Nan M Laird

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Incidence of major depression: prediction from subthreshold categories in the Stirling County Study
    Jane M Murphy
    Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Affect Disord 68:251-9. 2002
  2. pmc Power calculations for a general class of family-based association tests: dichotomous traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA
    Am J Hum Genet 71:575-84. 2002
  3. ncbi request reprint Family study of affective spectrum disorder
    James I Hudson
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Arch Gen Psychiatry 60:170-7. 2003
  4. ncbi request reprint Regression methods for assessing familial aggregation of disease
    Nan M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Stat Med 22:1447-55. 2003
  5. pmc Using the noninformative families in family-based association tests: a powerful new testing strategy
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 73:801-11. 2003
  6. pmc Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
    Hortensia Moreno-Macias
    Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H 001, Col Vicentina, 09430, D F, Mexico City, Mexico
    Respir Res 14:14. 2013
  7. pmc Identifying rare variants using a Bayesian regression approach
    Aimin Yan
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Proc 5:S99. 2011
  8. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
  9. pmc Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set
    Wai Ki Yip
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Building II, Boston, MA 02115, USA
    BMC Proc 5:S21. 2011
  10. pmc A general semi-parametric approach to the analysis of genetic association studies in population-based designs
    Sharon Lutz
    Department of Biostatistics, University of Colorado Anschutz Medical Campus, Aurora, USA
    BMC Genet 14:13. 2013

Detail Information

Publications60

  1. ncbi request reprint Incidence of major depression: prediction from subthreshold categories in the Stirling County Study
    Jane M Murphy
    Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Affect Disord 68:251-9. 2002
    ..In this report, the subsequent incidence of MDE was assessed in terms of baseline evidence about the two subthreshold categories and Dysthymic Disorder (DysD)...
  2. pmc Power calculations for a general class of family-based association tests: dichotomous traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA
    Am J Hum Genet 71:575-84. 2002
    ..When the population prevalence is high, it can be worthwhile to genotype unaffected offspring. For many scenarios, high power can be achieved with reasonable sample sizes, even when no parental information is available...
  3. ncbi request reprint Family study of affective spectrum disorder
    James I Hudson
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Arch Gen Psychiatry 60:170-7. 2003
    ..Two predictions of the ASD hypothesis were tested: that ASD, taken as a single entity, would aggregate in families and that MDD would coaggregate with other forms of ASD in families...
  4. ncbi request reprint Regression methods for assessing familial aggregation of disease
    Nan M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Stat Med 22:1447-55. 2003
    ..An example involving eating disorders and depression is given...
  5. pmc Using the noninformative families in family-based association tests: a powerful new testing strategy
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 73:801-11. 2003
    ....
  6. pmc Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
    Hortensia Moreno-Macias
    Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H 001, Col Vicentina, 09430, D F, Mexico City, Mexico
    Respir Res 14:14. 2013
    ....
  7. pmc Identifying rare variants using a Bayesian regression approach
    Aimin Yan
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Proc 5:S99. 2011
    ..However, the model also generated several apparent false positives and missed many true positives, suggesting that there is room for improvement in this model...
  8. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
    ....
  9. pmc Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set
    Wai Ki Yip
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Building II, Boston, MA 02115, USA
    BMC Proc 5:S21. 2011
    ..Our results suggest that both linkage and association tests with families show promise for identifying rare variants...
  10. pmc A general semi-parametric approach to the analysis of genetic association studies in population-based designs
    Sharon Lutz
    Department of Biostatistics, University of Colorado Anschutz Medical Campus, Aurora, USA
    BMC Genet 14:13. 2013
    ..In the analysis of complex phenotypes, especially in the presence of ascertainment conditions, the specification of such model assumptions is not straight-forward and is error-prone, potentially causing misleading results...
  11. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
    ..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...
  12. pmc EFBAT: exact family-based association tests
    Kady Schneiter
    Department of Mathematics and Statistics, Utah State University, 3900 Old Main Hill, Logan, UT 84322 3900, USA
    BMC Genet 8:86. 2007
    ..These tests are especially valuable for being robust to population structure. We introduce a tool, EFBAT, which performs exact family-based tests of association for X-chromosome and autosomal biallelic markers...
  13. ncbi request reprint Family-based designs in the age of large-scale gene-association studies
    Nan M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Genet 7:385-94. 2006
    ..Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies...
  14. doi request reprint On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
    Genet Epidemiol 32:273-84. 2008
    ..A software implementation of the approach is freely available at http://www.hsph.harvard.edu/research/iuliana-ionita/software. The approach has also been completely integrated in the PBAT software package...
  15. pmc Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
    ..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati...
  16. ncbi request reprint A new multimarker test for family-based association studies
    Cyril S Rakovski
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Genet Epidemiol 31:9-17. 2007
    ..We confirm the conclusions of our study with an application to Alzheimer's disease data...
  17. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
    ..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14...
  18. ncbi request reprint Co-occurrence of binge eating disorder with psychiatric and medical disorders
    Kristin N Javaras
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass, USA
    J Clin Psychiatry 69:266-73. 2008
    ..We used data from that type of study to assess the co-occurrence of various psychiatric and medical disorders with DSM-IV BED and with subthreshold BED...
  19. pmc Gene-environment interaction tests for dichotomous traits in trios and sibships
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 33:691-9. 2009
    ..Lastly, we apply these three tests to a group of nuclear families ascertained according to affection with Bipolar Disorder...
  20. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  21. doi request reprint FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests
    Cyril S Rakovski
    Department of Biostatistics, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Hum Hered 66:122-6. 2008
    ..Develop a new test for family-based association studies and continuous traits that incorporates power- enhancing techniques from two existing testing strategies...
  22. pmc Combining disease models to test for gene-environment interaction in nuclear families
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 67:1260-70. 2011
    ..We utilize this hybrid approach to analyze a chronic obstructive pulmonary disorder dataset to test for gene-environment interaction in the Serpine2 gene with smoking. The methods are freely available in the R package fbati...
  23. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
    ..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association...
  24. pmc Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus
    Jinbo Fan
    Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:29-37. 2010
    ..Further studies in larger samples are warranted to clarify which, if any, genes in the 6q region confer risk for bipolar disorder...
  25. pmc On the frequency of copy number variants
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Bioinformatics 24:2350-5. 2008
    ..We employ a two-step procedure for the CNV frequency estimation process. We use family information a posteriori to select only the most reliable CNV regions, i.e. those showing high rates of Mendelian transmission...
  26. ncbi request reprint A multivariate family-based association test using generalized estimating equations: FBAT-GEE
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 4:195-206. 2003
    ..Application of the proposed test to an asthma study illustrates the power of the approach...
  27. ncbi request reprint Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program
    Edwin K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 112:870-6. 2003
    ..Beta2-adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies...
  28. pmc Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 81:607-14. 2007
    ..The proposed method is of general applicability; it extends to any setting in which prior, independent ranking of hypotheses is available...
  29. ncbi request reprint Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  30. pmc Power and design considerations for a general class of family-based association tests: quantitative traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 71:1330-41. 2002
    ..We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study...
  31. ncbi request reprint Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
  32. pmc Prospective association of common eating disorders and adverse outcomes
    Alison E Field
    Division of Adolescent Medicine, Department of Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 130:e289-95. 2012
    ..Our objective was to evaluate whether BN and subtypes of EDNOS are predictive of developing adverse outcomes...
  33. pmc Variance calculations for identity-by-descent estimation
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 78:914-21. 2006
    ..Mean IBD and its standard errors are valuable tools for the further assessment and evaluation of linkage-scan samples involving complex disease...
  34. ncbi request reprint Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
    Michael H Cho
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA, USA Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA, USA Electronic address
    Lancet Respir Med 2:214-25. 2014
    ..We sought to identify risk loci for moderate to severe and severe COPD with data from several cohort studies...
  35. pmc Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers
    Jin J Zhou
    1 Biostatistics Department, Harvard School of Public Health, Boston, Massachusetts
    Am J Respir Crit Care Med 188:941-7. 2013
    ..These phenotypes are highly predictive of disease, and family studies have shown that spirometric phenotypes are heritable...
  36. ncbi request reprint On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 23:165-80. 2002
    ..The proposed methodology is illustrated with a genetic study of asthma...
  37. ncbi request reprint Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study
    Kristin N Javaras
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Eat Disord 41:174-9. 2008
    ..To estimate the familiality and heritability of binge eating disorder (BED)...
  38. doi request reprint Family-based methods for linkage and association analysis
    Nan M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Adv Genet 60:219-52. 2008
    ..This chapter focuses on family-based designs. We describe some basic study designs as well as general approaches to analysis for qualitative, quantitative, and complex traits. Finally, we review available software...
  39. pmc Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures
    Hortensia Moreno-Macias
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Genomics 4:302-26. 2010
    ..Our results indicate that use of this method allows both main genetic and gene-environment interaction effects to be estimated without bias, even in the presence of population substructure...
  40. pmc Impact of population stratification on family-based association tests with longitudinal measurements
    Xiao Ding
    Harvard School of Public Health
    Stat Appl Genet Mol Biol 8:Article 17. 2009
    ..An application of these approaches to the Childhood Asthma Management Program (CAMP) study data for testing an association between body mass index and a previously reported candidate SNP is given as an example...
  41. ncbi request reprint Binge-eating disorder as a distinct familial phenotype in obese individuals
    James I Hudson
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Mass 02478, USA
    Arch Gen Psychiatry 63:313-9. 2006
    ..However, it remains unclear whether BED represents an etiologically distinct behavioral phenotype of obesity or simply a nonspecific eating pattern sometimes seen in obese individuals...
  42. doi request reprint A structural approach to the familial coaggregation of disorders
    James I Hudson
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Epidemiology 19:431-9. 2008
    ..For illustration, we applied our method to a family study of binge eating disorder and bipolar disorder...
  43. ncbi request reprint The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 57:1485-92. 2005
    ..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
  44. ncbi request reprint Cigarette smoking in relation to depression: historical trends from the Stirling County Study
    Jane M Murphy
    Department of Psychiatry, Room 10028, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 2000, USA
    Am J Psychiatry 160:1663-9. 2003
    ..Building on findings about the prevalence and incidence of depression over a 40-year period, the authors provide data on trends in cigarette smoking and associations with depression...
  45. ncbi request reprint LongCriSP: a test for bump hunting in longitudinal data
    Jaroslaw Harezlak
    Department of Biostatistics, Harvard University, Boston, MA 02115, USA
    Stat Med 26:1383-97. 2007
    ..Finally, we apply our testing procedure to the longitudinal measurements of body mass index of former prisoners of war in Vietnam and conclude that the mean population curve exhibits non-monotone behaviour...
  46. ncbi request reprint Family-based association tests for survival and times-to-onset analysis
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Stat Med 23:179-89. 2004
    ..Based on the results of the simulation study, we suggest rules of thumb about which statistics to use in a given situation. An application of all three tests to an Alzheimer study illustrates the practical relevance of our discussion...
  47. pmc Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study
    Frank B Yoon
    Harvard Medical School, Boston, MA, USA
    Stat Med 30:1917-32. 2011
    ..Results of a simulation study are reported, and the methods are illustrated in an example from the Clinical Antipsychotic Trials of Intervention Effectiveness for schizophrenia...
  48. pmc Family, peer, and media predictors of becoming eating disordered
    Alison E Field
    Division of Adolescent Young Adult Medicine, Department of Medicine, Children s Hospital, 300 Longwood Ave, Room LO 649, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 162:574-9. 2008
    ..To identify predictors of becoming eating disordered among adolescents...
  49. pmc Tests for compositional epistasis under single interaction-parameter models
    Tyler J VanderWeele
    Harvard School of Public Health Departments of Epidemiology and Biostatistics, Boston, Massachusetts 02115, United States
    Ann Hum Genet 75:146-56. 2011
    ..We describe the implications of these tests for cohort, case-control, case-only and family-based study designs and we illustrate the methods using an example of gene-gene interaction already reported in the literature...
  50. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  51. doi request reprint Mortality associated with depression: a forty-year perspective from the Stirling County Study
    Jane M Murphy
    Dept of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Room 215, 5 Longfellow Place, Boston, MA 02114, USA
    Soc Psychiatry Psychiatr Epidemiol 43:594-601. 2008
    ....
  52. ncbi request reprint Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics
    Steve Horvath
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genet Epidemiol 26:61-9. 2004
    ..00005) and the measure of bronchodilator responsiveness (P value =0.016)...
  53. ncbi request reprint Regression analysis of multiple-source longitudinal outcomes: a "Stirling County" depression study
    Constantine Daskalakis
    Biostatistics Section, Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Epidemiol 155:88-94. 2002
    ..In addition, stability of the DPAX over time was significantly higher than that of the DIS. No covariates were found to affect significantly the association between outcomes...
  54. ncbi request reprint Self-disparagement as feature and forerunner of depression: findings from the Stirling County Study
    Jane M Murphy
    Department of Psychiatry, Harvard Medical School and School of Public Health, 149 13th St, Charlestown, MA, USA
    Compr Psychiatry 43:13-21. 2002
    ..Feelings of personal inadequacy deserve particular attention in the population at large because they are strongly associated with lifetime diagnoses and forecast the incidence of depression when people are followed over time...
  55. pmc Marginal regression models with a time to event outcome and discrete multiple source predictors
    Heather J Litman
    New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
    Lifetime Data Anal 12:249-65. 2006
    ..Thus, the GEE is recommended to fit marginal models for its flexibility, ease of interpretation and comparable efficiency to ML in the presence of missing data...
  56. ncbi request reprint On the parsing of statistical information in family-based association testing
    Matthew B McQueen
    Nat Genet 39:281-2. 2007
  57. pmc Incorporating missingness for estimation of marginal regression models with multiple source predictors
    Heather J Litman
    New England Research Institutes, 9 Galen St, Watertown, MA 02472, USA
    Stat Med 26:1055-68. 2007
    ..We implement both methods in a study investigating the association between physical activity and obesity with activity measured using multiple informants (children and their mothers)...
  58. pmc PBAT: tools for family-based association studies
    Christoph Lange
    Am J Hum Genet 74:367-9. 2004
  59. ncbi request reprint Non-linear hierarchical models for monitoring compliance
    Donna K Pauler
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 557, Seattle, WA 98109 1024, USA
    Stat Med 21:219-29. 2002
    ....
  60. ncbi request reprint Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
    Aleister J Saunders
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hum Mol Genet 12:2765-76. 2003
    ..However, the negative case - control studies suggest that any underlying pathogenic polymorphisms have a modest effect, and may operate primarily among individuals with a family history of AD...