Research Topics
Genomes and Genes | Ashish LalSummaryAffiliation: Harvard Medical School Country: USA Publications
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Publications
p16(INK4a) translation suppressed by miR-24Ashish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland, United States of America
PLoS ONE 3:e1864. 2008..Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence...- Ubiquitin-mediated proteolysis of HuR by heat shockKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
EMBO J 28:1271-82. 2009..Our findings reveal that HS transiently lowers HuR by proteolysis linked to K182 ubiquitination and that HuR reduction enhances cell survival following HS... 
Posttranscriptional orchestration of an anti-apoptotic program by HuRKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 6:1288-92. 2007....- Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuRTomoko Kawai
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program NIH, Box 12, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Mol Cell Biol 26:3295-307. 2006.... - Nuclear HuR accumulation through phosphorylation by Cdk1Hyeon Ho Kim
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
Genes Dev 22:1804-15. 2008..Our findings suggest that Cdk1 phosphorylates HuR during G2, thereby helping to retain it in the nucleus in association with 14-3-3 and hindering its post-transcriptional function and anti-apoptotic influence... - Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAsRudolf Pullmann
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21228, USA
Mol Cell Biol 27:6265-78. 2007..Together, our findings underscore the notion that TTR-RBP expression is controlled, at least in part, at the posttranscriptional level through a complex circuitry of self- and cross-regulatory RNP interactions... - Phosphorylation of HuR by Chk2 regulates SIRT1 expressionKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mol Cell 25:543-57. 2007..Our findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes... - Posttranscriptional derepression of GADD45alpha by genotoxic stressAshish Lal
Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Mol Cell 22:117-28. 2006..We propose that the posttranscriptional derepression of GADD45alpha critically contributes to its potent upregulation after DNA damage... - Growth inhibition by miR-519 via multiple p21-inducing pathwaysKotb Abdelmohsen
Laboratory of Molecular Biology and Immunology, Research Resources Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA
Mol Cell Biol 32:2530-48. 2012..Our results indicate that miR-519 promotes DNA damage, alters Ca(2+) homeostasis, and enhances energy production; together, these processes elevate the expression level of p21, promoting growth inhibition and cell survival... - Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1Rudolf Pullmann
Laboratory of Cellular and Molecular Biology, NIA IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
J Biol Chem 281:23456-63. 2006..Our results illustrate the functional consequences of ribonucleoprotein associations involving a polymorphic RNA sequence and uncover a novel mechanism of action for non-coding RNA polymorphisms... - Translational repression by RNA-binding protein TIARKrystyna Mazan-Mamczarz
Laboratory of Cellular and Molecular Biology, Box 12, LCMB, National Institute on Aging Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, Maryland 21224, USA
Mol Cell Biol 26:2716-27. 2006..We propose that the TIAR-mediated inhibition of translation factor expression elicits a sustained repression of protein biosynthesis in cells responding to stress... - Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alphaAshish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
EMBO J 24:1852-62. 2005..Together, our data support a regulatory scheme whereby HuR binds the ProTalpha mRNA, elevates its cytoplasmic abundance and translation, and thereby elicits an antiapoptotic program... - HuR: post-transcriptional paths to malignancyIsabel Lopez de Silanes
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA
RNA Biol 2:11-3. 2005..We describe a paradigm consistent with a central role of HuR in oncogenesis... - Identification of a signature motif in target mRNAs of RNA-binding protein AUF1Krystyna Mazan-Mamczarz
Laboratory of Cellular and Molecular Biology, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Nucleic Acids Res 37:204-14. 2009.... - Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuRXiaoling Yang
Laboratory of Cellular and Molecular Biology, NIA, National Institutes of Health, Baltimore, MD 21224, USA
J Biol Chem 279:49298-306. 2004..Collectively, our results indicate that PGA2 stabilizes the p21 mRNA through an ERK-independent increase in cytoplasmic HuR levels and an ERK-dependent association of HuR with the p21 mRNA... - Egad, more forms of gene regulation: the gadd45a storyAshish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 5:1422-5. 2006.... - Clean Western blot signals from immunoprecipitated samplesAshish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Box 12, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Mol Cell Probes 19:385-8. 2005..Here, we show that HRP-conjugated Protein A and Protein G, which detect almost exclusively intact antibody molecules, can be effectively used to obtain clean and specific WB signals of target proteins... - Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAsAshish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, MD 21224, USA
EMBO J 23:3092-102. 2004.... - RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alphaStefanie Galban
LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Mol Cell Biol 28:93-107. 2008..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)...