L Laffel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
    L Laffel
    Harvard Medical School, Joslin Clinic, One Joslin Place, Boston, MA 02215, USA
    Diabetes Metab Res Rev 15:412-26. 1999
  2. ncbi General quality of life in youth with type 1 diabetes: relationship to patient management and diabetes-specific family conflict
    Lori M B Laffel
    Pediatric and Adolescent Unit, Behavioral Research and Mental Health Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 26:3067-73. 2003
  3. ncbi Sick day management using blood 3-hydroxybutyrate (3-OHB) compared with urine ketone monitoring reduces hospital visits in young people with T1DM: a randomized clinical trial
    L M B Laffel
    Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabet Med 23:278-84. 2006
  4. ncbi Impact of ambulatory, family-focused teamwork intervention on glycemic control in youth with type 1 diabetes
    Lori M B Laffel
    Pediatric and Adolescent Unit, the Behavioral Research and Mental Health Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Pediatr 142:409-16. 2003
  5. ncbi Continued use of an integrated meter with electronic logbook maintains improvements in glycemic control beyond a randomized, controlled trial
    Lori M B Laffel
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Technol Ther 9:254-64. 2007
  6. ncbi Sick-day management in type 1 diabetes
    L Laffel
    Pediatric and Adolescent Unit, Joslin Clinic, Joslin Diabetes Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 29:707-23. 2000
  7. ncbi The Blood Glucose Monitoring Communication questionnaire: an instrument to measure affect specific to blood glucose monitoring
    Korey K Hood
    Pediatric and Adolescent Unit, Genetics and Epidemiology Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 27:2610-5. 2004
  8. ncbi Dietary behaviors predict glycemic control in youth with type 1 diabetes
    Sanjeev N Mehta
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 31:1318-20. 2008
  9. ncbi The impact of physiological, therapeutic and psychosocial variables on glycemic control in youth with type 1 diabetes mellitus
    Elaine C Moreland
    Pediatric and Adolescent Unit, Behavioral Research and Mental Health Section, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Pediatr Endocrinol Metab 17:1533-44. 2004
  10. ncbi Depressive symptoms in children and adolescents with type 1 diabetes: association with diabetes-specific characteristics
    Korey K Hood
    Pediatric and Adolescent Section, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Care 29:1389-91. 2006

Research Grants

  1. Optimizing CGM Use and Metabolic Outcomes in Youth with Type 1 Diabetes
    Lori M Laffel; Fiscal Year: 2010
  2. OPTIMIZING ADHERENCE AND GLYCEMIA IN YOUTH WITH NEW IDDM
    Lori Laffel; Fiscal Year: 2001
  3. Training Grant in Diabetes for Pediatric Endocrinologis*
    Lori Laffel; Fiscal Year: 2006
  4. Career Development in Diabetes for Pediatric Endocrinolo
    Lori Laffel; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
    L Laffel
    Harvard Medical School, Joslin Clinic, One Joslin Place, Boston, MA 02215, USA
    Diabetes Metab Res Rev 15:412-26. 1999
    ..These tests offer new options for monitoring and treating diabetes and other states characterized by the abnormal metabolism of ketone bodies...
  2. ncbi General quality of life in youth with type 1 diabetes: relationship to patient management and diabetes-specific family conflict
    Lori M B Laffel
    Pediatric and Adolescent Unit, Behavioral Research and Mental Health Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 26:3067-73. 2003
    ....
  3. ncbi Sick day management using blood 3-hydroxybutyrate (3-OHB) compared with urine ketone monitoring reduces hospital visits in young people with T1DM: a randomized clinical trial
    L M B Laffel
    Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabet Med 23:278-84. 2006
    ..This prospective, two-centre study assessed sick day management using blood 3-hydroxybutyrate (3-OHB) monitoring compared with traditional urine ketone testing, aimed at averting emergency assessment and hospitalization...
  4. ncbi Impact of ambulatory, family-focused teamwork intervention on glycemic control in youth with type 1 diabetes
    Lori M B Laffel
    Pediatric and Adolescent Unit, the Behavioral Research and Mental Health Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Pediatr 142:409-16. 2003
    ..To evaluate an ambulatory, family-focused intervention aimed at optimizing..
  5. ncbi Continued use of an integrated meter with electronic logbook maintains improvements in glycemic control beyond a randomized, controlled trial
    Lori M B Laffel
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Technol Ther 9:254-64. 2007
    ....
  6. ncbi Sick-day management in type 1 diabetes
    L Laffel
    Pediatric and Adolescent Unit, Joslin Clinic, Joslin Diabetes Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 29:707-23. 2000
    ..quot; This new technology may provide an opportunity to improve the management of uncontrolled diabetes and sick days in an attempt to reduce the human and economic burden of DKA...
  7. ncbi The Blood Glucose Monitoring Communication questionnaire: an instrument to measure affect specific to blood glucose monitoring
    Korey K Hood
    Pediatric and Adolescent Unit, Genetics and Epidemiology Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 27:2610-5. 2004
    ..The aim of this study was to present the psychometric properties of a new tool for evaluating affective response to blood glucose monitoring (BGM) in youths with type 1 diabetes and their parents...
  8. ncbi Dietary behaviors predict glycemic control in youth with type 1 diabetes
    Sanjeev N Mehta
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 31:1318-20. 2008
    ..To investigate the association between dietary adherence and glycemic control among youth with type 1 diabetes...
  9. ncbi The impact of physiological, therapeutic and psychosocial variables on glycemic control in youth with type 1 diabetes mellitus
    Elaine C Moreland
    Pediatric and Adolescent Unit, Behavioral Research and Mental Health Section, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Pediatr Endocrinol Metab 17:1533-44. 2004
    ..Interventions to optimize glycemic control may include minimizing DM-specific conflict, increasing BGM frequency, and implementing CSII use...
  10. ncbi Depressive symptoms in children and adolescents with type 1 diabetes: association with diabetes-specific characteristics
    Korey K Hood
    Pediatric and Adolescent Section, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Care 29:1389-91. 2006
  11. ncbi Plasma aldosterone concentration in the patient with diabetes mellitus
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 65:1435-9. 2004
    ..Evidence for renin-system activation in many patients with type 1 diabetes mellitus has raised the possibility that aldosterone-widely recognized as a contributor to vascular injury-could play a role...
  12. ncbi Accuracy of administrative coding for type 2 diabetes in children, adolescents, and young adults
    Erinn T Rhodes
    Division of Endocrinology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Diabetes Care 30:141-3. 2007
  13. ncbi Durability of insulin pump use in pediatric patients with type 1 diabetes
    Jamie R Wood
    Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes Care 29:2355-60. 2006
    ..Patients discontinuing the pump were less adherent and did not achieve equivalent glycemic benefit compared with continued users; these patients require ongoing support aimed at improving adherence and outcomes...
  14. ncbi Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11
    Yee Ming Chan
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Boston, MA, USA
    Pediatr Diabetes 8:235-8. 2007
    ..Dosing of glyburide three times daily was critical for her successful transition...
  15. ncbi Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus
    Norman K Hollenberg
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 63:172-8. 2003
    ..This constellation is generally attributed to predominant efferent arteriolar dilation...
  16. ncbi The impact of modifiable family factors on glycemic control among youth with type 1 diabetes
    Deborah A Butler
    Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Pediatr Diabetes 9:373-81. 2008
    ..To identify modifiable family factors impacting glycemic control in youth with type 1 diabetes (T1DM) beyond the anticipated physical, developmental, and behavioral issues associated with adolescence...
  17. ncbi Significant vitamin D deficiency in youth with type 1 diabetes mellitus
    Britta M Svoren
    Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Boston, MA 02215, USA
    J Pediatr 154:132-4. 2009
    ..Because individuals with type 1 diabetes mellitus possess multiple risk factors for skeletal fragility, ensuring vitamin D sufficiency throughout childhood and adolescence in this population seems especially warranted...
  18. ncbi Impact of carbohydrate counting on glycemic control in children with type 1 diabetes
    Sanjeev N Mehta
    Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 32:1014-6. 2009
    ..To study the association between parent carbohydrate counting knowledge and glycemic control in youth with type 1 diabetes...
  19. ncbi Depressive symptoms in mothers of infants identified as genetically at risk for type 1 diabetes
    Korey K Hood
    Pediatric and Adolescent Unit, Genetics and Epidemiology Section, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Diabetes Care 28:1898-903. 2005
    ..This study describes maternal depression associated with newborn genetic screening for type 1 diabetes after risk notification...
  20. ncbi Emphasis on carbohydrates may negatively influence dietary patterns in youth with type 1 diabetes
    Sanjeev N Mehta
    Joslin Diabetes Center, Section of Genetics and Epidemiology, Boston, Massachusetts, USA
    Diabetes Care 32:2174-6. 2009
    ..To assess perceptions of healthful eating and the influence of diabetes management on dietary behaviors among youth with type 1 diabetes and parents...
  21. ncbi Updated and revised Diabetes Family Conflict Scale
    Korey K Hood
    Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Care 30:1764-9. 2007
    ..The purpose of this study was to update the Diabetes Family Conflict Scale (DFCS) in the era of intensive diabetes management and provide an indication of its psychometric properties...
  22. ncbi Temporal trends in the treatment of pediatric type 1 diabetes and impact on acute outcomes
    Britta M Svoren
    Pediatric and Adolescent Section, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Pediatr 150:279-85. 2007
    ..To evaluate temporal trends in pediatric type 1 diabetes (T1DM) management and resultant effects on outcomes...
  23. ncbi Reducing acute adverse outcomes in youths with type 1 diabetes: a randomized, controlled trial
    Britta M Svoren
    Pediatric and Adolescent Unit, Behavioral Research and Mental Health Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Pediatrics 112:914-22. 2003
    ..Nonmedical case management incorporating psychoeducational modules seems to be a cost-effective approach to improving outcomes in youths with diabetes...
  24. ncbi Use of a blood glucose monitoring manual to enhance monitoring adherence in adults with diabetes: a randomized controlled trial
    Elaine C Moreland
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Arch Intern Med 166:689-95. 2006
    ..03). CONCLUSION: As an adjunct to standard diabetes education and support, a manual such as the BGMOM can help optimize BG monitoring and glycemic control...
  25. ncbi Brief screening tool for disordered eating in diabetes: internal consistency and external validity in a contemporary sample of pediatric patients with type 1 diabetes
    Jessica T Markowitz
    Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 33:495-500. 2010
    ..Future studies should focus on using the DEPS-R to identify high-risk populations for prevention of and early intervention for disordered eating behaviors...
  26. ncbi von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes
    D Feng
    Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 23:1694-8. 2000
    ..Because von Willebrand factor (vWF) is a marker for endothelial dysfunction and mediates platelet adhesion, we determined if there was an association between vWF and retinal circulation in the early stages of diabetic retinopathy...
  27. ncbi Technology and intensive management in youth with type 1 diabetes: state of the art
    Jamie R Wood
    Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 7:104-13. 2007
    ....
  28. ncbi Younger age at onset of type 1 diabetes in concordant sibling pairs is associated with increased risk for autoimmune thyroid disease
    Gregory Goodwin
    Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Care 29:1397-8. 2006
  29. ncbi A randomized trial comparing continuous subcutaneous insulin infusion of insulin aspart versus insulin lispro in children and adolescents with type 1 diabetes
    Stuart A Weinzimer
    Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Diabetes Care 31:210-5. 2008
    ..The safety and efficacy of insulin aspart continuous subcutaneous insulin infusion (CSII) was compared with that of insulin lispro CSII in children and adolescents with type 1 diabetes...
  30. ncbi Avoiding nocturnal hypoglycemia: consideration of an extra injection at bedtime
    Andrew W Norris
    Ann Intern Med 136:547-9. 2002
  31. ncbi ACE and non-ACE pathways in the renal vascular response to RAS interruption in type 1 diabetes mellitus
    M Cecilia Lansang
    Department of Medicine, University of Florida, Gainesville, Florida 32610 0226, USA
    Kidney Int 67:1033-7. 2005
    ..Our aim was to determine the degree to which the non-ACE pathways contribute to RAS activation in type 1 diabetes mellitus (DM)...
  32. ncbi Parent and youth assessments of a handheld wireless device to enhance diabetes mellitus management
    David A Hanauer
    Arch Pediatr Adolesc Med 160:321. 2006

Research Grants5

  1. Optimizing CGM Use and Metabolic Outcomes in Youth with Type 1 Diabetes
    Lori M Laffel; Fiscal Year: 2010
    ..The current application will evaluate the long-term acceptability and durability of CGM, and assess the metabolic outcomes and behavioral impact of CGM on pediatric patients with T1D and their families. ..
  2. OPTIMIZING ADHERENCE AND GLYCEMIA IN YOUTH WITH NEW IDDM
    Lori Laffel; Fiscal Year: 2001
    ....
  3. Training Grant in Diabetes for Pediatric Endocrinologis*
    Lori Laffel; Fiscal Year: 2006
    ..We have demonstrated the ability to attract highly qualified candidates to our training program and look forward to meeting the challenge of training and developing successful pediatric endocrinologists in diabetes research. ..
  4. Career Development in Diabetes for Pediatric Endocrinolo
    Lori Laffel; Fiscal Year: 2007
    ..abstract_text> ..