Kasper Lage

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development
    Kasper Lage
    Pediatric Surgical Research Laboratories, Department of Molecular Biology, and Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:14035-40. 2012
  2. pmc Dissecting spatio-temporal protein networks driving human heart development and related disorders
    Kasper Lage
    Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Syst Biol 6:381. 2010
  3. pmc Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics
    Mauro Longoni
    The Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA 02114 Department of Surgery, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:12450-5. 2014
  4. doi request reprint MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus
    Fabiola Quintero-Rivera
    Molecular Neurogenetics Unit and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Hum Mol Genet 24:2375-89. 2015
  5. pmc Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks
    Mauro Longoni
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet A 158:3148-58. 2012
  6. pmc Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 149:525-37. 2012

Collaborators

Detail Information

Publications6

  1. pmc Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development
    Kasper Lage
    Pediatric Surgical Research Laboratories, Department of Molecular Biology, and Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:14035-40. 2012
    ..This integrative analysis of CHD risk factors and responses suggests a complex pattern of functional interactions between genomic variation and environmental exposures that modulate critical biological systems during heart development...
  2. pmc Dissecting spatio-temporal protein networks driving human heart development and related disorders
    Kasper Lage
    Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Syst Biol 6:381. 2010
    ....
  3. pmc Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics
    Mauro Longoni
    The Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA 02114 Department of Surgery, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:12450-5. 2014
    ..Furthermore, we propose that these genes and pathways will enhance our understanding of the heterogeneous molecular etiology of CDH. ..
  4. doi request reprint MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus
    Fabiola Quintero-Rivera
    Molecular Neurogenetics Unit and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Hum Mol Genet 24:2375-89. 2015
    ..Thus, subtle perturbations in Matrin 3 expression appear to cause similar LVOT defects in human and mouse. ..
  5. pmc Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks
    Mauro Longoni
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet A 158:3148-58. 2012
    ..This combination of bioinformatics and expression studies can be applied to other chromosomal hotspots, as well as private microdeletions or microduplications, to identify causative genes and their interaction networks...
  6. pmc Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 149:525-37. 2012
    ....