Galit Lahav

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Stimulus-dependent dynamics of p53 in single cells
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Syst Biol 7:488. 2011
  2. ncbi request reprint How to survive and thrive in the mother-mentor marathon
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:477-80. 2010
  3. ncbi request reprint Oscillations by the p53-Mdm2 feedback loop
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 641:28-38. 2008
  4. pmc Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 142:89-100. 2010
  5. doi request reprint p53 dynamics control cell fate
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 336:1440-4. 2012
  6. pmc The ups and downs of p53: understanding protein dynamics in single cells
    Eric Batchelor
    Harvard Medical School Systems Biology, Boston, MA 02115, USA
    Nat Rev Cancer 9:371-7. 2009
  7. pmc Dynamics of the DNA damage response: insights from live-cell imaging
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA
    Brief Funct Genomics 12:109-17. 2013
  8. pmc The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    BMC Biol 11:114. 2013
  9. pmc Activation and control of p53 tetramerization in individual living cells
    Giorgio Gaglia
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:15497-501. 2013
  10. pmc Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 30:277-89. 2008

Collaborators

  • Alexander Loewer
  • Ran Kafri
  • Paul H Lerou
  • Qing Zhang
  • Xiao Guan
  • Wenyi Wei
  • James D Orth
  • Eric Batchelor
  • Jeremy E Purvis
  • Caroline Mock
  • Julia C Liu
  • Ketki Karanam
  • Giorgio Gaglia
  • Hiroyuki Inuzuka
  • Jared E Toettcher
  • Naama Geva-Zatorsky
  • Vishesh Agarwal
  • Ana G Rivera
  • Jagesh V Shah
  • Vishesh Agrawal
  • Jeremy A Ryan
  • Yinghua Guan
  • Anthony Letai
  • Kyle W Karhohs
  • Zhi Xiong Jim Xiao
  • Lixin Wan
  • Jayne M Stommel
  • Bo Zhai
  • John Asara
  • DaMing Gao
  • Alan Tseng
  • Xiaolu L Ang
  • Haoqiang Yin
  • William G Kaelin
  • J Wade Harper
  • Shavali Shaik
  • Steven Gygi
  • Caroline S Mock
  • Irun Bhan
  • Paz Polak
  • Ron Milo
  • Alex Sigal
  • Yuvalal Liron
  • Talia Yarnitzky
  • Shalev Itzkovitz
  • Uri Alon
  • Nitzan Rosenfeld
  • Erez Dekel

Detail Information

Publications24

  1. pmc Stimulus-dependent dynamics of p53 in single cells
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Syst Biol 7:488. 2011
    ..Our study shows that different stresses elicit different temporal profiles of p53, suggesting that modulation of p53 dynamics might be used to achieve specificity in this network...
  2. ncbi request reprint How to survive and thrive in the mother-mentor marathon
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:477-80. 2010
    ..It is also for those working with, bosses of, or married to such women, giving them a better feel for the challenges mothers in academia face, and the strategies that can be used to survive and thrive in both of these worlds...
  3. ncbi request reprint Oscillations by the p53-Mdm2 feedback loop
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 641:28-38. 2008
    ....
  4. pmc Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 142:89-100. 2010
    ..Our approach of quantifying basal dynamics in individual cells can now be used to study how other pathways in human cells achieve sensitivity in noisy environments...
  5. doi request reprint p53 dynamics control cell fate
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 336:1440-4. 2012
    ..Our results show that protein dynamics can be an important part of a signal, directly influencing cellular fate decisions...
  6. pmc The ups and downs of p53: understanding protein dynamics in single cells
    Eric Batchelor
    Harvard Medical School Systems Biology, Boston, MA 02115, USA
    Nat Rev Cancer 9:371-7. 2009
    ..Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function...
  7. pmc Dynamics of the DNA damage response: insights from live-cell imaging
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA, USA
    Brief Funct Genomics 12:109-17. 2013
    ..Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique...
  8. pmc The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    BMC Biol 11:114. 2013
    ..However, it is possible that by averaging over a population of cells important features of the dependency between DNA breaks and p53 dynamics are missed...
  9. pmc Activation and control of p53 tetramerization in individual living cells
    Giorgio Gaglia
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:15497-501. 2013
    ..Many other transcription factors homo-oligomerize, and our approach provides a unique way for probing the dynamics and functional consequences of oligomerization. ..
  10. pmc Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 30:277-89. 2008
    ....
  11. pmc A synthetic-natural hybrid oscillator in human cells
    Jared E Toettcher
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17047-52. 2010
    ..The approaches taken here may be useful for the rational design of synthetic networks with defined dynamics, and for identifying perturbations that control dynamics in natural biological circuits for research or therapeutic purposes...
  12. ncbi request reprint The strength of indecisiveness: oscillatory behavior for better cell fate determination
    Galit Lahav
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Sci STKE 2004:pe55. 2004
    ....
  13. pmc Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase
    Ketki Karanam
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 47:320-9. 2012
    ....
  14. pmc Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
    James D Orth
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 23:567-76. 2012
    ..More speculatively, partial activation of CAD may explain the DNA-damaging effects of diverse cellular stresses that do not immediately trigger apoptosis...
  15. ncbi request reprint Stem cells: balancing resistance and sensitivity to DNA damage
    Julia C Liu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 24:268-74. 2014
    ....
  16. pmc Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
    Hiroyuki Inuzuka
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 18:147-59. 2010
    ..Our results provide insight into the signaling pathways controlling Mdm2 destruction and further suggest that compromised regulation of Mdm2 results in attenuated p53 activity, thereby facilitating tumor progression...
  17. pmc Encoding and decoding cellular information through signaling dynamics
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 152:945-56. 2013
    ..We conclude by discussing potential functional roles for transmitting cellular information through the dynamics of signaling molecules and possible applications for the treatment of disease...
  18. pmc Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle
    Ran Kafri
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 494:480-3. 2013
    ..Using ERA we find evidence for a size-discriminatory process at the G1/S transition that acts to decrease cell-to-cell size variation...
  19. pmc High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis
    Julia C Liu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 13:483-91. 2013
    ....
  20. pmc Decoding the insulin signal
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 46:715-6. 2012
    ..In this issue of Molecular Cell, Kubota et al. (2012) show how different temporal patterns of insulin are decoded by the AKT signaling network, providing both new mechanistic insights and physiological relevance...
  21. ncbi request reprint Cellular conference call: external feedback affects cell-fate decisions
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 124:1128-30. 2006
    ..These results suggest that an individual cell's decision to die or survive is not wholly independent but depends, at least in part, on feedback from its neighbors...
  22. pmc Oscillations and variability in the p53 system
    Naama Geva-Zatorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 2:2006.0033. 2006
    ..This study provides a view of the extensive variability of the behavior of a protein circuit in living human cells, both from cell to cell and in the same cell over time...
  23. ncbi request reprint Dynamics of the p53-Mdm2 feedback loop in individual cells
    Galit Lahav
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 36:147-50. 2004
    ..This approach can be used to study other signaling systems and suggests that the p53-Mdm2 feedback loop generates a 'digital' clock that releases well-timed quanta of p53 until damage is repaired or the cell dies...

Research Grants4