Affiliation: Harvard University
- Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart developmentKasper Lage
Pediatric Surgical Research Laboratories, Department of Molecular Biology, and Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 109:14035-40. 2012..This integrative analysis of CHD risk factors and responses suggests a complex pattern of functional interactions between genomic variation and environmental exposures that modulate critical biological systems during heart development...
- Dissecting spatio-temporal protein networks driving human heart development and related disordersKasper Lage
Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Syst Biol 6:381. 2010....
- Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networksMauro Longoni
Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet A 158:3148-58. 2012..This combination of bioinformatics and expression studies can be applied to other chromosomal hotspots, as well as private microdeletions or microduplications, to identify causative genes and their interaction networks...
- Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundariesMichael E Talkowski
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Cell 149:525-37. 2012....