Galit Lahav

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Dynamics of the DNA damage response: insights from live-cell imaging
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA
    Brief Funct Genomics 12:109-17. 2013
  2. ncbi How to survive and thrive in the mother-mentor marathon
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:477-80. 2010
  3. ncbi Oscillations by the p53-Mdm2 feedback loop
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 641:28-38. 2008
  4. ncbi Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 142:89-100. 2010
  5. ncbi p53 dynamics control cell fate
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 336:1440-4. 2012
  6. ncbi The ups and downs of p53: understanding protein dynamics in single cells
    Eric Batchelor
    Harvard Medical School Systems Biology, Boston, MA 02115, USA
    Nat Rev Cancer 9:371-7. 2009
  7. ncbi Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 47:320-9. 2012
  8. ncbi A synthetic-natural hybrid oscillator in human cells
    Jared E Toettcher
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17047-52. 2010
  9. ncbi Stimulus-dependent dynamics of p53 in single cells
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Syst Biol 7:488. 2011
  10. ncbi The strength of indecisiveness: oscillatory behavior for better cell fate determination
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Sci STKE 2004:pe55. 2004

Research Grants

  1. Dynamics of Signaling Pathways: Mechanism and Function
    Galit Lahav; Fiscal Year: 2010
  2. Dynamics of Signaling Pathways: Mechanism and Function
    Galit Lahav; Fiscal Year: 2009

Collaborators

  • James D Orth
  • Alexander Loewer
  • Eric Batchelor
  • Jeremy E Purvis
  • Ketki Karanam
  • Caroline Mock
  • Ran Kafri
  • Hiroyuki Inuzuka
  • Jared E Toettcher
  • Naama Geva-Zatorsky
  • Seungeun Oh
  • Miriam B Ginzberg
  • Jason Levy
  • Marc W Kirschner
  • Kyle W Karhohs
  • Qing Zhang
  • John Asara
  • DaMing Gao
  • Alan Tseng
  • Xiaolu L Ang
  • Wenyi Wei
  • Lixin Wan
  • Jayne M Stommel
  • Giorgio Gaglia
  • Bo Zhai
  • William G Kaelin
  • J Wade Harper
  • Steven Gygi
  • Zhi Xiong Jim Xiao
  • Haoqiang Yin
  • Shavali Shaik
  • Caroline S Mock
  • Irun Bhan
  • Yuvalal Liron
  • Nitzan Rosenfeld
  • Ron Milo
  • Uri Alon
  • Erez Dekel
  • Paz Polak
  • Shalev Itzkovitz
  • Alex Sigal
  • Talia Yarnitzky

Detail Information

Publications19

  1. ncbi Dynamics of the DNA damage response: insights from live-cell imaging
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA
    Brief Funct Genomics 12:109-17. 2013
    ..Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique...
  2. ncbi How to survive and thrive in the mother-mentor marathon
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:477-80. 2010
    ..It is also for those working with, bosses of, or married to such women, giving them a better feel for the challenges mothers in academia face, and the strategies that can be used to survive and thrive in both of these worlds...
  3. ncbi Oscillations by the p53-Mdm2 feedback loop
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 641:28-38. 2008
    ....
  4. ncbi Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 142:89-100. 2010
    ..Our approach of quantifying basal dynamics in individual cells can now be used to study how other pathways in human cells achieve sensitivity in noisy environments...
  5. ncbi p53 dynamics control cell fate
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 336:1440-4. 2012
    ..Our results show that protein dynamics can be an important part of a signal, directly influencing cellular fate decisions...
  6. ncbi The ups and downs of p53: understanding protein dynamics in single cells
    Eric Batchelor
    Harvard Medical School Systems Biology, Boston, MA 02115, USA
    Nat Rev Cancer 9:371-7. 2009
    ..Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function...
  7. ncbi Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 47:320-9. 2012
    ....
  8. ncbi A synthetic-natural hybrid oscillator in human cells
    Jared E Toettcher
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17047-52. 2010
    ..The approaches taken here may be useful for the rational design of synthetic networks with defined dynamics, and for identifying perturbations that control dynamics in natural biological circuits for research or therapeutic purposes...
  9. ncbi Stimulus-dependent dynamics of p53 in single cells
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Syst Biol 7:488. 2011
    ..Our study shows that different stresses elicit different temporal profiles of p53, suggesting that modulation of p53 dynamics might be used to achieve specificity in this network...
  10. ncbi The strength of indecisiveness: oscillatory behavior for better cell fate determination
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Sci STKE 2004:pe55. 2004
    ....
  11. ncbi Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
    James D Orth
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 23:567-76. 2012
    ..More speculatively, partial activation of CAD may explain the DNA-damaging effects of diverse cellular stresses that do not immediately trigger apoptosis...
  12. ncbi Encoding and decoding cellular information through signaling dynamics
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 152:945-56. 2013
    ..We conclude by discussing potential functional roles for transmitting cellular information through the dynamics of signaling molecules and possible applications for the treatment of disease...
  13. ncbi Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 30:277-89. 2008
    ....
  14. ncbi Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle
    Ran Kafri
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 494:480-3. 2013
    ..Using ERA we find evidence for a size-discriminatory process at the G1/S transition that acts to decrease cell-to-cell size variation...
  15. ncbi Decoding the insulin signal
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 46:715-6. 2012
    ..In this issue of Molecular Cell, Kubota et al. (2012) show how different temporal patterns of insulin are decoded by the AKT signaling network, providing both new mechanistic insights and physiological relevance...
  16. ncbi Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
    Hiroyuki Inuzuka
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 18:147-59. 2010
    ..Our results provide insight into the signaling pathways controlling Mdm2 destruction and further suggest that compromised regulation of Mdm2 results in attenuated p53 activity, thereby facilitating tumor progression...
  17. ncbi Cellular conference call: external feedback affects cell-fate decisions
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 124:1128-30. 2006
    ..These results suggest that an individual cell's decision to die or survive is not wholly independent but depends, at least in part, on feedback from its neighbors...
  18. ncbi Oscillations and variability in the p53 system
    Naama Geva-Zatorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 2:2006.0033. 2006
    ..This study provides a view of the extensive variability of the behavior of a protein circuit in living human cells, both from cell to cell and in the same cell over time...
  19. ncbi Dynamics of the p53-Mdm2 feedback loop in individual cells
    Galit Lahav
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 36:147-50. 2004
    ..This approach can be used to study other signaling systems and suggests that the p53-Mdm2 feedback loop generates a 'digital' clock that releases well-timed quanta of p53 until damage is repaired or the cell dies...

Research Grants4

  1. Dynamics of Signaling Pathways: Mechanism and Function
    Galit Lahav; Fiscal Year: 2010
    ....
  2. Dynamics of Signaling Pathways: Mechanism and Function
    Galit Lahav; Fiscal Year: 2009
    ....