Research Topics
| Nan M LairdSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Incidence of major depression: prediction from subthreshold categories in the Stirling County StudyJane M Murphy
Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
J Affect Disord 68:251-9. 2002..In this report, the subsequent incidence of MDE was assessed in terms of baseline evidence about the two subthreshold categories and Dysthymic Disorder (DysD)...
Power calculations for a general class of family-based association tests: dichotomous traitsChristoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA
Am J Hum Genet 71:575-84. 2002..When the population prevalence is high, it can be worthwhile to genotype unaffected offspring. For many scenarios, high power can be achieved with reasonable sample sizes, even when no parental information is available...- Family study of affective spectrum disorderJames I Hudson
Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
Arch Gen Psychiatry 60:170-7. 2003..Two predictions of the ASD hypothesis were tested: that ASD, taken as a single entity, would aggregate in families and that MDD would coaggregate with other forms of ASD in families... - Regression methods for assessing familial aggregation of diseaseNan M Laird
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Stat Med 22:1447-55. 2003..An example involving eating disorders and depression is given... - Using the noninformative families in family-based association tests: a powerful new testing strategyChristoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Am J Hum Genet 73:801-11. 2003.... - Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigationMichael H Cho
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 11:30. 2010..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity... - EFBAT: exact family-based association testsKady Schneiter
Department of Mathematics and Statistics, Utah State University, 3900 Old Main Hill, Logan, UT 84322 3900, USA
BMC Genet 8:86. 2007..These tests are especially valuable for being robust to population structure. We introduce a tool, EFBAT, which performs exact family-based tests of association for X-chromosome and autosomal biallelic markers... - Family-based designs in the age of large-scale gene-association studiesNan M Laird
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nat Rev Genet 7:385-94. 2006..Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies... - Parsing the effects of individual SNPs in candidate genes with family dataThomas J Hoffmann
Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
Hum Hered 69:91-103. 2010..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati... 
On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association testIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
Genet Epidemiol 32:273-84. 2008..A software implementation of the approach is freely available at http://www.hsph.harvard.edu/research/iuliana-ionita/software. The approach has also been completely integrated in the PBAT software package...- A new multimarker test for family-based association studiesCyril S Rakovski
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Genet Epidemiol 31:9-17. 2007..We confirm the conclusions of our study with an application to Alzheimer's disease data... - Comparison of linkage and association strategies for quantitative traits using the COGA datasetMatthew B McQueen
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
BMC Genet 6:S96. 2005..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14... - Gene-environment interaction tests for dichotomous traits in trios and sibshipsThomas J Hoffmann
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Genet Epidemiol 33:691-9. 2009..Lastly, we apply these three tests to a group of nuclear families ascertained according to affection with Bipolar Disorder... - Co-occurrence of binge eating disorder with psychiatric and medical disordersKristin N Javaras
Department of Biostatistics, Harvard School of Public Health, Boston, Mass, USA
J Clin Psychiatry 69:266-73. 2008..We used data from that type of study to assess the co-occurrence of various psychiatric and medical disorders with DSM-IV BED and with subthreshold BED... - FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association testsCyril S Rakovski
Department of Biostatistics, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
Hum Hered 66:122-6. 2008..Develop a new test for family-based association studies and continuous traits that incorporates power- enhancing techniques from two existing testing strategies... - A common genetic variant is associated with adult and childhood obesityAlan Herbert
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
Science 312:279-83. 2006..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity... - Combining disease models to test for gene-environment interaction in nuclear familiesThomas J Hoffmann
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Biometrics 67:1260-70. 2011..We utilize this hybrid approach to analyze a chronic obstructive pulmonary disorder dataset to test for gene-environment interaction in the Serpine2 gene with smoking. The methods are freely available in the R package fbati... - Genomic screening in family-based association testingAmy Murphy
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
BMC Genet 6:S115. 2005..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association... - Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management programEdwin K Silverman
Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Allergy Clin Immunol 112:870-6. 2003..Beta2-adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies... - A multivariate family-based association test using generalized estimating equations: FBAT-GEEChristoph Lange
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Biostatistics 4:195-206. 2003..Application of the proposed test to an asthma study illustrates the power of the approach... - On the frequency of copy number variantsIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
Bioinformatics 24:2350-5. 2008.... - Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locusJinbo Fan
Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 153:29-37. 2010..Further studies in larger samples are warranted to clarify which, if any, genes in the 6q region confer risk for bipolar disorder... - Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scanIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Am J Hum Genet 81:607-14. 2007..The proposed method is of general applicability; it extends to any setting in which prior, independent ranking of hypotheses is available... - Power and design considerations for a general class of family-based association tests: quantitative traitsChristoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Am J Hum Genet 71:1330-41. 2002..We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study... - Genomic screening and replication using the same data set in family-based association testingKristel Van Steen
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nat Genet 37:683-91. 2005..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do... - Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibitionJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 54:1376-81. 2003..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype... - Prospective association of common eating disorders and adverse outcomesAlison E Field
Division of Adolescent Medicine, Department of Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Pediatrics 130:e289-95. 2012..Our objective was to evaluate whether BN and subtypes of EDNOS are predictive of developing adverse outcomes... - Variance calculations for identity-by-descent estimationMatthew B McQueen
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Hum Genet 78:914-21. 2006..Mean IBD and its standard errors are valuable tools for the further assessment and evaluation of linkage-scan samples involving complex disease... - On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerationsChristoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Genet Epidemiol 23:165-80. 2002..The proposed methodology is illustrated with a genetic study of asthma... - Family-based methods for linkage and association analysisNan M Laird
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Adv Genet 60:219-52. 2008..This chapter focuses on family-based designs. We describe some basic study designs as well as general approaches to analysis for qualitative, quantitative, and complex traits. Finally, we review available software... - Familiality and heritability of binge eating disorder: results of a case-control family study and a twin studyKristin N Javaras
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
Int J Eat Disord 41:174-9. 2008..To estimate the familiality and heritability of binge eating disorder (BED)... - Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measuresHortensia Moreno-Macias
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Hum Genomics 4:302-26. 2010..Our results indicate that use of this method allows both main genetic and gene-environment interaction effects to be estimated without bias, even in the presence of population substructure... - Impact of population stratification on family-based association tests with longitudinal measurementsXiao Ding
Harvard School of Public Health
Stat Appl Genet Mol Biol 8:Article 17. 2009..An application of these approaches to the Childhood Asthma Management Program (CAMP) study data for testing an association between body mass index and a previously reported candidate SNP is given as an example... - A structural approach to the familial coaggregation of disordersJames I Hudson
Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
Epidemiology 19:431-9. 2008..For illustration, we applied our method to a family study of binge eating disorder and bipolar disorder... - Cigarette smoking in relation to depression: historical trends from the Stirling County StudyJane M Murphy
Department of Psychiatry, Room 10028, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 2000, USA
Am J Psychiatry 160:1663-9. 2003..Building on findings about the prevalence and incidence of depression over a 40-year period, the authors provide data on trends in cigarette smoking and associations with depression... - The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorderJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Biol Psychiatry 57:1485-92. 2005..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus... - Binge-eating disorder as a distinct familial phenotype in obese individualsJames I Hudson
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Mass 02478, USA
Arch Gen Psychiatry 63:313-9. 2006..However, it remains unclear whether BED represents an etiologically distinct behavioral phenotype of obesity or simply a nonspecific eating pattern sometimes seen in obese individuals... - Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case studyFrank B Yoon
Harvard Medical School, Boston, MA, USA
Stat Med 30:1917-32. 2011..Results of a simulation study are reported, and the methods are illustrated in an example from the Clinical Antipsychotic Trials of Intervention Effectiveness for schizophrenia... - LongCriSP: a test for bump hunting in longitudinal dataJaroslaw Harezlak
Department of Biostatistics, Harvard University, Boston, MA 02115, USA
Stat Med 26:1383-97. 2007..Finally, we apply our testing procedure to the longitudinal measurements of body mass index of former prisoners of war in Vietnam and conclude that the mean population curve exhibits non-monotone behaviour... - Family-based association tests for survival and times-to-onset analysisChristoph Lange
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Stat Med 23:179-89. 2004..Based on the results of the simulation study, we suggest rules of thumb about which statistics to use in a given situation. An application of all three tests to an Alzheimer study illustrates the practical relevance of our discussion... - Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8qMatthew B McQueen
Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
Am J Hum Genet 77:582-95. 2005..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches... - Tests for compositional epistasis under single interaction-parameter modelsTyler J VanderWeele
Harvard School of Public Health Departments of Epidemiology and Biostatistics, Boston, Massachusetts 02115, United States
Ann Hum Genet 75:146-56. 2011..We describe the implications of these tests for cohort, case-control, case-only and family-based study designs and we illustrate the methods using an example of gene-gene interaction already reported in the literature... - Family, peer, and media predictors of becoming eating disorderedAlison E Field
Division of Adolescent Young Adult Medicine, Department of Medicine, Children s Hospital, 300 Longwood Ave, Room LO 649, Boston, MA 02115, USA
Arch Pediatr Adolesc Med 162:574-9. 2008..To identify predictors of becoming eating disordered among adolescents... - Mortality associated with depression: a forty-year perspective from the Stirling County StudyJane M Murphy
Dept of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Room 215, 5 Longfellow Place, Boston, MA 02114, USA
Soc Psychiatry Psychiatr Epidemiol 43:594-601. 2008.... - Self-disparagement as feature and forerunner of depression: findings from the Stirling County StudyJane M Murphy
Department of Psychiatry, Harvard Medical School and School of Public Health, 149 13th St, Charlestown, MA, USA
Compr Psychiatry 43:13-21. 2002..Feelings of personal inadequacy deserve particular attention in the population at large because they are strongly associated with lifetime diagnoses and forecast the incidence of depression when people are followed over time... - Family-based tests for associating haplotypes with general phenotype data: application to asthma geneticsSteve Horvath
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Genet Epidemiol 26:61-9. 2004..00005) and the measure of bronchodilator responsiveness (P value =0.016)... - Marginal regression models with a time to event outcome and discrete multiple source predictorsHeather J Litman
New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
Lifetime Data Anal 12:249-65. 2006..Thus, the GEE is recommended to fit marginal models for its flexibility, ease of interpretation and comparable efficiency to ML in the presence of missing data... - On the parsing of statistical information in family-based association testingMatthew B McQueen
Nat Genet 39:281-2. 2007 - Regression analysis of multiple-source longitudinal outcomes: a "Stirling County" depression studyConstantine Daskalakis
Biostatistics Section, Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Epidemiol 155:88-94. 2002..In addition, stability of the DPAX over time was significantly higher than that of the DIS. No covariates were found to affect significantly the association between outcomes... - PBAT: tools for family-based association studiesChristoph Lange
Am J Hum Genet 74:367-9. 2004 - Incorporating missingness for estimation of marginal regression models with multiple source predictorsHeather J Litman
New England Research Institutes, 9 Galen St, Watertown, MA 02472, USA
Stat Med 26:1055-68. 2007..We implement both methods in a study investigating the association between physical activity and obesity with activity measured using multiple informants (children and their mothers)... - Non-linear hierarchical models for monitoring complianceDonna K Pauler
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 557, Seattle, WA 98109 1024, USA
Stat Med 21:219-29. 2002.... - Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulinAleister J Saunders
Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hum Mol Genet 12:2765-76. 2003..However, the negative case - control studies suggest that any underlying pathogenic polymorphisms have a modest effect, and may operate primarily among individuals with a family history of AD...