Stephen Lake

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
  2. ncbi Sample size re-estimation in cluster randomization trials
    Stephen Lake
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Stat Med 21:1337-50. 2002
  3. ncbi Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
  4. ncbi Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
  5. ncbi Association of the DTNBP1 locus with schizophrenia in a U.S. population
    Birgit Funke
    Harvard Medical School Partners Center for Genetics and Genomics, Boston, MA 02115, USA
    Am J Hum Genet 75:891-8. 2004
  6. ncbi PRKCA: a positional candidate gene for body mass index and asthma
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:87-96. 2009
  7. ncbi Functional MRI detection of pharmacologically induced memory impairment
    Reisa Sperling
    Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 99:455-60. 2002
  8. ncbi Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
  9. ncbi IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
  10. ncbi The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006

Detail Information

Publications12

  1. ncbi Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
    ..Since the A2M gene lies in a chromosomal region (chromosome 12p) that consistently has been linked to AD, association tests should be conducted under the null hypothesis that there is linkage but no association...
  2. ncbi Sample size re-estimation in cluster randomization trials
    Stephen Lake
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Stat Med 21:1337-50. 2002
    ..The effect of this design on the power, significance level and sample size is analysed via simulation and is shown to provide a flexible and practical approach to cluster randomization trials...
  3. ncbi Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
    ..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness...
  4. ncbi Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  5. ncbi Association of the DTNBP1 locus with schizophrenia in a U.S. population
    Birgit Funke
    Harvard Medical School Partners Center for Genetics and Genomics, Boston, MA 02115, USA
    Am J Hum Genet 75:891-8. 2004
    ..005). Our study provides further evidence for a role of the DTNBP1 gene in the genetic etiology of schizophrenia...
  6. ncbi PRKCA: a positional candidate gene for body mass index and asthma
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:87-96. 2009
    ..6 x 10(-)(5)). PRKCA is a pleiotropic locus that is associated with both BMI and asthma and that has been identified via linkage analysis of BMI in a population ascertained on asthma...
  7. ncbi Functional MRI detection of pharmacologically induced memory impairment
    Reisa Sperling
    Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 99:455-60. 2002
    ....
  8. ncbi Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
    ....
  9. ncbi IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  10. ncbi The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  11. ncbi Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research
    Nicholas Lange
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Stat Med 23:327-50. 2004
    ....
  12. ncbi The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation
    Philippe Menasche
    Département de Chirurgie Cardio vasculaire, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France
    Circulation 117:1189-200. 2008
    ..Phase I clinical studies have demonstrated the feasibility of implanting autologous skeletal myoblasts in postinfarction scars. However, they have failed to determine whether this procedure was functionally effective and arrhythmogenic...