Genomes and Genes
Affiliation: Harvard University
- miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elementsAshish Lal
Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
Mol Cell 35:610-25. 2009..The E2F2 3'UTR lacks a predicted miR-24 recognition element. In fact, miR-24 regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences...
- Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signalingAshish Lal
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, United States of America
PLoS Genet 7:e1002363. 2011..Thus miR-34a tempers the proliferative and pro-survival effect of growth factor stimulation by interfering with growth factor signal transduction and downstream pathways required for cell division...
- miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cellsAshish Lal
Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Nat Struct Mol Biol 16:492-8. 2009..Therefore, miR-24 upregulation in postreplicative cells reduces H2AX and makes them vulnerable to DNA damage...
- miR-200 enhances mouse breast cancer cell colonization to form distant metastasesDerek M Dykxhoorn
Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 4:e7181. 2009..Because some miRNAs are dysregulated in cancer and affect cellular transformation, tumor formation, and metastasis, we examined whether changes in miRNA expression might explain the differences in metastasis of these cells...
- Desperately seeking microRNA targetsMarshall Thomas
Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Nat Struct Mol Biol 17:1169-74. 2010..Bioinformatic analysis of over-represented pathways and nodes in protein-DNA interactomes formed from experimental candidate miRNA gene target lists can focus attention on biologically significant target genes...
- Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host geneYichao Wu
The Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Cell Host Microbe 5:84-94. 2009..Combining siRNAs targeting a viral and host gene protects mice from HSV-2 for a week, irrespective of the time of challenge. Therefore, intravaginal siRNAs could provide sustained protection against viral transmission...
- MicroRNAs and their target gene networks in breast cancerElizabeth O'Day
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Breast Cancer Res 12:201. 2010..Here we report how the observed perturbations in miRNA expression profiles may lead to disruption of key pathways involved in breast cancer...