Research Topics
Genomes and Genes
Species | Pagona LagiouSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Legislative measures and tobacco control in EuropePagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
Prev Med 45:121-2. 2007
Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancerJingmei Li
Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
Breast Cancer Res 12:R19. 2010..In this study, we evaluate the association between mammographic density and genetic variants of the estrogen metabolic pathway...
Low carbohydrate-high protein diet and mortality in a cohort of Swedish womenP Lagiou
Department of Hygiene and Epidemiology, University of Athens Medical School, Goudi, Athens, Greece
J Intern Med 261:366-74. 2007..We have evaluated the association of the frequently recommended low carbohydrate diets - usually characterized by concomitant increase in protein intake - with long-term mortality...
Parental family structure, Helicobacter pylori, and gastric adenocarcinomaPagona Lagiou
Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
PLoS Med 4:e25. 2007
Energy intake during pregnancy in relation to offspring gender by maternal heightPagona Lagiou
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Eur J Epidemiol 26:39-44. 2011....
Estrogen alpha and progesterone receptor expression in the normal mammary epithelium in relation to breast cancer riskPagona Lagiou
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, and First Department of Surgery, Elena Venizelou Hospital, Athens, Greece
Int J Cancer 124:440-2. 2009....
Diet during pregnancy and levels of maternal pregnancy hormones in relation to the risk of breast cancer in the offspringPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Eur J Cancer Prev 15:20-6. 2006..This advice does not contradict current dietary advice on prudent diet during pregnancy and throughout life...
Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese womenPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Goudi, Athens, Greece
Eur J Cancer Prev 16:178-83. 2007..39 to -0.05). In normal pregnancies, maternal alpha-fetoprotein is inversely related to prepregnancy body mass index and appears to have a physiologic role on duration of gestation rather than on birth weight...
Maternal height, pregnancy estriol and birth weight in reference to breast cancer risk in Boston and ShanghaiPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Int J Cancer 117:494-8. 2005....
Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control studyDimitrios Trichopoulos
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
J Natl Cancer Inst 103:1686-95. 2011..To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors...
Birth weight, breast cancer susceptibility loci, and breast cancer riskRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Cancer Causes Control 21:689-96. 2010....
Mediterranean dietary pattern and mortality among young women: a cohort study in SwedenPagona Lagiou
Department of Hygiene and Epidemiology, University of Athens Medical School, Greece
Br J Nutr 96:384-92. 2006..The findings of the present study in a northern European population of young women indicate that closer adherence to a Mediterranean dietary pattern reduces mortality even among young persons...
Birth weight and mammographic density among postmenopausal women in SwedenRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 126:985-91. 2010..These results indicate that adult breast density, a powerful predictor of breast cancer risk, has intrauterine roots, as reflected in birth size...
Mediterranean diet and upper aerodigestive tract cancer: the Greek segment of the Alcohol-Related Cancers and Genetic Susceptibility in Europe studyEvangelia Samoli
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 Mikras Asias Street, Goudi, GR 115 27 Athens, Greece
Br J Nutr 104:1369-74. 2010..Adherence to the traditional Mediterranean diet is associated with reduced risk of UADT cancers, and may explain the lower incidence of UADT cancers in Greece, in spite of the smoking and drinking habits of this population...
Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collectionPagona Lagiou
Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
Eur J Cancer Prev 18:76-84. 2009..Close to 90% of UADT cancers were squamous cell carcinomas. A clear preponderance of smokers and alcohol drinkers among UADT cases compared with controls was observed...
Diet and expression of estrogen alpha and progesterone receptors in malignant mammary tissueAreti Lagiou
Department of Hygiene, Epidemiology and Biostatistics, University of Athens Medical School, Goudi, Athens, Greece
Nutr Cancer 63:65-72. 2011....
Occupational physical activity in relation with prostate cancer and benign prostatic hyperplasiaAreti Lagiou
Faculty of Health Professions, Athens Technological Institute, University of Athens, Athens, Greece
Eur J Cancer Prev 17:336-9. 2008..Given the high frequency of occurrence of the examined conditions in the male population and our limited knowledge about other modifiable risk factors, preventive measures may have to focus on increasing physical activity...
Diet and expression of estrogen alpha and progesterone receptors in the normal mammary glandPagona Lagiou
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M Asias Street, Goudi 115 27, Greece
Cancer Causes Control 20:601-7. 2009..We investigated whether dietary intakes are associated with the expression of ER-alpha and PR receptors in the apparently normal, as opposed to pathological, mammary tissue...
A prospective study of pregravid oral contraceptive use in relation to fetal growthLorelei A Mucci
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
BJOG 111:989-95. 2004..CONCLUSIONS: Pregravid oral contraceptive use is positively associated with fetal growth, and this effect may be mediated through oestriol and progesterone...
Vegetables and fruits in relation to cancer risk: evidence from the Greek EPIC cohort studyVassiliki Benetou
Department of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece
Cancer Epidemiol Biomarkers Prev 17:387-92. 2008....
Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort studyPagona Lagiou
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M Asias Street, Goudi, GR 115 27 Athens, Greece
BMJ 344:e4026. 2012..To study the long term consequences of low carbohydrate diets, generally characterised by concomitant increases in protein intake, on cardiovascular health...
Conformity to traditional Mediterranean diet and breast cancer risk in the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohortAntonia Trichopoulou
WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, Athens, Greece
Am J Clin Nutr 92:620-5. 2010..No study, however, has evaluated the association of the traditional Mediterranean diet with breast cancer in a Mediterranean country...
Flavonoid intake and liver cancer: a case-control study in GreecePagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, 75 M Asias Street, Goudi 11527, Athens, Greece
Cancer Causes Control 19:813-8. 2008..We conclude that flavones may be inversely associated with HCC risk, irrespective of its dominant etiology (viral or non viral)...
Nondense mammographic area and risk of breast cancerAndreas Pettersson
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res 13:R100. 2011..We investigated separately the absolute dense area and the absolute nondense area on mammograms in relation to breast cancer risk...
Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspringRulla Tamimi
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 12:647-50. 2003..Our findings indicate that progesterone may have a role in the late manifestation of pre-eclampsia pathology but are also compatible with the hypothesis that increases in progesterone represent an early compensatory mechanism...
The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control studySungshim Lani Park
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA
Int J Cancer 128:1449-61. 2011..These findings may be influenced by smoking and/or drinking behaviors and/or the development of preclinical UADT cancers and should be corroborated in studies of a prospective nature...
Are mammotropic hormones mainly permissive for the development of breast cancer?Dimitrios Trichopoulos
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 118:2863-5. 2006..A corollary is that studies of mammotropic hormones in relation to breast cancer risk may also need to focus on the lower end of the distributions of these growth-enhancing hormones...
Micronutrient intake during pregnancy in relation to birth sizePagona Lagiou
Dept. of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Eur J Nutr 44:52-9. 2005..The results of this exploratory analysis need to be confirmed before pathophysiologic interpretations and generalizations are attempted...
Early life events and conditions and breast cancer risk: from epidemiology to etiologyDimitrios Trichopoulos
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 122:481-5. 2008..This perspective accommodates much of what is known about the epidemiology and natural history of breast cancer and highlights the role of early life in the origin of this cancer...
Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cellsDimitrios Trichopoulos
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Breast Cancer Res 7:13-7. 2005....
Mediterranean diet and CHD: the Greek European Prospective Investigation into Cancer and Nutrition cohortVardis Dilis
Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
Br J Nutr 108:699-709. 2012..The MD, as an integral entity, is inversely associated with CHD incidence and, particularly, mortality...
Pregnancy estriol, estradiol, progesterone and prolactin in relation to birth weight and other birth size variables (United States)Lorelei A Mucci
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 14:311-8. 2003..CONCLUSIONS: Because E3 is a dominant estrogen during pregnancy, the positive association of it with birth weight allows the use of the latter as a proxy of in utero exposure to estrogens in breast cancer investigations...
Early life diet and the risk for adult breast cancerPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
Nutr Cancer 56:158-61. 2006....
Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE studyPagona Lagiou
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
Int J Cancer 124:2671-6. 2009..In conclusion, the results of this large multicentric study indicate that diet plays an important role in the etiology of UADT cancer...
Average energy intake among pregnant women carrying a boy compared with a girlRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
BMJ 326:1245-6. 2003
Flavonoid intake in relation to lung cancer risk: case-control study among women in GreecePagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
Nutr Cancer 49:139-43. 2004....
Birthweight differences between USA and China and their relevance to breast cancer aetiologyPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
Int J Epidemiol 32:193-8. 2003....
Intrauterine exposures, pregnancy estrogens and breast cancer risk: where do we currently stand?Pagona Lagiou
Department of Hygiene and Epidemiology, University of Athens Medical School, 75 M, Asias Street, Goudi, GR 115 27, Athens, Greece
Breast Cancer Res 8:112. 2006..Recent results from a unique cohort of women with documented exposure to diethylstilbestrol in utero have provided direct evidence in support of a potential role of pregnancy oestrogens on breast cancer risk in offspring...
The epidemiology of cataract: a study in GreeceSofia Theodoropoulou
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece
Acta Ophthalmol 89:e167-73. 2011..Three hundred and fourteen cases and 314 frequency-matched controls of both genders, aged 45-85, attending the ophthalmology department of a major teaching hospital in Athens, Greece, were included in the study...
Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancerFangyi Gu
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 19:2877-87. 2010..Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins...
Mediterranean diet and overall mortality differences in the European UnionDimitrios Trichopoulos
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
Public Health Nutr 7:949-51. 2004..Design: Routinely recorded adjusted overall mortality and food availability data in Mediterranean and non-Mediterranean EU countries. A Mediterranean diet score designed a priori was used as instrument...
Comparison of age at first full-term pregnancy between women with breast cancer and women with benign breast diseasesAreti Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Int J Cancer 107:817-21. 2003..The finding is accentuated by the fact that women with benign breast diseases are already at a relatively high risk for breast cancer...
Causality in cancer epidemiologyPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Goudi, Athens, Greece
Eur J Epidemiol 20:565-74. 2005..The review concludes with estimates of mortality from cancer around the world that can be attributed to specific factors under the light of the current scientific knowledge...
Nutritional epidemiology of cancer: accomplishments and prospectsPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
Proc Nutr Soc 61:217-22. 2002..It is noted that, notwithstanding the substantial gaps in our scientific knowledge, preventive nutritional approaches can be envisaged and they are likely to be moderately successful...
Nausea and vomiting in pregnancy in relation to prolactin, estrogens, and progesterone: a prospective studyPagona Lagiou
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Obstet Gynecol 101:639-44. 2003..We found no evidence that estriol, progesterone, or sex hormone-binding globulin is associated with this condition...
Genetic implications of bilateral breast cancer: a population based cohort studyMikael Hartman
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
Lancet Oncol 6:377-82. 2005..Women with breast cancer are at high risk of bilateral breast cancer. We aimed to assess the incidence of bilateral breast cancer in relation to age and time since diagnosis of first cancer...
Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic populationUte Nöthlings
Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, 14558 Germany
J Nutr 138:775-81. 2008....
Stem cells and prenatal origin of breast cancerInkyung Baik
Cancer Research Center and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cancer Causes Control 15:517-30. 2004..We conclude by outlining a feasible population-based study that measures stem cell potential to explore mechanisms mediating the relation between in utero exposure to pregnancy hormones and breast cancer risk in the offspring...
Cord serum estrogens, androgens, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 in Chinese and U.S. Caucasian neonatesRebecca Troisi
Dartmouth Hitchcock Medical Center, Room 854, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
Cancer Epidemiol Biomarkers Prev 17:224-31. 2008..The meaning of the change in findings for estrogens after controlling for factors related to the pregnancy is unclear with regard to explaining international breast cancer differences...
Intake of specific flavonoids and risk of acute myocardial infarction in ItalyAlessandra Tavani
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
Public Health Nutr 9:369-74. 2006....
Consumption of vegetables and fruits and risk of breast cancerPagona Lagiou
JAMA 293:2209; author reply 2210. 2005
Flavonoids and breast cancer risk in ItalyCristina Bosetti
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62 20157 Milan, Italy
Cancer Epidemiol Biomarkers Prev 14:805-8. 2005..95), flavan-3-ols (OR, 0.86), anthocyanidins (OR, 1.09), as well as for isoflavones (OR, 1.05). The findings of this large study of an inverse association between flavones and breast cancer risk confirm the results of a Greek study...
Association of fetal hormone levels with stem cell potential: evidence for early life roots of human cancerInkyung Baik
Cancer Research Center and Department of Cancer Biology, ILAT Steroid RIA Laboratory, University of Massachusetts Medical School, Worchester, MA 01605, USA
Cancer Res 65:358-63. 2005....
Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort studyPer Hall
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, PO Box 281, SE 171 77 Stockholm, Sweden
BMJ 328:19. 2004..To determine whether exposure to low doses of ionising radiation in infancy affects cognitive function in adulthood...
Oesophageal adenocarcinoma: a paradigm of mechanical carcinogenesis?Carlo La Vecchia
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
Int J Cancer 102:269-70. 2002..Abdominal pressure is further accentuated mainly in men by the shift in Western male dressing towards the general use of belts...
Physical activity as a determinant of mortality in womenYlva Trolle-Lagerros
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Epidemiology 16:780-5. 2005..We aimed to quantify the effect of physical activity on overall mortality in younger women and to assess the effect of past versus current activity...
Low-fat diet and risk of breast cancerPagona Lagiou
JAMA 296:278; author reply 279. 2006
Intrauterine factors and breast cancer riskPagona Lagiou
Lancet Oncol 8:1047-8. 2007
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25Rayjean J Hung
International Agency for Research on Cancer IARC, Lyon 69008, France
Nature 452:633-7. 2008..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and NutritionFrancesca L Crowe
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 87:1405-13. 2008..However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear...
Plasma volume expansion in pregnancy: implications for biomarkers in population studiesJessica M Faupel-Badger
Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, MSC 4254, 37 Convent Drive, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:1720-3. 2007..We present PVE as a topic for consideration in population-based studies, examples of the types of studies where PVE may be relevant, and our own analysis of one such study in the text below...
Flavonoids and the risk of oral and pharyngeal cancer: a case-control study from ItalyMarta Rossi
Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy
Cancer Epidemiol Biomarkers Prev 16:1621-5. 2007..None of the associations were significant after further allowance for vitamin C, probably on account of the high collinearity between these compounds...
Assessment of physical activity and energy expenditure in epidemiological research of chronic diseasesYlva Trolle Lagerros
Unit of Clinical Epidemiology, Karolinska Institutet, M9 01, 17176, Stockholm, Sweden
Eur J Epidemiol 22:353-62. 2007..This paper describes different methods to measure physical activity and energy expenditure from the epidemiological perspective, and attempts to address the concepts related to the measurement of physical activity...
Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesisTodd M Savarese
Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Breast Cancer Res 9:R29. 2007..We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential...
Family history of cancer provided by hospital controls was satisfactorily reliableFrancesca Bravi
Laboratorio di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
J Clin Epidemiol 60:171-5. 2007..Our aim was to investigate the reliability of the information on family history of cancer in first-degree relatives in a hospital-based case-control study...
Flavonoids and risk of squamous cell esophageal cancerMarta Rossi
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Int J Cancer 120:1560-4. 2007..In conclusion, this study suggests that flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer...
Olive oil, seed oils and other added fats in relation to ovarian cancer (Italy)Cristina Bosetti
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Cancer Causes Control 13:465-70. 2002..This study investigates the potential role of olive oil and other added fats used for seasoning or cooking on ovarian carcinogenesis...
