N M Laird

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Implementing a unified approach to family-based tests of association
    N M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 19:S36-42. 2000
  2. pmc Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions
    K L Lunetta
    Department of Biostatistical Science, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Am J Hum Genet 66:605-14. 2000
  3. pmc Obesity and weight gain in relation to depression: findings from the Stirling County Study
    J M Murphy
    Psychiatric Epidemiology, Department of Psychiatry, Massachusetts General Hospital, 5 Longfellow Place, Boston, MA 02114, USA
    Int J Obes (Lond) 33:335-41. 2009
  4. ncbi request reprint Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity
    J M Murphy
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 109:355-75. 2004
  5. ncbi request reprint Tests of gene-environment interaction for case-parent triads with general environmental exposures
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Hum Genet 68:55-64. 2004
  6. ncbi request reprint Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hum Hered 55:56-65. 2003
  7. ncbi request reprint An alternative parameterization of the general linear mixture model for longitudinal data with non-ignorable drop-outs
    G M Fitzmaurice
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston MA 02115, USA
    Stat Med 20:1009-21. 2001
  8. ncbi request reprint Multivariate logistic regression for familial aggregation of two disorders. II. Analysis of studies of eating and mood disorders
    J I Hudson
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Epidemiol 153:506-14. 2001
  9. ncbi request reprint Multivariate logistic regression for familial aggregation of two disorders. I. Development of models and methods
    J I Hudson
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Epidemiol 153:500-5. 2001
  10. ncbi request reprint A mixture model for longitudinal data with application to assessment of noncompliance
    D K Pauler
    Biostatistics Center, Massachusetts General Hospital, Boston 02114, USA
    Biometrics 56:464-72. 2000

Detail Information

Publications22

  1. ncbi request reprint Implementing a unified approach to family-based tests of association
    N M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 19:S36-42. 2000
    ..The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture...
  2. pmc Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions
    K L Lunetta
    Department of Biostatistical Science, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Am J Hum Genet 66:605-14. 2000
    ..We apply our methods to a sample of families with attention-deficit/hyperactivity disorder and provide examples of how covariates and gene-environment and gene-gene interactions can be incorporated...
  3. pmc Obesity and weight gain in relation to depression: findings from the Stirling County Study
    J M Murphy
    Psychiatric Epidemiology, Department of Psychiatry, Massachusetts General Hospital, 5 Longfellow Place, Boston, MA 02114, USA
    Int J Obes (Lond) 33:335-41. 2009
    ..This study concerns the question of whether obese subjects in a community sample experience depression in a different way from the nonobese, especially whether they overeat to the point of gaining weight during periods of depression...
  4. ncbi request reprint Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity
    J M Murphy
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 109:355-75. 2004
    ..Methods for conducting such time trend analysis are reviewed...
  5. ncbi request reprint Tests of gene-environment interaction for case-parent triads with general environmental exposures
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Hum Genet 68:55-64. 2004
    ..We present a test, FBAT-I, that can be used to investigate gene-environment interaction. The test uses the case-parent triad design and protects the statistical inference from potential spurious results due to population admixture...
  6. ncbi request reprint Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hum Hered 55:56-65. 2003
    ..Simulations were run to illustrate the salient features of the method. In addition, the method was used to test for haplotype-smoking exposure interaction with data from the Childhood Asthma Management Program...
  7. ncbi request reprint An alternative parameterization of the general linear mixture model for longitudinal data with non-ignorable drop-outs
    G M Fitzmaurice
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston MA 02115, USA
    Stat Med 20:1009-21. 2001
    ..In this paper we describe a particular parameterization of the general linear mixture model that circumvents both of these problems...
  8. ncbi request reprint Multivariate logistic regression for familial aggregation of two disorders. II. Analysis of studies of eating and mood disorders
    J I Hudson
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Epidemiol 153:506-14. 2001
    ..In comparison with the univariate model, the multivariate models provided greater flexibility, improved precision, and wider generality for interpreting aggregation effects...
  9. ncbi request reprint Multivariate logistic regression for familial aggregation of two disorders. I. Development of models and methods
    J I Hudson
    Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Epidemiol 153:500-5. 2001
    ..The models are more realistic, flexible, and powerful than univariate models. Methods for estimation and testing account for the correlation of outcomes among family members and can be implemented by using commercial software...
  10. ncbi request reprint A mixture model for longitudinal data with application to assessment of noncompliance
    D K Pauler
    Biostatistics Center, Massachusetts General Hospital, Boston 02114, USA
    Biometrics 56:464-72. 2000
    ..As part of our fully Bayesian analysis, we assess the sensitivity of conclusions to prior and modeling assumptions and demonstrate how external information and covariates can be incorporated to distinguish subgroups...
  11. ncbi request reprint A comparison of diagnostic interviews for depression in the Stirling County study: challenges for psychiatric epidemiology
    J M Murphy
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston 02129 2000, USA
    Arch Gen Psychiatry 57:230-6. 2000
    ..This issue is explored relevant to depression using data from the Stirling County Study...
  12. ncbi request reprint A 40-year perspective on the prevalence of depression: the Stirling County Study
    J M Murphy
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston 02129 2000, USA
    Arch Gen Psychiatry 57:209-15. 2000
    ..This report from the Stirling County Study compares rates of current depression among representative samples of adults from a population in Atlantic Canada...
  13. pmc Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
    ..Since the A2M gene lies in a chromosomal region (chromosome 12p) that consistently has been linked to AD, association tests should be conducted under the null hypothesis that there is linkage but no association...
  14. ncbi request reprint Maximum likelihood analysis of generalized linear models with missing covariates
    N J Horton
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Stat Methods Med Res 8:37-50. 1999
    ..In this paper, we will describe the method of weights in detail, illustrate its application with several examples, discuss its advantages and limitations, and review extensions and applications of the method...
  15. doi request reprint A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies
    Y Sato
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Pharmacogenomics J 9:137-46. 2009
    ..An application of all three methods to an actual genome-wide pharmacogenomics study illustrates the practical relevance of our discussion...
  16. ncbi request reprint Tests for homogeneity of the risk difference when data are sparse
    S R Lipsitz
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 54:148-60. 1998
    ..The weighted least squares statistic has the most anticonservative Type I error rates of all the statistics compared. We suggest the use of one of our proposed test statistics instead of the weighted least squares statistic...
  17. ncbi request reprint Tutorial in Biostatistics: Evaluating the impact of 'critical periods' in longitudinal studies of growth using piecewise mixed effects models
    E N Naumova
    Tufts University School of Medicine, Department of Family Medicine and Community Health, Boston, MA 02111, USA
    Int J Epidemiol 30:1332-41. 2001
    ..A detailed example that examines the influence of menarche on changes in body fat accretion will be presented using data from a prospective study of 162 girls measured annually from approximately age 10 until 4 years post menarche...
  18. ncbi request reprint Multiple informants: mortality associated with psychiatric disorders in the Stirling County Study
    N J Horton
    Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Am J Epidemiol 154:649-56. 2001
    ..The results for self-reports and physician-reports of disorders were comparable: Psychiatric diagnosis was associated with higher mortality, particularly among younger subjects...
  19. ncbi request reprint Family study of the aggregation of eating disorders and mood disorders
    B Mangweth
    Department of Psychiatry, University of Innsbruck, Innsbruck University Clinics, Innsbruck, Austria
    Psychol Med 33:1319-23. 2003
    ..Family studies have suggested that eating disorders and mood disorders may coaggregate in families. To study further this question, data from a family interview study of probands with and without major depressive disorder was examined...
  20. ncbi request reprint Alpha-2 macroglobulin is genetically associated with Alzheimer disease
    D Blacker
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Nat Genet 19:357-60. 1998
    ....
  21. ncbi request reprint Approaches to handling incomplete data in family-based association testing
    K Van Steen
    Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium
    Ann Hum Genet 71:141-51. 2007
    ..In this paper we provide some perspectives on the occurrence and analysis of different forms of incomplete data in family-based genetic association testing...
  22. ncbi request reprint A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD families
    J Lasky-Su
    Medical Genetics Research Program, Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Behav Genet 37:487-97. 2007
    ..The two exons within BDNF represent potential functional variants that may be causing the observed associations...