
    Julie Y Ji
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Biol Chem 282:20015-26. 2007
  5. pmc Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Clin Invest 113:370-8. 2004
  6. pmc An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:2682-94. 2010
  7. pmc Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling
    Monika Zwerger
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 22:2335-49. 2013
  8. pmc Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice
    Catherine Coffinier
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 285:20818-26. 2010
  9. doi Experimental techniques for study of chromatin mechanics in intact nuclei and living cells
    Valerie L R M Verstraeten
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Chromosome Res 16:499-510. 2008
  10. pmc Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
    Valerie L R M Verstraeten
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:4997-5002. 2011

Detail Information

Publications30

  1. doi Mechanics of the nucleus
    Jan Lammerding
    Brigham and Women s Hospital Harvard Medical School, Cambridge, Massachusetts, USA
    Compr Physiol 1:783-807. 2011
    ....
  2. ncbi Lamins A and C but not lamin B1 regulate nuclear mechanics
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 281:25768-80. 2006
    ..Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness...
  3. pmc Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells
    Jan Lammerding
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 170:781-91. 2005
    ....
  4. ncbi Cell nuclei spin in the absence of lamin b1
    Julie Y Ji
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Biol Chem 282:20015-26. 2007
    ..These findings demonstrate that lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton...
  5. pmc Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Clin Invest 113:370-8. 2004
    ..These findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation...
  6. pmc An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:2682-94. 2010
    ..The latter finding is potentially relevant to the long-term use of protein farnesyltransferase inhibitors, which lead to an accumulation of non-farnesylated prelamin A...
  7. pmc Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling
    Monika Zwerger
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 22:2335-49. 2013
    ..In conclusion, our results indicate that although defective nuclear stability may play a role in the development of muscle diseases, other factors, such as impaired nucleo-cytoskeletal coupling, likely contribute to the muscle phenotype...
  8. pmc Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice
    Catherine Coffinier
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 285:20818-26. 2010
    ..We conclude that prelamin A processing is dispensable in mice and that direct synthesis of mature lamin A has little if any effect on the targeting of lamin A to the nuclear rim in mouse tissues...
  9. doi Experimental techniques for study of chromatin mechanics in intact nuclei and living cells
    Valerie L R M Verstraeten
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Chromosome Res 16:499-510. 2008
    ..In the end, a combination of these technologies can provide important insights into the delicate relationship between form and function of chromatin organization in the living cell...
  10. pmc Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
    Valerie L R M Verstraeten
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:4997-5002. 2011
    ....
  11. pmc The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton
    Maria L Lombardi
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 286:26743-53. 2011
    ....
  12. pmc Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse
    Mihaela Cupesi
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 65 Landsdowne St, Cambridge, MA 02139, USA
    J Mol Cell Cardiol 48:1290-7. 2010
    ....
  13. pmc Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors
    Valerie L R M Verstraeten
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 7:383-93. 2008
    ....
  14. doi Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function
    Maria L Lombardi
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Biochem Soc Trans 39:1729-34. 2011
    ....
  15. doi Nuclear mechanics in disease
    Monika Zwerger
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Biomed Eng 13:397-428. 2011
    ....
  16. pmc Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins
    Parth Patwari
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:24996-5003. 2009
    ..These data demonstrate that Txnip regulates cellular metabolism independent of its binding to thioredoxin and reveal the arrestin domains as crucial structural elements in metabolic functions of alpha-arrestin proteins...
  17. pmc A three-dimensional viscoelastic model for cell deformation with experimental verification
    Helene Karcher
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 85:3336-49. 2003
    ..Modulation of cell height has little effect on the results, provided the monolayer is >5 micro m thick. NIH 3T3 fibroblasts exhibited a viscoelastic timescale of approximately 1 s and a shear modulus of approximately 1000 Pa...
  18. ncbi The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C deficient cells
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Novartis Found Symp 264:264-73; discussion 273-8. 2005
    ..Individual mutations in the lamin A/C gene could potentially selectively interfere with any of these functions, explaining the tissue-specific effects observed in the laminopathies...
  19. doi Mechanical properties of interphase nuclei probed by cellular strain application
    Jan Lammerding
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Cambridge, MA, USA
    Methods Mol Biol 464:13-26. 2009
    ....
  20. doi Altered mechanical properties of the nucleus in disease
    Maria Lucia Lombardi
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Methods Cell Biol 98:121-41. 2010
    ..Here, we provide a brief overview of the most common experimental techniques and their application and discuss the implication of their results on our current understanding of nuclear mechanics...
  21. pmc Mechanotransduction gone awry
    Diana E Jaalouk
    Brigham and Women s Hospital, Harvard Medical School, Department of Medicine, Cardiovascular Division, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    Nat Rev Mol Cell Biol 10:63-73. 2009
    ....
  22. ncbi Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells
    Daihiko Hakuno
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 280:39534-44. 2005
    ..These data indicate that FAK is a key regulator of cardiogenesis in mouse ES cells and that FAK signaling within embryoid bodies can direct stem cell lineage commitment...
  23. ncbi Mechanotransduction in cardiac myocytes
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ann N Y Acad Sci 1015:53-70. 2004
    ..New and refined experimental techniques will exploit advances in molecular biology and biological imaging to study mechanotransduction in isolated cells and genetically engineered mice to explore the function of individual proteins...
  24. doi Towards an integrated understanding of the structure and mechanics of the cell nucleus
    Amy C Rowat
    Department of Physics School of Engineering and Applied Science, Harvard University, Cambridge, MA 02138, USA
    Bioessays 30:226-36. 2008
    ..Here we review our current understanding of what determines the shape and mechanical properties of the cell nucleus...
  25. pmc Three-dimensional cardiac architecture determined by two-photon microtomy
    Hayden Huang
    Brigham and Women s Hospital, Department of Medicine, Cardiovascular Division, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 14:044029. 2009
    ....
  26. ncbi Nuclear mechanics and methods
    Jan Lammerding
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Methods Cell Biol 83:269-94. 2007
    ..Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail...
  27. pmc Torn apart: membrane rupture in muscular dystrophies and associated cardiomyopathies
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    J Clin Invest 117:1749-52. 2007
    ..Thus, in addition to repetitive membrane damage, inadequate membrane repair may participate in the pathogenesis of muscular dystrophies and cardiomyopathies...
  28. pmc Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:7616-21. 2003
    ..Hence, CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1...
  29. pmc Prelamin A and lamin A appear to be dispensable in the nuclear lamina
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    J Clin Invest 116:743-52. 2006
    ..These studies suggest a new therapeutic strategy for treating progeria and other lamin A diseases...
  30. pmc Nuclear shape, mechanics, and mechanotransduction
    Kris Noel Dahl
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Circ Res 102:1307-18. 2008
    ..Together, these studies suggest that the nucleus itself may play an important role in the response of the cell to force...

Research Grants8