Research Topics
Species | Alvaro C LagaSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biologyAlvaro C Laga
Department of Pathology, Program in Dermatopathology, Boston, MA 02115, USA
Am J Pathol 176:903-13. 2010..In aggregate, these findings suggest that SOX2 is a novel biomarker for subpopulations of normal skin cells that reside in established stem cell niches and that might relate to Merkel cell and melanocyte ontogeny and tumorigenesis...
Cellular heterogeneity in vertical growth phase melanomaAlvaro C Laga
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Pathol Lab Med 134:1750-7. 2010..At a considerably small tumor size, it incurs significant risk for widespread metastatic dissemination. There are no effective means of surgical intervention, chemical therapy, or immunologic therapy for advanced and metastatic melanoma...
SOX2 contributes to melanoma cell invasionSasha D Girouard
Program in Dermatopathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lab Invest 92:362-70. 2012..These data implicate SOX2 expression in melanoma invasion, and suggest a role for MMP-3 as one potential mediator of this process...
SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental studyAlvaro C Laga
Department of Pathology, Program in Dermatopathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Exp Dermatol 20:339-45. 2011..In aggregate, these data further support a biologically significant linkage between SOX2 and nestin expression in human melanoma...
Histopathologic spectrum of psoriasiform skin reactions associated with tumor necrosis factor-α inhibitor therapy. A study of 16 biopsiesAlvaro C Laga
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Dermatopathol 32:568-73. 2010..Because the different histopathologic findings may be subtle, clinical correlation is crucial to make the diagnosis...
Cutaneous gnathostomiasis: report of 6 cases with emphasis on histopathological demonstration of the larvaAlvaro C Laga
Program in Dermatopathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Acad Dermatol 68:301-5. 2013..Cutaneous gnathostomiasis is an emerging food-borne parasitic zoonosis. Histopathological demonstration of the larva on random biopsy specimen of erythematous plaques is infrequent because of its migrating nature...
