S L Lake

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
  2. ncbi request reprint Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hum Hered 55:56-65. 2003
  3. ncbi request reprint Tests of gene-environment interaction for case-parent triads with general environmental exposures
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Hum Genet 68:55-64. 2004
  4. pmc Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
  5. ncbi request reprint Family-based tests of association in the presence and absence of known linkage
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genet Epidemiol 21:S292-7. 2001

Collaborators

Detail Information

Publications5

  1. pmc Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  2. ncbi request reprint Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hum Hered 55:56-65. 2003
    ..Simulations were run to illustrate the salient features of the method. In addition, the method was used to test for haplotype-smoking exposure interaction with data from the Childhood Asthma Management Program...
  3. ncbi request reprint Tests of gene-environment interaction for case-parent triads with general environmental exposures
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Hum Genet 68:55-64. 2004
    ..We present a test, FBAT-I, that can be used to investigate gene-environment interaction. The test uses the case-parent triad design and protects the statistical inference from potential spurious results due to population admixture...
  4. pmc Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
    ..Since the A2M gene lies in a chromosomal region (chromosome 12p) that consistently has been linked to AD, association tests should be conducted under the null hypothesis that there is linkage but no association...
  5. ncbi request reprint Family-based tests of association in the presence and absence of known linkage
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genet Epidemiol 21:S292-7. 2001
    ..Our results indicate that both tests generally perform comparably in either setting...